Abstract:
:The aim of this study was to estimate the risk of viable unbalanced offspring for a parental carrier of reciprocal translocation. On a large computerized database of reciprocal translocations we used logistic regression to model this risk. The status of the progeny is the outcome variable. Explanatory covariates are cytogenetic characteristics of the translocation, age and sex of the parental carrier, and potential viability of the gametes. The results obtained by the logistic model demonstrate the important role of certain variables such as the sex of the parental carrier and the R band length of the translocated segments. Within the group of lower risk (risk of viable unbalanced offspring less than 5%), 97% of the individuals are correctly classified with this model. For this group, the choice prenatal diagnosis can be best discussed by considering both the risk for viable unbalanced offspring and the risk of induced abortion following prenatal diagnosis.
journal_name
Hum Genetjournal_title
Human geneticsauthors
Cans C,Cohen O,Lavergne C,Mermet MA,Demongeot J,Jalbert Pdoi
10.1007/BF00420946subject
Has Abstractpub_date
1993-12-01 00:00:00pages
598-604issue
6eissn
0340-6717issn
1432-1203journal_volume
92pub_type
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