A method for localized and longlasting microapplication of drugs into nervous tissue of freely moving animals.

abstract：:Motor control tasks like stance or object handling require sensory feedback from proprioception, vision and touch. The distinction between tactile and proprioceptive sensors is not frequently made in dynamic motor control tasks, and if so, mostly based on signal latency. We previously found that force control tasks en...

journal_title：Experimental brain research

authors： Mugge W,Abbink DA,Schouten AC,van der Helm FC,Arendzen JH,Meskers CG

更新日期：2013-02-01 00:00:00

abstract：:In this work a statistical study is made of the final outcome of the quantification of the nerve cell labelling in the adult, after prenatal injection of tritiated thymidine. This outcome is presented in the form of histograms which are the superposition of elementary Poisson distributions. A theoretical model, based...

journal_title：Experimental brain research

authors： Bisconte JC,Marty R

更新日期：1975-01-01 00:00:00

abstract：:The effects of altered gravitational forces (AGF) on the development of the static vestibulo-ocular reflex (VOR) were investigated in Xenopus laevis tadpoles exposed to hypergravity (1.4g; 3g) or microgravity conditions (German spacelab mission D-2) for 9-10 days. The effects of light conditions during development wer...

journal_title：Experimental brain research

authors： Sebastian C,Esseling K,Horn E

更新日期：1996-11-01 00:00:00

abstract：:This study addressed the anticonvulsant effects of phenobarbital, valproate, and ethosuximide in the amygdala of kindled guinea pigs to further validate this model for the screening of anticonvulsant drugs. Behavioral toxic effects were assessed at 30 min following drug administration using quantitative locomotor test...

journal_title：Experimental brain research

authors： Gilbert TH,Corley SM,Teskey GC

更新日期：2002-10-01 00:00:00

abstract：:Despite holding significant promise for counteracting the deleterious effects of ageing on cognitive and motor function, little is known of the effects of facilitatory non-invasive brain stimulation (NBS) techniques on corticospinal excitability (CSE) in older adults. Thirty-three older adults (≥60 years) participated...

journal_title：Experimental brain research

authors： Puri R,Hinder MR,Canty AJ,Summers JJ

更新日期：2016-12-01 00:00:00

abstract：:The static ocular torsional position of both eyes of 23 patients was measured by means of fundus photographs one day before and one week after unilateral vestibular neurectomy for the treatment of acoustic neuroma, Ménière's disease or paroxysmal vertigo. The results showed that in all patients the vestibular neurecto...

journal_title：Experimental brain research

authors： Curthoys IS,Dai MJ,Halmagyi GM

更新日期：1991-01-01 00:00:00

abstract：:We recognize objects even when they are partially degraded by visual noise. Using monkeys performing a sequential delayed match-to-sample task, we studied the relation between the amount of visual noise (5, 10, 15, 20 or 25%) degrading the eight black and white stimuli used here, and the accuracy and speed with which ...

journal_title：Experimental brain research

authors： Shidara M,Richmond BJ

更新日期：2005-05-01 00:00:00

abstract：:In order to investigate the role of mental rotation in the directional control of eye movements, we instructed subjects to make saccades in directions different from that of a visual stimulus (rotated saccades). Saccadic latency increased linearly with the amount of directional transformation imposed between the stimu...

journal_title：Experimental brain research

authors： de'Sperati C

更新日期：1999-06-01 00:00:00

abstract：:The development of visual cell properties was studied in cortical Area 18 (A18) of normal (NRs) and dark-reared kittens (DRs), from 2 weeks of age to adulthood. In addition to the orientation selective (S) and non-selective (NS) cells, we describe a new type of non-selective cell with a peripheral zone (NSp), which co...

journal_title：Experimental brain research

authors： Milleret C,Gary-Bobo E,Buisseret P

更新日期：1988-01-01 00:00:00

abstract：:Experiments were done to investigate the role of glutamatergic systems in the median preoptic nucleus (MnPO) in the water ingestion induced by administration of angiotensin II (ANG II) in the subfornical organ (SFO) in the awake rat. Microdialysis methods were utilized to quantify the extracellular content of glutamat...

journal_title：Experimental brain research

authors： Ushigome A,Momoi K,Takahashi M,Tanaka J

更新日期：2020-01-01 00:00:00

abstract：:Parkinsonian rigidity is characterized by an increased resistance of a joint to externally imposed motion that remains uniform with changing joint angle. Two candidate mechanisms are proposed for the uniformity of rigidity, involving neural-mediated excitation of shortening muscles, i.e., shortening reaction (SR), or ...

journal_title：Experimental brain research

authors： Xia R,Powell D,Rymer WZ,Hanson N,Fang X,Threlkeld AJ

更新日期：2011-04-01 00:00:00

abstract：:Many activities of daily living involve multi-digit, voluntary rotational manipulations of grasped objects. Yet, only a few studies have focused on coordination of individual fingertip forces during such tasks. The objective of this study was to investigate individual digit contributions to a three-digit task in which...

journal_title：Experimental brain research

authors： Manis RP,Santos VJ

更新日期：2015-07-01 00:00:00

abstract：:Transcranial direct current stimulation (TDCS) is a non-invasive form of brain stimulation applied via a weak electrical current passed between electrodes on the scalp. In recent studies, TDCS has been shown to improve learning when applied to the prefrontal cortex (e.g., Kincses et al. in Neuropsychologia 42:113-117,...

journal_title：Experimental brain research

authors： Bullard LM,Browning ES,Clark VP,Coffman BA,Garcia CM,Jung RE,van der Merwe AJ,Paulson KM,Vakhtin AA,Wootton CL,Weisend MP

更新日期：2011-08-01 00:00:00

abstract：:Percutaneous electrical stimulation of the motor cortex was used to activate rapidly conducting corticofugal pathways to human abdominal muscles. Following cortical stimulation the response latencies for the abdominal muscles were similar to those for limb muscles which are a similar distance from the motor cortex. Co...

journal_title：Experimental brain research

authors： Plassman BL,Gandevia SC

更新日期：1989-01-01 00:00:00

abstract：:Quick detection of changes in the sensory environment is very important for survival, resulting in automatic shifts of attention to the event and the facilitation of subsequent processes to execute appropriate behaviors. The abrupt onset or offset of a sensory stimulus should also activate the neural network detecting...

journal_title：Experimental brain research

authors： Yamashiro K,Inui K,Otsuru N,Kida T,Akatsuka K,Kakigi R

更新日期：2008-09-01 00:00:00

abstract：:Rats with unilateral or bilateral partial section of the fornix were impaired on an eight arm radial maze task. Neurochemical analysis of hippocampal tissue four weeks after the lesions revealed a 50% reduction of choline acetyltransferase (ChAT) activity. The cholinergic marker was correlated negatively with the numb...

journal_title：Experimental brain research

authors： Sara SJ,Dyon-Laurent C,Guibert B,Leviel V

更新日期：1992-01-01 00:00:00

abstract：:The mechanisms underlying stress-induced hyperalgesia (SIH) remain poorly understood. Recent findings have provided strong evidence indicating that SIH could be related, at least in part, to alterations in spinal cord GABA activity. In the present study, we first investigated how acute restraint stress impacted pain r...

journal_title：Experimental brain research

authors： Ma X,Bao W,Wang X,Wang Z,Liu Q,Yao Z,Zhang D,Jiang H,Cui S

更新日期：2014-11-01 00:00:00

abstract：:Selective lesions of the noradrenergic locus coeruleus (LC) system have recently been shown to aggravate both ischemic and epileptic brain damage. This study explores the possibility that the LC system also influences hypoglycemic brain injury. Bilateral 6-hydroxydopamine lesions of the LC projection to the forebrain ...

journal_title：Experimental brain research

authors： Lindvall O,Auer RN,Siesjö BK

更新日期：1988-01-01 00:00:00

abstract：:The extent to which attending to one stimulus while ignoring another influences the integration of visual and inertial (vestibular, somatosensory, proprioceptive) stimuli is currently unknown. It is also unclear how cue integration is affected by an awareness of cue conflicts. We investigated these questions using a t...

journal_title：Experimental brain research

authors： Berger DR,Bülthoff HH

更新日期：2009-09-01 00:00:00

abstract：:A force-matching task was used to study the influence of constraining tactile information from the hand on the perception of forces generated with the index finger flexors, the palmar prehensile grasp and with the elbow flexors. Subjects generated the same reference forces (2-10 N) with each muscle group and matched t...

journal_title：Experimental brain research

authors： Jones LA,Piateski E

更新日期：2006-01-01 00:00:00

abstract：:The firing patterns of alpha and gamma efferent fibres and of group I and group II afferent fibres innervating the gastrocnemius muscle were observed during spontaneous locomotor movements in the thalamic cat. Multi-unit discharges of each kind of fibre were obtained by electronic sorting of the action potentials from...

journal_title：Experimental brain research

authors： Bessou P,Cabelguen JM,Joffroy M,Montoya R,Pagès B

更新日期：1986-01-01 00:00:00

abstract：:We investigated the relationships between cortical arousal and cholinergic facilitation of evoked responses in the auditory cortex. The basal forebrain (BF) was stimulated unilaterally, while cluster recordings were obtained simultaneously from both auditory cortices in urethane-anesthetized rats. The global electroen...

journal_title：Experimental brain research

authors： Edeline JM,Hars B,Maho C,Hennevin E

更新日期：1994-01-01 00:00:00

abstract：:Voluntary movements are preceded by a slow electrical potential of the brain (Bereitschafts-potential, BP) or readiness potential. The BP is accompanied by a magnetic field shift of similar time characteristics (Bereitschaftsmagnetfeld, BM). The BM preceding volitional right foot or toe movements was recorded from ant...

journal_title：Experimental brain research

authors： Deecke L,Boschert J,Weinberg H,Brickett P

更新日期：1983-01-01 00:00:00

abstract：:Control of velocity in rapid flexion movements of the interphalangeal joint of the thumb was investigated by examining movement trajectories and patterns of activity in the extensor pollicis longus (EPL) and flexor pollicis longus (FPL) muscles. Although velocity was controlled with considerable accuracy, it was not s...

journal_title：Experimental brain research

authors： Milner TE

更新日期：1986-01-01 00:00:00

abstract：:This study was undertaken to elucidate neural control of the arterial blood pressure (ABP) in head-down postural change which causes both stimulation to the vestibular system and head-ward fluid shift. Experiments were carried out with urethane-anesthetized rabbits. The animal was mounted on a tilting table, tilted to...

journal_title：Experimental brain research

authors： Nakamura Y,Matsuo S,Hosogai M,Kawai Y

更新日期：2009-04-01 00:00:00

abstract：:Paired-pulse transcranial magnetic stimulation was used in three experiments to measure the properties of long-latency intracortical inhibition (LICI) acting on the relaxed first dorsal interosseus muscle of the left and right hand in right-handed volunteers. The experiments show that LICI is asymmetrical: it emerges ...

journal_title：Experimental brain research

authors： Hammond GR,Garvey CA

更新日期：2006-07-01 00:00:00

abstract：:In this study, we investigated the effects of ginkgolides (Gins A, B, C and J), the main constituent of the non-flavone fraction of EGb 761, on hypoxic injury induced by potassium cyanide (KCN) in primary cortical neurons. The neurons were pretreated with or without ginkgolides for 24 h before incubation with KCN for ...

journal_title：Experimental brain research

authors： Zhu L,Xu YJ,Du F,Qian ZM

更新日期：2007-06-01 00:00:00

abstract：:The main belly of the macaque's flexor digitorum profundus (FDP) is divided by a dissectible plane into radial and ulnar regions. The present report describes three findings which suggest that the radial and ulnar regions represent separate functional subdivisions of the FDP. First, electromyographic (EMG) recordings ...

journal_title：Experimental brain research

authors： Schieber MH

更新日期：1993-01-01 00:00:00

abstract：:The afternystagmus that occurs in the dark after gaze fixation during optokinetic stimulation is directed in the opposite direction relative to the previous optokinetic stimulus. The mechanism responsible for such afternystagmus after suppression of optokinetic nystagmus (ASOKN) is unclear. Several hypotheses have bee...

journal_title：Experimental brain research

authors： Chen CC,Huang MY,Weber KP,Straumann D,Bockisch CJ

更新日期：2014-09-01 00:00:00

abstract：:This review summarizes anatomical and electrophysiological observations related to corticovestibular interactions as a step toward understanding their possible functions. Vestibular information is represented in at least three distinct regions of the cerebral cortex in cats and monkeys: the parietal and somatosensory ...

journal_title：Experimental brain research

authors： Fukushima K

更新日期：1997-10-01 00:00:00