当前位置： SCI文献检索 > EXPERIMENTAL HEMATOLOGY期刊下所有文献 > Effect of in vitro treatment with indomethacin on mouse granulocyte-macrophage colony-forming cells in culture (CFUC). Possible role of prostaglandins.

Effect of in vitro treatment with indomethacin on mouse granulocyte-macrophage colony-forming cells in culture (CFUC). Possible role of prostaglandins.

Abstract：

:The effect of indomethacin (6 mg/kg daily orally for 2, 3 or 4 days) on myelopoiesis was studied in mice by estimating 1) differential cell counts of bone marrow, 2) proliferation of the CFUC in presence of GM-CSF, 3) proliferative state of CFUC after tritiated thymidine suicide. After 4 days of treatment, a rise in the recognizable myeloid precursors, an increase of both the colony forming capacity and the number of CFUC in S-phase were observed. These data suggest that indomethacin produced an hyperplasia of the committed stem cell compartment. The decrease of PGE2 amounts in bone marrow cells following treatment with indomethacin could explain the hyperplasia observed. These in vivo results are in accordance with the in vitro data which show that PG could control the proliferation and differentiation of myeloid progenitor cells.

journal_name

Exp Hematol

journal_title

Experimental hematology

authors

Fontagné J,Adolphe M,Semichon M,Zizine L,Lechat P

subject

Has Abstract

pub_date

1980-10-01 00:00:00

pages

1157-64

issue

9

eissn

0301-472X

issn

1873-2399

journal_volume

8

pub_type

杂志文章

相关文献

EXPERIMENTAL HEMATOLOGY文献大全
  • Validation of flow-cytometric determination of Ki67 expression as a measure of growth factor response in acute myelogenous leukemia.

    abstract：:Despite its growing use as a marker of proliferation, the relationship between expression of the nuclear antigen Ki67 and other indices of proliferation in acute myelogenous leukemia (AML) has not been elucidated. In this study, short-term primary suspension cultures of human AML bone marrow cells were used to compare...

    journal_title：Experimental hematology

    pub_type： 杂志文章

    doi：

    authors： Gore SD,Weng LJ,Burke PJ

    更新日期：1993-12-01 00:00:00

  • Clonal hematopoiesis in hematological disorders: Three different scenarios.

    abstract：:Clonality studies can establish the single-cell origin of tumors and thus differentiate clonal malignant and premalignant processes from reactive polyclonal processes. Detection of clonal cells may be based on direct tracking of cell lineage-specific sequences or disease-specific somatic mutations identifying the clon...

    journal_title：Experimental hematology

    pub_type： 杂志文章,评审

    doi：10.1016/j.exphem.2020.01.013

    authors： Swierczek S,Prchal JT

    更新日期：2020-03-01 00:00:00

  • Bone marrow-derived endothelial progenitor cells do not contribute significantly to new vessels during incisional wound healing.

    abstract：OBJECTIVE:To assess the contribution of bone marrow (BM)-derived endothelial progenitor cells (EPCs) to the neovascularisation of cutaneous incisional wounds. METHODS:Lethally irradiated C57Bl/6 mice were transplanted with BM mononuclear cells from Tie2/lacZ mice, which constitutively overexpressed beta-galactosidase ...

    journal_title：Experimental hematology

    pub_type： 杂志文章

    doi：10.1016/j.exphem.2006.10.016

    authors： Bluff JE,Ferguson MW,O'Kane S,Ireland G

    更新日期：2007-03-01 00:00:00

  • The critical role of germinal center-associated nuclear protein in cell biology, immunohematology, and hematolymphoid oncogenesis.

    abstract：:Germinal center-associated nuclear protein (GANP) is a unique and multifunctional protein that plays a critical role in cell biology, neurodegenerative disorders, immunohematology, and oncogenesis. GANP is an orthologue of Saccharomyces Sac3, one of the components of the transcription export 2 (TREX-2) complex and a m...

    journal_title：Experimental hematology

    pub_type： 杂志文章,评审

    doi：10.1016/j.exphem.2020.08.007

    authors： Sakai Y,Phimsen S,Okada S,Kuwahara K

    更新日期：2020-10-01 00:00:00

  • Insulin-like growth factor 2 modulates murine hematopoietic stem cell maintenance through upregulation of p57.

    abstract：:Hematopoietic stem cells (HSC) rely on a highly regulated molecular network to balance self-renewal and lineage specification to sustain life-long hematopoiesis. Despite a plethora of studies aimed at identifying molecules governing HSC fate, our current knowledge of the genes responsible is limited. We have found ins...

    journal_title：Experimental hematology

    pub_type： 杂志文章

    doi：10.1016/j.exphem.2016.01.010

    authors： Thomas DD,Sommer AG,Balazs AB,Beerman I,Murphy GJ,Rossi D,Mostoslavsky G

    更新日期：2016-05-01 00:00:00

  • Efficient transformation and frequent single-site, single-copy insertion of DNA can be obtained in mouse erythroleukemia cells transformed by electroporation.

    abstract：:Electroporation has recently been shown to have advantages over the commonly used method of calcium phosphate precipitation for obtaining DNA-mediated transformation of certain types of cells. Although mouse erythroleukemia cells and other cells of hematopoietic origin are not transformed at useful frequencies by calc...

    journal_title：Experimental hematology

    pub_type： 杂志文章

    doi：

    authors： Boggs SS,Gregg RG,Borenstein N,Smithies O

    更新日期：1986-11-01 00:00:00

  • Alterations in erythropoiesis in TGF-beta 1-treated mice.

    abstract：:Chronic treatment of mice with transforming growth factor beta 1 (TGF-beta 1) resulted in a dose-dependent inhibition of erythropoiesis. Following 14 daily s.c. injections of 5 or 25 micrograms of TGF-beta 1, a significant degree of anemia was observed. In addition, erythroid progenitor cells were present in reduced n...

    journal_title：Experimental hematology

    pub_type： 杂志文章

    doi：

    authors： Miller KL,Carlino JA,Ogawa Y,Avis PD,Carroll KG

    更新日期：1992-09-01 00:00:00

  • Effects of androgen on transient endogenous spleen colonies and other hemopoietic stem cells in mice.

    abstract：:To clarify the effects of androgen on hemopoiesis in mice, we investigated changes in hemopoietic stem cells at various stages of differentiation after injection of 19-nandrolone decanoate (19-ND). 19-ND induced (a) a marked increase in the population of CFUe, especially in the spleen, and (b) a less significant incre...

    journal_title：Experimental hematology

    pub_type： 杂志文章

    doi：

    authors： Kamamoto T,Sakoda H,Yoshida Y,Uchino H,Imai N,Mori KJ

    更新日期：1985-08-01 00:00:00

  • Osteoblasts promote engraftment of allogeneic hematopoietic stem cells.

    abstract：:Hematopoietic progenitor cells (low density, lineage negative [Lin-], depleted of CD4+, CD8+, B220+, Gr-1+, Mac-1+, CD71+, and Thy1.2+ cells) can engraft lethally irradiated mice when transplanted within, but not across the major histocompatibility (MHC) antigen barrier. We hypothesized that our progenitor cell prepar...

    journal_title：Experimental hematology

    pub_type： 杂志文章

    doi：

    authors： El-Badri NS,Wang BY,Cherry,Good RA

    更新日期：1998-02-01 00:00:00

  • Oncogenic Ras blocks transforming growth factor-beta-induced cell-cycle arrest by degradation of p27 through a MEK/Erk/SKP2-dependent pathway.

    abstract：OBJECTIVE:To examine whether oncogenic Ras affects transforming growth factor (TGF)-beta-mediated cell-cycle arrest in hematopoietic cells and the downstream signal transduction pathway involved in the interference with TGF-beta-induced cell-cycle arrest. MATERIALS AND METHODS:Two leukemic cell lines bearing N-Ras(L61...

    journal_title：Experimental hematology

    pub_type： 杂志文章

    doi：10.1016/j.exphem.2005.04.006

    authors： Schepers H,Wierenga AT,Eggen BJ,Vellenga E

    更新日期：2005-07-01 00:00:00

  • Flt3 ligand and granulocyte-macrophage colony-stimulating factor preferentially expand and stimulate different dendritic and T-cell subsets.

    abstract：OBJECTIVE:Mechanisms of T-cell stimulation by Flt3 ligand (Flt3L) and granulocyte-macrophage colony-stimulating factor (GM-CSF) remain unclear. Herein, we compared the effects of Flt3L and GM-CSF on the expansion of dendritic cells (DC) and T-cell subsets and cytokine expression. METHODS:Naïve and effector/memory T ce...

    journal_title：Experimental hematology

    pub_type： 杂志文章

    doi：10.1016/s0301-472x(01)00722-6

    authors： Parajuli P,Mosley RL,Pisarev V,Chavez J,Ulrich A,Varney M,Singh RK,Talmadge JE

    更新日期：2001-10-01 00:00:00

  • Differential expression of AURKA and AURKB genes in bone marrow stromal mesenchymal cells of myelodysplastic syndrome: correlation with G-banding analysis and FISH.

    abstract：:It has been demonstrated that genomic alterations of cells in the hematopoietic microenvironment could induce myelodysplastic syndromes (MDS) with ineffective hematopoiesis and dysmorphic hematopoietic cells, and subsequent transformation to acute myeloid leukemia. This investigation is the first attempt to correlate ...

    journal_title：Experimental hematology

    pub_type： 杂志文章

    doi：10.1016/j.exphem.2012.10.009

    authors： Oliveira FM,Lucena-Araujo AR,Favarin Mdo C,Palma PV,Rego EM,Falcão RP,Covas DT,Fontes AM

    更新日期：2013-02-01 00:00:00

  • Heterozygous kit mutants with little or no apparent anemia exhibit large defects in overall hematopoietic stem cell function.

    abstract：OBJECTIVE:The evolutionarily conserved Kit receptor is vital for function of hematopoietic stem cells (HSC). Kit(W-41) (W-41) and Kit(W-42) (W-42) are single residue changes in the KIT intracellular phosphotransferase domain, while Kit(W-v) (W-v) is a single residue change in the ATP binding domain. This study tests ho...

    journal_title：Experimental hematology

    pub_type： 杂志文章

    doi：10.1016/j.exphem.2006.10.001

    authors： Sharma Y,Astle CM,Harrison DE

    更新日期：2007-02-01 00:00:00

  • Targeted gene correction of RUNX1 in induced pluripotent stem cells derived from familial platelet disorder with propensity to myeloid malignancy restores normal megakaryopoiesis.

    abstract：:Familial platelet disorder with propensity to acute myeloid leukemia (FPD/AML) is an autosomal dominant disease associated with a germline mutation in the RUNX1 gene and is characterized by thrombocytopenia and an increased risk of developing myeloid malignancies. We generated induced pluripotent stem cells (iPSCs) fr...

    journal_title：Experimental hematology

    pub_type： 杂志文章

    doi：10.1016/j.exphem.2015.05.004

    authors： Iizuka H,Kagoya Y,Kataoka K,Yoshimi A,Miyauchi M,Taoka K,Kumano K,Yamamoto T,Hotta A,Arai S,Kurokawa M

    更新日期：2015-10-01 00:00:00

  • Cinemicroscopic studies of lymphocyte behavior in semi-solid medium: the polyclonal origin of lymphocyte colonies.

    abstract：:Time-lapse cinemicroscopy was used to observe the development of lymphocyte colonies in a phytohemagglutinin-dependent one-step, two-layer agar culture system. More than 1000 h of culture time were recorded in a total of 14 independent experiments. Blast formation and organization of lymphocytes into highly motile pai...

    journal_title：Experimental hematology

    pub_type： 杂志文章

    doi：

    authors： Donnenberg AD,Cameron J

    更新日期：1985-01-01 00:00:00

  • Preparation of human erythropoietin for tissue culture.

    abstract：:A simple two-step procedure has been developed for the production of human urinary erythropoietin suitable for tissue culture use. Lyophilized human urinary protein was fractionated by phenyl-Sepharose chromatography, the erythropoietin binding in 2 M lithium chloride and being eluted by an ascending linear gradient t...

    journal_title：Experimental hematology

    pub_type： 杂志文章

    doi：

    authors： Cutler RL,Johnson GR,Nicola NA

    更新日期：1985-09-01 00:00:00

  • A rare subgroup of leukemia stem cells harbors relapse-inducing potential in acute lymphoblastic leukemia.

    abstract：:After initially successful chemotherapy, relapse frequently jeopardizes the outcome of patients with acute leukemia. Because of their adverse characteristics of self-renewal and dormancy, leukemia stem cells have been hypothesized to play a critical role in resistance to antiproliferative chemotherapy and the developm...

    journal_title：Experimental hematology

    pub_type： 杂志文章,评审

    doi：10.1016/j.exphem.2018.09.006

    authors： Senft D,Jeremias I

    更新日期：2019-01-01 00:00:00

  • In vivo regulation of hemopoiesis by transforming growth factor beta 1: stimulation of GM-CSF- and M-CSF-dependent murine bone marrow precursors.

    abstract：:Injection of mice with either natural bovine bone-derived or human recombinant transforming growth factor beta 1 (TGF-beta 1) resulted in a significant increase of the macrophage and macrophage-granulocyte-forming capacity of their macrophage colony-stimulating factor (M-CSF)- and granulocyte-macrophage colony-stimula...

    journal_title：Experimental hematology

    pub_type： 杂志文章

    doi：

    authors： Bursuker I,Neddermann KM,Petty BA,Schacter B,Spitalny GL,Tepper MA,Pasternak RD

    更新日期：1992-05-01 00:00:00

  • Leukemia patient-derived lymphoblastoid cell lines exhibit increased induction of leukemia-associated transcripts following high-dose irradiation.

    abstract：:Improvement in diagnostic cytogenetic techniques has led to the recognition of an increasing number of leukemia-associated chromosomal translocations and inversions. These genetic lesions frequently are associated with the disruption of putative transcription factors and the production of hybrid transcripts that are i...

    journal_title：Experimental hematology

    pub_type： 杂志文章

    doi：10.1016/s0301-472x(99)00082-x

    authors： Spencer A,Granter N

    更新日期：1999-09-01 00:00:00

  • Investigations on the pool size, proliferative state and differentiation pattern of splenic CFUC in normal dogs.

    abstract：:In the present study we investigated the absolute numbers of granulocytic progenitor cells (CFUc) in the spleens of adult normal dogs, their differentiation pattern and also their proliferative state. Between 10 and 40 times as many CFUc were found in the spleens of individual dogs as were present in the total blood v...

    journal_title：Experimental hematology

    pub_type： 杂志文章

    doi：

    authors： Nothdurft W,Calvo W,Fliedner TM,Schnappauf HP

    更新日期：1980-09-01 00:00:00

  • Identification of small Sca-1(+), Lin(-), CD45(-) multipotential cells in the neonatal murine retina.

    abstract：OBJECTIVE:Bone marrow contains a subset of stem cells that give rise to nonhematopoietic lineages. These nonhematopoietic stem cells appear heterogeneous and contain cells committed to mesenchymal and endothelial lineages, as well as more primitive multipotential cells resembling progenitors of germ cells and very smal...

    journal_title：Experimental hematology

    pub_type： 杂志文章

    doi：10.1016/j.exphem.2009.05.014

    authors： Liu Y,Gao L,Zuba-Surma EK,Peng X,Kucia M,Ratajczak MZ,Wang W,Enzmann V,Kaplan HJ,Dean DC

    更新日期：2009-09-01 00:00:00

  • Oncostatin M suppresses generation of lymphoid progenitors in fetal liver by inhibiting the hepatic microenvironment.

    abstract：OBJECTIVE:Interaction between hematopoietic cells and stromal cells is important for regulation of hematopoiesis. Numerous soluble and membrane-bound factors directly regulating hematopoiesis have been documented, but little is known about how stromal cell activity is controlled. We previously reported that fetal hepat...

    journal_title：Experimental hematology

    pub_type： 杂志文章

    doi：10.1016/s0301-472x(01)00686-5

    authors： Kinoshita T,Nagata K,Sorimachi N,Karasuyama H,Sekiguchi T,Miyajima A

    更新日期：2001-09-01 00:00:00

  • Functional expression of CD80 and CD86 allows immunogenicity of malignant B cells from non-Hodgkin's lymphomas.

    abstract：:We analyzed the accessory function of malignant B cells from non-Hodgkin's lymphomas (NHLs). Among the 70 samples of malignant B cells included, four patterns of expression of the costimulatory molecules CD80 and CD86 were distinguished (+/+, +/-, -/+ and -/-). In two-thirds of the cases, CD80, CD86, or both were expr...

    journal_title：Experimental hematology

    pub_type： 杂志文章

    doi：10.1016/s0301-472x(98)00059-9

    authors： Chaperot L,Plumas J,Jacob MC,Bost F,Molens JP,Sotto JJ,Bensa JC

    更新日期：1999-03-01 00:00:00

  • Bone marrow repopulation by human marrow stem cells after long-term expansion culture on a porcine endothelial cell line.

    abstract：:In vitro exposure of murine hematopoietic stem cells (HSCs) to cell cycle-inducing cytokines has been shown to result in a defect in the ability of these cells to engraft. We used a porcine microvascular endothelial cell (PMVEC) line in conjunction with exogenous interleukin (IL)-3, IL-6, granulocyte-macrophage colony...

    journal_title：Experimental hematology

    pub_type： 杂志文章

    doi：

    authors： Brandt JE,Galy AH,Luens KM,Travis M,Young J,Tong J,Chen S,Davis TA,Lee KP,Chen BP,Tushinski R,Hoffman R

    更新日期：1998-09-01 00:00:00

  • Reduced expression of flavocytochrome b558, a component of the NADPH oxidase complex, in neutrophils from patients with myelodysplasia.

    abstract：OBJECTIVE:Patients with myelodysplasia (MDS) show a disturbed production of ROS in response to N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP) in granulocyte-macrophage colony-stimulating factor (GM-CSF)-primed neutrophils. Because generation of ROS is mediated by the NADPH oxidase complex, a component of which is...

    journal_title：Experimental hematology

    pub_type： 杂志文章

    doi：10.1016/s0301-472x(03)00188-7

    authors： Fuhler GM,Hooijenga F,Drayer AL,Vellenga E

    更新日期：2003-09-01 00:00:00

  • Biological implications of clonal hematopoiesis.

    abstract：:Adult hematological malignancies, such as acute myeloid leukemia, are thought to arise through the gradual acquisition of oncogenic mutations within long-lived hematopoietic stem cells (HSCs). Genomic analysis of peripheral blood DNA has recently identified leukemia-associated genetic mutations within otherwise health...

    journal_title：Experimental hematology

    pub_type： 杂志文章,评审

    doi：10.1016/j.exphem.2019.08.004

    authors： Luis TC,Wilkinson AC,Beerman I,Jaiswal S,Shlush LI

    更新日期：2019-09-01 00:00:00

  • Marrow repopulating cells, but not CFU-S, establish long-term in vitro hemopoiesis on a marrow-derived stromal layer.

    abstract：:We have studied the ability of subpopulations of hemopoietic stem cells, obtained from murine bone marrow using elutriation and multiparameter sorting, to establish and maintain hemopoiesis following their deposition on irradiated stromal layers of long-term bone marrow cultures. Two fractions were obtained that diffe...

    journal_title：Experimental hematology

    pub_type： 杂志文章

    doi：

    authors： van der Sluijs JP,de Jong JP,Brons NH,Ploemacher RE

    更新日期：1990-09-01 00:00:00

  • Mobilization with granulocyte colony-stimulating factor blocks medullar erythropoiesis by depleting F4/80(+)VCAM1(+)CD169(+)ER-HR3(+)Ly6G(+) erythroid island macrophages in the mouse.

    abstract：:Similarly to other tissues, the bone marrow contains subsets of resident tissue macrophages, which are essential to maintain bone formation, functional hematopoietic stem cell (HSC) niches, and erythropoiesis. Pharmacologic doses of granulocyte colony-stimulating factor (G-CSF) mobilize HSC in part by interfering with...

    journal_title：Experimental hematology

    pub_type： 杂志文章

    doi：10.1016/j.exphem.2014.03.009

    authors： Jacobsen RN,Forristal CE,Raggatt LJ,Nowlan B,Barbier V,Kaur S,van Rooijen N,Winkler IG,Pettit AR,Levesque JP

    更新日期：2014-07-01 00:00:00

  • Regulation of human B lymphopoiesis by the transforming growth factor-beta superfamily in a newly established coculture system using human mesenchymal stem cells as a supportive microenvironment.

    abstract：OBJECTIVES:To characterize and evaluate the validity of a novel coculture system for studying human B-lymphocyte developmental biology. MATERIALS AND METHODS:We developed a long-term culture system to produce B lymphocytes from human CD34(+) cells purified from umbilical cord blood using human mesenchymal stem cells (...

    journal_title：Experimental hematology

    pub_type： 杂志文章

    doi：10.1016/j.exphem.2007.12.013

    authors： Ichii M,Oritani K,Yokota T,Nishida M,Takahashi I,Shirogane T,Ezoe S,Saitoh N,Tanigawa R,Kincade PW,Kanakura Y

    更新日期：2008-05-01 00:00:00

  • Modulation of intercellular communication mediated at the cell surface and on extracellular, plasma membrane-derived vesicles by ionizing radiation.

    abstract：:The plasma membrane is a dynamic organelle whose function includes receptor-mediated signal transduction into the cell. Conversely, the plasma membrane is the origin of inter-cellular signaling. In addition to expressing and releasing growth factors in a soluble form(through exocytosis) and via proteolysis of cell sur...

    journal_title：Experimental hematology

    pub_type： 杂志文章,评审

    doi：10.1016/s0301-472x(03)00050-x

    authors： Albanese J,Dainiak N

    更新日期：2003-06-01 00:00:00