Thalamotomy and caudatotomy with the Gamma Knife as a treatment for parkinsonism with a comment on lesion sizes.


:Radiosurgery with the Gamma Knife was performed in 12 patients with parkinsonism. In 9 patients small lesions were created in the head of the caudate nucleus bilaterally. Two patients underwent radiosurgical thalamotomy, and 1 patient was treated with caudatotomy and thalamotomy. After a follow-up period of 1-12 months, 9 patients of the caudatotomy group and all patients with thalamotomies showed clear benefit. There was no complication or side effect that could be related to the treatment. Pre- and postoperative testing was performed with the Unified Parkinson Rating Scale and with objective motor tasks. Caudatotomy proved to be an effective treatment for bradykinesia and rigidity, while tremor was ameliorated by thalamotomy. Functional neurosurgery with the Gamma Knife would seem to be a good alternative to open procedures with low morbidity and no mortality. Advantages and drawbacks of radiosurgical techniques for the treatment of parkinsonism are discussed.


Friehs GM,Ojakangas CL,Pachatz P,Schröttner O,Ott E,Pendl G




Has Abstract


1995-01-01 00:00:00








64 Suppl 1


  • A noncontacting 3-D digitizer for use in image-guided neurosurgery.

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    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章


    authors: Sun H,Farid H,Roberts DW,Rick K,Hartov A,Paulsen KD

    更新日期:2003-01-01 00:00:00

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    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章,评审


    authors: Rzesnitzek L,Hariz M,Krauss JK

    更新日期:2019-01-01 00:00:00

  • Fractionated stereotactic radiotherapy for intracranial neoplasms.

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    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章


    authors: Olivier A,Sadikot AF,Villemure JG,Pokrupa R,Souhami L,Podgorsak EB,Hazel J

    更新日期:1992-01-01 00:00:00

  • Optimization of cranial resections.

    abstract::Soon after its development, CT imaging, which provided direct visualization of neural structures, was used for stereotactic guidance. There has been progressive expansion of stereotactic methodology for image guided surgical intervention through minimally invasive corridors. Today, the development of high resolution M...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章


    authors: Heilbrun MP

    更新日期:2001-01-01 00:00:00

  • Gamma Knife radiosurgery in cerebral arteriovenous malformations: postobliteration nidus changes observed on neurodiagnostic imaging.

    abstract::Computed tomographic (CT), magnetic resonance (MR), MR angiographic and angiographic images, obtained after complete nidus obliteration had been angiographically confirmed, were reviewed in 9 patients who had undergone Gamma Knife treatment for cerebral arteriovenous malformations (AVMs). The period between angiograph...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章


    authors: Yamamoto M,Jimbo M,Ide M,Lindquist C,Steiner L

    更新日期:1995-01-01 00:00:00

  • Gamma Knife Radiosurgery for Metastatic Brain Tumors from Malignant Melanomas: A Japanese Multi-Institutional Cooperative and Retrospective Cohort Study (JLGK1501).

    abstract:BACKGROUND:The incidences of metastatic brain tumors from malignant melanomas have increased and survival has been prolonged by novel molecular targeted agents and immunotherapy. However, malignant melanomas are uncommon in Asian populations. OBJECTIVES:We retrospectively analyzed treatment efficacy and identified pro...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章


    authors: Matsunaga S,Shuto T,Yamamoto M,Yomo S,Kondoh T,Kobayashi T,Sato M,Okamoto H,Serizawa T,Nagano O,Kenai H,Obara T,Iwai Y,Yasuda S,Hasegawa T,Kubo K,Shidoh S,Mori K,Hayashi M,Inoue A,Onoue S,Gondo M

    更新日期:2018-01-01 00:00:00

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    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章


    authors: Mathieu D,Kondziolka D,Niranjan A,Flickinger J,Lunsford LD

    更新日期:2006-01-01 00:00:00

  • Effects of bilateral deep brain stimulation of the subthalamic nucleus on olfactory function in Parkinson's disease patients.

    abstract:OBJECTIVE:The goal of the present study was to evaluate the effects of bilateral deep brain stimulation (DBS) of the subthalamic nucleus (STN) on olfaction in patients with Parkinson's disease (PD). METHODS:15 patients suffering from sporadic PD-related dysosmia were implanted with bilateral electrodes aimed at the ST...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章


    authors: Guo X,Gao G,Wang X,Li L,Li W,Liang Q,Zhang H

    更新日期:2008-01-01 00:00:00

  • The effect of bilateral globus pallidus internus deep brain stimulation plus ventralis oralis thalamotomy on patients with cerebral palsy.

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    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章


    authors: Kim JP,Chang WS,Cho SR,Chang JW

    更新日期:2012-01-01 00:00:00

  • Using Preimplanted Deep Brain Stimulation Electrodes for Rescue Thalamotomy in a Case of Holmes Tremor: A Case Report and Review of the Literature.

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    journal_title:Stereotactic and functional neurosurgery



    authors: Razmkon A,Yousefi O,Vaidyanathan J

    更新日期:2020-01-01 00:00:00

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    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章


    authors: Neudorfer C,Hunsche S,Hellmich M,El Majdoub F,Maarouf M

    更新日期:2018-01-01 00:00:00

  • MRI-guided stereotactic thalamotomy for cerebral palsy patients with mixed dyskinesia.

    abstract::The author has performed 108 stereotactic thalamotomies using MRI (MGSTs) without ventriculography in 77 cerebral palsy (CP) patients with dyskinesia(s) from January 1992 to January 1997. The clinical results were verified in terms of improvement of major preoperative symptom and patient's (or relative's) satisfaction...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章


    authors: Lee KH

    更新日期:1997-01-01 00:00:00

  • Remarks upon the term stereotaxy: a linguistic and historical note.

    abstract::The correct explanation of the term 'stereotaxy' is linguistically not self-evident because the Greek term stereon means not spatial but 'hard' or 'solid'. The aim of our study was to clarify the term stereotaxy historically and linguistically. We carried out our study by reviewing the neurosurgical and ancient Greek ...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 历史文章,杂志文章


    authors: Grunert P Sr,Keiner D,Oertel J

    更新日期:2015-01-01 00:00:00

  • Neuropsychological outcome following pallidotomy and thalamotomy for Parkinson's disease.

    abstract::Cognitive and emotional outcomes were assessed after unilateral posteroventral pallidotomy (PVP) and ventral intermediate nucleus thalamotomy (Vim-Th) in patients suffering from idiopathic Parkinson's disease (PD). PVP was performed on 12 PD patients (8 men and 4 women, mean age 56.4 years, 6 left lesions and 6 right ...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章


    authors: Fukuda M,Kameyama S,Yoshino M,Tanaka R,Narabayashi H

    更新日期:2000-01-01 00:00:00

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    abstract::The authors present a series of 47 patients with craniopharyngiomas treated by stereotaxy in the past 15 years. There was no mortality nor immediate postoperative morbidity in the treatment of the cystic portion of the neoplasm. Intracavitary colloidal yttrium (90Y) was extremely effective in obtaining long-lasting di...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章


    authors: Frank F,Fabrizi AP,Frank G,Fioravanti A

    更新日期:1995-01-01 00:00:00

  • Image guidance: the Foundation for the Future Design of Neurosurgical Procedural Facilities.

    abstract::Today's image guidance systems are the foundation of minimally invasive diagnosis and therapy and are the basis for the rational design of the neurosurgical operating room of the future. The building blocks of this procedural arena will be (1) high-resolution MR/CT anatomic imaging supplemented with (2) functional ima...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章,评审


    authors: Heilbrun P

    更新日期:1999-01-01 00:00:00

  • Comparison of radiosurgery planning modalities for acoustic neuroma with regard to conformity and mean target dose.

    abstract:PURPOSE:To evaluate dose conformity and mean target dose in light of previous comparative studies and state-of-the-art radiosurgery delivery modalities. MATERIALS AND METHODS:Seven patients with acoustic neuromas deemed clinically suitable for linear accelerator or Gamma Knife radiosurgery were planned such that the m...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章


    authors: Perks JR,El-Hamri K,Blackburn TP,Plowman PN

    更新日期:2005-01-01 00:00:00

  • Bilateral subthalamic deep brain stimulation for camptocormia associated with Parkinson's disease.

    abstract:BACKGROUND:Few multiple case studies of the effects of deep brain stimulation for camptocormia associated with Parkinson's disease have been reported. Although deep brain stimulation was in some cases not effective against camptocormia, it is unclear in which types of patients it was effective in treating camptocormia....

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章


    authors: Asahi T,Taguchi Y,Hayashi N,Hamada H,Dougu N,Takashima S,Tanaka K,Endo S

    更新日期:2011-01-01 00:00:00

  • Gamma knife stereotactic radiosurgical boost for patients treated primarily with neutron radiotherapy for salivary gland neoplasms.

    abstract:OBJECT:To determine the feasibility of utilizing a Gamma Knife stereotactic boost for patients at high risk of local recurrence from minor salivary gland tumors invading the base of skull. METHODS:Eight patients with minor salivary gland tumors invading the base of skull were treated with primary neutron radiotherapy ...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章


    authors: Douglas JG,Silbergeld DL,Laramore GE

    更新日期:2004-01-01 00:00:00

  • Late local and remote structural changes after capsulotomy for obsessive compulsive disorder.

    abstract::Stereotactic subcaudate capsulotomy (SC) is used to treat medically intractable obsessive compulsive disorders (OCD). Although clinical improvement has been observed, post-SC structural correlates are lacking in this biological disorder. Our study provides imaging evidence for local and distant alterations in structur...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章


    authors: Taren JA,Curtis GC,Gebarski SS

    更新日期:1994-01-01 00:00:00

  • Transplantation of adrenal medullary tissue to caudate nucleus using stereotactic techniques.

    abstract::Stereotactic techniques were used to transplant adrenal medullary tissue to the head of the right caudate nucleus in 12 patients with Parkinson's disease. No significant lasting complications were seen. All patients had an initial improvement. 11 of the 12 patients remain improved over their preoperative condition aft...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章


    authors: Gildenberg PL,Pettigrew LC,Merrell R,Butler I,Conklin R,Katz J,DeFrance J

    更新日期:1990-01-01 00:00:00

  • Perfusion MRI as a neurosurgical tool for improved targeting in stereotactic tumor biopsies.

    abstract:OBJECTIVE:Stereotactic biopsies are subject to sampling errors (essentially due to target selection). The presence of contrast enhancement is not a reliable marker of malignancy. The goal of the present study was to determine whether perfusion-weighted imaging can improve target selection in stereotactic biopsies. MET...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章


    authors: Lefranc M,Monet P,Desenclos C,Peltier J,Fichten A,Toussaint P,Sevestre H,Deramond H,Le Gars D

    更新日期:2012-01-01 00:00:00

  • Multiple target deep brain stimulation for multiple sclerosis related and poststroke Holmes' tremor.

    abstract:BACKGROUND:The results from thalamic deep brain stimulation (DBS) for atypical tremor syndromes including tremor from multiple sclerosis (MS) and stroke are often disappointing. Three recent case reports have suggested that simultaneous stimulation of multiple thalamic targets can result in sustained improvement in suc...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章


    authors: Lim DA,Khandhar SM,Heath S,Ostrem JL,Ringel N,Starr P

    更新日期:2007-01-01 00:00:00

  • Topographic analysis of the gyral patterns of the central area.

    abstract::Great advances in imaging technology allows the surgeon to visualize the entire brain surface during surgery. However, the cerebral convolutions are extremely complex, so that it is often difficult to define the central area precisely. Using the curvilinear reconstruction technique (Gyroview) and MRI, we have analyzed...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章


    authors: Lee U,Bastos AC,Alonso-Vanegas MA,Morris R,Olivier A

    更新日期:1998-01-01 00:00:00

  • Subthalamic nucleus stimulation does not cause deterioration of preexisting hallucinations in Parkinson's disease patients.

    abstract:BACKGROUND:Among the neuropsychiatric symptoms in Parkinson's disease (PD) patients, hallucination can result from the disease itself or medical treatment. Hallucination associated with subthalamic nucleus stimulation (STN-DBS) has been reported; however, it is still unclear whether PD patients with a history of halluc...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章


    authors: Yoshida F,Miyagi Y,Kishimoto J,Morioka T,Murakami N,Hashiguchi K,Samura K,Sakae N,Yamasaki R,Kawaguchi M,Sasaki T

    更新日期:2009-01-01 00:00:00

  • Gamma knife radiosurgery for growth hormone-secreting pituitary adenomas invading the cavernous sinus.

    abstract::The authors assessed whether gamma knife radiosurgery is effective for patients with acromegaly where the pituitary tumors invaded the cavernous sinus. Radiosurgery was performed on 9 patients (average of 20 Gy to the tumor margin), 8 of whom had already undergone transsphenoidal surgery and/or craniotomy with occasio...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章


    authors: Fukuoka S,Ito T,Takanashi M,Hojo A,Nakamura H

    更新日期:2001-01-01 00:00:00

  • Acute and Subacute Presentations of Cerebral Edema following Deep Brain Stimulation Lead Implantation.

    abstract:BACKGROUND/AIMS:Postoperative cerebral edema around a deep brain stimulation (DBS) electrode is an uncommon reported complication. The goal of this study was to identify instances of postoperative edema based on clinical presentation, and to remark on their management. METHODS:A retrospective chart review was performe...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章


    authors: Fenoy AJ,Villarreal SJ,Schiess MC

    更新日期:2017-01-01 00:00:00

  • Functional recovery after combined cerebral and cerebellar hemispherectomy in the rat.

    abstract::The cerebellum seems to be one of the structures responsible for early neurological improvement after cerebral hemispherectomy and its consequent deficits. Considered as an accessory brain, the cerebellum may constitute a neurobiological substrate for the recovery of such extensive cortical and subcortical lesions. It...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章


    authors: Marino R Jr,Machado AG,Timo-Iaria C

    更新日期:2001-01-01 00:00:00

  • Bilateral pallidal stimulation for cervical dystonia. An optimal paradigm from our experiences.

    abstract::We sought to identify optimal paradigms of bilateral globus pallidus internus (GPi) stimulation in 3 subsequent patients with severe cervical dystonia. At low frequency stimulation (50-60 Hz) with wide pulse width (500 micros) and high amplitude (4.5-8.0 V), we observed immediate and consistent improvement of dystonia...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 临床试验,杂志文章


    authors: Goto S,Mita S,Ushio Y

    更新日期:2002-01-01 00:00:00

  • Behavioral changes in 6-hydroxydopamine-treated rotation rats after delivery of various neuromodifying agents by means of a stereotactically implanted pellet to the brain.

    abstract::Small pellets loaded with apomorphine, thyrotropin-releasing hormone, and bromocriptine were implanted into the right striatum of 6-hydroxydopamine-treated rotation rats, and the efficacy of this drug delivery system was examined. Pellets containing neuromodifying agents, when implanted into the brain, may be just as ...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章


    authors: Yoshida M,Torigoe R,Ohtsuru K,Kuramoto S

    更新日期:1990-01-01 00:00:00