Abstract:
:Because of its special pharmacokinetic properties, plasma levels of theophylline show significant differences between individuals and also its therapeutic index is very low. So, plasma theophylline concentration measurements are essential for an effective and safe treatment. In the present study, age related differences in plasma theophylline levels were evaluated in patients from different age groups. Patients were divided randomly into two groups. Group I included patients under the age of 50 years, group II included patients over 50 years of age. Plasma theophylline levels were measured before and 3, 7, 12 and 19 h after a single dose given orally. The results show that 3, 7 and 19 h post dose, levels of theophylline were significantly higher in group II than in group I (P < 0.001).
journal_name
Eur J Drug Metab Pharmacokinetjournal_title
European journal of drug metabolism and pharmacokineticsauthors
Elidemir O,Kośay S,Hepözden O,Aysan T,Tufan Mdoi
10.1007/BF03188821subject
Has Abstractpub_date
1994-01-01 00:00:00pages
37-9issue
1eissn
0378-7966issn
2107-0180journal_volume
19pub_type
临床试验,杂志文章,随机对照试验abstract::Although the application of medical marijuana and cannabinoid drugs is controversial, it is a part of modern-day medicine. The list of diseases in which cannabinoids are promoted as a treatment is constantly expanding. Cases of significant improvement in patients with a very poor prognosis of glioma or epilepsy have a...
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