Abstract：
:Direct measurements of parathyroid activity are available in only small numbers of children with vitamin D deficiency rickets (VDR). Therefore serum immunoreactive parathyroid hormone (iPTH) and the urinary cyclic adenosine-3',5'-monophosphate excretion (UcAMP) were measured together with other important indices of calcium metabolism in 24 patients (aged 2-42 months) with VDR before vitamin D treatment. iPTH and UcAMP were significantly elevated in comparison to age-matched controls. In patients there was a highly significant positive correlation between iPTH and UcAMP and a negative relationship between both indices of parathyroid activity to serum phosphate and urine calcium, respectively, indicating that the simple measurement of serum phosphate and/or urine cAMP and Ca provides a reliable tool for the assessment of secondary hyperparathyroidism in VDR. In two patients classified as being in the early stage of VDR the parathyroid activity was not elevated despite hypocalcemia indicating relative hypoparathyroidism. Twelve patients with VDR were followed during vitamin D therapy: Within the first 2 weeks of treatment UcAMP slightly increased and thereafter decreased in most patients, but was still elevated in three patients even after 7 weeks, whereas iPTH became normal within 3 weeks of treatment. This favors the concept that vitamin D deficiency diminishes the activation of renal adenylate cyclase by PTH which is overcome by the highly increased PTH secretion in the advanced stages of rickets. The basal and calcium-stimulated serum calcitonin (CT) levels, determined in some of the patients, were normal, ruling out a significant disturbance of CT secretion in VDR.
journal_name
Eur J Pediatrjournal_title
European journal of pediatricsauthors
Kruse K,Bartels H,Kracht Udoi
10.1007/BF00443214subject
Has Abstractpub_date
1984-01-01 00:00:00pages
158-62issue
3eissn
0340-6199issn
1432-1076journal_volume
141pub_type
杂志文章abstract：:Inappropriate use of antibiotics in human and animal is one of the causes of antimicrobial resistance. This study evaluates the prevalence and predictors of antibiotic use among pediatric patients visiting the Emergency Department (ED) in Malaysia. A retrospective cross-sectional study was conducted in the ED of a ter...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-019-03560-z
更新日期：2020-05-01 00:00:00
abstract：UNLABELLED:Schimke immuno-osseous dysplasia is a multisystem disorder consisting of spondylo-epiphysial dysplasia, progressive renal insufficiency due to focal segmental glomerulosclerosis, and immunodeficiency. Cerebrovascular complications have only been described in five patients. Here we report a patient with promi...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s004310050714
更新日期：1997-10-01 00:00:00
abstract：UNLABELLED:Lymphocytic hypophysitis is a rare disorder predominantly affecting females during the antepartum or postpartum period. It is characterized by destruction and lymphocytic infiltration of the pituitary gland, probably by an autoimmune process, leading to a pituitary mass lesion and/or various degrees of hypop...
journal_title：European journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/s004310050690
更新日期：1997-09-01 00:00:00
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journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-003-1292-x
更新日期：2003-11-01 00:00:00
abstract：:Vitamin K prophylaxis in infancy aims to prevent life-threatening vitamin K deficiency bleeding (VKDB). The Dutch prophylactic oral daily regimen was increased sixfold from 25 to 150 μg because of a high failure rate. To evaluate the efficacy of this new regimen, incidences of intracranial VKDB under both regimens wer...
journal_title：European journal of pediatrics
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journal_title：European journal of pediatrics
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doi：10.1007/BF02126298
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journal_title：European journal of pediatrics
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journal_title：European journal of pediatrics
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journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF01959087
更新日期：1992-10-01 00:00:00
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journal_title：European journal of pediatrics
pub_type： 杂志文章
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更新日期：2017-07-01 00:00:00
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journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF01957008
更新日期：1994-07-01 00:00:00
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journal_title：European journal of pediatrics
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：1996-08-01 00:00:00
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journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-013-1996-5
更新日期：2013-08-01 00:00:00
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journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-018-3302-z
更新日期：2019-03-01 00:00:00
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journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-010-1147-1
更新日期：2010-08-01 00:00:00
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journal_title：European journal of pediatrics
pub_type： 杂志文章
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更新日期：1999-03-01 00:00:00
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journal_title：European journal of pediatrics
pub_type： 杂志文章,评审
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journal_title：European journal of pediatrics
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journal_title：European journal of pediatrics
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journal_title：European journal of pediatrics
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journal_title：European journal of pediatrics
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journal_title：European journal of pediatrics
pub_type： 杂志文章
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journal_title：European journal of pediatrics
pub_type： 杂志文章
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更新日期：2013-02-01 00:00:00
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journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02115616
更新日期：1996-01-01 00:00:00
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journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00441663
更新日期：1983-04-01 00:00:00
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journal_title：European journal of pediatrics
pub_type： 杂志文章
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journal_title：European journal of pediatrics
pub_type： 杂志文章
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journal_title：European journal of pediatrics
pub_type： 杂志文章
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journal_title：European journal of pediatrics
pub_type： 杂志文章
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