Cytokine mediators of renal inflammation.

abstract：PURPOSE OF REVIEW:Incidence of end-stage renal disease has increased dramatically during the last 30 years and screening for early stages of chronic kidney disease is often suggested as a preventive measure. The relationship between chronic kidney disease and end-stage renal disease is complex, however, and recent stud...

journal_title：Current opinion in nephrology and hypertension

authors： Hallan SI,Vikse BE

更新日期：2008-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Autonomic dysfunction is well recognized in chronic kidney disease. The baroreflex arc is an important component of the autonomic nervous system and influences vasodilatation and heart rate in response to information derived from baroreceptors located in the aorta and common carotid arteries. Appropri...

journal_title：Current opinion in nephrology and hypertension

authors： Chesterton LJ,McIntyre CW

更新日期：2005-11-01 00:00:00

abstract：:An increasing number of population-based studies and clinical trials have examined the role of blood pressure in renal disease. Recent reports indicate that elevations of blood pressure, even within the normotensive range, may result in renal damage. The available evidence suggests that blood pressure reduction dimini...

journal_title：Current opinion in nephrology and hypertension

authors： Perneger TV,Whelton PK

更新日期：1993-05-01 00:00:00

abstract：PURPOSE OF REVIEW:MRI can noninvasively assess the structure and function of the kidney in a single MRI scan session. This review summarizes recent advancements in functional renal MRI techniques, with a particular focus on clinical applications. RECENT FINDINGS:A number of MRI techniques now provide measures of relev...

journal_title：Current opinion in nephrology and hypertension

authors： Mahmoud H,Buchanan C,Francis ST,Selby NM

更新日期：2016-11-01 00:00:00

abstract：PURPOSE OF REVIEW:The sodium-hydrogen exchanger isoform-1 (NHE1) functions in intracellular pH and cell volume homeostasis by catalyzing an electroneutral exchange of extracellular sodium and intracellular hydrogen. Recent studies have revealed the structural functions of NHE1 as an anchor for actin filaments and a sca...

journal_title：Current opinion in nephrology and hypertension

authors： Meima ME,Mackley JR,Barber DL

更新日期：2007-07-01 00:00:00

abstract：:Secondary hyperparathyroidism remains the predominant histologic lesion in pediatric patients undergoing regular dialysis, but recent evidence indicates that the regulation of parathyroid hormone secretion by calcium does not differ substantially between patients with osteitis fibrosa and subjects with normal renal fu...

journal_title：Current opinion in nephrology and hypertension

authors： Salusky IB,Ramirez JA,Goodman WG

更新日期：1993-07-01 00:00:00

abstract：:In spite of the popular belief that "nervous tension," "stress," and hypertension are causally related, it has been difficult to prove a role of autonomic dysfunction in the genesis of essential hypertension. There are three major reasons for this: 1) autonomic function cannot be assessed with one simple test, 2) the ...

journal_title：Current opinion in nephrology and hypertension

authors： Julius S

更新日期：1992-12-01 00:00:00

abstract：:Aldosterone plays a major role in the regulation of renal sodium reabsorption, of extracellular fluid volume and blood pressure. Such specific mineralocorticoid physiological adaptations occur despite the large prevalence of glucocorticoid hormones over aldosterone in the plasma. Indeed both classes of hormones bind w...

journal_title：Current opinion in nephrology and hypertension

authors： Farman N

更新日期：1999-01-01 00:00:00

abstract：PURPOSE OF REVIEW:The current article reviews the available literature on the incidence, complications, outcomes, and management of pregnancies in kidney transplant recipients. RECENT FINDINGS:Pregnancy can be a reasonable option for women with a kidney transplant. More than 4700 successful pregnancies have been repor...

journal_title：Current opinion in nephrology and hypertension

authors： Vijayan M,Pavlakis M

更新日期：2017-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Acute kidney injury (AKI) is a serious problem. Understanding an individual patient's risk profile may offer opportunities for prevention or early intervention. The aim of this review is to describe novel nontraditional risk factors. RECENT FINDINGS:The risk of AKI is determined by patient factors an...

journal_title：Current opinion in nephrology and hypertension

authors： Varrier M,Ostermann M

更新日期：2014-11-01 00:00:00

abstract：:The recognition that cell death in the myocardium is not only necrotic in nature but is also mediated by activation of the suicide program of myocytes has raised several questions concerning the magnitude of this phenomenon, and whether these two distinct forms of cell death are disease-dependent or coexist in the pat...

journal_title：Current opinion in nephrology and hypertension

authors： Anversa P,Olivetti G,Leri A,Liu Y,Kajstura J

更新日期：1997-03-01 00:00:00

abstract：:Experimental animal models and cell culture techniques, highlighting the central role of glucose metabolism, have provided important insight into the pathogenesis of diabetic nephropathy. Microalbuminuria and other candidate phenotypic or genotypic markers for the early onset of disease are discussed. Management recom...

journal_title：Current opinion in nephrology and hypertension

authors： Mogyorósi A,Ziyadeh FN

更新日期：1996-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Secretion and reabsorption of organic cations in kidney is mediated by polyspecific transporters with broadly overlapping substrate specificity. Knowledge concerning function, transported compounds, clinical impact of mutations in the transporters and drug-drug interactions is rapidly increasing. Rece...

journal_title：Current opinion in nephrology and hypertension

authors： Koepsell H

更新日期：2013-09-01 00:00:00

abstract：PURPOSE OF REVIEW:To summarize the latest information on body composition among patients with chronic kidney disease and its association with outcomes. RECENT FINDINGS:Obesity is increasing among patients with end-stage renal disease and is more prevalent when direct measures of adiposity are used rather than BMI. Hig...

journal_title：Current opinion in nephrology and hypertension

authors： Johansen KL,Lee C

更新日期：2015-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Epigenetic modifications are reversible changes to a cell's DNA or histones that alter gene expression but not DNA sequence. The present review will explore epigenomic profiling and bioinformatics techniques for the study of kidney development and disease. RECENT FINDINGS:Reversible DNA and histone m...

journal_title：Current opinion in nephrology and hypertension

authors： Wilson PC,Ledru N,Humphreys BD

更新日期：2020-05-01 00:00:00

abstract：PURPOSE OF REVIEW:The success of any given kidney transplant is closely tied to the ability to monitor patients and responsively change their medications. Transplant monitoring is still, however, dependent on relatively old technologies: serum creatinine levels, urine output, blood pressure, blood glucose and histopath...

journal_title：Current opinion in nephrology and hypertension

authors： Wishart DS

更新日期：2006-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Strong epidemiological and pathologic evidence associates NSAIDs with kidney disease, both acute and chronic. Hence, the usage of NSAIDs has decreased in patients with, or at risk for, chronic kidney disease (CKD). Coupled with this has been a rise in use of opioids and other non-NSAID alternatives, w...

journal_title：Current opinion in nephrology and hypertension

authors： Sriperumbuduri S,Hiremath S

更新日期：2019-03-01 00:00:00

abstract：PURPOSE OF REVIEW:The renin-angiotensin system, traditionally viewed as a circulatory system, has significantly expanded in the last two decades to include independently regulated local systems in several tissues, newly identified active products of angiotensin II, and new receptors and functions of renin-angiotensin s...

journal_title：Current opinion in nephrology and hypertension

authors： Kumar R,Singh VP,Baker KM

更新日期：2008-03-01 00:00:00

abstract：PURPOSE OF REVIEW:To describe the direct and indirect effects of estrogen on bone with special emphasis on the analysis of the recent findings related to the putative role of FGF23 in the estrogen-dependent parathyroid hormone (PTH) suppression. RECENT FINDINGS:Estrogens act directly on bone cells, downregulating oste...

journal_title：Current opinion in nephrology and hypertension

authors： Cannata-Andía JB,Carrillo-López N,Naves-Díaz M

更新日期：2010-07-01 00:00:00

abstract：:It has been 6 years since the first reports of the use of recombinant human erythropoietin for the treatment of renal anemia appeared in the medical literature. During this period, erythropoietin has become established as a safe and highly effective therapy, and it is currently being evaluated for other nonrenal types...

journal_title：Current opinion in nephrology and hypertension

authors： Macdougall IC

更新日期：1992-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Phosphate homeostasis is tightly controlled by the coordinated activity of bone, kidney, intestine, and parathyroid gland. The renal phosphate transporters have emerged as key regulators of both total body phosphate homeostasis and serum phosphate concentration. This review focuses on the latest updat...

journal_title：Current opinion in nephrology and hypertension

authors： Lederer E

更新日期：2014-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Recent data have highlighted the shortcomings of the usual blood pressure hypothesis in posthoc analyses of randomized controlled trials led in populations at high cardiovascular risk and have emphasized the importance of an increased visit-to-visit variability of blood pressure in predicting cardiova...

journal_title：Current opinion in nephrology and hypertension

authors： Rossignol P,Kessler M,Zannad F

更新日期：2013-01-01 00:00:00

abstract：:Renal synthesis of the active form of vitamin D, 1,25-dihydroxyvitamin D3 [1,25(OH)2D3], is a pivotal step in calcium and phosphate homeostasis. Production of 1,25(OH)2D3 is catalyzed by the mitchondrial cytochrome P450, 25-hydroxyvitamin D3-1alpha-hydroxylase (1alpha-HYD). As a consequence of the tight regulation of ...

journal_title：Current opinion in nephrology and hypertension

authors： Bland R,Zehnder D,Hewison M

更新日期：2000-01-01 00:00:00

abstract：PURPOSE OF REVIEW:The glomerular filtration barrier is a unique structure characterized by a specialized three-dimensional framework of podocytes. This review is aimed at describing the latest advances made in the understanding of polarity signalling pathways regulating the formation and the maintenance of the complex ...

journal_title：Current opinion in nephrology and hypertension

authors： Simons M,Hartleben B,Huber TB

更新日期：2009-07-01 00:00:00

abstract：PURPOSE OF REVIEW:This review focuses on recent efforts in identifying with-no-lysine kinase 4 (WNK4) as a physiological intracellular chloride sensor and exploring regulators of intracellular chloride concentration ([Cl-]i) in the distal convoluted tubule (DCT). RECENT FINDINGS:The discovery of WNK1's chloride-bindin...

journal_title：Current opinion in nephrology and hypertension

authors： Chen JC,Lin MX,Cheng CJ

更新日期：2021-03-01 00:00:00

abstract：PURPOSE OF REVIEW:The direct oral anticoagulants (DOACs) have emerged as an effective and safe alternative to vitamin K antagonists (VKAs) for stroke and venous thromboembolism (VTE) prevention. However, patients with chronic kidney disease (CKD) experience an increase in the risk of both thromboembolism and bleeding, ...

journal_title：Current opinion in nephrology and hypertension

authors： Ha JT,Badve SV,Jun M

更新日期：2019-05-01 00:00:00

abstract：PURPOSE OF REVIEW:The association between dysbiosis and CKD is well established. This review focuses on the current understanding of microbiome, in normal individuals and CKD patients, in order to hypothesize how to correct uremic toxins levels and preserve the renal function and reduce associated comorbidities. Here w...

journal_title：Current opinion in nephrology and hypertension

authors： Caggiano G,Cosola C,Di Leo V,Gesualdo M,Gesualdo L

更新日期：2020-01-01 00:00:00

abstract：PURPOSE OF REVIEW:This review examines the maturational changes that occur in renal tubules during postnatal development. RECENT FINDINGS:The ability to study transport in neonatal tubules and the use of molecular techniques have allowed studies that not only examine the mechanism of solute and water transport in neon...

journal_title：Current opinion in nephrology and hypertension

authors： Baum M,Quigley R,Satlin L

更新日期：2003-09-01 00:00:00

abstract：PURPOSE OF REVIEW:The discovery of the extracellular calcium-sensing receptor, CasR has broadened our understanding of calcium homeostasis and led to the development of new pharmacological agents, calcimimetics, for treating hyperparathyroidism. In the present review, I discuss the function of CasR as well as provide e...

journal_title：Current opinion in nephrology and hypertension

authors： Quarles LD

更新日期：2003-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Over the past decade post-hoc analyses of clinical trials and observational studies have tended to show that participants treated with thiazide diuretics are at greater risk for newly diagnosed diabetes mellitus than those treated with other medication classes. We review the results of several recent ...

journal_title：Current opinion in nephrology and hypertension

authors： Barzilay JI,Cutler JA,Davis BR

更新日期：2007-05-01 00:00:00