Abstract：
UNLABELLED:Lymphocytic hypophysitis is a rare disorder predominantly affecting females during the antepartum or postpartum period. It is characterized by destruction and lymphocytic infiltration of the pituitary gland, probably by an autoimmune process, leading to a pituitary mass lesion and/or various degrees of hypopituitarism. The lesion is usually confined to the adenohypophysis. Posterior pituitary gland or stalk involvement is rare, although patients presenting with diabetes insipidus have been reported. We describe a girl aged 13 years 9 months with lymphocytic hypophysitis who presented with diabetes insipidus and secondary amenorrhea. MRI of the brain revealed a 1 cm enhancing mass in the pituitary stalk. A biopsy of the mass by right pterional craniotomy showed lymphocytic infiltration without neoplastic cells or granuloma formation. To our knowledge, this is the youngest reported patient with a diagnosis of lymphocytic hypophysitis. In this case report, her clinical presentation is discussed along with a review of the literature. CONCLUSION:We present the first childhood case of lymphocytic hypophysitis which is an autoimmune inflammatory disorder of the pituitary gland. Although this is a rare condition in adults, it also needs to be considered in the pediatric population. Conservative management is preferred unless there are signs of increased intracranial pressure. Most importantly, close monitoring for multiple hormone deficiencies is indicated in this condition.
journal_name
Eur J Pediatrjournal_title
European journal of pediatricsauthors
Cemeroglu AP,Blaivas M,Muraszko KM,Robertson PL,Vázquez DMdoi
10.1007/s004310050690subject
Has Abstractpub_date
1997-09-01 00:00:00pages
684-8issue
9eissn
0340-6199issn
1432-1076journal_volume
156pub_type
杂志文章,评审abstract：UNLABELLED:Patients with glycogen storage disease type 1b (GSD1b) not only show hepatomegaly, hypoglycaemia and lactic acidosis, but also neutropenia and neutrophil dysfunction. Here, we report improvement of neutropenia and neutrophil function in a 22-year-old male GSD1b patient who had undergone living-related partia...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-004-1405-1
更新日期：2004-04-01 00:00:00
abstract：:Twelve preterm infants, median gestational age 31.5 weeks, were entered into a randomised, placebo-controlled trial of bronchodilator therapy. Their postnatal age was a median of 17.5 months and all suffered from recurrent respiratory symptoms. The infants received either inhaled placebo or 40 micrograms of ipratropiu...
journal_title：European journal of pediatrics
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF01955008
更新日期：1991-10-01 00:00:00
abstract：UNLABELLED:Smith-Lemli-Opitz syndrome (SLOS), a multiple congenital anomaly with severe mental retardation, is caused by decreased activity of 7-dehydrocholesterol reductase. Fifteen Hungarian patients were diagnosed with SLOS on the basis of clinical symptoms, serum cholesterol, 7-dehydrocholesterol, and molecular gen...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-012-1925-z
更新日期：2013-05-01 00:00:00
abstract：:When a mother with tetralogy of Fallot has a conotruncal anomaly face, her child might have a 22q11.2 deletion and severe congenital heart disease. ...
journal_title：European journal of pediatrics
pub_type： 信件
doi：10.1007/s00431-001-0890-8
更新日期：2002-03-01 00:00:00
abstract：:The study was planned to determine identifiable starting points of a trend towards obesity and the influence of variables in preschool children aged 0 to 6 years. In this longitudinal follow-up study, 102 children were enrolled. Anthropometric measurements such as weight-height centiles (specific for gender and age gr...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-010-1343-z
更新日期：2011-06-01 00:00:00
abstract：:Adolescents have specific healthcare needs distinct from adults or younger children secondary to anatomical, physiological and socio-behavioural differences. Healthcare providers have been slow to address this, leading the UK Department of Health (2011) to publish 'You're Welcome' quality criteria for services for you...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-016-2815-6
更新日期：2017-02-01 00:00:00
abstract：UNLABELLED:Storage of human breast milk by freezing or refrigeration of milk with and without heating have been recommended. This can hardly be avoided because of the social circumstances of most mothers who are regularly separated from their infants because of work or schooling as well as the particular needs of some ...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s004310000577
更新日期：2000-11-01 00:00:00
abstract：:To elucidate the basis for the recurrent infections in patients with glycogen storage disease (GSD) Ib we tested polymorphonuclear leukocyte (PMN) function in one patient. Bactericidal capacity and phagocytosis-induced O2 consumption were reduced. Also, phorbol myristate acetate-stimulated superoxide production and gl...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00442674
更新日期：1983-09-01 00:00:00
abstract：:Tonsillectomy is one of the commonest ENT paediatric procedures. Recovery is best achieved at home, and cost-effectiveness of the day case pathway is significant in tonsillectomy. This project scrutinised the local practice regarding the effectiveness of day case pathway in paediatric tonsillectomy in a large regional...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-018-3220-0
更新日期：2018-11-01 00:00:00
abstract：:Arterial hypertension in childhood is less frequent as compared to adulthood but is more likely to be secondary to an underlying disorder. After ruling out more obvious causes, some patients still present with strongly suspected secondary hypertension of yet unknown etiology. A number of these children have hypertensi...
journal_title：European journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/s00431-011-1440-7
更新日期：2012-10-01 00:00:00
abstract：:The board game Kaledo was proven to be effective in improving nutrition knowledge and in modifying dietary behavior in students attending middle and high school. The present pilot study aims to reproduce these results in younger students (7-11 years old) attending primary school. A total of 1313 children from ten scho...
journal_title：European journal of pediatrics
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00431-018-3091-4
更新日期：2018-09-01 00:00:00
abstract：UNLABELLED:Repeated invasive procedures occur routinely in neonates who require intensive care, causing pain at a time when it is developmentally unexpected. Multiple lines of evidence suggest that repeated and prolonged pain exposure alters their subsequent pain processing, long-term development, and behaviour. Primar...
journal_title：European journal of pediatrics
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00431-011-1655-7
更新日期：2012-06-01 00:00:00
abstract：:A girl, now three years old, is reported, in whom at the age of 5 months the diagnosis of 3-HMG-CoA lyase deficiency was established. The characteristic excretion pattern consisted of 3-HMG, 3-CH3-glutaconic acid, 3-CH3-glutaric acid and 3-HIVA. Activity of 3-HMG-CoA lyase in leucocytes was very low. She had compensat...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00442334
更新日期：1982-02-01 00:00:00
abstract：:The triad of adrenocortical insufficiency with alacrima and achalasia is an unusual disease entity in paediatrics. The association of autonomic and peripheral neuropathies has more commonly been reported in older individuals. We describe four children (two siblings) with this disorder, aged between 3 and 6 years at di...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF01972967
更新日期：1995-01-01 00:00:00
abstract：:Mutation in the orphan nuclear receptor DAX-1 gene causes X-linked adrenal hypoplasia congenita (AHC). Affected male children classically suffer a salt-losing crisis and adrenal insufficiency in their early infancy or, in some rare exceptions, with late-onset subtype. We report here a patient manifesting late-onset ad...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-008-0779-x
更新日期：2009-03-01 00:00:00
abstract：:Vitamin D is important for calcium homeostasis, muscle, and bone health. It has also immunomodulatory capacities in vivo and in vitro. Regulatory T cells (Treg) have been found to suppress a number of T cell-mediated immune disorders, including allergic responses and autoimmune diseases. This study aimed to investigat...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-012-1688-6
更新日期：2012-08-01 00:00:00
abstract：:Patients with childhood-onset systemic lupus erythematosus (cSLE) are at risk of becoming short adults. To evaluate the growth patterns and risk factors of short final height, a retrospective study was conducted in 97 patients (87 females, 90%) with cSLE who grew from the time of diagnosis and reached their final heig...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-020-03910-2
更新日期：2021-01-03 00:00:00
abstract：:A technetium-99m pertechnetate Meckel scan is the standard diagnostic test to diagnose Meckel diverticulum. Although a negative scan does not exclude Meckel diverticulum, it should be kept in mind that the diagnosis can be missed on the basis of a single negative scan. Another important point is the typical position o...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-009-0946-8
更新日期：2009-12-01 00:00:00
abstract：:Understanding which children are at increased risk for poor outcome with COVID-19 is critical. In this study, we link pediatric population-based data from the US Center for Disease Control and Prevention to COVID-19 hospitalization and in-hospital death. In 27,045 US children with confirmed COVID-19, we demonstrate th...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-021-03955-x
更新日期：2021-01-20 00:00:00
abstract：:The first Scandinavian cases of Zellweger syndrome (ZS) are described. A brother and sister, children of first cousins, had the typical clinical symptoms and pathological findings. Extensive metabolic studies in the boy were negative. Pipecolic acid in the urine was not elevated. Both children died at 14 weeks of age....
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00493539
更新日期：1978-04-20 00:00:00
abstract：:Neonatal stroke is a diverse clinical entity. Terminology and aetiology described in the literature are very varied. While numerous risk factors are cited, only few case-control studies have investigated them in a systematic fashion. This equipoise extends to the investigational and management profile of perinatal str...
journal_title：European journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/s00431-011-1509-3
更新日期：2012-02-01 00:00:00
abstract：:Acute pharyngitis is one of the most frequent causes of primary care physician visits; however, there is no agreement about which is the best strategy to diagnose and manage acute pharyngitis in children. The aim of the current study was to evaluate the cost-effectiveness of the recommended strategies to diagnose and ...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-011-1410-0
更新日期：2011-08-01 00:00:00
abstract：:In order to determine the hepatotoxicity of rifampicin in children treated for tuberculosis, a survey was performed of 18 children receiving this medicine in combination with isoniazid. Fifteen of the 18 children (83%) showed a rise in ASAT values and 11 (61%) in ALAT values exceeding 29U/L. Seven children with maxima...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00441477
更新日期：1980-09-01 00:00:00
abstract：UNLABELLED:In a 2 year period seven patients who presented with stridor, without respiratory compromise, and three patients without obstructive symptoms were prospectively selected, and underwent MRI. In eight patients with a vascular ring and a pulmonary sling, MRI delineated the vascular abnormality and normal great ...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s004310050651
更新日期：1997-07-01 00:00:00
abstract：:This article summarizes some research on the development of motion perception in early infancy. The sensitivity for slow and rapid motion was studied with 1-month-old and 3-month-old babies. The findings suggest that there are different developmental courses for the detection of slow and rapid motion. The ability to d...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02191506
更新日期：1995-01-01 00:00:00
abstract：:Five patients, 11 months to 3 4/12 years old with severe normochromic, normocytis anemia and reticulocytopenia are reported. At the height of erythropoietic arrest when erythroid precursor cells were completely absent, undifferentiated stem cells (transitional cells), accumulated in the bone marrow. They disappeared a...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00497680
更新日期：1976-08-16 00:00:00
abstract：:A developmental approach to the management of sleep disturbances was successful in 85% (44/52) of the children (aged 2-36 months) within 2-6 weeks. No drugs were used. The approach was based on the following two principles: taking into account the characteristics of sleep behavior in infants and young children by sett...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00442443
更新日期：1984-08-01 00:00:00
abstract：UNLABELLED:The symptoms of urinary tract infections in infants are very non-specific and have historically included prolonged hyperbilirubinaemia. We studied the results of routine urine samples in 319 infants with prolonged jaundice. Convincing findings of UTI was not found in any of these children even if one of them...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-015-2499-3
更新日期：2015-07-01 00:00:00
abstract：UNLABELLED:Over the last decade, substantial progress has been made in the field of pertussis research. This includes better understanding of virulence mechanisms and their influence on the pathogenicity of Bordetella pertussis, increased awareness of the broad spectrum of disease and more insight into the host's immun...
journal_title：European journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/pl00008429
更新日期：2001-04-01 00:00:00
abstract：UNLABELLED:The objective of this analysis was to determine the relationship between wheezing at different age groups in children and the prevalence of bronchial hyperreactivity at the age of 10. A population-based cross-sectional study was conducted in Leipzig and the region around Halle in Germany. Of 3105 10-year-old...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02190692
更新日期：1994-09-01 00:00:00
