c-Ha-ras-1 alleles in bladder cancer, Wilms' tumour and malignant melanoma.

Abstract:

:Polymorphism of the human c-Ha-ras-1 gene has been analysed in DNA from 168 individuals using the enzymes MspI and HpaII. In all, 35 bladder cancer patients, 28 melanoma patients, 22 Wilms' tumour patients, 24 first-degree relatives of Wilms' tumour or melanoma patients and 59 unaffected controls were studied. A total of 13 different fragment sizes was detected, 4 "common" and 9 "unusual". Of the latter, 4 were observed only in cancer patients or their first-degree relatives. The frequency of unusual alleles was significantly greater in bladder cancer patients and in the combined tumour group than in controls, thus providing support for the association of unique Ha-ras alleles and cancer. Some unaffected relatives of patients carried unusual alleles, and thus there is no absolute relationship between Ha-ras genotype and disease.

journal_name

Hum Genet

journal_title

Human genetics

authors

Hayward NK,Keegan R,Nancarrow DJ,Little MH,Smith PJ,Gardiner RA,Seymour GJ,Kidson C,Lavin MF

doi

10.1007/BF00278178

subject

Has Abstract

pub_date

1988-02-01 00:00:00

pages

115-20

issue

2

eissn

0340-6717

issn

1432-1203

journal_volume

78

pub_type

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