Screening test of anticancer drugs on human osteosarcoma heterotransplanted in nude mice.

Abstract:

:Following amputation of a limb for osteosarcoma, the tumour was serially transferred to nude mice. The rate of growth was determined and the inhibitory effect of Cyclophosphamide, Adriamycin and 5-Fluorouracil was assessed in three separate experimental animal groups. In the tumour studied. Cyclophosphamide produced the greatest inhibition of tumour growth, mitotic index and cytokinetic studies. The technique may be helpful in screening the sensitivity of other types of human malignant tumour.

journal_name

Int Orthop

authors

Munehiro C

doi

10.1007/BF00267728

subject

Has Abstract

pub_date

1982-01-01 00:00:00

pages

181-4

issue

3

eissn

0341-2695

issn

1432-5195

journal_volume

6

pub_type

杂志文章
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