Comparison of a mixture of papaverine, phentolamine and prostaglandin E1 with other intracavernous injections.

Abstract:

OBJECTIVE:evaluation of a self-injection program with a mixture of papaverine, phentolamine and prostaglandin E1 (PGE1). METHOD:a self-injection program for erectile dysfunction was started by 48 patients, using a 1-ml mixture of 4.5 mg papaverine, 0.2 mg phentolamine and 1.5 micrograms PGE1. Patients completed a questionnaire at 6 weeks and at 3 months and were followed at the Outpatients Department for an average of 1 year. RESULT:of these patients 25 had previous experience with 20 micrograms PGE1 for intracavernous use and 22 patients had previously used 30 mg papaverine with 1 mg phentolamine. None of these 3 self-injection drugs is obviously superior in its ability to induce erections. Priapism occurred twice on a total of 1,290 injections. After 1-year follow-up, 4 patients had developed problems with fibrosis of the corpora, 2 of whom had encountered this problem also in a previous self-injection program. CONCLUSION:this triple mixture has the disadvantage of causing fibrosis and priapism in susceptible patients.

journal_name

Eur Urol

journal_title

European urology

authors

Meinhardt W,Lycklama à Nijeholt AA,Kropman RF,Vermeij P,Zwartendijk J

doi

10.1159/000475407

subject

Has Abstract

pub_date

1994-01-01 00:00:00

pages

319-21

issue

4

eissn

0302-2838

issn

1873-7560

journal_volume

26

pub_type

临床试验,杂志文章
  • Upregulation of penile brain-derived neurotrophic factor (BDNF) and activation of the JAK/STAT signalling pathway in the major pelvic ganglion of the rat after cavernous nerve transection.

    abstract:OBJECTIVES:Increasing attention is being focused on identifying novel approaches to recover cavernous nerve (CN) function after injury or secondary to disease states such as diabetes mellitus. We examined penile brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) expression, and activation of the Janus k...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1016/j.eururo.2006.10.043

    authors: Bella AJ,Lin G,Garcia MM,Tantiwongse K,Brant WO,Lin CS,Lue TF

    更新日期:2007-08-01 00:00:00

  • Topography of lymph node metastases in prostate cancer patients undergoing radical prostatectomy and extended lymphadenectomy: results of a combined molecular and histopathologic mapping study.

    abstract:BACKGROUND:To determine the anatomic extent of pelvic lymph node dissection (PLND) in prostate cancer (PCa) patients at the time of radical prostatectomy (RP), knowledge about the topography of lymph node (LN) metastases is required. OBJECTIVE:Because small-volume LN metastases may be missed by standard histopathologi...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1016/j.eururo.2013.02.007

    authors: Heck MM,Retz M,Bandur M,Souchay M,Vitzthum E,Weirich G,Mollenhauer M,Schuster T,Autenrieth M,Kübler H,Maurer T,Thalgott M,Herkommer K,Gschwend JE,Nawroth R

    更新日期:2014-08-01 00:00:00

  • Lateralized lumbar pain during sexual intercourse. Early clinical sign of single ectopic ureter?

    abstract::Although a single ectopic ureter opening into the vagina has frequently been reported in literature, lateralized lumbar pain during sexual intercourse and urinary incontinence after pregnancy due to a single ectopic ureter are uncommon. The etiology and pathogenesis are unknown but some clinical, pathological and embr...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1159/000473017

    authors: Cisternino A,Artibani W,Aragona F,Bassi P

    更新日期:1988-01-01 00:00:00

  • Sleep polygraphic studies using cystomanometry in twenty patients with enuresis.

    abstract::Polygraphic exploration during sleep using cystomanometry was performed in 20 patients aged 7-17 years with primary (17) or secondary (3) enuresis. In this group of patients, 9 presented with isolated nocturnal enuresis while 11 patients had associated diurnal micturition troubles. During this study we documented 24 e...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1159/000474272

    authors: Robert M,Averous M,Besset A,Carlander B,Billiard M,Guiter J,Grasset D

    更新日期:1993-01-01 00:00:00

  • Paclitaxel in pretreated metastatic penile cancer: final results of a phase 2 study.

    abstract:BACKGROUND:Previously published preliminary findings showed promising activity of paclitaxel in chemotherapy-pretreated metastatic penile cancer. OBJECTIVE:To evaluate the activity and safety of paclitaxel in pretreated metastatic penile cancer. DESIGN, SETTING, AND PARTICIPANTS:Twenty-five patients were enrolled in ...

    journal_title:European urology

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.eururo.2011.08.028

    authors: Di Lorenzo G,Federico P,Buonerba C,Longo N,Cartenì G,Autorino R,Perdonà S,Ferro M,Rescigno P,D'Aniello C,Matano E,Altieri V,Palmieri G,Imbimbo C,De Placido S,Mirone V

    更新日期:2011-12-01 00:00:00

  • Next-generation RNA Sequencing-based Biomarker Characterization of Chromophobe Renal Cell Carcinoma and Related Oncocytic Neoplasms.

    abstract:BACKGROUND:Renal cell carcinomas (RCCs) are a heterogeneous group of neoplasms. Recent sequencing studies revealed various molecular features associated with histologic RCC subtypes, including chromophobe renal cell carcinoma (ChRCC). OBJECTIVE:To characterize the gene expression and biomarker signatures associated wi...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1016/j.eururo.2020.03.003

    authors: Skala SL,Wang X,Zhang Y,Mannan R,Wang L,Narayanan SP,Vats P,Su F,Chen J,Cao X,Siddiqui J,Argani P,Cieślik MP,Giordano TJ,Chinnaiyan AM,Dhanasekaran SM,Mehra R

    更新日期:2020-07-01 00:00:00

  • T lymphocytes infiltrating the bladder wall of patients with carcinoma of urinary bladder are in vivo activated.

    abstract:OBJECTIVES:This paper studies the phenotypical characteristics of the lymphocytes present in mononuclear cell (MNC) preparations from peripheral blood (PBMNC), lymph nodes (LNMNC), tumor bladder (TBMNC), and tumor-free bladder (TFBMNC) from patients with infiltrated transitional cell carcinoma (TCC) of the bladder and ...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1159/000474509

    authors: Reyes E,Carballido J,Prieto A,Molto L,Manzano L,Alvarez-Mon M

    更新日期:1997-01-01 00:00:00

  • External Validation of the European Association of Urology Biochemical Recurrence Risk Groups to Predict Metastasis and Mortality After Radical Prostatectomy in a European Cohort.

    abstract::The impact of biochemical recurrence (BCR) after radical treatment of prostate cancer on oncological outcomes remains unclear. A new European Association of Urology BCR risk stratification (low and high risk) has been proposed. To validate these risk groups, we retrospectively analyzed data for 1125 post-radical prost...

    journal_title:European urology

    pub_type: 评论,杂志文章

    doi:10.1016/j.eururo.2019.03.016

    authors: Tilki D,Preisser F,Graefen M,Huland H,Pompe RS

    更新日期:2019-06-01 00:00:00

  • Selective estrogen receptor alpha agonist GTx-758 decreases testosterone with reduced side effects of androgen deprivation therapy in men with advanced prostate cancer.

    abstract:BACKGROUND:A need remains for new therapeutic approaches for men with advanced prostate cancer, particularly earlier in the disease course. OBJECTIVE:To assess the ability of an oral selective estrogen receptor α agonist (GTx-758) to lower testosterone concentrations compared with leuprolide while minimizing estrogen ...

    journal_title:European urology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1016/j.eururo.2014.06.011

    authors: Yu EY,Getzenberg RH,Coss CC,Gittelman MM,Keane T,Tutrone R,Belkoff L,Given R,Bass J,Chu F,Gambla M,Gaylis F,Bailen J,Hancock ML,Smith J,Dalton JT,Steiner MS

    更新日期:2015-02-01 00:00:00

  • Hybrid transvaginal nephrectomy.

    abstract::This case study reports one case of transvaginal natural orifice transluminal endoscopic surgery (NOTES) in a 23-yr-old woman with right flank pain and recurrent urinary tract infection due to a nonfunctional right kidney. She underwent nephrectomy by transvaginal NOTES using the endoscope by vaginal access and two ad...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1016/j.eururo.2007.10.053

    authors: Branco AW,Branco Filho AJ,Kondo W,Noda RW,Kawahara N,Camargo AA,Stunitz LC,Valente J,Rangel M

    更新日期:2008-06-01 00:00:00

  • Prostate specific antigen doubling time as auxiliary end point in hormone refractory prostatic carcinoma.

    abstract:OBJECTIVE:In hormone refractory prostatic carcinoma (HRPCa), the majority of patients have bone metastases only, which are by definition non-measurable. This makes objective evaluation of chemotherapeutic agents difficult. Prostate specific antigen (PSA) as a dynamic model was analyzed as potential auxiliary end point ...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1016/s0302-2838(02)00539-0

    authors: Schmid HP,Morant R,Bernhard J,Maibach R,Swiss Group for Clinical Cancer Research (SAKK).

    更新日期:2003-01-01 00:00:00

  • Villous adenoma of the prostatic urethra.

    abstract::We present a case of villous adenoma of the prostatic urethra, without malignant transformation. A review of the diagnostic and therapeutic criteria and pathogenic hypotheses on this kind of lesion in the lower urinary tract are made. ...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1159/000472952

    authors: Algaba F,Matias-Guiu X,Badia F,Solé-Balcells F

    更新日期:1988-01-01 00:00:00

  • A novel robotic system for single-port urologic surgery: first clinical investigation.

    abstract:BACKGROUND:The idea of performing a laparoscopic procedure through a single abdominal incision was conceived with the aim of expediting postoperative recovery. OBJECTIVE:To determine the clinical feasibility and safety of single-port urologic procedures by using a novel robotic surgical system. DESIGN, SETTING, AND P...

    journal_title:European urology

    pub_type: 临床试验,杂志文章

    doi:10.1016/j.eururo.2014.06.039

    authors: Kaouk JH,Haber GP,Autorino R,Crouzet S,Ouzzane A,Flamand V,Villers A

    更新日期:2014-12-01 00:00:00

  • Prostate Cancer Prevention Trial (PCPT) update.

    abstract::The Prostate Cancer Prevention Trial is an intergroup effort in the USA managed by the Southwest Oncology Group (SWOG) in collaboration with the Eastern Cooperative Oncology Group (ECOG) and the Cancer and Leukemia Group B (CALGB). This 10-year study began approximately 5 years ago and will achieve its primary endpoin...

    journal_title:European urology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1159/000019895

    authors: Coltman CA Jr,Thompson IM Jr,Feigl P

    更新日期:1999-01-01 00:00:00

  • Sequence therapy in patients with metastatic renal cell carcinoma: comparison of common targeted treatment options following failure of receptor tyrosine kinase inhibitors.

    abstract:BACKGROUND:The best sequence of targeted therapy in patients with metastatic renal cell carcinoma (mRCC) has not been sufficiently defined. OBJECTIVE:To describe the efficacy and toxicity of sequential everolimus (EV) versus receptor tyrosine kinase inhibitor (rTKI) following failure of first rTKI treatment. DESIGN, ...

    journal_title:European urology

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.eururo.2011.07.037

    authors: Busch J,Seidel C,Kempkensteffen C,Johannsen M,Wolff I,Hinz S,Magheli A,Miller K,Grünwald V,Weikert S

    更新日期:2011-12-01 00:00:00

  • Orthotopic kidney transplantation: an alternative surgical technique in selected patients.

    abstract:BACKGROUND:A renal transplant is the treatment of choice for patients with end-stage renal disease due to its superior short- and long-term survival benefits compared with dialysis treatment. A common trend for kidney transplantation in developed countries is an increasing acceptance of older patients, patients with co...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1016/j.eururo.2010.09.023

    authors: Musquera M,Peri LL,Alvarez-Vijande R,Oppenheimer F,Gil-Vernet JM,Alcaraz A

    更新日期:2010-12-01 00:00:00

  • Metastasectomy in renal cell carcinoma: A multicenter retrospective analysis.

    abstract:OBJECTIVE:In 60-70% of patients with renal cell carcinoma (RCC), metastases develop in the course of the disease. In the present analysis, the surgical management of metastases is described, and survival data are presented. This retrospective analysis may help in the management of future cases. Due to the retrospective...

    journal_title:European urology

    pub_type: 杂志文章,多中心研究

    doi:10.1159/000019849

    authors: van der Poel HG,Roukema JA,Horenblas S,van Geel AN,Debruyne FM

    更新日期:1999-01-01 00:00:00

  • A (-5, -7) proPSA based artificial neural network to detect prostate cancer.

    abstract:OBJECTIVE:The pro-forms of prostate specific antigen (-2,-5,-7 proPSA) and also %free PSA based artificial neural networks (ANN) have been suggested to enhance the discrimination between prostate cancer (PCa) and no evidence of malignancy (NEM). This study reports on the combined use of proPSA within a %free PSA based ...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1016/j.eururo.2006.04.011

    authors: Stephan C,Meyer HA,Kwiatkowski M,Recker F,Cammann H,Loening SA,Jung K,Lein M

    更新日期:2006-11-01 00:00:00

  • Scrotal ultrasound in male infertility.

    abstract::During an 18-month period, 200 male infertility patients had scrotal sonography examination. Fifty-seven percent showed abnormal sonogram; such as epididymitis, epididymo-orchitis, orchitis, varicocele, spermatocele, epididymal cyst and undescended testis. Among all lesions, infection was the commonest finding. There ...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1159/000471634

    authors: Patel PJ,Pareek SS

    更新日期:1989-01-01 00:00:00

  • Radical prostatectomy or wait-and-watch?

    abstract::With intensified screening and the use of new diagnostic tools for prostate cancer (prostate-specific antigen, rectal ultrasound, magnetic resonance imaging with rectal coils, etc), the number of newly diagnosed cases of prostate cancer is rising rapidly, whereas the frequency of death due to prostate cancer remains a...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1159/000474384

    authors: Studer UE,Thalmann G,Zingg EJ

    更新日期:1993-01-01 00:00:00

  • Adjuvant chemotherapy for invasive bladder cancer: a 2013 updated systematic review and meta-analysis of randomized trials.

    abstract:CONTEXT:The role of adjuvant chemotherapy remains poorly defined for the management of muscle-invasive bladder cancer (MIBC). The last meta-analysis evaluating adjuvant chemotherapy, conducted in 2005, had limited power to fully support its use. OBJECTIVE:To update the current evidence of the benefit of postoperative ...

    journal_title:European urology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1016/j.eururo.2013.08.033

    authors: Leow JJ,Martin-Doyle W,Rajagopal PS,Patel CG,Anderson EM,Rothman AT,Cote RJ,Urun Y,Chang SL,Choueiri TK,Bellmunt J

    更新日期:2014-07-01 00:00:00

  • Learning Curve in Robot-assisted Kidney Transplantation: Results from the European Robotic Urological Society Working Group.

    abstract:BACKGROUND:Recently, robot-assisted kidney transplantation (RAKT) was recently introduced as renal replacement mini-invasive surgery. OBJECTIVE:To report surgical technique, including tips and tricks, and the learning curve for RAKT. DESIGN, SETTING, AND PARTICIPANTS:All consecutive RAKTs performed in the five highes...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1016/j.eururo.2019.12.008

    authors: Gallioli A,Territo A,Boissier R,Campi R,Vignolini G,Musquera M,Alcaraz A,Decaestecker K,Tugcu V,Vanacore D,Serni S,Breda A

    更新日期:2020-08-01 00:00:00

  • Tamsulosin, the first prostate-selective alpha 1A-adrenoceptor antagonist. Analysis of a multinational, multicentre, open-label study assessing the long-term efficacy and safety in patients with benign prostatic obstruction (symptomatic BPH). European Tam

    abstract:OBJECTIVE:This open-label extension study evaluated the efficacy and safety of tamsulosin (0.4 mg as a modified release formulation) once daily in patients with benign prostatic enlargement, lower urinary tract symptoms and benign prostatic obstruction (symptomatic BPH) for up to 60 weeks. METHODS:Patients were enroll...

    journal_title:European urology

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:

    authors: Schulman CC,Cortvriend J,Jonas U,Lock TM,Vaage S,Speakman MJ

    更新日期:1996-01-01 00:00:00

  • Impact of urinary tract infection and detrusor pressure on renal tubular function in patients with vesicoureteral reflux.

    abstract:OBJECTIVE:The aim of this study was to evaluate prospectively the impact of bacteriuria with or without pyuria and/or detrusor pressure on renal tubular function in patients with secondary vesicoureteral reflux. METHODS:From October 1994 to December1998, we evaluated 54 patients with secondary vesicoureteral reflux (2...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1159/000052464

    authors: Everaert K,Van Laecke E,Dekuyper P,Hoebeke P,Delanghe J,Oosterlinck W,Vande Walle J

    更新日期:2001-03-01 00:00:00

  • Nanotechnology and its relevance to the urologist.

    abstract:OBJECTIVES:We review important aspects of nanotechnology, and discuss the wide range of research and clinical applications of nanomedicine in the field of urology. There is particular emphasis on key clinical and pre-clinical studies to provide an update on recent and potential applications in the care of urological pa...

    journal_title:European urology

    pub_type: 杂志文章,评审

    doi:10.1016/j.eururo.2007.04.065

    authors: Gommersall L,Shergill IS,Ahmed HU,Hayne D,Arya M,Patel HR,Hashizume M,Gill IS

    更新日期:2007-08-01 00:00:00

  • Oncologic outcome and patterns of recurrence after salvage radical prostatectomy.

    abstract:BACKGROUND:Limited data on patterns of recurrence (local or metastatic) after salvage radical prostatectomy (SP) is available. OBJECTIVE:To examine biochemical, local and metastatic patterns of recurrence in patients undergoing SP for radiation-recurrent prostate cancer. DESIGN, SETTING, AND PARTICIPANTS:146 patients...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1016/j.eururo.2008.07.007

    authors: Paparel P,Cronin AM,Savage C,Scardino PT,Eastham JA

    更新日期:2009-02-01 00:00:00

  • A Multicentre Study of 5-year Outcomes Following Focal Therapy in Treating Clinically Significant Nonmetastatic Prostate Cancer.

    abstract:BACKGROUND:Clinically significant nonmetastatic prostate cancer (PCa) is currently treated using whole-gland therapy. This approach is effective but can have urinary, sexual, and rectal side effects. OBJECTIVE:To report on 5-yr PCa control following focal high-intensity focused ultrasound (HIFU) therapy to treat indiv...

    journal_title:European urology

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.eururo.2018.06.006

    authors: Guillaumier S,Peters M,Arya M,Afzal N,Charman S,Dudderidge T,Hosking-Jervis F,Hindley RG,Lewi H,McCartan N,Moore CM,Nigam R,Ogden C,Persad R,Shah K,van der Meulen J,Virdi J,Winkler M,Emberton M,Ahmed HU

    更新日期:2018-10-01 00:00:00

  • Stage-specific impact of tumor location on oncologic outcomes in patients with upper and lower tract urothelial carcinoma following radical surgery.

    abstract:BACKGROUND:Dissimilarities in management and outcomes exist between upper tract urothelial carcinoma (UTUC) and urothelial carcinoma of the bladder (UCB). OBJECTIVE:The aim of this study was to analyze the stage-specific impact of upper or lower urinary tract tumor location on oncologic outcomes. DESIGN, SETTING, AND...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1016/j.eururo.2012.02.018

    authors: Rink M,Ehdaie B,Cha EK,Green DA,Karakiewicz PI,Babjuk M,Margulis V,Raman JD,Svatek RS,Fajkovic H,Lee RK,Novara G,Hansen J,Daneshmand S,Lotan Y,Kassouf W,Fritsche HM,Pycha A,Fisch M,Scherr DS,Shariat SF,Bladder C

    更新日期:2012-10-01 00:00:00

  • Renal lesions in Von Hippel-Lindau disease: the benign, the malignant, the unknown.

    abstract:OBJECTIVES:To describe the features and treatment of renal lesions in von Hippel-Lindau disease (VHL) from a series of patients, to highlight important issues in the management of these lesions. MATERIALS AND METHODS:We performed a retrospective study in 7 patients with VHL who underwent surgery for renal lesions betw...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1159/000019771

    authors: Salomé F,Colombeau P,Fermeaux V,Cazaux P,Dumas JP,Pfeifer P,Moreau JJ,Richard S,Labrousse F

    更新日期:1998-01-01 00:00:00

  • A comparison of the efficacy and tolerability of solifenacin succinate and extended release tolterodine at treating overactive bladder syndrome: results of the STAR trial.

    abstract:OBJECTIVE:To compare two new generation antimuscarinics at their recommended doses for treatment of overactive bladder syndrome (OAB). METHODS:A prospective, double blind, double-dummy, two-arm, parallel-group, 12-week study was conducted to compare the efficacy and safety of solifenacin 5 or 10 mg and tolterodine ext...

    journal_title:European urology

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.eururo.2005.05.015

    authors: Chapple CR,Martinez-Garcia R,Selvaggi L,Toozs-Hobson P,Warnack W,Drogendijk T,Wright DM,Bolodeoku J,STAR study group.

    更新日期:2005-09-01 00:00:00