Abstract:
:The relation between steady-state plasma ethosuximide level and drug dose was studied in 46 patients. In this population, plasma drug levels were proportional to drug dose, expressed on a body weight basis. Age did not alter this relationship, but plasma levels increased more rapidly, relative to dose, in females than in males. Intake of methylphenobarbitone, but not intake of certain other anticonvulsants (phenytoin, phenobarbitone, primidone and carbamazepine) altered the relationship between plasma ethosuximide level and ethosuximide dose. In individual patients, successive dose increments of equal size produced progressively greater increases in steady-state plasma ethosuximide levels. This phenomenon has obvious therapeutic implications.
journal_name
Clin Pharmacokinetjournal_title
Clinical pharmacokineticsauthors
Smith GA,McKauge L,Dubetz D,Tyrer JH,Eadie MJdoi
10.2165/00003088-197904010-00004subject
Has Abstractpub_date
1979-01-01 00:00:00pages
38-52issue
1eissn
0312-5963issn
1179-1926journal_volume
4pub_type
杂志文章abstract::Vedolizumab is a humanized anti-α4β7 integrin monoclonal antibody that selectively blocks trafficking of memory T cells to inflamed gut tissue by inhibiting the α4β7-mucosal addressin cell adhesion molecule-1 (MAdCAM-1) interaction. Approved for treating patients with moderately to severely active ulcerative colitis (...
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journal_title:Clinical pharmacokinetics
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journal_title:Clinical pharmacokinetics
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journal_title:Clinical pharmacokinetics
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pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2015-10-01 00:00:00
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doi:10.2165/00003088-198900171-00003
更新日期:1989-01-01 00:00:00
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doi:10.2165/00003088-198815060-00001
更新日期:1988-12-01 00:00:00
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更新日期:2018-02-01 00:00:00
abstract:OBJECTIVE:To assess the dose proportionality of lacidipine after single and repeated oral doses, and to obtain new information on the pharmacokinetics of the compound since improvement of the plasma assay method. DESIGN:Open, randomised, four-way cross-over trial. PARTICIPANTS:24 healthy male and female volunteers, a...
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更新日期:1994-05-01 00:00:00
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更新日期:1999-01-01 00:00:00