Risk factors for post-pneumonectomy acute lung injury/acute respiratory distress syndrome in primary lung cancer patients.


:Acute lung injury/acute respiratory distress syndrome (ALI / ARDS) is the most serious pulmonary complication after lung resection. This study investigated the incidence and outcome of patients with ALI / ARDS who required mechanical ventilation within one week of undergoing pneumonectomy for primary lung cancer and analysed the risk factors. We retrospectively reviewed the medical records of 146 patients who underwent pneumonectomy for primary lung cancer between May 2001 and April 2006. Preoperative, perioperative and postoperative clinical data were analysed. Post-pneumonectomy ALI / ARDS developed within the first postoperative week in 18 (12%) patients. Patients who developed ALI / ARDS had a longer hospital duration of stay (median [interquartile range], 26 [18 to 75] vs. 8 [7 to 11] days; P < 0.001) and higher in-hospital mortality (12 [67%] vs. 0 [0%]; P < 0.001). In an univariate analysis, post-pneumonectomy ALI / ARDS was associated with larger tidal volume (V(T)) and higher airway pressure (P(aw)) during one-lung ventilation (V(T) 8.2 [7.5 to 9.0] vs. 7.7 [6.9 to 8.2] ml/kg predicted body weight, P = 0.016; P(aw), 28.9 [27.6 to 30.0] vs. 27.2 [25.6 to 28.5] cmH2O, P = 0.001). V(T) during two-lung ventilation was also greater in patients who developed ALI / ARDS (P = 0.014) than in those who did not, but P(aw) during two-lung ventilation did not differ (P = 0.950). In a multiple logistic regression analysis, post-pneumonectomy ALI / ARDS was independently associated with a larger V(T) (OR 3.37 per 1 ml/kg predicted body weight increase; 95% confidence interval 1.65 to 6.86) and higher P(aw) (OR 2.32 per 1 cmH2O increase; 95% confidence interval 1.46 to 3.67) during the period of one-lung ventilation. In conclusion, a large V(T) and high P(aw) during one-lung ventilation were associated with an increased risk of post-pneumonectomy ALI / ARDS in primary lung cancer patients.


Anaesth Intensive Care


Jeon K,Yoon JW,Suh GY,Kim J,Kim K,Yang M,Kim H,Kwon OJ,Shim YM




Has Abstract


2009-01-01 00:00:00














  • Thyroid storm presenting as intra-abdominal sepsis with multi-organ failure requiring intensive care.

    abstract::Thyroid storm is a rare but life-threatening condition manifesting with several clinical presentations. Atypical thyroid storm should be part of the differential diagnosis in patients with multiple organ dysfunction of unknown aetiology. In this case report, delayed recognition of thyroid storm in a young female who p...

    journal_title:Anaesthesia and intensive care

    pub_type: 杂志文章


    authors: Karanikolas M,Velissaris D,Karamouzos V,Filos KS

    更新日期:2009-11-01 00:00:00

  • Equivalent metabolic acidosis with four colloids and saline on ex vivo haemodilution.

    abstract::Colloid infusions can cause metabolic acidosis. Mechanisms and relative severity with different colloids are incompletely understood. We compared haemodilution acid-base effects of 4% albumin, 3.5% polygeline, 4% succinylated gelatin (all weak acid colloids, strong ion difference 12 mEq/l, 17.6 mEq/l and 34 mEq/l resp...

    journal_title:Anaesthesia and intensive care

    pub_type: 杂志文章


    authors: Morgan TJ,Vellaichamy M,Cowley DM,Weier SL,Venkatesh B,Jones MA

    更新日期:2009-05-01 00:00:00

  • Elective use of veno-venous extracorporeal membrane oxygenation and high-flow nasal oxygen for resection of subtotal malignant distal airway obstruction.

    abstract::We describe the use of peripheral veno-venous extracorporeal membrane oxygenation (VV ECMO) and high-flow nasal oxygen as procedural support in a patient undergoing debulking of a malignant tumour of the lower airway. Due to the significant risk of complete airway obstruction upon induction of anaesthesia, ECMO was es...

    journal_title:Anaesthesia and intensive care

    pub_type: 杂志文章


    authors: Fung R,Stellios J,Bannon PG,Ananda A,Forrest P

    更新日期:2017-01-01 00:00:00

  • Abdominal trauma: pre-operative assessment and postoperative problems in intensive care.

    abstract::Although penetrating abdominal trauma is on the increase in Australia, blunt trauma continues to account for the majority of cases and usually presents a more challenging problem than the former. Diagnosis has been greatly facilitated by the widespread use of peritoneal lavage and computerised tomography. Conservative...

    journal_title:Anaesthesia and intensive care

    pub_type: 杂志文章


    authors: Webster VJ

    更新日期:1985-08-01 00:00:00

  • Case report: anaesthesia in myotonic dystrophy.

    abstract::Pancuronium and a continuous infusion of althesin was used to produce muscular relaxation in a patient with myotonic dystrophy. Excellent muscle relaxation with absence of percussion or surgically induced myotonia was obtained but the EMG was not modified; an intracellular site of action of althesin is postulated. Car...

    journal_title:Anaesthesia and intensive care

    pub_type: 杂志文章


    authors: Muller J,Suppan P

    更新日期:1977-02-01 00:00:00

  • Tracheobronchial injury secondary to blunt chest trauma: diagnosis and management.

    abstract::Tracheobronchial injury is an uncommon complication in blunt chest trauma. The typical clinical features include haemoptysis, dyspneoa, and air leak. Tracheobronchial injury occurs after high energy impact and is commonly associated with injuries of other vital organs. If tracheobronchial injury is undetected and left...

    journal_title:Anaesthesia and intensive care

    pub_type: 杂志文章,评审


    authors: Chu CP,Chen PP

    更新日期:2002-04-01 00:00:00

  • Analysis of the entire ryanodine receptor type 1 and alpha 1 subunit of the dihydropyridine receptor (CACNA1S) coding regions for variants associated with malignant hyperthermia in Australian families.

    abstract::Defects in the genes coding for the skeletal muscle ryanodine receptor (RYR1) and alpha 1 subunit of the dihydropyridine receptor (CACNA1S) have been identified as causative for malignant hyperthermia (MH). Sixty-two MH susceptible individuals presenting to the same diagnostic centre had copy deoxyribonucleic acid, de...

    journal_title:Anaesthesia and intensive care

    pub_type: 杂志文章


    authors: Gillies RL,Bjorksten AR,Du Sart D,Hockey BM

    更新日期:2015-03-01 00:00:00

  • A study of preoperative fasting in infants aged less than three months.

    abstract::The effects of preoperative fasting on plasma glucose and gastric emptying was studied in 62 infants aged less than three months after a feed of either breast milk or an infant milk formula. Prior to induction of anaesthesia no infant was hypoglycaemic, defined as plasma glucose less than 2.2 mmol/l. Five per cent of ...

    journal_title:Anaesthesia and intensive care

    pub_type: 杂志文章


    authors: van der Walt JH,Foate JA,Murrell D,Jacob R,Bentley M

    更新日期:1990-11-01 00:00:00

  • Comparison of the efficacy of paracetamol versus paracetamol, codeine and promethazine (Painstop) for premedication and analgesia for myringotomy in children.

    abstract::This prospective double-blinded study compared the analgesic effectiveness and incidence of complications of a compound preparation Painstop (Paedpharm Pty Ltd) containing paracetamol 12 mg, codeine 0.5 mg and promethazine 0.65 mg per 1.0 ml, dosage 1.0 ml/kg, with paracetamol 20 mg/kg. Ninety-five children aged 1 to ...

    journal_title:Anaesthesia and intensive care

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Ragg P,Davidson A

    更新日期:1997-02-01 00:00:00

  • The influence of obesity on the relationship between body mass index and the distance to the epidural space from the skin.

    abstract::This study confirms that distance to the epidural space from the skin at the L3-4 interspace is only moderately correlated with body mass index in obstetric patients. A similar moderate linear correlation was found in the non-obstetric patients. However, in obese patients (BMI > 25), distance to epidural space from th...

    journal_title:Anaesthesia and intensive care

    pub_type: 杂志文章


    authors: Watts RW

    更新日期:1993-06-01 00:00:00

  • Pancuronium requirements during hypothermic cardiopulmonary bypass in man.

    abstract::Eight patients were studied to determine the changes in pancuronium requirements during hypothermic cardiopulmonary bypass. They were anaesthetised with fentanyl as the principal agent, ventilated with oxygen and the neuromuscular junction was monitored using train-of-four stimulation. After a bolus dose of pancuroniu...

    journal_title:Anaesthesia and intensive care

    pub_type: 杂志文章


    authors: Futter ME,Whalley DG,Wynands JE,Bevan DR

    更新日期:1983-08-01 00:00:00

  • Primary anaesthetic deaths in Western Australia from 1985-2008: causation and preventability.

    abstract::This paper reports on the causes and preventability of primary anaesthetic deaths in Western Australia between 1985 and 2008. In Western Australia, it is a legal requirement to report all deaths that occur within 48 hours of an anaesthetic and later deaths if an anaesthetic complication is implicated. A committee asse...

    journal_title:Anaesthesia and intensive care

    pub_type: 杂志文章


    authors: Gibbs NM,Rodoreda P

    更新日期:2013-05-01 00:00:00

  • Human serum albumin induced hypotension in the postoperative phase of cardiac surgery.

    abstract::Hypotension associated with the rapid infusion of human serum albumin products was first recognised in Australasia in the early 1970s. An association with the angiotensin converting enzyme inhibitor class of drugs (ACE-I) followed, leading to a proposed mechanism involving bradykinin generation through pre-kallikrein ...

    journal_title:Anaesthesia and intensive care

    pub_type: 杂志文章


    authors: Howard G,Downward G,Bowie D

    更新日期:2001-12-01 00:00:00

  • Intrathecal pethidine: pharmacology and clinical applications.

    abstract::Pethidine is the only member of the opioid family that has clinically important local anaesthetic activity in the dose range normally used for analgesia. Pethidine is unique as the only opioid in current use that is effective as the sole agent for spinal anaesthesia. In lower doses, intrathecal pethidine is also an ef...

    journal_title:Anaesthesia and intensive care

    pub_type: 杂志文章,评审


    authors: Ngan Kee WD

    更新日期:1998-04-01 00:00:00

  • A versatile computing system for sampling, manipulation and display of biological signals using high-level language.

    abstract::A medium sized minicomputer system is presented as an attractive way of balancing the cost of computing equipment with that of programme development. A versatile circuit has been coupled to a computer system and programmes have been developed to control the functions of this circuit. With such a system it is possible ...

    journal_title:Anaesthesia and intensive care

    pub_type: 杂志文章


    authors: Crankshaw DP,Hall BR

    更新日期:1977-11-01 00:00:00

  • The role of preoperative cervical spine X-rays in rheumatoid arthritis.

    abstract::The cervical spine is frequently involved in rheumatoid arthritis and yet there exists no consensus on the need to screen for cervical spine subluxations preoperatively. We reviewed retrospectively 77 patients who underwent 132 operations under general or regional anaesthesia over a 44-month period. We found that whil...

    journal_title:Anaesthesia and intensive care

    pub_type: 杂志文章


    authors: Kwek TK,Lew TW,Thoo FL

    更新日期:1998-12-01 00:00:00

  • Performance of sequential organ failure assessment, logistic organ dysfunction and multiple organ dysfunction score in severe sepsis within Chinese intensive care units.

    abstract::This study assessed the performance of Sequential Organ Failure Assessment, Logistic Organ Dysfunction Score and Multiple Organ Dysfunction Score in outcome prediction in severe sepsis. A total of 528 consecutive patients with a diagnosis of severe sepsis were enrolled from two surgical intensive care units of univers...

    journal_title:Anaesthesia and intensive care

    pub_type: 杂志文章


    authors: Wang H,Ye L,Yu L,Xie G,Cheng B,Liu X,Jin Y,Wu S,Zhu T,Chen Q,Fang X

    更新日期:2011-01-01 00:00:00

  • A comparison of patient self-administered and investigator-administered measurement of quality of recovery using the QoR-40.

    abstract::A 40-item questionnaire (the QoR-40) had been previously developed to measure five dimensions of quality of recovery after anaesthesia and surgery. Each of the 40 items is rated on a scale of 1 to 5, with a maximum score of 200. In this study we compared patient self-administered with investigator-administered QoR-40....

    journal_title:Anaesthesia and intensive care

    pub_type: 杂志文章


    authors: Gower ST,Quigg CA,Hunt JO,Wallace SK,Myles PS

    更新日期:2006-10-01 00:00:00

  • Depth of central venous catheter insertion in adults: an audit and assessment of a technique to improve tip position.

    abstract::A technique of subclavian vein catheterization is described, tailored to the individual patient, to reduce the risk of right atrial placement with central venous catheter (CVC) insertion. Using data gathered retrospectively for Quality Improvement purposes, CVC tip location was assessed. The standard technique used in...

    journal_title:Anaesthesia and intensive care

    pub_type: 临床试验,杂志文章


    authors: Chalkiadis GA,Goucke CR

    更新日期:1998-02-01 00:00:00

  • The influence of unrestricted use of sugammadex on clinical anaesthetic practice in a tertiary teaching hospital.

    abstract::This retrospective casenote audit involving 374 patients requiring intubation for an anaesthetic found that when the availability of sugammadex became unrestricted, its use increased from 7.1 to 65.3% (P <0.0001) of all muscle relaxant reversals, while neostigmine use decreased from 59.6 to 12.5%. Rocuronium use decre...

    journal_title:Anaesthesia and intensive care

    pub_type: 杂志文章


    authors: Watts RW,London JA,van Wijk RM,Lui YL

    更新日期:2012-03-01 00:00:00

  • Performance of the Atom 235 syringe infusion pump under hyperbaric conditions.

    abstract::Inotrope-dependent patients may become haemodynamically unstable during treatment in the hyperbaric chamber. One possible cause is altered performance of infusion devices. We tested six Atom 235 syringe infusion pumps under hyperbaric conditions of 2.8 atmospheres absolute in a multiplace chamber using a gravimetric m...

    journal_title:Anaesthesia and intensive care

    pub_type: 杂志文章


    authors: Story DA,Houston JJ,Millar IL

    更新日期:1998-04-01 00:00:00

  • The effect of dabigatran on the kaolin-activated whole blood thromboelastogram.

    abstract::Dabigatran is a direct thrombin inhibitor, which is increasingly likely to be encountered in patients presenting for surgery. This study examines whether there is a consistent effect of dabigatran on the thromboelastogram (TEG) and whether this correlates with the effects of dabigatran on traditional coagulation param...

    journal_title:Anaesthesia and intensive care

    pub_type: 杂志文章


    authors: 'Aho A,Byrne K

    更新日期:2016-11-01 00:00:00

  • An outbreak of hepatitis A in an intensive care unit.

    abstract::We describe an outbreak of hepatitis A that occurred in an Intensive Care Unit (ICU) in a regional hospital in North Queensland. Seven people were infected including two patients, two close contacts of the index patient and three ICU nursing staff. The index case was admitted with an overdose and multiple trauma; he w...

    journal_title:Anaesthesia and intensive care

    pub_type: 杂志文章


    authors: Hanna JN,Loewenthal MR,Negel P,Wenck DJ

    更新日期:1996-08-01 00:00:00

  • The impact of intraoperative transoesophageal echocardiography on an unselected cardiac surgical population: a review of 2343 cases.

    abstract::Although intraoperative transoesophageal echocardiography (TOE) has an established role in the management of some cardiac surgical procedures, there is little data on its impact on coronary artery bypass graft (CABG) cases that are stratified for clinical risk. This is a retrospective review of the surgical impact of ...

    journal_title:Anaesthesia and intensive care

    pub_type: 杂志文章


    authors: Forrest AP,Lovelock ND,Hu JM,Fletcher SN

    更新日期:2002-12-01 00:00:00

  • Pharmacokinetics and pharmacodynamics of suxamethonium.

    abstract::A study was undertaken to determine the time constants of elimination and effect compartment equilibration of suxamethonium and for the slope exponent of the Hill equation. Twelve patients were anaesthetized with thiopentone, fentanyl, and isoflurane in nitrous oxide and oxygen. After allowing conditions to become sta...

    journal_title:Anaesthesia and intensive care

    pub_type: 杂志文章


    authors: Torda TA,Graham GG,Warwick NR,Donohue P

    更新日期:1997-06-01 00:00:00

  • Patient- and operator-related factors associated with successful Glidescope intubations: a prospective observational study in 742 patients.

    abstract::The Glidescope Video Laryngoscope (Glidescope, Verathon Medical, Bothell, WA, U.S.A.) is a relatively new intubating device. It has been proposed to be useful for securing both routine airways and those where direct laryngoscopy may be difficult. In this prospective observational study, data for 742 intubations using ...

    journal_title:Anaesthesia and intensive care

    pub_type: 杂志文章


    authors: Siu LW,Mathieson E,Naik VN,Chandra D,Joo HS

    更新日期:2010-01-01 00:00:00

  • Subarachnoid morphine, bupivacaine and fentanyl as part of combined spinal-epidural analgesia for low anterior resection. A prospective, randomised, double-blind clinical trial.

    abstract::This study was designed to compare the efficacy of subarachnoid morphine alone or in combination with bupivacaine and fentanyl for combined spinal-epidural analgesia in colorectal surgery. This is a prospective, randomised, double-blind clinical trial. Sixty patients undergoing low anterior resection were assigned to ...

    journal_title:Anaesthesia and intensive care

    pub_type: 杂志文章,随机对照试验


    authors: Stamenkovic D,Geric V,Djordjevic M,Raskovic J,Slavkovic Z,Randjelovic T,Karanikolas M

    更新日期:2009-07-01 00:00:00

  • Audit of cardiac pathology detection using a criteria-based perioperative echocardiography service.

    abstract::Transthoracic echocardiography is often used to screen patients prior to non-cardiac surgery to detect conditions associated with perioperative haemodynamic compromise and to stratify risk. However, anaesthetists' use of echocardiography is quite variable. A consortium led by the American College of Cardiology Foundat...

    journal_title:Anaesthesia and intensive care

    pub_type: 杂志文章


    authors: Faris JG,Hartley K,Fuller CM,Langston RB,Royse CF,Veltman MG

    更新日期:2012-07-01 00:00:00

  • Haemodynamic compromise during thoracoscopic/laparoscopic oesophagectomy.

    abstract::Minimally invasive oesophagectomy is a relatively new procedure that is performed by means of thoracoscopy and laparoscopy. One stage of the procedure involves creation of a peritoneo-pleural communication in the presence of a pneumoperitoneum. In the case presented, severe hypotension occurred at this point. We belie...

    journal_title:Anaesthesia and intensive care

    pub_type: 杂志文章


    authors: McConkey PP,Moore PG,Nguyen NT

    更新日期:2001-12-01 00:00:00

  • Immediate management of inadvertent dural puncture during insertion of a labour epidural: a survey of Australian obstetric anaesthetists.

    abstract::Immediate management of inadvertent dural puncture during insertion of an epidural needle during labour is controversial and evidence to guide clinical practice is limited. We surveyed Australian obstetric anaesthetists by anonymous postal questionnaire. Of the 671 surveys sent, 417 (62%) were returned. Following dura...

    journal_title:Anaesthesia and intensive care

    pub_type: 杂志文章


    authors: Newman MJ,Cyna AM

    更新日期:2008-01-01 00:00:00