Abstract:
OBJECTIVE:This study was done to determine the feasibility and potential utility of whole-body PET using the glucose analogue 2-[18F]fluoro-2-deoxy-D-glucose (FDG) for the detection of primary malignancies and metastatic lesions. MATERIALS AND METHODS:This was a prospective, nonrandomized study of whole-body FDG-PET imaging carried out at a large university teaching hospital in Los Angeles, CA, U.S.A. The study group consisted of all patients referred for PET imaging (87) with a suspected diagnosis of primary or recurrent malignancy and who had eventual histological confirmation of their lesions. RESULTS:In the 87 patients, whole-body PET studies were positive (presence of focal FDG uptake relative to surrounding tissues uptake) in 61 of 70 patients (87%) with subsequent biopsy-confirmed primary or recurrent malignant lesions, including carcinomas of breast, lung, ovary, prostate, colon, urinary bladder, and gallbladder origin, as well as malignant melanoma, carcinoid, osteosarcoma, lymphoma, and spinal cord astrocytoma. The PET images revealed no focal hypermetabolism at the known site of tumor in patients with primary prostate carcinoma (two), microscopic ovarian carcinoma (two), breast carcinoma (one), low-grade carcinoid tumors (two), and one patient with recurrent microscopic osteogenic sarcoma. The PET studies detected the primary lesion in 15 of 17 patients with breast carcinoma and in 6 of 6 patients with primary lung carcinoma. Of the 17 patients with benign biopsies, 13 patients had FDG-PET studies without focal areas of uptake. CONCLUSION:Because of the high glycolytic rate of malignant tissue, the whole-body FDG-PET technique has promise in the detection of a wide variety of both primary and metastatic malignancies. The presence of FDG uptake in benign inflammatory conditions may limit the specificity of the technique. The sensitivity for the detection of malignant lesions was 87% and the positive predictive value was 94%. The whole-body FDG-PET method is promising both in determining the nature of a localized lesion and in defining the systemic extent of malignant disease.
journal_name
J Comput Assist Tomogrjournal_title
Journal of computer assisted tomographyauthors
Hoh CK,Hawkins RA,Glaspy JA,Dahlbom M,Tse NY,Hoffman EJ,Schiepers C,Choi Y,Rege S,Nitzsche Edoi
10.1097/00004728-199307000-00012subject
Has Abstract,Author List Incompletepub_date
1993-07-01 00:00:00pages
582-9issue
4eissn
0363-8715issn
1532-3145journal_volume
17pub_type
杂志文章abstract::The use of magnetic resonance (MR) to preoperatively evaluate patients with primary hyperparathyroidism was assessed using a 1.5 T system and surface coil reception. Twenty-five patients with primary hyperparathyroidism were studied before surgical exploration. Axial images, 5 mm thick, were obtained from the thyroid ...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-198709000-00023
更新日期:1987-09-01 00:00:00
abstract::This is a preliminary investigation of the cerebrospinal fluid (CSF) spaces using cardiac gated magnetic resonance imaging. A variation of intensity of the signal from the cerebral aqueduct is demonstrated during the cardiac cycle. The pattern of this variation suggests pulsatile CSF flow. Calculations that have been ...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-198511000-00001
更新日期:1985-11-01 00:00:00
abstract::The preoperative temporal bone CT scans of 13 patients with surgically proven acquired cholesteatoma were retrospectively reviewed for bony erosions and for extension beyond the temporal bone. A correlation with the clinical and surgical findings was also carried out. The CT findings are discussed and illustrated as w...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-198505000-00021
更新日期:1985-05-01 00:00:00
abstract::In children it is often necessary to ligate the splenic artery and the main collateral supply to the spleen during liver transplantation. The complication of splenic infarction has been observed on postoperative CT in such patients. The purpose of our study was to determine the incidence and CT appearance of splenic i...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-199005000-00007
更新日期:1990-05-01 00:00:00
abstract::In a consecutive group of 1,067 noncholecystectomized patients referred for computed tomography including the upper abdomen, gallstones were seen in 13%. In 4% of the patients with gallstones, gas-containing calculi were found. On reviewing the conventional plain films such stones were revealed in less than one-half o...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-198310000-00009
更新日期:1983-10-01 00:00:00
abstract:OBJECTIVE:To evaluate the distal extent and attenuation of bowel opacification achieved after administration of a single low volume dose of oral contrast 2 hours before computed tomographic colonography (CTC) after incomplete optical colonoscopy. METHODS:This retrospective study included 144 patients undergoing CTC af...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章,多中心研究
doi:10.1097/RCT.0b013e3181f5a610
更新日期:2011-01-01 00:00:00
abstract::Computed tomography circumvents many of the problems encountered in the traditional radiographic investigation of mummies. This case report demonstrates that CT provides an improved evaluation of mummification techniques and bony pathology as well as a better capability of characterizing preserved soft tissue. ...
journal_title:Journal of computer assisted tomography
pub_type: 历史文章,杂志文章
doi:
更新日期:1984-10-01 00:00:00
abstract::Hepatocellular carcinoma and cholangiocarcinoma are the most common primary liver malignancies in adults (comprising >85%); however, liver is also host to some unusual primary malignant tumors. Some of these tumors show distinct demographic, clinicopathologic, and imaging features. Imaging features of these uncommon p...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章,评审
doi:10.1097/RCT.0000000000000382
更新日期:2016-05-01 00:00:00
abstract::Neutrons and X-rays are mathematically equivalent as probes in computed tomography. However, structure in the energy dependence of neutron total cross sections and the feasibility of using time-of-flight techniques for energy sensitivity in neutron detection suggest that spatial distributions of specific substances ca...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-198302000-00021
更新日期:1983-02-01 00:00:00
abstract:OBJECTIVE:The aims of this study were to describe the computed tomographic features of organizing pneumonia (OP) in an oncologic patient population and to also identify features associated with lung cancer and patients undergoing hematopoietic stem cell transplant (HSCT). METHODS:In retrospective computed tomographies...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/RCT.0000000000000520
更新日期:2017-05-01 00:00:00
abstract:OBJECTIVE:Among the various organs that may be affected by hereditary hemorrhagic telangiectasia (HHT), the liver can show various degrees of vascular and parenchymal involvement. The purpose of this prospective study comprising a large series of patients was to reassess the computed tomography (CT) features of hepatic...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-200407000-00009
更新日期:2004-07-01 00:00:00
abstract::Fast MR techniques and the application of water-soluble contrast agents allow the simultaneous examination of renal morphology and the functional aspects of glomerular filtration using bolus injections of Gd-DTPA. Spatial resolution is sufficient to resolve individual renal pyramids, but the quantitative examination o...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-199109000-00002
更新日期:1991-09-01 00:00:00
abstract::Pick's disease is a rare cause of dementia. It often shows a characteristic pattern of atrophy affecting primarily the anterior portions of the frontal and temporal lobes. This pattern, as shown by computed tomography, may suggest the diagnosis. ...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-197902000-00021
更新日期:1979-02-01 00:00:00
abstract::Several inconstant skull base foramina can be observed on multi-detector-row computed tomographic studies. These include the meningo-orbital foramen, foramen of Vesalius, canaliculus innominatus, palatovaginal canal, persistent craniopharyngeal canal, transsphenoidal canal, canalis basilaris medianus, and fossa navicu...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/RCT.0b013e318289b370
更新日期:2013-07-01 00:00:00
abstract:OBJECTIVE:Our goal was to assess the accuracy of estimating the time course of the arterial plasma concentration of meglumine iothalamate from cranial CT images of different vascular structures in the brain. MATERIALS AND METHODS:Dynamic CT studies of transcapillary transport in various brain lesions were analyzed. Va...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-199405000-00005
更新日期:1994-05-01 00:00:00
abstract::The magnetic resonance (MR) cine display of flexion and extension (F/E) manoeuvres in the cervical spine has proved useful in the evaluation of cord compression due to bone and joint instability, spondylosis, and multiple tumours. It has advantages over X-ray F/E and CT myelography in that it is noninvasive and produc...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-198811000-00008
更新日期:1988-11-01 00:00:00
abstract::Previous reports of magnetic resonance imaging of the prostate have described a homogeneous appearance to the normal prostate gland. The T2-weighted images of the normal prostate obtained at higher field strength (1.5 T) reveal an inhomogeneous appearance of the normal gland, with apparent differentiation of normal pr...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-198611000-00017
更新日期:1986-11-01 00:00:00
abstract:OBJECTIVES:This article describes magnetic resonance imaging (MRI) findings in 3 cases of atypical polypoid adenomyoma (APAM). METHODS:Clinical and MRI manifestations of 3 patients with APAM were evaluated. High b value diffusion-weighted and dynamic contrast-enhanced images were performed. The size, shape, site of or...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/RCT.0000000000000169
更新日期:2015-01-01 00:00:00
abstract:PURPOSE:The purpose of this study was to clarify characteristics of combined hepatocellular and cholangiocarcinoma (HCC-CC) on CT and clinicopathological examinations. METHODS:Dynamic incremental CT was performed on 15 combined HCC-CC patients. CT of the early phase was started at 30 s and of the late phase at 120-140...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-199701000-00011
更新日期:1997-01-01 00:00:00
abstract::A technique is described that permits the 19F nuclear magnetic resonance (NMR) imaging of the vascular system in animals that have been infused with certain perfluorocarbon blood substitutes. The essence of the technique is the selection for imaging of a narrow group of spectral lines from the fluorocarbon using a com...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-198511000-00003
更新日期:1985-11-01 00:00:00
abstract:OBJECTIVE:Dynamic MRI was used to analyze patterns of contrast enhancement in muscle layers in the normal uterine body and to evaluate the depth of myometrial invasion by endometrial carcinoma. MATERIALS AND METHODS:Dynamic MRI was performed in 18 normal volunteers and 22 patients with endometrial carcinoma. Eight of ...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-199401000-00017
更新日期:1994-01-01 00:00:00
abstract::Congenital hyperinsulinism can be divided into diffuse or focal form. The treatment and outcome depend on distinguishing between the 2 forms. Pancreatic venous sampling was the only method available to localize the insulin secretion. [F]Fluoro-levodopa, 3,4-dihydroxy-L-phenylalanine positron emission tomography/comput...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/RCT.0b013e318031f55c
更新日期:2007-09-01 00:00:00
abstract::The following report describes the computed tomographic (CT) features of oncocytic papillary renal cell carcinoma (OPRCC), a new subtype. An experienced genitourinary pathologist identified each tumor as type 1 or 2, oncocytic, or other. Two radiologists independently reviewed CT images and assessed maximal tumor diam...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/RCT.0b013e3181d1dde8
更新日期:2010-05-01 00:00:00
abstract::The extent of pathologic processes involving the mesentery is frequently difficult to assess by clinical examination and standard radiography. Contrast studies of the gastrointestinal tract only identify the effect of these processes on adjacent opacified bowel loops and frequently underestimate the extent of mesenter...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-198601000-00014
更新日期:1986-01-01 00:00:00
abstract::We review our preliminary experience with the use of three-dimensional (3D) time-of-flight (TOF) magnetic resonance (MR) angiography (MRA) in the assessment of intra- and extracranial aneurysms. Six patients were examined: Five had intracranial aneurysms and one had a cervical carotid pseudoaneurysm. A 3D rephased gra...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-199011000-00002
更新日期:1990-11-01 00:00:00
abstract::A whole-body, multislice positron emission tomograph, Positologica III, has been constructed based on a sampling method "positology." The scanner consists of four continuously rotating detector rings with 192 bismuth germanate (BGO) crystals (12 X 24 X 24 mm) arranged at irregular intervals along each ring, providing ...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-198509000-00018
更新日期:1985-09-01 00:00:00
abstract:OBJECTIVES:This study aimed to assess if dual-energy computed tomography (DECT) quantitative analysis and radiomics can differentiate normal liver, hepatic steatosis, and cirrhosis. MATERIALS AND METHODS:Our retrospective study included 75 adult patients (mean age, 54 ± 16 years) who underwent contrast-enhanced, dual-...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/RCT.0000000000000989
更新日期:2020-03-01 00:00:00
abstract::This is the fourth of a series of 4 white papers that represent expert consensus documents developed by the Society of Computed Body Tomography and Magnetic Resonance through its task force on dual-energy computed tomography. This article, part 4, discusses DECT for abdominal and pelvic applications and, at the end of...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/RCT.0000000000000546
更新日期:2017-01-01 00:00:00
abstract::This report describes the imaging findings of the first reported case of a bronchobiliary fistula that developed as a complication of liver transplantation. The diagnosis was confirmed by the aspiration of bile from the bronchus. ...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/01.rct.0000131583.52386.cf
更新日期:2004-09-01 00:00:00
abstract:PURPOSE:Quantitative measurement of change in brain size and shape (e.g., to estimate atrophy) is an important current area of research. New methods of change analysis attempt to improve robustness, accuracy, and extent of automation. A fully automated method has been developed that achieves high estimation accuracy. ...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-200105000-00022
更新日期:2001-05-01 00:00:00