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Structure and regulated expression of the SpoC1 gene cluster from Aspergillus nidulans.

Abstract：

:We have previously described the organization of a 13.3 kb region of the Aspergillus nidulans genome, designated SpoC1, coding for multiple poly(A)+ RNAs that accumulate in asexual spores but not in somatic cells. We have determined the limits of the SpoC1 gene cluster by investigating the transcriptional features of 53 kb of chromosomal DNA. This segment of the genome codes for at least 19 poly(A)+ RNAs, some of which are transcribed from overlapping regions. The area of developmental regulation is approximately 38 kb in length and is delimited by 1.1-kb direct repeats. With one exception, RNAs transcribed from the central part of the cluster appear late during conidiophore development and accumulate specifically in spores. The exceptional transcript appears earlier during development and accumulates specifically in cells of the conidiophore. In contrast, RNAs encoded at the borders of the cluster occur in both somatic cells and spores. The results indicate that if a chromatin-level control mechanism operates to regulate expression of the SpoC1 gene cluster, as previously suggested by us, additional levels of regulation must also exist.

journal_name

J Mol Biol

journal_title

Journal of molecular biology

authors

Gwynne DI,Miller BL,Miller KY,Timberlake WE

doi

10.1016/0022-2836(84)90432-7

subject

Has Abstract

pub_date

1984-11-25 00:00:00

pages

91-109

issue

1

eissn

0022-2836

issn

1089-8638

pii

0022-2836(84)90432-7

journal_volume

180

pub_type

杂志文章

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