D-tubocurarine requirement during hypothermia.

Abstract:

:The effect of hypothermia on the action of d-tubocurarine (d-TC) was studied under carefully controlled experimental conditions. It was found that with computer controlled infusion, 60% less d-TC was required to sustain 75% muscle paralysis in cats, during steady-state, in vivo, when the temperature was changed from 37 degrees C to 30 degrees C. The corresponding relaxant consumption rates were 0.136 +/- 0.025 and 0.055 +/- 0.012 mg/kg/1/2 hr respectively. When there was no temperature change the maintenance dosage of d-TC remained constant for up to four hours denoting the equilibrium phase of the relaxant kinetics. Temperature transitions introduced dynamic changes in these kinetics and altered the constancy of the maintenance dosage.

journal_name

Anaesth Intensive Care

authors

Lam HS,Brown TC,Lampard DG

doi

10.1177/0310057X7900700303

subject

Has Abstract

pub_date

1979-08-01 00:00:00

pages

222-8

issue

3

eissn

0310-057X

issn

1448-0271

journal_volume

7

pub_type

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