Pulmonary extraction of catecholamines in critically ill patients.

Abstract:

:Plasma catecholamine concentrations in blood obtained simultaneously from the pulmonary and radial arteries of ten critically ill patients have been measured. The mean mixed venous concentrations of noradrenaline, adrenaline and dopamine were extremely high, noradrenaline 11.3 pmol/ml (SD 11.6), adrenaline 2.7 pmol/ml (SD 3.0) and dopamine 7.1 pmol/ml (SD 12.3). An appreciable drop in the concentrations occurred as the blood passed from the pulmonary artery to the radial artery (mean fall 24.1, 29.7 and 45.8% respectively). Four patients receiving a therapeutic dopamine infusion were also studied and demonstrated similar trends in catecholamine concentrations. The results suggest a substantial pulmonary clearance mechanism for all three catecholamines.

journal_name

Anaesth Intensive Care

authors

Russell WJ,Frewin DB,Jonsson JR

doi

10.1177/0310057X8201000404

subject

Has Abstract

pub_date

1982-11-01 00:00:00

pages

319-23

issue

4

eissn

0310-057X

issn

1448-0271

journal_volume

10

pub_type

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