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Pharmacology on rat ileum of certain 2-substituted 3-(dimethylamino)-5,6-dimethoxyindenes related to 5,6-(methylenedioxy)indene calcium antagonists.

Abstract：

:Whereas the 2-propyl- and 2-butyl-5,6-(methylenedioxy)indene calcium antagonists reversed the spasmogenic action of several agonists including PGF2alpha and acetylcholine at 5 X 10(-5) to 10(-4) M on the rat ileum, the corresponding 5,6-dimethoxy analogues exhibited spasmogenic activity at higher concentration (10(-4)-10(-3) M) and exhibited neither spasmogenic nor spasmolytic activity at lower (10(-6)-10(-5) M) concentration. The results are compared to the methyl and 2-ethyl analogues. At 10(-4) M only the butyl analogue was capable of moderate antagonism of acetylcholine and at 10(-3) M all four analogues were capable of moderately antagonizing the actions of acetylcholine.

journal_name

J Med Chem

journal_title

Journal of medicinal chemistry

authors

Witiak DT,Kakodkar SV,Brunst GE,Baldwin JR,Rahwan RG

doi

10.1021/jm00210a028

subject

Has Abstract

pub_date

1978-12-01 00:00:00

pages

1313-5

issue

12

eissn

0022-2623

issn

1520-4804

journal_volume

21

pub_type

杂志文章

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