Furazolidone in typhoid fever--correlation of clinical efficacy with serum bactericidal activity.

Abstract:

:Treatment of typhoid fever with furazolidone produces a high cure rate. This is a clinical curiosity, as furazolidone is described to be poorly absorbed. The present study examined whether furazolidone could produce unequivocal clinical response and, if so whether this was due to the drug producing bactericidal levels in the serum. Twenty one patients selected by defined criteria were treated with furazolidone and evaluated for definite clinical response in 5-7 days. Bactericidal activity of pre dose and post dose sera were estimated in seven patients showing definite clinical response. All the seven patients had a clinical cure without the drug producing significant bactericidal levels in the blood. Hence we concluded that the major site of action of furazolidone was in the intestine. It is our postulate that the organisms reaching the intestine in large numbers from bile are prevented from gaining re-entry into the circulation by the action of furazolidone in the intestine. After repeated cycles of entry of organisms into the intestine from bile and the simultaneous prevention of its re-entry into the circulation, the number of organisms remaining in circulation comes down considerably, thus helping the immune system to bring about a cure.

journal_name

Indian Pediatr

journal_title

Indian pediatrics

authors

Kumar AS,Legori M,Sathy N,Mathew R

subject

Has Abstract

pub_date

1995-05-01 00:00:00

pages

533-8

issue

5

eissn

0019-6061

issn

0974-7559

journal_volume

32

pub_type

临床试验,杂志文章
  • Early dimercaptosuccinic acid renal scan in children with first febrile urinary tract infection.

    abstract:OBJECTIVE:To determine use of early Tc-99m dimercaptosuccinic acid scintigraphy in screening for vesicoureteral reflux following first febrile urinary tract infection. METHODS:43 children (1 mo-5 yr) with first febrile urinary tract infection underwent micturating cystourethrography, abdominal sonogram and early dimer...

    journal_title:Indian pediatrics

    pub_type: 杂志文章

    doi:10.1007/s13312-015-0631-0

    authors: Umamageswari K,Terance BA,Anirudhan N

    更新日期:2015-04-01 00:00:00

  • Diagnosis and Management of Gaucher Disease in India - Consensus Guidelines of the Gaucher Disease Task Force of the Society for Indian Academy of Medical Genetics and the Indian Academy of Pediatrics.

    abstract:JUSTIFICATION:Gaucher disease (GD) is amongst the most frequently occurring lysosomal storage disorder in all ethnicities. The clinical manifestations and natural history of GD is highly heterogeneous with extreme geographic and ethnic variations. The literature on GD has paucity of information and optimal management g...

    journal_title:Indian pediatrics

    pub_type: 杂志文章

    doi:

    authors: Puri RD,Kapoor S,Kishnani PS,Dalal A,Gupta N,Muranjan M,Phadke SR,Sachdeva A,Verma IC,Mistry PK,Gaucher Disease Task Force.

    更新日期:2018-02-15 00:00:00

  • Occupational morbidity among children employed in brassware industry.

    abstract::Fifty seven male children between ages of 10-16 years engaged in the brassware industry at Moradabad in Northern India were studied for occupational morbidity. The finding were compared with those obtained in the children (n = 29) engaged in other ancillary units which did not involve exposure to the metal fumes and d...

    journal_title:Indian pediatrics

    pub_type: 杂志文章

    doi:

    authors: Bihari V,Rastogi SK,Gupta BN,Husain T,Mathur N,Mahendra PN,Srivastava S,Garg N

    更新日期:1992-02-01 00:00:00

  • Three-year experience with neonatal ventilation from a tertiary care hospital in Delhi.

    abstract::Ninety neonates were ventilated over a period of 33 months of whom 50 (55.5%) survived. Fifty seven babies received IPPV while 33 CPAP. IPPV mode was being used more frequently recently and survival rates have steadily improved over past 3 years. Survival was cent per cent in babies above 1.5 kg on CPAP mode while 16/...

    journal_title:Indian pediatrics

    pub_type: 杂志文章

    doi:

    authors: Singh M,Deorari AK,Paul VK,Mittal M,Shanker S,Munshi U,Jain Y

    更新日期:1993-06-01 00:00:00

  • Long-term Outcome of Children with Recurrent Abdominal Pain.

    abstract::We report on long-term follow-up [mean (SD) duration, 44.7 (4.3) mo] of 48 out of 132 children with recurrent abdominal pain, who were a part of an earlier study at our hospital. 31 (64.5%) children still experienced pain; 26 (54.1%) reported their pain to be better than before, 4 children reported it to be same as be...

    journal_title:Indian pediatrics

    pub_type: 信件

    doi:

    authors: Rawlley B,Shah D,Narang M,Pandey M

    更新日期:2020-05-15 00:00:00

  • Biophysical profile of blood pressure in school children.

    abstract::The study was conducted in an industrial and prosperous city of Punjab to evaluate the biophysical profile of blood pressure (BP) in apparently healthy school children. A total of 2560 children between the ages of 5-15 years were enrolled. Their age, religion, dietary and family history were recorded. Weight and heigh...

    journal_title:Indian pediatrics

    pub_type: 杂志文章

    doi:

    authors: Verma M,Chhatwal J,George SM

    更新日期:1995-07-01 00:00:00

  • Epidemiological and Clinical Characteristics of COVID-19 in Indian Children in the Initial Phase of the Pandemic.

    abstract:OBJECTIVE:To assess the epidemiological and clinical characteristics of pediatric inpatients with COVID-19, early in the pandemic. METHODS:Clinical and laboratory profile and outcomes were studied for children (aged 1 month - 18 years) presenting between 1 April, 2020 and 20 May, 2020 with positive nasopharyngeal swab...

    journal_title:Indian pediatrics

    pub_type: 杂志文章

    doi:

    authors: Sarangi B,Reddy VS,Oswal JS,Malshe N,Patil A,Chakraborty M,Lalwani S

    更新日期:2020-10-15 00:00:00

  • Standing up for Science.

    abstract:: ...

    journal_title:Indian pediatrics

    pub_type: 杂志文章

    doi:

    authors: Soans ST

    更新日期:2018-12-15 00:00:00

  • Systemic melioidosis presenting as suppurative parotitis.

    abstract::A 3 year old child was brought with fever, left parotid swelling and altered sensorium. Cultures from blood, pus and throat swab grew Burkholderia pseudomallei. A diagnosis of septicemic melioidosis with encephalopathy was made. She recovered following treatment with parenteral ceftazidime for 14 days, and 6 months of...

    journal_title:Indian pediatrics

    pub_type: 杂志文章

    doi:10.1007/s13312-010-0106-2

    authors: Shivbalan S,Reddy N,Tiru V,Thomas K

    更新日期:2010-09-01 00:00:00

  • Defining the Best Interest of a Child: Who Comes First - The Child or the Fetus?

    abstract::In 2017, a 10-year-old girl, who was allegedly raped and impregnated, was denied an abortion on the basis of the Medical Termination of Pregnancy Act 1971. This perspective re-examines this issue while prioritizing the best interest of the child. We recommend that boards should be constituted at district-level hospita...

    journal_title:Indian pediatrics

    pub_type: 杂志文章

    doi:

    authors: Dalwai SH,Soans ST

    更新日期:2018-10-15 00:00:00

  • Neonatal behavior in full-term small for date.

    abstract::Fifty newborns, 25 full term SFDs (small for date) and 25 full term AGAs (appropriate for gestational age) were taken up for comparative study of their behavior using BNBAS (Brazelton's neonatal behavior assessment scale). The study revealed that full term SFDs performed significantly poorly on all items under cluster...

    journal_title:Indian pediatrics

    pub_type: 杂志文章

    doi:

    authors: Abrol P,Kapoor R,Gathwala G,Tiwari S,Tiwari AD

    更新日期:1994-07-01 00:00:00

  • White matter changes in GM1 gangliosidosis.

    abstract:BACKGROUND:GM1 gangliosidosis is a disorder due to GLB1 gene mutation. CASE CHARACTERISTICS:A 4-yr-old boy with neuroregression and optic atrophy with periventricular hyperintensity on magnetic resonance imaging. OUTCOME:Beta galactosidase enzyme activity was low which was confirmed by GLB1 sequencing. MESSAGE:We hi...

    journal_title:Indian pediatrics

    pub_type: 杂志文章

    doi:10.1007/s13312-015-0593-2

    authors: Tuteja M,Bidchol AM,Girisha KM,Phadke S

    更新日期:2015-02-01 00:00:00

  • Maternal weight, height and risk of poor pregnancy outcome in Ahmedabad, India.

    abstract::This paper explores the relationships between maternal weight, height and poor pregnancy outcome using a data set from a case-control study of low birth weight (LBW) and perinatal mortality in Ahmedabad, India. Maternal height and weights were compared between mothers of 611 perinatal deaths, 644 preterm-LBW, and 1465...

    journal_title:Indian pediatrics

    pub_type: 杂志文章,多中心研究

    doi:

    authors: Mavalankar DV,Trivedi CC,Gray RH

    更新日期:1994-10-01 00:00:00

  • Serum neutrophil gelatinase-associated lipocalin as a marker of acute kidney injury in asphyxiated neonates.

    abstract:OBJECTIVE:To determine the clinical utility of serum neutrophil gelatinase-associated lipocalin (NGAL) as an early marker of acute kidney injury in asphyxiated neonates with hypoxic ischemic encephalopathy (HIE). DESIGN:Cohort study. SETTINGS:National Intensive Care Unit of Maternity Hospital, Ain Shams University, C...

    journal_title:Indian pediatrics

    pub_type: 杂志文章

    doi:10.1007/s13312-013-0153-6

    authors: Raggal NE,Khafagy SM,Mahmoud NH,Beltagy SE

    更新日期:2013-05-08 00:00:00

  • Time required to document temperature by electronic skin thermometer in a healthy neonate.

    abstract::We studied the actual time taken to document temperature in a stable neonate by an electronic digital skin thermometer with automatic time beeper. We studied 100 neonates after initial stabilization. The mean time required for documenting the temperature by a electronic thermometer in axilla was 56.34+/-1.54 secs for ...

    journal_title:Indian pediatrics

    pub_type: 信件

    doi:

    authors: Roy AS,Chowdhury T,Bandhopadhya D,Ghosh G

    更新日期:2009-12-01 00:00:00

  • Resuscitation of asphyxiated newborns with room air or 100% oxygen at birth: a multicentric clinical trial.

    abstract:OBJECTIVE:To compare the short-term efficacy of room air versus 100% oxygen for resuscitation of asphyxic newborns at birth. DESIGN:Multicentric quasi randomized controlled trial. SETTING:Teaching hospitals. INCLUSION CRITERIA:Asphyxiated babies weighing greater than 1000 grams, with heart rate less than 100 per min...

    journal_title:Indian pediatrics

    pub_type: 临床试验,杂志文章,多中心研究

    doi:

    authors: Ramji S,Rasaily R,Mishra PK,Narang A,Jayam S,Kapoor AN,Kambo I,Mathur A,Saxena BN

    更新日期:2003-06-01 00:00:00

  • Isosporiasis in children.

    abstract::The clinical, laboratory and therapeutic data of patients with diarrhea in Human immunodeficiency virus (HIV) antibody positive, immunocompromised and immunocompetent individuals were studied especially to look for prevalence of intestinal coccidiosis. During a study period of one decade, Isospora belli were identifie...

    journal_title:Indian pediatrics

    pub_type: 杂志文章

    doi:

    authors: Mirdha BR,Kabra SK,Samantray JC

    更新日期:2002-10-01 00:00:00

  • Effect of oil massage on growth and neurobehavior in very low birth weight preterm neonates.

    abstract:OBJECTIVE:To study the effect of oil massage on growth and neurobehavior in preterm babies less than 1500 g. DESIGN:Randomized Controlled Trial. SETTING:Tertiary level neonatal unit of a teaching hospital. SUBJECTS:Neonates with birth weight <1500 grams, gestation >37 weeks, receiving enteral feeds of at least 100 m...

    journal_title:Indian pediatrics

    pub_type: 杂志文章,随机对照试验

    doi:

    authors: Arora J,Kumar A,Ramji S

    更新日期:2005-11-01 00:00:00

  • B-type Natriuretic peptide Levels and Outcome in Children With Severe Acute Malnutrition With Co-morbidity.

    abstract::We studied the ability of B-type natriuretic peptide (BNP) in predicting mortality among 86 in-patients with severe acute malnutrition presenting with co-morbidity, and found that cut-off level of BNP ≥201 pg/mL in Receiver operating characteristics curve [AU-ROC 0.96 (95% CI 0.92,1.003, P<0.0001)] had high discrimina...

    journal_title:Indian pediatrics

    pub_type: 信件

    doi:

    authors: Kumar D,Rao SK

    更新日期:2020-04-15 00:00:00

  • Flexible Fiberoptic Bronchoscopy Directed Interventions in Neonatal Intensive Care Unit.

    abstract:OBJECTIVE:To describe the utility of flexible fiberoptic bronchoscopy for the diagnosis and management in the neonatal ICU. METHODS:A retrospective, medical chart review was conducted in neonates who underwent flexible fiberoptic bronchoscopy over a period of 7 years. Besides demographic data and diagnostic findings, ...

    journal_title:Indian pediatrics

    pub_type: 杂志文章

    doi:

    authors: Sachdev A,Chhawchharia R,Gupta D,Gupta N

    更新日期:2019-07-15 00:00:00

  • Transfusion related acute lung injury in a child with leukemia.

    abstract::Transfusion-related acute lung injury is a rare form of acute respiratory distress syndrome of possible immune etiology that develops immediately after a blood product transfusion. Clinicians need to be aware of this condition as prompt recognition and supportive management can prevent unwanted morbidity and mortality...

    journal_title:Indian pediatrics

    pub_type: 杂志文章

    doi:

    authors: Radhakrishnan V,Coshic P,Bakhshi S

    更新日期:2012-02-01 00:00:00

  • Effect of Delayed Cord Clamping on Hematocrit, and Thermal and Hemodynamic Stability in Preterm Neonates: A Randomized Controlled Trial.

    abstract:OBJECTIVE:To evaluate the short term clinical effects of delayed cord clamping in preterm neonates. DESIGN:Randomized controlled trial. SETTING:A tertiary care neonatal unit from October 2013 to September 2014. PARTICIPANTS:78 mothers with preterm labor between 27 to 316/7 weeks gestation. INTERVENTION:Early cord c...

    journal_title:Indian pediatrics

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s13312-017-1011-8

    authors: Dipak NK,Nanavat RN,Kabra NK,Srinivasan A,Ananthan A

    更新日期:2017-02-15 00:00:00

  • Guillain-Barre syndrome following dengue fever.

    abstract::Guillain-Barre syndrome is a post infectious polyradiculoneuropathy. It is equally prevalent in both the adult and the pediatric populations. Guillain-Barre syndrome following dengue fever is not a classically described entity and has not been reported in children. ...

    journal_title:Indian pediatrics

    pub_type: 杂志文章

    doi:

    authors: Sulekha C,Kumar S,Philip J

    更新日期:2004-09-01 00:00:00

  • Biliary atresia and cytomegalovirus and response to valganciclovir.

    abstract::Biliary atresia has been commonly reported with cytomegalovirus (CMV) infection. CMV positive patients may present with a later onset however long term outcome is similar to non-CMV patients. There are very few case reports of role of antivirals in CMV and biliary atresia. We treated a 2 month old girl with biliary at...

    journal_title:Indian pediatrics

    pub_type: 杂志文章

    doi:10.1007/s13312-012-0092-7

    authors: Shah I,Bhatnagar S

    更新日期:2012-06-01 00:00:00

  • Optimum age of a child for BCG vaccination.

    abstract::The objectives of this study were to evaluate whether a newborn or a neonate is capable of responding immunologically after BCG vaccination and to find out if this immunity persists for one year. Normal infants aged between 0 days-3 months brought to immunization centre were included in the study. In vitro leukocyte m...

    journal_title:Indian pediatrics

    pub_type: 杂志文章

    doi:

    authors: Vijayalakshmi V,Kumar S,Kiran AL,Rani HS,Murthy KJ

    更新日期:1994-12-01 00:00:00

  • Molecular Testing of MECP2 Gene in Rett Syndrome Phenotypes in Indian Girls.

    abstract:OBJECTIVE:To assess yield of MECP2 gene sequence variations analysis and large deletions in suspected cases of Rett syndrome. DESIGN:Descriptive study. SETTING:Tertiary-care medical genetics center. PATIENTS:Girls with neuroregression, postnatal microcephaly and signs and symptoms suggestive of classical and atypica...

    journal_title:Indian pediatrics

    pub_type: 杂志文章

    doi:

    authors: Lallar M,Rai A,Srivastava P,Mandal K,Gupta N,Kabra M,Phadke SR

    更新日期:2018-06-15 00:00:00

  • Prevalence of Non-Exclusive Breastfeeding and Associated Out-of-Pocket Expenditure on Feeding and Treatment of Morbidity Among Infants Aged 0-6 Months in an Urban Slum.

    abstract:OBJECTIVE:To estimate the prevalence of non-exclusive breastfeeding (NEBF) and quantify the out-of-pocket expenditure (OOPE) associated with NEBF and treatment of morbidity among infants up to six months of age. METHODS:Community based in an urban slum, among 172 mother-infant dyads selected by systematic random sampl...

    journal_title:Indian pediatrics

    pub_type: 杂志文章

    doi:

    authors: Kumar A,Khan AM,Saini NK,Shah D

    更新日期:2020-12-15 00:00:00

  • Computer-aided Facial Analysis in Diagnosing Dysmorphic Syndromes in Indian Children.

    abstract:OBJECTIVE:To assess the utility of computer-aided facial analysis in identifying dysmorphic syndromes in Indian children. METHODS:Fifty-one patients with a definite molecular or cytogenetic diagnosis and recognizable facial dysmorphism were enrolled in the study and their facial photographs were uploaded in the Face2G...

    journal_title:Indian pediatrics

    pub_type: 杂志文章

    doi:

    authors: Narayanan DL,Ranganath P,Aggarwal S,Dalal A,Phadke SR,Mandal K

    更新日期:2019-12-15 00:00:00

  • Mucoepidermoid Carcinoma of Parotid as a Second Malignancy in Acute Lymphoblastic Leukemia.

    abstract:BACKGROUND:Improved survival seen in Acute Lymphoblastic Leukemia (ALL) cases has led to increased reports of second malignant neoplasms. CASE CHARACTERISTICS:A 12-year-old female treated for ALL using UK ALL XI protocol nine years back presented with progressively increasing pre-auricular swelling. OBSERVATION:Inves...

    journal_title:Indian pediatrics

    pub_type: 杂志文章

    doi:10.1007/s13312-015-0757-0

    authors: Tikku G,Jain D,Kumari A,Grover R

    更新日期:2015-11-01 00:00:00

  • Nasal foreign body presenting as unilateral headache.

    abstract::We report a 6 year old female child, who presented with history of right sided recurrent headache for four months. On diagnostic nasal endoscopy, a metallic foreign body was seen impacted between superior turbinate, middle turbinate and nasal septum which was removed using pediatric nasal endoscope. Following removal,...

    journal_title:Indian pediatrics

    pub_type: 杂志文章

    doi:

    authors: Jain A,Shah M,Jain S

    更新日期:2011-08-01 00:00:00