Can Dual-Energy Computed Tomography Quantitative Analysis and Radiomics Differentiate Normal Liver From Hepatic Steatosis and Cirrhosis?

Abstract:

OBJECTIVES:This study aimed to assess if dual-energy computed tomography (DECT) quantitative analysis and radiomics can differentiate normal liver, hepatic steatosis, and cirrhosis. MATERIALS AND METHODS:Our retrospective study included 75 adult patients (mean age, 54 ± 16 years) who underwent contrast-enhanced, dual-source DECT of the abdomen. We used Dual-Energy Tumor Analysis prototype for semiautomatic liver segmentation and DECT and radiomic features. The data were analyzed with multiple logistic regression and random forest classifier to determine area under the curve (AUC). RESULTS:Iodine quantification (AUC, 0.95) and radiomic features (AUC, 0.97) differentiate between healthy and abnormal liver. Combined fat ratio percent and mean mixed CT values (AUC, 0.99) were the strongest differentiators of healthy and steatotic liver. The most accurate differentiating parameters of normal liver and cirrhosis were a combination of first-order statistics (90th percentile), gray-level run length matrix (short-run low gray-level emphasis), and gray-level size zone matrix (gray-level nonuniformity normalized; AUC, 0.99). CONCLUSION:Dual-energy computed tomography iodine quantification and radiomics accurately differentiate normal liver from steatosis and cirrhosis from single-section analyses.

journal_name

J Comput Assist Tomogr

authors

Doda Khera R,Homayounieh F,Lades F,Schmidt B,Sedlmair M,Primak A,Saini S,Kalra MK

doi

10.1097/RCT.0000000000000989

subject

Has Abstract

pub_date

2020-03-01 00:00:00

pages

223-229

issue

2

eissn

0363-8715

issn

1532-3145

pii

00004728-202003000-00010

journal_volume

44

pub_type

杂志文章
  • Clinical and Payer-Based Analysis of Value of Dual-Energy Computed Tomography for Workup of Incidental Abdominal Findings.

    abstract:OBJECTIVE:To perform a clinical and payer-based analysis of the value of dual-energy computed tomography (DECT) for workup of incidental abdominal findings. METHODS:This was a single-center, retrospectively designed, Health Insurance Portability and Accountability Act-compliant study approved by our institutional revi...

    journal_title:Journal of computer assisted tomography

    pub_type: 杂志文章

    doi:10.1097/RCT.0000000000000886

    authors: Itani M,Bresnahan BW,Rice K,Gunn ML,Wang SS,Revels JW,Mileto A

    更新日期:2019-07-01 00:00:00

  • Diffusely calcified renal cell carcinoma: CT features.

    abstract::Calcifications of renal masses are common. They are usually dense, partial, small, punctate, and linear opacities. Diffuse calcification is an extremely rare feature of renal masses. Generally, calcified renal cell carcinomas are hypovascular, with calcifications in the interstitium, and they also contain fibrotic cap...

    journal_title:Journal of computer assisted tomography

    pub_type: 杂志文章

    doi:

    authors: Onitsuka H,Murakami J,Naito S,Souda R,Shioyama Y,Honda H,Araki A,Torii Y,Masuda K

    更新日期:1992-07-01 00:00:00

  • Predominant white matter involvement in subcortical arteriosclerotic encephalopathy (Binswanger disease).

    abstract::Fifteen of 605 examinations of patients aged 60 to 85 years showed symmetrical white matter hypodensity on computed tomography (CT). Six of these showed severe white matter hypodensity, low grade atrophy, and dilated ventricles. A diagnosis of encephalopathia subcorticalis chronica progressiva, or Binswanger disease, ...

    journal_title:Journal of computer assisted tomography

    pub_type: 杂志文章

    doi:10.1097/00004728-198002000-00003

    authors: Zeumer H,Schonsky B,Sturm KW

    更新日期:1980-02-01 00:00:00

  • Papillary adenocarcinoma of the lung: radiologic and pathologic findings.

    abstract::We describe the radiologic and pathologic findings of papillary adenocarcinoma of the lung in three patients. The tumor appeared as a peripheral lung nodule (n = 1) or a mass (n = 2) on chest radiographs. On CT, the tumor appeared as a solitary pulmonary nodule, as a mass containing internal bubble lucencies with surr...

    journal_title:Journal of computer assisted tomography

    pub_type: 杂志文章

    doi:10.1097/00004728-199901000-00024

    authors: Hwang JH,Lee KS,Han J,Kim TS,Lee JY,Kim J

    更新日期:1999-01-01 00:00:00

  • Invasive carcinomas derived from intraductal papillary mucinous neoplasms of the pancreas: a long-term follow-up assessment with CT imaging.

    abstract:OBJECTIVE:To describe computed tomography (CT) findings of invasive carcinoma derived from intraductal papillary mucinous neoplasms (IPMNs) of the pancreas during long-term follow-up. METHODS:Follow-up CT findings of 5 patients with IPMNs progressing to invasive carcinomas were respectively reviewed for 12 to 63 month...

    journal_title:Journal of computer assisted tomography

    pub_type: 杂志文章

    doi:10.1097/01.rct.0000220801.76276.0f

    authors: Yamada Y,Mori H,Matsumoto S,Kamei N,Hongo N

    更新日期:2006-11-01 00:00:00

  • Web-based Conferencing: Tips, Tricks, and Scenario-based Best Practices for Clinicians During a Pandemic Crisis.

    abstract::This article will familiarize the reader with useful tools and trouble-shooting tips for web-based conferencing. Radiology-based scenarios for web conferencing are also provided. ...

    journal_title:Journal of computer assisted tomography

    pub_type: 杂志文章

    doi:10.1097/RCT.0000000000001072

    authors: Catanzano TM,Nandwana SB,Folio LR

    更新日期:2020-07-01 00:00:00

  • Combined hepatocellular and cholangiocarcinoma: correlation between CT findings and clinicopathological features.

    abstract:PURPOSE:The purpose of this study was to clarify characteristics of combined hepatocellular and cholangiocarcinoma (HCC-CC) on CT and clinicopathological examinations. METHODS:Dynamic incremental CT was performed on 15 combined HCC-CC patients. CT of the early phase was started at 30 s and of the late phase at 120-140...

    journal_title:Journal of computer assisted tomography

    pub_type: 杂志文章

    doi:10.1097/00004728-199701000-00011

    authors: Fukukura Y,Taguchi J,Nakashima O,Wada Y,Kojiro M

    更新日期:1997-01-01 00:00:00

  • Cerebral computed tomography in maple syrup urine disease.

    abstract::Maple syrup urine disease (MSUD) is an inherited metabolic disorder due to decreased decarboxylation of branched chain keto acids triggering an accumulation of leucine, isoleucine, and valine. We describe two infants with biochemically confirmed MSUD in whom computed tomography (CT) revealed cerebral edema. In one of ...

    journal_title:Journal of computer assisted tomography

    pub_type: 杂志文章

    doi:10.1097/00004728-198406000-00007

    authors: Romero FJ,Ibarra B,Rovira M,Natal A,Herrera M,Segarra A

    更新日期:1984-06-01 00:00:00

  • CT diagnosis of cystic hygroma of the neck.

    abstract::Cystic hygromas of the neck can simulate other benign lesions and occasionally extend into the mediastinum. Using computed tomography, we were able to confirm the suspected diagnosis, exclude other diagnostic considerations, and clearly demonstrate absence of mediastinal extension. ...

    journal_title:Journal of computer assisted tomography

    pub_type: 杂志文章

    doi:10.1097/00004728-198306000-00026

    authors: Silverman PM,Korobkin M,Moore AV

    更新日期:1983-06-01 00:00:00

  • Renal xanthogranulomatosis: radiological, clinical, and pathological features in two cases.

    abstract::Xanthogranulomatosis is a multicentric or systemic proliferative disorder of histiocytes. Two cases of xanthogranulomas are reported, each involving the kidneys. One patient also had concomitant orbital and CNS involvement. Primary renal involvement without associated retroperitoneal masses is an uncommon manifestatio...

    journal_title:Journal of computer assisted tomography

    pub_type: 杂志文章

    doi:

    authors: Merine D,Fishman EK,Siegelman SS

    更新日期:1987-09-01 00:00:00

  • Poor detection of a hepatoma with a hepatic specific contrast agent (EOE 13).

    abstract::A hepatic specific contrast agent was used in an attempt to detect a biopsy-proven hepatoma. This lesion had been missed by routine computed tomography and was poorly detected with the hepatic specific contrast agent EOE 13. It was also poorly detected by technetium-sulfur colloid hepatic scintigraphy. The true extent...

    journal_title:Journal of computer assisted tomography

    pub_type: 杂志文章

    doi:10.1097/00004728-198310000-00032

    authors: Witrak BJ,Bernardino ME

    更新日期:1983-10-01 00:00:00

  • Percutaneous CT-guided biopsy: improved confirmation of sampling site and needle positioning using a multistep technique at CT fluoroscopy.

    abstract::We describe a new multistep procedure for CT fluoroscopy-guided core biopsy, which allows confirmation of the biopsy-sampling trough and the final needle tip position prior to sampling. Twelve lesions measuring < or =2 cm or in close proximity to vital structures were biopsied using commercially available biopsy syste...

    journal_title:Journal of computer assisted tomography

    pub_type: 临床试验,杂志文章

    doi:10.1097/00004728-200003000-00015

    authors: Goldberg SN,Keogan MT,Raptopoulos V

    更新日期:2000-03-01 00:00:00

  • Radiologic findings of gastrointestinal tract involvement in hepatocellular carcinoma.

    abstract:PURPOSE:The purpose of this work was to evaluate the radiologic findings of gastrointestinal (GI) tract involvement in hepatocellular carcinoma (HCC) and to discuss mechanisms of spread. METHOD:Eighteen patients with histologically proven GI tract metastasis in HCC for 4.5 years underwent CT and five also underwent up...

    journal_title:Journal of computer assisted tomography

    pub_type: 杂志文章

    doi:10.1097/00004728-200201000-00014

    authors: Park MS,Kim KW,Yu JS,Kim MJ,Yoon SW,Chung KW,Lee JT,Yoo HS

    更新日期:2002-01-01 00:00:00

  • Assessment of the Relationship Between the Coronary Venous and Arterial Systems Using 256-Slice Computed Tomography.

    abstract:OBJECTIVES:To investigate the coronary venous system (CVS) and its spatial relationship with coronary arteries by using 256-slice computed tomography (CT). METHODS:One hundred one patients underwent coronary CT angiography by using a 256-slice CT. In each patient, the CVS and its spatial relationship with coronary art...

    journal_title:Journal of computer assisted tomography

    pub_type: 杂志文章

    doi:10.1097/RCT.0000000000000949

    authors: Bai W,Xu X,Ma H,Zhong L,Xie H,Sun C,Shi Y,Che K,Liu M,Yang J

    更新日期:2020-01-01 00:00:00

  • Organ-based computed tomographic (CT) radiation dose reduction to the lenses: impact on image quality for CT of the head.

    abstract:PURPOSE:Recently, a new specific organ dose adaption and reduction protocol, or SODAR tool (X-CARE, Siemens Healthcare), which reduces dose to the anterior aspect of the body of patients, was installed on our computed tomographic scanner. The purpose of this pilot project was to evaluate image quality and dose distribu...

    journal_title:Journal of computer assisted tomography

    pub_type: 杂志文章

    doi:10.1097/RCT.0b013e318251ec61

    authors: Reimann AJ,Davison C,Bjarnason T,Thakur Y,Kryzmyk K,Mayo J,Nicolaou S

    更新日期:2012-05-01 00:00:00

  • Asymmetries of the cerebral hemispheres on computed tomograms.

    abstract::Numerous cerebral asymmetries are shown on cerebral computed tomography (CT). Those seen most commonly are: (a) the left occipital pole is frequently wider and protrudes further posteriorly than the right; (b) the right frontal area often measures wider than the left, and the right frontal pole usually protrudes eithe...

    journal_title:Journal of computer assisted tomography

    pub_type: 杂志文章

    doi:10.1097/00004728-197809000-00018

    authors: Le May M,Kido DK

    更新日期:1978-09-01 00:00:00

  • Computed tomography in the evaluation of abdominal trauma.

    abstract::Four patients with blunt abdominal trauma underwent computed tomography (CT) as part of their diagnostic evaluation. In each case CT accurately demonstrated the pathology and the extent of injury. The results suggest that routine use of CT scanning may be an effective screening modality in the traumatized patient. It ...

    journal_title:Journal of computer assisted tomography

    pub_type: 杂志文章

    doi:

    authors: Druy EM,Rubin BE

    更新日期:1979-02-01 00:00:00

  • Craniofacial melorheostosis.

    abstract::Melorheostosis is a rare benign disease of cortical bone most frequently presenting as peripheral hyperostosis with a characteristic "melting wax" appearance on conventional radiographs. The disease most frequently affects the appendicular skeleton and is seen only rarely in the craniofacial bones. We discuss a case o...

    journal_title:Journal of computer assisted tomography

    pub_type: 杂志文章

    doi:10.1097/RCT.0b013e3181572998

    authors: McDermott M,Branstetter BF 4th,Seethala RR

    更新日期:2008-09-01 00:00:00

  • MRI of destructive achilles tendon rupture associated with skin ulceration.

    abstract::We present a case series of the MR findings of destructive tears of the Achilles tendon secondary to overlying soft tissue ulcerations. ...

    journal_title:Journal of computer assisted tomography

    pub_type: 杂志文章

    doi:10.1097/00004728-200011000-00016

    authors: Kihiczak D,Colletti PM,Terk MR

    更新日期:2000-11-01 00:00:00

  • Comparison of Time-of-Flight-Magnetic Resonance Angiography From Silent Scan Magnetic Resonance Angiography in Depiction of Arteriovenous Malformation of the Brain.

    abstract:OBJECTIVE:Silent magnetic resonance angiography (MRA) was compared with time-of-flight (TOF)-MRA in imaging of arteriovenous malformations (AVMs) of the brain. METHODS:Thirty-five consecutive patients with AVMs of the brain were included. Quantitative analyses were performed by measuring both signal-to-noise ratio and...

    journal_title:Journal of computer assisted tomography

    pub_type: 杂志文章

    doi:10.1097/RCT.0000000000000935

    authors: Tomura N,Saginoya T,Kokubun M,Horiuchi K,Watanabe Z

    更新日期:2019-11-01 00:00:00

  • Economic/reimbursement issues in MR imaging with gadolinium contrast agents.

    abstract::Implementation of an accurate, reliable index of cost effectiveness would help to advance technology assessment and reimbursement of MR imaging procedures, including gadolinium enhancement. To this end, an objective, consensual measure that satisfies the need for "gold-standard" confirmation of diagnostic impressions ...

    journal_title:Journal of computer assisted tomography

    pub_type: 杂志文章

    doi:10.1097/00004728-199301001-00008

    authors: Wolf GL

    更新日期:1993-01-01 00:00:00

  • Utilization patterns and diagnostic yield of 3421 consecutive multidetector row computed tomography pulmonary angiograms in a busy emergency department.

    abstract:OBJECTIVE:To compare examination volume and diagnostic yield of computed tomography (CT) pulmonary angiography (CTPA) and ventilation-perfusion (V/Q) scintigraphy for detection of suspected pulmonary embolism (PE) in emergency department patients. METHODS:Every CTPA and V/Q scan result for emergency department patient...

    journal_title:Journal of computer assisted tomography

    pub_type: 杂志文章

    doi:10.1097/RCT.0b013e31812e6af3

    authors: Donohoo JH,Mayo-Smith WW,Pezzullo JA,Egglin TK

    更新日期:2008-05-01 00:00:00

  • Focally spared area of fatty liver caused by arterioportal shunt.

    abstract::We describe a case with a focally spared area in fatty liver caused by arterioportal shunt. Furthermore, we discuss the cause of the focally spared area related to a localized dilution or reduction in portal blood flow. ...

    journal_title:Journal of computer assisted tomography

    pub_type: 杂志文章

    doi:10.1097/00004728-199605000-00005

    authors: Arita T,Matsunaga N,Honma Y,Nishikawa E,Nagaoka S

    更新日期:1996-05-01 00:00:00

  • Hematoma after femoral arterial blood sampling: incidence, imaging features, and course of hematoma.

    abstract:OBJECTIVE:This study evaluated the incidence and course of a hematoma occurring after femoral arterial sampling. MATERIALS AND METHODS:We studied 270 patients who underwent computed tomography (CT) including the pelvis and blood gas sampling from femoral artery using a 22-gauge needle during 2010. This population comp...

    journal_title:Journal of computer assisted tomography

    pub_type: 杂志文章

    doi:10.1097/RCT.0b013e3182483c55

    authors: Ishii S,Miyajima M,Shishido F,Sakuma K

    更新日期:2012-03-01 00:00:00

  • Blurring of vessels in spiral CT angiography: effects of collimation width, pitch, viewing plane, and windowing in maximum intensity projection.

    abstract:PURPOSE:Our goal was to examine the effects of collimation width (CW), pitch, viewing plane, and windowing on the display of in-plane vessels in maximum intensity projection (MIP). METHOD:A theoretical concept based on partial volume averaging of vessels was developed to describe the contents of voxels (densities) in ...

    journal_title:Journal of computer assisted tomography

    pub_type: 杂志文章

    doi:10.1097/00004728-199611000-00018

    authors: Diederichs CG,Keating DP,Glatting G,Oestmann JW

    更新日期:1996-11-01 00:00:00

  • Coronary artery calcification scoring by prospectively triggered multidetector-row computed tomography: is it reproducible?

    abstract::The objective of this study was to measure the interobserver and interscan variation of coronary artery calcium scores using multidetector-row computed tomography (MDCT). Seventy-five patients underwent 2 sequential MDCT scans for coronary artery calcification. Each patient's score was separately measured by 3-blinded...

    journal_title:Journal of computer assisted tomography

    pub_type: 杂志文章

    doi:10.1097/00004728-200401000-00006

    authors: Lawler LP,Horton KM,Scatarige JC,Phelps J,Thompson RE,Choi L,Fishman EK

    更新日期:2004-01-01 00:00:00

  • Computed tomography colonographic findings of pneumatosis cystoides coli.

    abstract::Pneumatosis cystoides coli (PCC) is an uncommon condition in which multiple gas-filled cysts in the walls of the colon. Patients with PCC initially complain of various symptoms including abdominal discomfort, constipation, diarrhea, hematochezia, vomiting, and fever. We recently diagnosed PCC by computed tomography (C...

    journal_title:Journal of computer assisted tomography

    pub_type: 杂志文章

    doi:10.1097/rct.0b013e31805d08ca

    authors: Kim YN,Lee SJ,Kim MJ,Kim YH,Jang DK

    更新日期:2008-01-01 00:00:00

  • Value of dynamic enhanced magnetic resonance imaging for distinguishing between ovarian fibroma and subserous uterine leiomyoma.

    abstract:PURPOSE:The purpose of this study was to assess the accuracy of magnetic resonance imaging (MRI), particularly, dynamic MRI, in distinguishing ovarian fibromas from subserous uterine leiomyomas. MATERIAL AND METHODS:Fifteen ovarian fibromas and 15 subserous uterine leiomyomas were retrospectively reviewed. All MR exam...

    journal_title:Journal of computer assisted tomography

    pub_type: 杂志文章

    doi:10.1097/01.rct.0000237810.88251.9e

    authors: Thomassin-Naggara I,Daraï E,Nassar-Slaba J,Cortez A,Marsault C,Bazot M

    更新日期:2007-03-01 00:00:00

  • Image noise and radiation dose using an automatic tube current modulation technique at 64-detector computed tomography: effect of off-center patient position, bowtie filter type, and scan projection radiograph.

    abstract::We describe the effect of the off-center position, the bowtie filter type, and the direction of scan projection radiograph on the radiation dose and image noise of 64-detector computed tomographic scans using the automatic tube current modulation technique. On anteroposterior scan projection radiographs, the tube curr...

    journal_title:Journal of computer assisted tomography

    pub_type: 杂志文章

    doi:10.1097/RCT.0b013e31819d6f6f

    authors: Funama Y,Taguchi K,Awai K,Sakabe D,Shimamura M,Yamashita Y

    更新日期:2009-11-01 00:00:00

  • Artifacts and thresholding in X-ray CT of a cortical bone and titanium composite.

    abstract:PURPOSE:X-Ray CT has the potential to provide precise and accurate data from which the mechanical properties of bone can be calculated. Such data would be useful in understanding the response of bone tissue to implants. Various artifacts can, however, degrade accuracy of the data. The aim of this study was to measure t...

    journal_title:Journal of computer assisted tomography

    pub_type: 杂志文章

    doi:10.1097/00004728-199605000-00035

    authors: Sutherland CJ,Gayou DE

    更新日期:1996-05-01 00:00:00