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Dibromodulcitol plus bleomycin compared with bleomycin alone in head and neck cancer.

Abstract：

:Advanced recurrent squamous cell head and neck cancer patients were prospectively randomized to receive or not receive dibromodulcitol 10 mg/kg PO weekly for 8 consecutive weeks in addition to bleomycin chemotherapy. Patients initially entered in the study received bleomycin 15 mu/m2 three times weekly for 8 weeks. This was later changed to 15 mu/m2 twice weekly for 8 weeks because of unacceptable stomatitis. Most patients had relapsed following surgery and/or radiotherapy, but none had received prior chemotherapy. A2 : 1 randomization in favor of the dibromodulcitol-containing therapy was used. There were 12 partial responses in the 44 evaluable patients receiving the combination (27%), and 4 partial responses in the 18 patients receiving single-agent bleomycin chemotherapy (22%). This difference was not statistically significant. Response durations were also relatively short for both therapies. Within the limitations of this study, we were unable to demonstrate that patient benefit resulted from the addition of dibromodulcitol to bleomycin chemotherapy for this patient population.

journal_name

Cancer Chemother Pharmacol

journal_title

Cancer chemotherapy and pharmacology

authors

Issell BF,Borsos G,D'Aoust JC,Banhidy F,Crooke ST,Eckhardt S

doi

10.1007/BF00255478

subject

Has Abstract

pub_date

1982-01-01 00:00:00

pages

171-3

issue

2

eissn

0344-5704

issn

1432-0843

journal_volume

8

pub_type

临床试验,杂志文章,随机对照试验

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