Abstract：
:Treatment of typhoid fever with furazolidone produces a high cure rate. This is a clinical curiosity, as furazolidone is described to be poorly absorbed. The present study examined whether furazolidone could produce unequivocal clinical response and, if so whether this was due to the drug producing bactericidal levels in the serum. Twenty one patients selected by defined criteria were treated with furazolidone and evaluated for definite clinical response in 5-7 days. Bactericidal activity of pre dose and post dose sera were estimated in seven patients showing definite clinical response. All the seven patients had a clinical cure without the drug producing significant bactericidal levels in the blood. Hence we concluded that the major site of action of furazolidone was in the intestine. It is our postulate that the organisms reaching the intestine in large numbers from bile are prevented from gaining re-entry into the circulation by the action of furazolidone in the intestine. After repeated cycles of entry of organisms into the intestine from bile and the simultaneous prevention of its re-entry into the circulation, the number of organisms remaining in circulation comes down considerably, thus helping the immune system to bring about a cure.
journal_name
Indian Pediatrjournal_title
Indian pediatricsauthors
Kumar AS,Legori M,Sathy N,Mathew Rsubject
Has Abstractpub_date
1995-05-01 00:00:00pages
533-8issue
5eissn
0019-6061issn
0974-7559journal_volume
32pub_type
临床试验,杂志文章abstract：:We performed a retrospective study of hospital records of children younger than 14 years with ocular trauma seen at our center in Sao Paulo, Brazil, between 2011 and 2012. From the total number of cases, 224 (89.2%) could be easily avoided. Accidents occurred with 5 children under 1 year of age; with one baby as young...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：2020-12-26 00:00:00
abstract：:We report a case of primary hyperparathyroidism associated with prolonged hungry syndrome (HBS) after parathyroid adenomectomy in a 10-year-old girl. Bone mineral density (BMD) revealed severe loss of cancellous BMD. Overt bone disease, high alkaline phosphatase, decreased cancellous BMD and a large adenoma can be use...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：2009-02-01 00:00:00
abstract：OBJECTIVE:To evaluate the frequency of non-autoimmune subclinical and overt hypothyroidism in children with idiopathic steroid-resistant nephrotic syndrome (SRNS). METHODS:This cross-sectional study recruited 30 children (age 1-18 y) with idiopathic SRNS; and 30 healthy controls. Serum T3, T4 and TSH were performed in...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：10.1007/s13312-017-1183-2
更新日期：2017-11-15 00:00:00
abstract：:In this cohort study, neurodevelopmental outcome of 20 of 24 surviving very low birth weight infants with sepsis followed up between 2008 and 2009 was compared with 20 control (uninfected infants). We found that plasma interleukin 6 and C reactive protein values were negatively correlated with mental developmental ind...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：10.1007/s13312-013-0091-3
更新日期：2013-03-01 00:00:00
abstract：:The prevalence of vitamin A deficiency was estimated in 366 rural children in the age group of 1 to 15 years. In a systematically selected subsample of 90 children, the dietary intake of vitamin A was assessed. The prevalence of vitamin A deficiency signs ranged from 24.1 to 34.8%. The adequacy of dietary intake of vi...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：1990-05-01 00:00:00
abstract：OBJECTIVE:To study the clinical profile and outcome of langerhans cell histiocytosis in children upto 2 years of life. DESIGN:Retrospective analysis. METHODS:Medical records of Children upto 2 years of age with a diagnosis of langerhans cell histiocytosis (LCH) were analyzed. Their clinical pattern, treatment modalit...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：1999-01-01 00:00:00
abstract：:Twenty five asphyxiated neonates had ECG changes consistent with degree of asphyxia. Equivocal changes were found in mild asphyxia and changes suggestive of myocardial infarction were seen with severe asphyxia. In most cases, the changes reverted to normal within two weeks signifying great ability of the neonatal hear...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：1990-11-01 00:00:00
abstract：: ...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：2018-12-15 00:00:00
abstract：OBJECTIVE:To assess the utility of computer-aided facial analysis in identifying dysmorphic syndromes in Indian children. METHODS:Fifty-one patients with a definite molecular or cytogenetic diagnosis and recognizable facial dysmorphism were enrolled in the study and their facial photographs were uploaded in the Face2G...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：2019-12-15 00:00:00
abstract：OBJECTIVE:To determine the role of intravenous administration of human albumin prior to blood exchange in term neonates for reduction of total serum bilirubin (TSB). DESIGN:Randomized controlled trial. SETTING:Neonatal Unit of Nemazee Hospital, affiliated with Shiraz University of Medical Sciences, southern Iran. PA...
journal_title：Indian pediatrics
pub_type： 杂志文章,随机对照试验
doi：10.1007/s13312-010-0046-x
更新日期：2010-03-01 00:00:00
abstract：BACKGROUND:Lysinuric protein intolerance is an inherited disorder of transport of cationic amino acids, causing amino aciduria. CASE CHARACTERISTICS:A 3-year-old boy with 12 month history of episodic change in behavior (decreased sleep, poor interaction), stunted growth and hyperammonemia. OUTCOME:Genetic analysis re...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：10.1007/s13312-016-0920-2
更新日期：2016-08-08 00:00:00
abstract：:Fifty two mother-infant pairs were studied. Twenty six of these were delivered by the normal vaginal route (NVD group) and twenty six by Cesarean section (CS group). The NVD babies were roomed in with their mothers soon after birth whereas the CS babies had a mean separation of 2.8 +/- 1.0 days. The mother baby intera...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：1991-01-01 00:00:00
abstract：:Two hundred and forty four girls with different hemoglobin levels were selected, of which forty-one were non-anemic. The rest were graded as mildly, moderately or severely anemic and supplemented with 60 mg of iron daily or twice weekly for twelve weeks. There was no significant difference in the increase in hemoglobi...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：2003-12-01 00:00:00
abstract：:Informed consent is a communication process of providing the patient/parents/guardians with relevant information regarding the treatment and the diagnosis, so that they can make informed decisions. The process of informed consent in pediatric patients is not well understood. The amount of information to be disclosed i...
journal_title：Indian pediatrics
pub_type： 杂志文章,评审
doi：10.1007/s13312-010-0173-4
更新日期：2010-12-01 00:00:00
abstract：OBJECTIVE:To study the incidence and risk factors predisposing to retinopathy of prematurity (ROP) and to assess the outcome after laser photocoagulation. DESIGN:Prospective cohort observational study. SETTING:Infants admitted to a neonatal intensive care unit of a referral hospital between 2000-2006 and followed up ...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：2009-03-01 00:00:00
abstract：:Hypocalcemia is a curable cause of myocardial dysfunction and clinical congestive cardiac failure, with only stray reports available in literature. We describe 15 infants presenting with severe left ventricular dysfunction, who were found to have hypocalcemia with or without hypomagnesemia. Vitamin D deficiency was id...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：10.1007/s13312-010-0117-z
更新日期：2010-09-01 00:00:00
abstract：: ...
journal_title：Indian pediatrics
pub_type： 信件
doi：
更新日期：2019-02-15 00:00:00
abstract：OBJECTIVE:To determine use of early Tc-99m dimercaptosuccinic acid scintigraphy in screening for vesicoureteral reflux following first febrile urinary tract infection. METHODS:43 children (1 mo-5 yr) with first febrile urinary tract infection underwent micturating cystourethrography, abdominal sonogram and early dimer...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：10.1007/s13312-015-0631-0
更新日期：2015-04-01 00:00:00
abstract：BACKGROUND:Improved survival seen in Acute Lymphoblastic Leukemia (ALL) cases has led to increased reports of second malignant neoplasms. CASE CHARACTERISTICS:A 12-year-old female treated for ALL using UK ALL XI protocol nine years back presented with progressively increasing pre-auricular swelling. OBSERVATION:Inves...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：10.1007/s13312-015-0757-0
更新日期：2015-11-01 00:00:00
abstract：OBJECTIVE:To assess the epidemiological and clinical characteristics of pediatric inpatients with COVID-19, early in the pandemic. METHODS:Clinical and laboratory profile and outcomes were studied for children (aged 1 month - 18 years) presenting between 1 April, 2020 and 20 May, 2020 with positive nasopharyngeal swab...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：2020-10-15 00:00:00
abstract：OBJECTIVES:To develop age and gender specific waist circumference references for urban Indian children aged 3 -16 years. DESIGN:Cross-sectional study. SETTING:Urban preschools and schools of Bangalore. PARTICIPANTS:9060 children (5172 boys and 3888 girls) in the age group of 3-16 years. METHODS:Weight, height, and ...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：10.1007/s13312-011-0126-6
更新日期：2011-10-01 00:00:00
abstract：:Participation in research is important in producing doctors with an understanding of evidence-based medicine. Though a mandatory part in post-graduate medical course, research has largely been invisible from the under graduation medical course in India. Very few research opportunities are available at under graduate l...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：10.1007/s13312-017-1104-4
更新日期：2017-05-15 00:00:00
abstract：:A modified technique for umbilical artery catheterization was assessed in babies in whom conventional method failed or if the cord was dry. Success rate attained with the modified technique was 90% (19/21). This modified technique could provide an easier and faster method for successful umbilical arterial catheterizat...
journal_title：Indian pediatrics
pub_type： 信件
doi：10.1007/s13312-014-0477-x
更新日期：2014-08-01 00:00:00
abstract：:Yunis-Varon syndrome is a rare, autosomal recessive syndrome characterized by growth retardation, defective growth of the cranial bones along with complete or partial absence of the clavicles (cleidocranial dysplasia), characteristic facial features, and/or abnormalities of the fingers and/or toes. ...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：2005-04-01 00:00:00
abstract：:The morbidity pattern and nutritional profile was evaluated of school children who resided around Mosaboni Copper Mines and in surrounding villages of Ghatsila subdivision in Singhbhum district of Bihar State, India. A total of 1424 school children (816 boys and 608 girls) between 5-17 years old were studied. Children...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：1989-06-01 00:00:00
abstract：:The phenotypic description of SHORT syndrome (OMIM- 269880) is expanding since its initial description in 1975. There have been 26 case reports till date but the genetic locus of this syndrome is elusive. Involvement of PITX2 gene initially envisaged is probably is not the only gene involved but has an important role ...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：10.1007/s13312-013-0099-8
更新日期：2013-04-01 00:00:00
abstract：:Trichotillomania, though uncommon, is one of the causes of unexplained hair loss, especially in children. Three girls in the age group of 4-6 years were observed in our pediatric dermatology clinic to have trichotillomania. In one child, there was co-existent alopecia areata. All were referred to the child guidance cl...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：2003-01-01 00:00:00
abstract：:We present the case of a 3-month-old girl who was admitted with complaints of loose stools and respiratory distress. She also had a history of rash and alopecia. Laboratory investigations revealed lymphopenia with reduced immunoglobulin G and immunoglobulin A. Lymphocyte subset analysis by flow cytometry revealed T-B+...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：2018-08-15 00:00:00
abstract：:Shwachman-Diamond Syndrome (SDS) is a rare inherited disorder characterized by pancreatic insufficiency, bone marrow dysfunction and skeletal abnormalities. It is the most common cause of pancreatic insufficiency in children after cystic fibrosis. We report a child with classical SDS who presented to us predominantly ...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：10.1007/s13312-012-0138-x
更新日期：2012-09-01 00:00:00
abstract：:The discussion section explains the meaning of results to the readers, and addresses the implications of the findings emanating from the particular study. Authors should compare their results with previous reports, and attempt to explain similarities and differences. It is useful to outline the limitations and strengt...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：10.1007/s13312-016-0955-4
更新日期：2016-10-08 00:00:00
