Stimulatory action of cycloheximide on glucose metabolism in the rat epididymal fat pad.

abstract：:Loss of function of Niemann-Pick C1 (NPC1) leads to lysosomal free cholesterol storage, resulting in the neurodegenerative disease Niemann-Pick disease type C (NPC). Significant numbers of patients with NPC also suffer from liver disease. Currently, no treatments exist that alter patient outcome, and it is unknown if ...

journal_title：Journal of lipid research

authors： Sayre NL,Rimkunas VM,Graham MJ,Crooke RM,Liscum L

更新日期：2010-08-01 00:00:00

abstract：:Leukotrienes (LTs) play major roles in lung immune responses, and LTD4 is the most potent agonist for cysteinyl LT1, leading to bronchoconstriction and tissue remodeling. Here, we studied LT crosstalk between myeloid cells and pulmonary epithelial cells. Monocytic cells (Mono Mac 6 cell line, primary dendritic cells) ...

journal_title：Journal of lipid research

authors： Lukic A,Ji J,Idborg H,Samuelsson B,Palmberg L,Gabrielsson S,Rådmark O

更新日期：2016-09-01 00:00:00

abstract：:The phospholipase A2(PLA2) activity of peroxiredoxin (Prdx)6 has important physiological roles in the synthesis of lung surfactant and in the repair of peroxidized cell membranes. These functions require the activity of a lysophospholipid acyl transferase as a critical component of the phospholipid remodeling pathway....

journal_title：Journal of lipid research

authors： Fisher AB,Dodia C,Sorokina EM,Li H,Zhou S,Raabe T,Feinstein SI

更新日期：2016-04-01 00:00:00

abstract：:Hyperlipoproteinemia contributes both to kidney disease progression and the development of atherosclerosis. Elevated high density lipoprotein cholesterol and apolipoprotein A-I (apoA-I) serum levels are independent factors protective against the atherosclerotic process. We examined the effects in a transgenic rat mode...

journal_title：Journal of lipid research

authors： Burkey BF,France D,Wang H,Ma X,Brand B,Abuhani C,Diffenderfer MR,Marsh JB,Paterniti JR Jr,Fisher EA

更新日期：1995-07-01 00:00:00

abstract：:The chromatographic behavior of 1,2-, 1,3-, 1,4-, and 1,12-long-chain alkane diols and 1-O-alkylglycerols and their derivatives has been compared. Thin-layer chromatography on Silica Gel G gives poor separations of the 1,2-, 1,3-, and 1,4-alkane diols, O-alkylglycerols, and some of their isopropylidene derivatives. Ho...

journal_title：Journal of lipid research

authors： Blank ML,Cress EA,Stephens N,Snyder F

更新日期：1971-09-01 00:00:00

abstract：:The enzymic incorporation of choline-1,2-(14)C from CDP-choline-1,2-(14)C into phosphatidylcholine by spinach leaf preparations was characterized. The enzyme catalyzing the incorporation, choline phosphotransferase, had a pH optimum of about 8.0 and required either Mn(2+) or Mg(2+) as cofactor. The saturation concentr...

journal_title：Journal of lipid research

authors： Devor KA,Mudd JB

更新日期：1971-07-01 00:00:00

abstract：:Paraoxonases (PONs) are a small family of antioxidant enzymes whose antiatherogenic activity is well known. The aim of the present study was the evaluation of the effects of moderate aerobic training on their expression using a rat model. In order to discriminate between PON1 and PON3 enzymatic activity, we took advan...

journal_title：Journal of lipid research

authors： Romani R,De Medio GE,di Tullio S,Lapalombella R,Pirisinu I,Margonato V,Veicsteinas A,Marini M,Rosi G

更新日期：2009-10-01 00:00:00

abstract：:The secondary bile acid lithocholic acid (LCA) and its derivatives act as selective modulators of the vitamin D receptor (VDR), although their structures fundamentally differ from that of the natural hormone 1α,25-dihydroxyvitamin D3 [1,25(OH)2D3)]. Here, we have determined the crystal structures of the ligand-binding...

journal_title：Journal of lipid research

authors： Masuno H,Ikura T,Morizono D,Orita I,Yamada S,Shimizu M,Ito N

更新日期：2013-08-01 00:00:00

abstract：:Ketone bodies (KBs), acetoacetate and β-hydroxybutyrate (βHB), were considered harmful metabolic by-products when discovered in the mid-19th century in the urine of patients with diabetic ketoacidosis. It took physicians many years to realize that KBs are normal metabolites synthesized by the liver and exported into t...

journal_title：Journal of lipid research

authors： Hashim SA,VanItallie TB

更新日期：2014-09-01 00:00:00

abstract：:Cyanidin-3-O-β-glucoside (C3G) (CAS number 7084-24-4), a typical anthocyanin pigment that exists in the human diet, has been reported to have anti-inflammatory properties. However, the effect of C3G on lipopolysaccharide (LPS)-induced mastitis and the molecular mechanisms have not been investigated. In this study, we ...

journal_title：Journal of lipid research

authors： Fu Y,Wei Z,Zhou E,Zhang N,Yang Z

更新日期：2014-06-01 00:00:00

abstract：:Serum paraoxonase (PON1) is a HDL-associated enzyme exhibiting potentially antiatherogenic properties. Here, we examined the common PON1-192R/Q human polymorphism. Despite numerous studies, the effect of this polymorphism on the antiatherogenic potential of PON1 is yet unresolved. Our structural model suggests that am...

journal_title：Journal of lipid research

authors： Gaidukov L,Rosenblat M,Aviram M,Tawfik DS

更新日期：2006-11-01 00:00:00

abstract：:The beta-oxidation of stearic acid and of alpha- and gamma-methyl isoprenoid-derived fatty acids (pristanic and tetramethylheptadecanoic acids, respectively) was investigated in normal skin fibroblasts and in fibroblasts from patients with inherited defects in peroxisomal biogenesis. Stearic acid beta-oxidation by nor...

journal_title：Journal of lipid research

authors： Singh H,Usher S,Johnson D,Poulos A

更新日期：1990-02-01 00:00:00

abstract：:A subgroup of peroxisomal disorders, peroxisome biogenesis defects (PBD), can be differentiated by elevated levels of C(27) bile acids in plasma and bile. Patients with peroxisomal disorders, who lack the ability to chain-shorten the C(27) bile acid intermediates into C(24) bile acids, show elevated levels of C(27) bi...

journal_title：Journal of lipid research

authors： Johnson DW,ten Brink HJ,Schuit RC,Jakobs C

更新日期：2001-01-01 00:00:00

abstract：:Retinoic acid (RA), the active metabolite of vitamin A, is required for spermatogenesis and many other biological processes. RA formation requires irreversible oxidation of retinal to RA by aldehyde dehydrogenase enzymes of the 1A family (ALDH1A). While ALDH1A1, ALDH1A2, and ALDH1A3 all form RA, the expression pattern...

journal_title：Journal of lipid research

authors： Arnold SL,Kent T,Hogarth CA,Schlatt S,Prasad B,Haenisch M,Walsh T,Muller CH,Griswold MD,Amory JK,Isoherranen N

更新日期：2015-02-01 00:00:00

abstract：:Rab GTPases require special machinery for protein prenylation, which include Rab escort protein (REP) and Rab geranylgeranyl transferase (RGGT). The current model of Rab geranylgeranylation proposes that REP binds Rab and presents it to RGGT. After geranylgeranylation of Rab C-terminal cysteines, REP delivers the pren...

journal_title：Journal of lipid research

authors： Leung KF,Baron R,Seabra MC

更新日期：2006-03-01 00:00:00

abstract：:Groups of gerbils were fed purified diets containing either 10 or 20% of safflower, olive, or coconut oil. Each diet was fed without cholesterol and with 0.1 and 0.2% of added cholesterol. The animals were bled after 2, 4, and 8 wk for the determination of the level of serum cholesterol. The major factors affecting th...

journal_title：Journal of lipid research

authors： Hegsted DM,Gallagher A

更新日期：1967-05-01 00:00:00

abstract：:Serine palmitoyltransferase [EC 2.3.1.50] catalyzes the first unique reaction of sphingolipid biosynthesis. To determine whether or not different rat tissues are capable of initiating this pathway, its activity was determined for microsomes from rat liver, lung, brain, kidney, intestine, spleen, muscle, heart, pancrea...

journal_title：Journal of lipid research

authors： Merrill AH Jr,Nixon DW,Williams RD

更新日期：1985-05-01 00:00:00

abstract：:The cellular mechanisms responsible for the lipoprotein-mediated stimulation of bile acid synthesis in cultured rat hepatocytes were investigated. Adding 280 micrograms/ml of cholesterol in the form of human or rat low density lipoprotein (LDL) to the culture medium increased bile acid synthesis by 1.8- and 1.6-fold, ...

journal_title：Journal of lipid research

authors： Junker LH,Davis RA

更新日期：1989-12-01 00:00:00

abstract：:Mitochondrial sterol 27-hydroxylase (EC 1.14.13.15) is an important enzyme, not only in the formation of bile acids from cholesterol intermediates in the liver but also in the removal of cholesterol by side chain hydroxylation in extrahepatic tissues. The enzyme has been assayed by complicated methods using radiolabel...

journal_title：Journal of lipid research

authors： Ota Y,Eto TA,Tanaka S,Sueta H,Shiotsuki H,Maeda Y,Une M,Chijiiwa K

更新日期：2003-12-01 00:00:00

abstract：:Chronic inflammation contributes to cardiovascular disease. Increased levels of the inflammatory cytokine, TNF-α, are often present in conditions associated with cardiovascular disease risk, and TNF-α induces a number of pro-atherogenic effects in macrovascular endothelial cells, including expression of adhesion molec...

journal_title：Journal of lipid research

authors： Jung HS,Shimizu-Albergine M,Shen X,Kramer F,Shao D,Vivekanandan-Giri A,Pennathur S,Tian R,Kanter JE,Bornfeldt KE

更新日期：2020-01-01 00:00:00

abstract：:Conventional ideas concerning the unidirectional movement of triacylglycerol from intestinal lumen to lymph with sn-2-monoacylglycerol being the major glyceride-glycerol precursor were challenged by our finding that steady state specific activities of radiolabeled triacylglycerol (glyceryl moiety) in the intestinal mu...

journal_title：Journal of lipid research

authors： Mansbach CM 2nd,Parthasarathy S

更新日期：1982-09-01 00:00:00

abstract：:The rate of peroxidation of unconjugated bilirubin (UCB), catalyzed by horseradish peroxidase (HRP), has been employed by Jacobsen (1969. FEBS Lett. 5: 112-114) to assess the fraction of unbound UCB in the presence of serum albumin. We used this method to examine the interactions of UCB with taurocholate (TC) at pH 8....

journal_title：Journal of lipid research

authors： Rege RV,Webster CC,Ostrow JD

更新日期：1987-06-01 00:00:00

abstract：:The group IVA calcium-dependent cytosolic phospholipase A2 (cPLA2α) enzyme directs a complex "eicosanoid storm" that accompanies the tissue response to injury. cPLA2α and its downstream eicosanoid mediators are also implicated in the pathogenesis of fibrosis in many organs, including the kidney. We aimed to determine ...

journal_title：Journal of lipid research

authors： Montford JR,Lehman AMB,Bauer CD,Klawitter J,Klawitter J,Poczobutt JM,Scobey M,Weiser-Evans M,Nemenoff RA,Furgeson SB

更新日期：2018-02-01 00:00:00

abstract：:Scavenger receptor class B type I (SR-BI) mediates the selective uptake of HDL cholesteryl esters (CEs) and facilitates the efflux of unesterified cholesterol. SR-BI expression in macrophages presumably plays a role in atherosclerosis. The role of SR-BI for selective CE uptake and cholesterol efflux in macrophages was...

journal_title：Journal of lipid research

authors： Brundert M,Heeren J,Bahar-Bayansar M,Ewert A,Moore KJ,Rinninger F

更新日期：2006-11-01 00:00:00

abstract：:The acylation of glycerol-3-phosphate by acyl-CoA is regarded as the first committed step for the synthesis of the lipoidal moiety in glycerolipids. The direct acylation of glycerol in mammalian tissues has not been demonstrated. In this study, lipid biosynthesis in myoblasts and hepatocytes was reassessed by conducti...

journal_title：Journal of lipid research

authors： Lee DP,Deonarine AS,Kienetz M,Zhu Q,Skrzypczak M,Chan M,Choy PC

更新日期：2001-12-01 00:00:00

abstract：:Hydroxy-3-methyl-glutaryl-CoA reductase (HMGR) is the rate-controlling enzyme of cholesterol synthesis, and owing to its biological and pharmacological relevance, researchers have investigated several compounds capable of modulating its activity with the hope of developing new hypocholesterolemic drugs. In particular,...

journal_title：Journal of lipid research

authors： Cuccioloni M,Mozzicafreddo M,Spina M,Tran CN,Falconi M,Eleuteri AM,Angeletti M

更新日期：2011-05-01 00:00:00

abstract：:Lipoproteins internalized by the LDL receptor (LDLR) are released from this receptor in endosomes through a process that involves acid-dependent conformational changes in the receptor ectodomain. How acidic pH promotes this release process is not well understood. Here, we assessed roles for six histidine residues for ...

journal_title：Journal of lipid research

authors： Dong H,Zhao Z,LeBrun DG,Michaely P

更新日期：2017-02-01 00:00:00

abstract：:The transport of LDL-derived cholesterol from lysosomes to peroxisomes is facilitated by membrane contacts formed between the lysosomal protein synaptotagmin VII and the peroxisomal lipid phosphatidylinositol 4, 5-bisphosphate [PI(4,5)P2]. Here, we used RNA interference to search for regulators of PI(4,5)P2 and to stu...

journal_title：Journal of lipid research

authors： Hu A,Zhao XT,Tu H,Xiao T,Fu T,Wang Y,Liu Y,Shi XJ,Luo J,Song BL

更新日期：2018-03-01 00:00:00

abstract：:Conditions leading to oxidation of LDL in vivo are still unknown. While the occurrence of oxidized lipoproteins and catalytic free iron in advanced atherosclerotic lesions has been demonstrated, the origin of both is unclear. In vivo, iron metabolism is tightly regulated by iron-binding proteins that ensure that virtu...

journal_title：Journal of lipid research

authors： Balagopalakrishna C,Paka L,Pillarisetti S,Goldberg IJ

更新日期：1999-07-01 00:00:00

abstract：:Reduced white adipose tissue (WAT) LPL activity delays plasma clearance of TG-rich lipoproteins (TRLs). We reported the secretion of apoC-I, an LPL inhibitor, from WAT ex vivo in women. Therefore we hypothesized that WAT-secreted apoC-I associates with reduced WAT LPL activity and TRL clearance. WAT apoC-I secretion a...

journal_title：Journal of lipid research

authors： Cyr Y,Wassef H,Bissonnette S,Lamantia V,Davignon J,Faraj M

更新日期：2016-06-01 00:00:00