Detection of common deletional alpha-thalassemia-2 determinants by PCR.

abstract：:Twenty-two normal volunteers had approximately eight, 2-hr-long leukapheresis procedures over a 2-year period and their natural killer (NK) cell function was prospectively measured. The NK activity of the preprocedure peripheral blood (pre-PB) was found to correlate well with the NK activity of the inital leukocytes r...

journal_title：American journal of hematology

authors： Stevenson HC,Beman JS,Crisp B,Coggin D,Kanapa DJ,Miller P,Herberman RB,Maluish AE

更新日期：1986-06-01 00:00:00

abstract：:Immunoglobulin light-chain amyloidosis (AL) is a rare disorder characterized by production of a monoclonal light chain. This insoluble light chain, or a fragment thereof, deposits in tissues as amyloid and results in disruption of organ function and, ultimately, in death. Although melphalan and prednisone are benefici...

journal_title：American journal of hematology

authors： Gertz MA,Lacy MQ,Lust JA,Greipp PR,Witzig TE,Kyle RA

更新日期：1999-06-01 00:00:00

abstract：:Reversible posterior leukoencephalopathy syndrome (RPLS) is an uncommon but distinctive clinicoradiological entity comprising of headache, seizures, visual disturbance, and altered mental function, in association with posterior cerebral white matter edema. With appropriate management, RPLS is reversible in the majorit...

journal_title：American journal of hematology

authors： Tam CS,Galanos J,Seymour JF,Pitman AG,Stark RJ,Prince HM

更新日期：2004-09-01 00:00:00

abstract：:A new density system for the separation of human red blood cells by density-gradient centrifugation is described. The gradient medium is made with colloidal silica particles coated with polyvinylpyrrolidone suspended in aqueous solution of meglamine diatrizoate. By this method, more than 10 red-cell fractions can be s...

journal_title：American journal of hematology

authors： Vettore L,De Matteis MC,Zampini P

更新日期：1980-01-01 00:00:00

abstract：:Disseminated intravascular coagulation (DIC) is a complex acquired coagulopathy resulting from excessive thrombin formation. Abnormal tissue factor (TF) expression is a major mechanism initiating DIC in many disorders, including obstetrical complications, sepsis, cancer, and trauma. Numerous laboratory tests are avail...

journal_title：American journal of hematology

authors： Carey MJ,Rodgers GM

更新日期：1998-09-01 00:00:00

abstract：:Non-Hodgkin lymphoma arising in the context of immunosuppression is an important adverse outcome after solid organ transplantation. Diffuse large B-cell lymphoma (DLBCL) is the most commonly diagnosed subtype of post-transplantation non-Hodgkin lymphoma, but few studies of transplant recipients have examined subtype-s...

journal_title：American journal of hematology

authors： Gibson TM,Engels EA,Clarke CA,Lynch CF,Weisenburger DD,Morton LM

更新日期：2014-07-01 00:00:00

abstract：:Hepcidin is a small defensin-like peptide whose production by hepatocytes is modulated in response to anemia, hypoxia, or inflammation. Hepcidin could also act as an indicator of functional iron deficiency in these patients. Cross-sectional study was performed to assess hepcidin correlations with renal function, iron ...

journal_title：American journal of hematology

authors： Malyszko J,Malyszko JS,Pawlak K,Mysliwiec M

更新日期：2006-11-01 00:00:00

abstract：:We evaluated T-lymphocyte functions in the peripheral blood of a patient with B-cell chronic lymphocytic leukemia after transformation to large cell lymphoma (Richter's syndrome). A subpopulation of E-rosette adherent cells were found with T-lymphocytic surface markers (OKT3+/8+/4+), monocytic characteristics (latex i...

journal_title：American journal of hematology

authors： Lahat N,Aghai E,Quitt M,Nir E,Froom P

更新日期：1985-11-01 00:00:00

abstract：:Heparin, employed clinically for more than 50 years, is still a widely used anticoagulant. Unfortunately, some patients given this agent develop thrombocytopenia and thrombosis. Because this side effect can have catastrophic consequences, it is imperative that all clinicians caring for patients who receive heparin hav...

journal_title：American journal of hematology

authors： Davoren A,Aster RH

更新日期：2006-01-01 00:00:00

abstract：:Individuals with more than one defect in natural coagulant/anticoagulant systems have been postulated to be at an increased risk for thrombotic events. We report a case of combined protein S and C deficiency in a young woman, which resulted in fatal arterial mesenteric thrombosis. The role of coagulation defects in ar...

journal_title：American journal of hematology

authors： Atkins KA,Zehnder JL

更新日期：1998-07-01 00:00:00

abstract：:We performed a laparoscopic splenectomy (LS) in 60 patients (age 9-83, 45 females) with idiopathic thrombocytopenic purpura (ITP) who did not achieve sustained remission on steroid therapy. Using a modified procedure, the mean duration of LS was 78 min (range 25-240 min) and surgery was associated with only 5% major a...

journal_title：American journal of hematology

authors： Szold A,Schwartz J,Abu-Abeid S,Bulvik S,Eldor A

更新日期：2000-01-01 00:00:00

abstract：:Sixty-two previously untreated patients with B-cell chronic lymphocytic leukaemia were analysed to study the prognostic value of both the immunologic phenotype and the clinicobiologic characteristics. Univariate studies showed that none of the immunological markers analysed, sheep-rosette, mouse-rosette, slg, and HLA/...

journal_title：American journal of hematology

authors： Orfao A,Gonzalez M,San Miguel JF,Rios A,Canizo MC,Hernandez J,Maricato ML,Lopez Borrasca A

更新日期：1989-05-01 00:00:00

abstract：:Achievement of a complete response has been associated with improved outcomes in patients with multiple myeloma. Recently, increasing application of minimal residual disease (MRD) assessment has shown that MRD negativity is a powerful prognostic factor for survival outcomes. We wanted to examine the impact of the poly...

journal_title：American journal of hematology

authors： Tschautscher MA,Jevremovic D,Rajkumar V,Dispenzieri A,Lacy MQ,Gertz MA,Buadi FK,Dingli D,Hwa YL,Fonder AL,Hobbs MA,Hayman SR,Zeldenrust SR,Lust JA,Russell SJ,Leung N,Kapoor P,Go RS,Lin Y,Gonsalves WI,Kourelis T,

更新日期：2019-07-01 00:00:00

abstract：:Human T-cell leukemia virus (HTLV-I) is known to be associated with certain hematologic malignancies, and a related virus, HTLV-III/LAV, might be the cause of AIDS. Some persons with AIDS have had evidence of HTLV-I infection. Unrelated to these findings, it has been suggested that HTLV-I is transmitted via blood prod...

journal_title：American journal of hematology

authors： Jason JM,McDougal JS,Cabradilla C,Kalyanaraman VS,Evatt BL

更新日期：1985-10-01 00:00:00

abstract：:Hypereosinophilic syndrome (HES) is a rare disorder that can manifest in various organ systems. We report the case of a 54-year-old woman with a remote history of seizure disorder who presented with early signs of right-sided heart failure. Laboratory studies showed significant eosinophilia (8 x 10(9) l(-1)). Computed...

journal_title：American journal of hematology

authors： Chao BH,Cline-Parhamovich K,Grizzard JD,Smith TJ

更新日期：2007-10-01 00:00:00

abstract：:Eosinophilia may represent an early paraclinical sign of hematological malignant disease, but no reports exist on its predictive value for hematological malignancies. From the Copenhagen Primary Care Differential Count (CopDiff) Database, we identified 356,196 individuals with at least one differential cell count (DIF...

journal_title：American journal of hematology

authors： Andersen CL,Siersma VD,Hasselbalch HC,Lindegaard H,Vestergaard H,Felding P,de Fine Olivarius N,Bjerrum OW

更新日期：2013-10-01 00:00:00

abstract：:Acute myeloid leukemia (AML) with mutated NPM1 is a newly recognized separate entity in the revised 2016 WHO classification, and is associated with a favorable prognosis. While previous studies have evaluated NPM1 in a binary fashion, we recently demonstrated a significant independent negative prognostic effect of hig...

journal_title：American journal of hematology

authors： Patel SS,Pinkus GS,Ritterhouse LL,Segal JP,Dal Cin P,Restrepo T,Harris MH,Stone RM,Hasserjian RP,Weinberg OK

更新日期：2019-08-01 00:00:00

abstract：:The relative importance of the resolution level of HLA typing has not been fully defined for related donor transplantation. To address this question, we retrospectively evaluated patients who underwent a first related hematopoietic stem cell transplantation (HSCT) from 2000 to 2011 from an HLA high-resolution matched ...

journal_title：American journal of hematology

authors： Fuji S,Kanda J,Kato S,Ikegame K,Morishima S,Miyamoto T,Hidaka M,Kubo K,Miyamura K,Tsudo M,Kobayashi H,Maesako Y,Eto T,Adachi S,Ichinohe T,Atsuta Y,Kanda Y,HLA Working Group of the Japan Society for Hematopoietic Cell Tr

更新日期：2015-07-01 00:00:00

abstract：:Intravenous (IV) granulocyte colony stimulating factor (G-CSF) might be safer and more convenient than subcutaneous (SC) administration to hospitalized hemato-oncological patients receiving chemotherapy. To compare IV vs. SC G-CSF administration, we conducted a randomized, open-label trial. We included inpatients rece...

journal_title：American journal of hematology

authors： Paul M,Ram R,Kugler E,Farbman L,Peck A,Leibovici L,Lahav M,Yeshurun M,Shpilberg O,Herscovici C,Wolach O,Itchaki G,Bar-Natan M,Vidal L,Gafter-Gvili A,Raanani P

更新日期：2014-03-01 00:00:00

abstract：:We have developed a murine monoclonal antibody (mAb) specific for the delta chain of hemoglobin (Hb) A2 that does not cross-react with alpha, beta, or gamma chains. The mAb reacted with Hb P-Nilotic (beta delta hybrid), but not with Hb Lepore-Boston (delta beta hybrid), indicating an epitope consisting of positions 11...

journal_title：American journal of hematology

authors： Shyamala M,Kiefer CR,Moscoso H,Garver FA

更新日期：1991-11-01 00:00:00

abstract：:Light chain deposition disease (LCDD) is characterized by monotypic immunoglobulin depositions which will eventually lead to loss of organ function if left untreated. While the kidney is almost always affected, the presence and degree of LCDD in other organs vary. Ten to thirty percent of LCDD patients have underlying...

journal_title：American journal of hematology

authors： Mohan M,Buros A,Mathur P,Gokden N,Singh M,Susanibar S,Jo Kamimoto J,Hoque S,Radhakrishnan M,Matin A,Davis C,Grazziutti M,Thanendrarajan S,van Rhee F,Zangari M,Davies F,Morgan G,Epstein J,Barlogie B,Schinke C

更新日期：2017-08-01 00:00:00

abstract：:We describe two patients with mild hemophilia A (MHA) who developed high titer inhibitor (HTI) following intensive recombinant factor VIII (rFVIII) concentrate replacement for surgery and trauma. Intranasal desmopressin was instituted shortly following immunosuppressive therapy (IST) and activated prothrombin complex ...

journal_title：American journal of hematology

authors： Robbins D,Kulkarni R,Gera R,Scott-Emuakpor AB,Bosma K,Penner JA

更新日期：2001-11-01 00:00:00

abstract：:We report a case of refractory anemia with excess blasts (RAEB) developing in a 67-year old man with a history of polycythemia vera; results of cytogenetic and immunophenotyping studies are described. In this report the clinical, cytogenetic and hematologic features of myelodysplasia complicating polycythemia vera are...

journal_title：American journal of hematology

authors： Shamdas GJ,Spier CM,List AF

更新日期：1991-05-01 00:00:00

abstract：:Seventeen adults received the antifibrinolytic drug tranexamic acid during cardiac surgery utilizing extracorporeal circulation (ECC). In 8 patients, drug administration began prior to skin incision (pre-ECC); infusions commenced after ECC and protamine administration in another 9 patients (post-ECC). Compared with th...

journal_title：American journal of hematology

authors： Soslau G,Horrow J,Brodsky I

更新日期：1991-10-01 00:00:00

abstract：:We report here the haplotypes of 10 MstII-defined SS patients and a S/beta o thalassemia from the Central African Republic, exhibiting 7 different atypical haplotypes that are different from the typical Bantu haplotype that characterize over 93% of the beta s bearing chromosomes in that region of Africa. Of the seven ...

journal_title：American journal of hematology

authors： Srinivas R,Dunda O,Krishnamoorthy R,Fabry ME,Georges A,Labie D,Nagel RL

更新日期：1988-09-01 00:00:00

abstract：:The serum free light chain (FLC) assay quantitates free immunoglobulin kappa and lambda light chains, which has prognostic value in plasma cell dyscrasias. However, there is limited data on serum FLC in lymphoid malignancies. We analyzed the association of pretreatment FLC with event-free survival (EFS) and overall su...

journal_title：American journal of hematology

authors： Thompson CA,Maurer MJ,Cerhan JR,Katzmann JA,Ansell SM,Habermann TM,Macon WR,Weiner GJ,Link BK,Witzig TE

更新日期：2011-12-01 00:00:00

abstract：:Alpha-hemoglobin stabilizing protein (AHSP) is a potential modifier of beta-thalassemia by virtue of its ability to detoxify excess free alpha-globin. However, examination of patients with beta-thalassemia from a few geographic regions failed to identify obvious AHSP mutations. We extended these studies by analyzing A...

journal_title：American journal of hematology

authors： dos Santos CO,Zhou S,Secolin R,Wang X,Cunha AF,Higgs DR,Kwiatkowski JL,Thein SL,Gallagher PG,Costa FF,Weiss MJ

更新日期：2008-02-01 00:00:00

abstract：:The roles of fibrinogen and fibronectin were contasted in the responses of human platelets to Staphylococcus aureus and collagen. Congenital afibrinogenemic (CA) platelets and washed normal platelets had delayed aggregation due to a prolonged latent phase in response to contact with the bacteria when fibrinogen was ab...

journal_title：American journal of hematology

authors： Clawson CC,White JG,Herzberg MC

更新日期：1980-01-01 00:00:00

abstract：:Patients with indolent non-Hodgkin lymphoma (NHL) have multiple treatment options yet there is no consensus as to the best initial therapy. Lenalidomide, an immunomodulatory agent, has single agent activity in relapsed lymphoma. This trial was conducted to assess feasibility, efficacy, and safety of adding lenalidomid...

journal_title：American journal of hematology

authors： Rosenthal A,Dueck AC,Ansell S,Gano K,Conley C,Nowakowski GS,Camoriano J,Leis JF,Mikhael JR,Keith Stewart A,Inwards D,Dingli D,Kumar S,Noel P,Gertz M,Porrata L,Russell S,Colgan J,Fonseca R,Habermann TM,Kapoor P,B

更新日期：2017-05-01 00:00:00

abstract：:We report a case of a 61-year-old man with head and neck cancer who presented with pancytopenia two months after the completion of his chemotherapy and was diagnosed with myelodysplasia on the basis of two bone marrow examinations, before the correct diagnosis of visceral leishmaniasis was established with splenectomy...

journal_title：American journal of hematology

authors： Kopterides P,Halikias S,Tsavaris N

更新日期：2003-11-01 00:00:00