Abstract:
:Five children with multiple relapsing steroid-dependent nephrotic syndrome were treated with continuous cyclosporin for periods ranging from 18 to 48 months. Renal biopsy showed mild mesangial proliferation in three of the children and minimal change in two. All children previously had been treated with cyclophosphamide. Cyclosporin was started during remission at 5 mg/kg per day. If a relapse occurred the dose was increased until a trough blood level of 100-250 ng/mL (HPLC) was achieved. In the initial 12 months of treatment, the mean number of relapses decreased from 6.4 +/- 0.54 (s.d.) per annum to 1.6 +/- 1.3 per annum (P < 0.01). Cyclosporin was effective in maintaining long-term remission in four of the five patients. Side effects included hypertrichosis (5) and gum hyperplasia (1). The mean creatinine clearance decreased from 126 +/- 16 to 97 +/- 22 mL/min per 1.73 m2 (P = NS). A renal biopsy in all five patients after 12 months therapy showed no nephrotoxicity. A further biopsy in one patient after 4 years therapy showed interstitial fibrosis. Cyclosporin should be considered in children with steroid-dependent nephrotic syndrome who show signs of steroid toxicity and have only a short remission period after cyclophosphamide. Serial renal biopsies are recommended if prolonged therapy is used.
journal_name
J Paediatr Child Healthjournal_title
Journal of paediatrics and child healthauthors
Webb KL,Sargent P,Burke JRdoi
10.1111/j.1440-1754.1993.tb00484.xsubject
Has Abstractpub_date
1993-06-01 00:00:00pages
188-91issue
3eissn
1034-4810issn
1440-1754journal_volume
29pub_type
杂志文章abstract::Within a 3-month period, two infants presented non-specifically to hospital and rapidly progressed developing flaccid paralysis. Both children were diagnosed with infant botulism. We briefly review these two cases and discuss the diagnostic and management issues involved with this rare childhood disease. ...
journal_title:Journal of paediatrics and child health
pub_type: 杂志文章,评审
doi:10.1111/jpc.12121
更新日期:2013-03-01 00:00:00
abstract::A 16 year old girl with an established diagnosis of tuberous sclerosis presented with a 1 year history of swelling of the left cheek. A 2 cm diameter tumour was excised which showed histological features of a solid variant of a minor salivary gland basal cell adenoma. One year later during laparotomy and excision of m...
journal_title:Journal of paediatrics and child health
pub_type: 杂志文章,评审
doi:10.1111/j.1440-1754.1991.tb00365.x
更新日期:1991-04-01 00:00:00
abstract:AIM:This study aims to determine factors impacting the parental burden in immunoglobulin E (IgE)-mediated food-allergic children (FAC), focusing on attitudes towards adrenaline autoinjectors (AAIs). METHODS:Questionnaires were sent to parents of diagnosed IgE-mediated FAC attending follow-up allergy clinic appointment...
journal_title:Journal of paediatrics and child health
pub_type: 杂志文章
doi:10.1111/jpc.12794
更新日期:2015-07-01 00:00:00
abstract:AIM:To describe the changes in the health and well-being of secondary school students from 2001 to 2007. METHODS:A total of 9107 secondary school students were randomly selected to participate in a comprehensive health and well-being survey using Internet tablets conducted in 2007. Comparisons are made with the first ...
journal_title:Journal of paediatrics and child health
pub_type: 杂志文章
doi:10.1111/j.1440-1754.2010.01945.x
更新日期:2011-04-01 00:00:00
abstract:AIM:To review the use of antifungal chemoprophylaxis to prevent neonatal invasive fungal infections (IFI) in very low birthweight infants (VLBW <1500 g). METHOD:Systematic review of randomised controlled trials. RESULTS:Nine trials were identified (2029 infants), with six comparing fluconazole with placebo/no treatme...
journal_title:Journal of paediatrics and child health
pub_type: 杂志文章,meta分析,评审
doi:10.1111/j.1440-1754.2012.02543.x
更新日期:2012-09-01 00:00:00
abstract::Circumcision has been the traditional treatment for phimosis, but now is not the only management option, the best of which appears to be topical steroid application. Importantly, the literature suggests that phimosis probably is over-diagnosed, indicating that a prospective, randomized controlled study is needed to co...
journal_title:Journal of paediatrics and child health
pub_type: 杂志文章,评审
doi:10.1111/j.1440-1754.1996.tb02554.x
更新日期:1996-08-01 00:00:00
abstract::The lysosomal storage disorders are a collection of progressive, multisystem disorders that frequently present in childhood. Their timely diagnosis is paramount as they are becoming increasingly treatable. Musculoskeletal manifestations often occur early in the disease course, hence are useful as diagnostics clues. No...
journal_title:Journal of paediatrics and child health
pub_type: 杂志文章,评审
doi:10.1111/jpc.13122
更新日期:2016-03-01 00:00:00
abstract::This report describes a patient with neonatal lupus erythematosus (NLE) in whom there was multisystem involvement including neonatal hepatitis. The hepatitis, defined pathologically as a giant cell hepatitis, presented with severe cholestasis, was unrelated to other known causes of neonatal hepatitis and resolved spon...
journal_title:Journal of paediatrics and child health
pub_type: 杂志文章
doi:10.1111/j.1440-1754.1993.tb03026.x
更新日期:1993-12-01 00:00:00
abstract:AIM:To report infant care practice prevalence for known modifiable sudden infant death syndrome (SIDS) risk factors among a generally disadvantaged yet low-SIDS rate population of mothers with Pacific infants. METHODS:The Pacific Islands Families study follows a cohort of Pacific infants born at a large tertiary hospi...
journal_title:Journal of paediatrics and child health
pub_type: 杂志文章
doi:10.1111/j.1440-1754.2007.01085.x
更新日期:2007-05-01 00:00:00
abstract:OBJECTIVE:To discuss treatment modalities for subglottic haemangioma (SGH). METHODOLOGY:Case report of two children definitively managed by different modalities. RESULTS:Management by CO2 laser vaporization in one child, and laser followed by interferon 2-alpha in the second child were both successful in controlling ...
journal_title:Journal of paediatrics and child health
pub_type: 杂志文章
doi:
更新日期:1999-08-01 00:00:00
abstract::We describe three infants born to mothers with poorly controlled Graves' disease, who developed transient central hypothyroidism in the immediate postnatal period. Suppression of the fetal pituitary-thyroid axis may be due to placental transfer of thyroxine from the hyperthyroid mother. This may persist for months pos...
journal_title:Journal of paediatrics and child health
pub_type: 杂志文章
doi:10.1046/j.1440-1754.2002.00741.x
更新日期:2002-04-01 00:00:00
abstract:AIM:To determine whether home-use icterometry improves parental recognition of neonatal jaundice, early care seeking and treatment to minimize risks of bilirubin encephalopathy. METHODS:Cluster-randomised controlled trial of community-level icterometry used at home by mothers in Chi Linh, Vietnam. Rural health-care wo...
journal_title:Journal of paediatrics and child health
pub_type: 杂志文章,随机对照试验
doi:10.1111/jpc.12611
更新日期:2014-09-01 00:00:00
abstract:AIM:This research investigated the mental health of mothers of school-aged children with disabilities in Victoria, Australia. METHODS:A mixed method triangulation design model was used to investigate the mental health of mothers (n= 152) of school-aged children with developmental disabilities. Self-reported medical hi...
journal_title:Journal of paediatrics and child health
pub_type: 杂志文章
doi:10.1111/j.1440-1754.2011.02060.x
更新日期:2012-02-01 00:00:00
abstract:AIM:Footprints have long been used as proxy measures of foot morphology, yet there is little consensus regarding footprints versus measures of foot posture, which address foot anatomy directly. Foot posture in children can be a confusing clinical presentation, with previous studies both supporting and refuting the rela...
journal_title:Journal of paediatrics and child health
pub_type: 杂志文章
doi:10.1111/jpc.14558
更新日期:2020-02-01 00:00:00
abstract:BACKGROUND:There is evidence that the rapid rise in Streptococcus pneumoniae (SP) antimicrobial resistance seen in other countries may have commenced in Australia. Streptococcus pneumoniae carriage and resistance levels are described for urban Northern Territory children in day care. METHODS:A prospective cohort study...
journal_title:Journal of paediatrics and child health
pub_type: 杂志文章
doi:10.1046/j.1440-1754.1999.355400.x
更新日期:1999-10-01 00:00:00
abstract:AIM:In adult medicine, rates of investigation and prescribing appear to be increasing. Such information is lacking for paediatrics. We audited Australian paediatricians' practices in 2013 to determine changes since 2008 in: (i) conditions seen; (ii) consultation duration; (iii) imaging and pathology ordered; and (iv) p...
journal_title:Journal of paediatrics and child health
pub_type: 杂志文章
doi:10.1111/jpc.13280
更新日期:2017-01-01 00:00:00
abstract::The aim of this study was to call the attention to the often disregarded message that hypertransaminasemia may be a marker of both liver and muscle diseases by presenting personal case reports and a systematic literature review. Three male children (mean age 5.7 years) were inappropriately addressed, during the last 1...
journal_title:Journal of paediatrics and child health
pub_type: 杂志文章,评审
doi:10.1111/j.1440-1754.2010.01730.x
更新日期:2012-10-01 00:00:00
abstract::Between April 1989 and October 1991, 13 severely ill infants, median age 13 days (range 1-180 days), median weight 3.5 kg (range 2.5-4.8 kg), received continuous venovenous haemofiltration (CVVH) for a median duration of 39 h (range 5-234 h). Filtration was performed through a double lumen catheter inserted into a cen...
journal_title:Journal of paediatrics and child health
pub_type: 杂志文章
doi:10.1111/j.1440-1754.1994.tb00566.x
更新日期:1994-02-01 00:00:00
abstract:OBJECTIVE:To examine how changes in the rates of sudden infant death syndrome (SIDS) have varied in different income groups during a 25 year period. METHODOLOGY:Census data were obtained for five census periods (1971, 1976, 1981, 1986 and 1991) on the number of SIDS cases and inevitable deaths. Census area units (CAU)...
journal_title:Journal of paediatrics and child health
pub_type: 杂志文章
doi:10.1111/j.1440-1754.1995.tb00848.x
更新日期:1995-10-01 00:00:00
abstract::The aim of this study was to determine whether the severity of symptoms associated with rotavirus infection was related to the serotype of the infecting virus. Severity of clinical symptoms in 108 children admitted to hospital for treatment of rotavirus diarrhoea was retrospectively assessed using a scoring system for...
journal_title:Journal of paediatrics and child health
pub_type: 杂志文章
doi:10.1111/j.1440-1754.1992.tb02618.x
更新日期:1992-02-01 00:00:00
abstract::The efficacy of Ketotifen was examined in the treatment of 113 infants between 6 and 36 months of age presenting with a history of cough and/or wheeze in a multicentre randomized placebo-controlled double-blind study. A 4 week no-medication baseline phase preceded the 16 week treatment phase in which infants took 2.5 ...
journal_title:Journal of paediatrics and child health
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1111/j.1440-1754.1992.tb02714.x
更新日期:1992-12-01 00:00:00
abstract::Routine childhood immunizations are compulsory in a small number of countries, including the United States of America. Arguments used to justify making immunizations compulsory include enhancing the health of the community and treating as paramount the rights of the child to be protected against vaccine-preventable di...
journal_title:Journal of paediatrics and child health
pub_type: 历史文章,杂志文章
doi:10.1111/j.1440-1754.2004.00399.x
更新日期:2004-07-01 00:00:00
abstract::Inhaled steroid therapy is one of the mainstays of treatment of asthma in children. Side effects, including suppression of the hypothalamic-pituitary-adrenal (HPA) axis, have been noted with high doses of inhaled steroids. Most studies concerning side effects have been done with mechanical nebulization devices or hand...
journal_title:Journal of paediatrics and child health
pub_type: 杂志文章
doi:10.1111/j.1440-1754.1991.tb00398.x
更新日期:1991-08-01 00:00:00
abstract::There is ever-increasing pressure on hospital resources in general and emergency departments (ED) in particular. At the same time, there is increasing recognition that traditional inpatient ward-based care is not necessary for the majority of children presenting to the ED with acute illness, and that there are patient...
journal_title:Journal of paediatrics and child health
pub_type: 杂志文章,评审
doi:10.1111/jpc.13100
更新日期:2016-02-01 00:00:00
abstract::Clinical audits should underpin everything we do as clinicians - to constantly evaluate and improve our day-to-day clinical practice. Errors in practice, suboptimal practice or inefficiencies can occur in any part of our health-care system, despite the training and best intentions of health-care professionals. Audits ...
journal_title:Journal of paediatrics and child health
pub_type: 杂志文章
doi:10.1111/jpc.15068
更新日期:2020-10-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to evaluate bone mineral density (BMD) in epileptic children receiving valproic acid (VPA) and to determine differences between osteopenic and non-osteopenic children. METHODS:Thirty-three epileptic children, receiving VPA for at least 6 months, were compared with 33 healthy childre...
journal_title:Journal of paediatrics and child health
pub_type: 临床试验,杂志文章
doi:10.1111/j.1440-1754.2004.00431.x
更新日期:2004-08-01 00:00:00
abstract:OBJECTIVES:Although enormous effort has been focused over the past two decades on examining the potential adverse effects of exposure to environmental lead on human health, there has been a debate over the persistence and dynamic pattern of these effects. METHODOLOGY:Articles relevant to this issue which were publishe...
journal_title:Journal of paediatrics and child health
pub_type: 杂志文章,评审
doi:10.1046/j.1440-1754.1998.00187.x
更新日期:1998-04-01 00:00:00
abstract:OBJECTIVE:To examine the risk of death for bed-sharing infants. METHODOLOGY:All unexpected infant deaths occurring in South Australia between 1970 and 1997, occurring after the infant was put to rest and diagnosed by after death scene investigation and autopsy as sudden death infant syndrome, accidental death, or 'und...
journal_title:Journal of paediatrics and child health
pub_type: 杂志文章
doi:10.1046/j.1440-1754.2000.00548.x
更新日期:2000-12-01 00:00:00
abstract::A study was conducted on 447 healthy high school students of southern Chinese descent to determine the prevalence of anaemia and thalassaemia. Haematological data and serum ferritin levels were determined on all venous blood samples. Haemoglobin (Hb) electrophoretic study was conducted on 43 students who had anaemia (...
journal_title:Journal of paediatrics and child health
pub_type: 杂志文章
doi:10.1111/j.1440-1754.1990.tb02448.x
更新日期:1990-12-01 00:00:00
abstract:AIM:Adenoidal hypertrophy (AH) in children is associated with obstructive manifestations like mouth breathing, snoring. Unfortunately, little is known regarding sleep architecture of AH in children. The purpose of this study was therefore undertaken to investigate the polysomnographic variables in children with AH. ME...
journal_title:Journal of paediatrics and child health
pub_type: 杂志文章
doi:10.1111/j.1440-1754.2006.00939.x
更新日期:2006-10-01 00:00:00