Recombinant human erythropoietin in severe anaemia: issues of dosing and duration.

Abstract:

:The majority of Jehovah's Witnesses refuse blood product transfusion, even when it can be lifesaving. Treatment with recombinant human erythropoietin (RHuEPO) is a valuable adjunct in Jehovah's Witness patients undergoing surgery. A number of additional strategies, including acute normovolaemic haemodilution, intra-operative blood salvage and reinfusion, iron and folate supplementation are also utilized to avoid blood transfusion. Critically ill patients have blunted erythropoietin production and decreased endogenous iron availability. This case report reviews the treatment of anaemia in critically ill Jehovah's Witness patients after surgery and discusses the potential need for higher RHuEPO dosing strategies and longer duration of therapy.

journal_name

Anaesth Intensive Care

authors

Charles A,Purtill M,Napolitano LM

doi

10.1177/0310057X0603400319

subject

Has Abstract

pub_date

2006-12-01 00:00:00

pages

793-6

issue

6

eissn

0310-057X

issn

1448-0271

pii

2006102

journal_volume

34

pub_type

杂志文章
  • Propofol is a 'safe' anaesthetic agent in malignant hyperthermia susceptible patients.

    abstract::In this study we investigated in vitro and in vivo effects of propofol in malignant hyperthermia susceptible (MHS) patients in order to assess the safety of propofol infusion as a non-triggering anaesthetic technique for diagnostic and therapeutic procedures. In vitro, human MHS muscle samples were exposed to propofol...

    journal_title:Anaesthesia and intensive care

    pub_type: 杂志文章

    doi:10.1177/0310057X9202000208

    authors: McKenzie AJ,Couchman KG,Pollock N

    更新日期:1992-05-01 00:00:00

  • Low dose chlormethiazole infusion as a supplement to central neural blockade: blood concentrations and clinical effects.

    abstract::Chlormethiazole ethanedisulphonate (Hemineurin) was administered to provide light sedation in patients undergoing surgery with neural blockade. A two stage intravenous infusion system was used and consisted of a loading dose 1520 mg over 30 minutes followed by a maintenance rate of 10 mg/min for the desired period. Pa...

    journal_title:Anaesthesia and intensive care

    pub_type: 杂志文章

    doi:10.1177/0310057X8000800405

    authors: Mather LE,Cousins MJ

    更新日期:1980-11-01 00:00:00

  • Adverse local reactions to amethocaine cream--audit and case reports.

    abstract::Amethocaine has recently been introduced as a topical local anaesthetic preparation. Following sporadic reports of severe local adverse effects, we conducted an audit of 372 children attending our hospital for day surgery. We conclude that 4% amethocaine cream is a safe and effective topical anaesthetic and that the i...

    journal_title:Anaesthesia and intensive care

    pub_type: 杂志文章

    doi:10.1177/0310057X9802600316

    authors: Wongprasartsuk P,Main BJ

    更新日期:1998-06-01 00:00:00

  • In situ simulation-based team training for post-cardiac surgical emergency chest reopen in the intensive care unit.

    abstract::Emergency chest reopen of the post cardiac surgical patient in the intensive care unit is a high-stakes but infrequent procedure which requires a high-level team response and a unique skill set. We evaluated the impact on knowledge and confidence of team-based chest reopen training using a patient simulator compared w...

    journal_title:Anaesthesia and intensive care

    pub_type: 杂志文章

    doi:10.1177/0310057X0903700109

    authors: Nunnink L,Welsh AM,Abbey M,Buschel C

    更新日期:2009-01-01 00:00:00

  • A closed loop microprocessor controller for treatment of hypertension after cardiac surgery.

    abstract::Hypertension after cardiac surgery is common and requires accurate control by carefully regulated infusions of drugs such as sodium nitroprusside. A microprocessor-based controller has been designed to close the loop between the blood pressure response and the infusion rate of a hypotensive drug. This system has been ...

    journal_title:Anaesthesia and intensive care

    pub_type: 杂志文章

    doi:10.1177/0310057X8601400211

    authors: Rosenfeldt FL,Chang V,Grigg M,Parker S,Cearns R,Rabinov M,Xu WG

    更新日期:1986-05-01 00:00:00

  • Congenital diaphragmatic hernia and the management of persistent foetal circulation.

    abstract::Twenty-two cases of diaphragmatic hernia, presenting from 1978 to 1982, were reviewed. Sixteen patients presented before 24 hours of life, of whom nine survived (56%). Six were late presenters who all did well. Seven babies had ten documented episodes of persistent foetal circulation (PFC) occurring as early as three ...

    journal_title:Anaesthesia and intensive care

    pub_type: 杂志文章

    doi:10.1177/0310057X8501300407

    authors: Fong LV,Pemberton PJ

    更新日期:1985-11-01 00:00:00

  • Altered aminoglycoside pharmacokinetics in the critically ill.

    abstract::We studied prospectively 49 patients being treated in an intensive care unit with aminoglycosides for gram-negative sepsis. Pharmacokinetic data were calculated from three post-dose serum levels using a one-compartment model. Doses required to achieve peak levels between 5 and 10 mg/l with trough levels approximately ...

    journal_title:Anaesthesia and intensive care

    pub_type: 杂志文章

    doi:10.1177/0310057X8801600406

    authors: Beckhouse MJ,Whyte IM,Byth PL,Napier JC,Smith AJ

    更新日期:1988-11-01 00:00:00

  • Pathophysiology and management of raised intracranial pressure.

    abstract::The mechanism of cerebral homeostasis is reviewed, paying particular attention to the way blood-brain barrier, cerebrospinal fluid and cerebral blood flow contribute to the maintenance of normal intracranial pressure. The pathophysiology of raised intracranial pressure is outlined delineating the different types of ce...

    journal_title:Anaesthesia and intensive care

    pub_type: 杂志文章,评审

    doi:10.1177/0310057X8100900405

    authors: Jones RF,Dorsch NW,Silverberg GD,Torda TA

    更新日期:1981-11-01 00:00:00

  • A comparison of outcomes among hospital survivors with and without severe comorbidity admitted to the intensive care unit.

    abstract::Little is known about the experiences of patients with severe comorbidity discharged from Intensive Care Units (ICUs). This project aimed to determine the effects of an ICU stay for patients with severe comorbidity by comparing 1) quality of life (QOL), 2) the symptom profile of hospital survivors and 3) health servic...

    journal_title:Anaesthesia and intensive care

    pub_type: 杂志文章

    doi:10.1177/0310057X1504300214

    authors: Williams TA,McConigley R,Leslie GD,Dobbs GJ,Phillips M,Davies H,Aoun S

    更新日期:2015-03-01 00:00:00

  • Standardised training program in spinal ultrasound for epidural insertion: protocol driven versus non-protocol driven teaching approach.

    abstract::Spinal ultrasonography provides guidance for epidural insertion in obstetric patients. The primary objective of the study was to develop a training program in spinal ultrasound for anaesthetists and to determine its effect on the skill acquisition of anaesthetists with no prior spinal ultrasound experience. Eighteen a...

    journal_title:Anaesthesia and intensive care

    pub_type: 杂志文章

    doi:10.1177/0310057X1404200406

    authors: Terblanche NC,Arzola C,Wills KE,Lawson R,Blackford D,Balki M

    更新日期:2014-07-01 00:00:00

  • Prone ventilation--it's time.

    abstract::Prone positioning to improve oxygenation in acute lung injury was first reported over 20 years ago. Although this and several subsequent studies have shown that prone positioning improved oxygenation in the majority of patients, it has failed to become common practice in intensive care units. This paper reviews the me...

    journal_title:Anaesthesia and intensive care

    pub_type: 杂志文章,评审

    doi:10.1177/0310057X9902700213

    authors: Tobin A,Kelly W

    更新日期:1999-04-01 00:00:00

  • Awareness in retrieval medicine.

    abstract::Awareness is the spontaneous recall of an event(s) that occurred during general anaesthesia and surgery. The incidence of awareness is approximately 0.2% of cases where neuromuscular blockers are used and half that where they are omitted. The majority of data relating to awareness is from anaesthetic practice. We repo...

    journal_title:Anaesthesia and intensive care

    pub_type: 杂志文章

    doi:10.1177/0310057X0603400519

    authors: Gibson J,Flabouris A

    更新日期:2006-10-01 00:00:00

  • Maternal and fetal levels of propofol at caesarean section.

    abstract::Twenty women were given a bolus induction of propofol 2.0 mg.kg-1 for elective caesarean section. Induction to delivery times ranged from five to fourteen minutes. At delivery the maternal venous (MV) concentrations of propofol ranged from 0.53 to 1.48 micrograms.ml-1 umbilical vein (UV) 0.39 to 1.4 micrograms.ml-1 an...

    journal_title:Anaesthesia and intensive care

    pub_type: 杂志文章

    doi:10.1177/0310057X9001800204

    authors: Gin T,Gregory MA,Chan K,Oh TE

    更新日期:1990-05-01 00:00:00

  • Duration of cortisol suppression following a single dose of dexamethasone in healthy volunteers: a randomised double-blind placebo-controlled trial.

    abstract::The synthetic glucocorticoid dexamethasone is administered to many patients receiving a general anaesthetic to reduce the risk of postoperative nausea and vomiting. Dexamethasone is known to suppress the hypothalamic-pituitary-adrenal axis; however, the duration of this suppression following the standard anti-emetic i...

    journal_title:Anaesthesia and intensive care

    pub_type: 杂志文章,随机对照试验

    doi:10.1177/0310057X1304100504

    authors: Elston MS,Conaglen HM,Hughes C,Tamatea JA,Meyer-Rochow GY,Conaglen JV

    更新日期:2013-09-01 00:00:00

  • Central venous and pulmonary artery occlusion pressures following air embolism in upright sheep.

    abstract::A study on five upright (head above thorax) anaesthetised sheep demonstrated a statistically significant increase in central venous pressure and decrease in pulmonary artery occlusion pressure, following the injection of air 2 ml per kg into the pulmonary artery. In two out of the five sheep after air embolism, right-...

    journal_title:Anaesthesia and intensive care

    pub_type: 杂志文章

    doi:10.1177/0310057X8401200408

    authors: Pfitzner J,McLean AG

    更新日期:1984-11-01 00:00:00

  • Tricyclic poisoning--successful management of ventricular fibrillation following massive overdose of imipramine.

    abstract::Serious complications from tricyclic antidepressant (TCA) overdose are uncommon. We present a case of massive imipramine overdose complicated by ventricular fibrillation and a prolonged period of cardiovascular collapse. A total of 400 mmol of sodium bicarbonate, 5 mg of adrenaline and 80 mg of sotalol were given duri...

    journal_title:Anaesthesia and intensive care

    pub_type: 杂志文章

    doi:10.1177/0310057X9702500516

    authors: Sandeman DJ,Alahakoon TI,Bentley SC

    更新日期:1997-10-01 00:00:00

  • An evaluation of the Hellige Transoxode (Servomed Oxymonitor SM 361 System): response to halothane and enflurane in vitro.

    abstract::The effects of halothane (0.5-2%) and enflurane (1-4%) on two Transoxode transcutaneous oxygen (TcPO2) electrodes (Hellige Servomed Oxymonitor SM.361 system) were serially tested in atmospheres of nitrogen, air and 50% nitrous oxide in oxygen. Both TcPO2 electrodes reduced and "read" halothane but no enflurane. Calibr...

    journal_title:Anaesthesia and intensive care

    pub_type: 杂志文章

    doi:10.1177/0310057X8100900207

    authors: Downing JW,Mankowitz M,Brock-Utne JG,Holloway AM

    更新日期:1981-05-01 00:00:00

  • Reinforcing a "low flow" anaesthesia policy with feedback can produce a sustained reduction in isoflurane consumption.

    abstract::A three-month audit of isoflurane consumption at Palmerston North Hospital in 1994 showed an averaged vapour flow rate of approx 85 ml per minute of anaesthesia, equivalent to 1.4% isoflurane at six litres per minute. After purchasing volatile agent analysers, a program encouraging low flow anaesthesia and providing a...

    journal_title:Anaesthesia and intensive care

    pub_type: 杂志文章

    doi:10.1177/0310057X9802600405

    authors: McKenzie AJ

    更新日期:1998-08-01 00:00:00

  • Anaesthetic management of a patient with Emery-Dreifuss muscular dystrophy.

    abstract::Emery-Dreifuss muscular dystrophy is a rare form of muscular dystrophy associated with cardiac implications such as cardiomyopathy and arrhythmias leading to sudden death. We describe the anesthetic management of a patient with Emery-Dreifuss muscular dystrophy who presented for orthopaedic surgery and discuss the dis...

    journal_title:Anaesthesia and intensive care

    pub_type: 杂志文章

    doi:10.1177/0310057X0203000320

    authors: Shende D,Agarwal R

    更新日期:2002-06-01 00:00:00

  • Risk factors for post-pneumonectomy acute lung injury/acute respiratory distress syndrome in primary lung cancer patients.

    abstract::Acute lung injury/acute respiratory distress syndrome (ALI / ARDS) is the most serious pulmonary complication after lung resection. This study investigated the incidence and outcome of patients with ALI / ARDS who required mechanical ventilation within one week of undergoing pneumonectomy for primary lung cancer and a...

    journal_title:Anaesthesia and intensive care

    pub_type: 杂志文章

    doi:10.1177/0310057X0903700110

    authors: Jeon K,Yoon JW,Suh GY,Kim J,Kim K,Yang M,Kim H,Kwon OJ,Shim YM

    更新日期:2009-01-01 00:00:00

  • Pulmonary mechanics in patients with prolonged mechanical ventilation requiring tracheostomy.

    abstract::This study was performed to assess the changes in pulmonary mechanics before and after tracheostomy in patients with prolonged mechanical ventilation and to detect pre-tracheostomy physiologic factors that predict the outcome of weaning from mechanical ventilation. Pulmonary mechanics were recorded before and after tr...

    journal_title:Anaesthesia and intensive care

    pub_type: 杂志文章

    doi:10.1177/0310057X9902700604

    authors: Lin MC,Huang CC,Yang CT,Tsai YH,Tsao TC

    更新日期:1999-12-01 00:00:00

  • The Lack and Bain systems in spontaneous respiration.

    abstract::In conscious subjects breathing spontaneously the performance of the Lack semi-closed system resembled the Magill attachment in that rebreathing was only detected at fresh gas flows of less than resting minute volume. With the Bain semi-closed system rebreathing was detectable at fresh gas flows of the order of 2.5 ti...

    journal_title:Anaesthesia and intensive care

    pub_type: 杂志文章

    doi:10.1177/0310057X8201000407

    authors: Nott MR,Walters FJ,Norman J

    更新日期:1982-11-01 00:00:00

  • Attitudes and practices of New Zealand anaesthetists with regard to emergency drugs.

    abstract::A postal survey of anaesthetists practising in New Zealand assessed practices with regard to the preparation of pre-drawn syringes of emergency drugs in theatre, and attitudes towards the drawing up of drugs by non-medically qualified assistants. Opinion and practice varied widely; a quarter of respondents routinely d...

    journal_title:Anaesthesia and intensive care

    pub_type: 杂志文章

    doi:10.1177/0310057X0002800616

    authors: Ducat CM,Merry AF,Webster CS

    更新日期:2000-12-01 00:00:00

  • Some prehistory of New Zealand intensive care medicine.

    abstract::In taking 1960 as the foundation year for the practice of intensive care medicine in New Zealand, this paper briefly looks into the previous two centuries for some interventions in life-threatening conditions. With the help of descriptions in early 19th century journals and books by perceptive observers, the author fo...

    journal_title:Anaesthesia and intensive care

    pub_type: 历史文章,杂志文章

    doi:10.1177/0310057X090370S105

    authors: Trubuhovich RV

    更新日期:2009-07-01 00:00:00

  • Post-traumatic severe fat embolism syndrome with uncommon CT findings.

    abstract::Although the diagnosis of fat embolism syndrome is usually based on clinical findings, we describe ill-defined centrilobular and subpleural nodules in addition to ground-glass opacities and consolidation on a computed tomography scan of the chest in a trauma patient with fat embolism syndrome. The nodules presumably r...

    journal_title:Anaesthesia and intensive care

    pub_type: 杂志文章,评审

    doi:10.1177/0310057X0603400120

    authors: Van den Brande FG,Hellemans S,De Schepper A,De Paep R,Op De Beeck B,De Raeve HR,Jorens PG

    更新日期:2006-02-01 00:00:00

  • Day 3 versus Day 1 disseminated intravascular coagulation score among sepsis patients: a prospective observational study.

    abstract::The role of disseminated intravascular coagulation (DIC) has not been extensively studied in patients with sepsis. A prospective study was performed in a single university hospital. The incidences of DIC at day 1 (<24 hours post-sepsis diagnosis) and day 3 (48 to 72 hours) were investigated among patients with sepsis....

    journal_title:Anaesthesia and intensive care

    pub_type: 杂志文章

    doi:10.1177/0310057X1604400110

    authors: Park JY,Park S,Park SY,Sim YS,Kim JH,Hwang YI,Jang SH,Jung KS

    更新日期:2016-01-01 00:00:00

  • Granulocyte transfusions--a review for the intensive care physician.

    abstract::In order to achieve the maximum therapeutic benefit in the treatment of malignancies, doses of chemotherapeutic agents are pushed to the point of severe marrow toxicity. This aggressive therapy can lead to iatrogenic complications including haemorrhage and sepsis due to the depletion of platelets and granulocytes. Pri...

    journal_title:Anaesthesia and intensive care

    pub_type: 杂志文章,评审

    doi:10.1177/0310057X9101900404

    authors: Tobias JD,Schleien C

    更新日期:1991-11-01 00:00:00

  • Successful perioperative management of a patient with C1 esterase inhibitor deficiency with a novel bradykinin receptor B2 antagonist.

    abstract::We present the case of a 28-year-old female with a previous diagnosis of C1 esterase inhibitor deficiency presenting for dental extractions under general anaesthesia. Following prophylaxis with a new bradykinin receptor 2 antagonist (icatibant), surgery was carried out uneventfully with an unremarkable postoperative c...

    journal_title:Anaesthesia and intensive care

    pub_type: 杂志文章

    doi:10.1177/0310057X1204000320

    authors: Senaratne KT,Cottrell AM,Prentice RI

    更新日期:2012-05-01 00:00:00

  • Opioid pharmacokinetics in relation to their effects.

    abstract::The chemical structure of drug molecules determines their fundamental pharmacological properties by 'fit' to the receptor, but the physicochemical properties, particularly lipid solubility and fraction un-ionised, dominate in determining distribution in the body and the rate of access to the biophase containing the dr...

    journal_title:Anaesthesia and intensive care

    pub_type: 杂志文章,评审

    doi:10.1177/0310057X8701500104

    authors: Mather LE

    更新日期:1987-02-01 00:00:00

  • Abdominal trauma: pre-operative assessment and postoperative problems in intensive care.

    abstract::Although penetrating abdominal trauma is on the increase in Australia, blunt trauma continues to account for the majority of cases and usually presents a more challenging problem than the former. Diagnosis has been greatly facilitated by the widespread use of peritoneal lavage and computerised tomography. Conservative...

    journal_title:Anaesthesia and intensive care

    pub_type: 杂志文章

    doi:10.1177/0310057X8501300305

    authors: Webster VJ

    更新日期:1985-08-01 00:00:00