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Sleep-inducing N-alkyl-5-[m-(trifluoromethyl)phenyl]-5-hydroxy-2-pyrrolidinones and N-alkyl-3-(trifluoromethyl)cinnamamides.

Abstract：

:A series of N-alkyl-3-[m-(trifluoromethyl)phenyl]-5-hydroxy-2-pyrrolidinones and N-alkyl-3-(trifluoromethyl)-cinnamamides were prepared and screened in a series of tests designed to detect potential sleep inducers. The more active members of the series were evaluated for their ability to induce sleep in Cebus monkeys. The most active compound, N-methyl-5-[m-(trifluoromethyl)phenyl]-5-hydroxy-2-pyrrolidinone, was equal to methaqualone.

journal_name

J Med Chem

journal_title

Journal of medicinal chemistry

authors

Houlihan WJ,Gogerty JH,Ryan EA,Schmitt G

doi

10.1021/jm00379a007

subject

Has Abstract

pub_date

1985-01-01 00:00:00

pages

28-31

issue

1

eissn

0022-2623

issn

1520-4804

journal_volume

28

pub_type

杂志文章

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