Effect of an inhibitor of aromatization, 1,4,6 androstatriene-3,17-dione (ATD) on LH release and steroid binding in hypothalamus of adult female rats.

Abstract:

:Prevention of testosterone aromatization in the female rat pups by perinatal treatment with 1,4,6 androstatriene-3,17-dione (ATD) induces an important defeminization as shown by a reduction of fluctuations of LH release after castration and estradiol implantation. The fact that, under our in vitro experimental conditions, ATD is able to displace testosterone binding in the hypothalamus whereas estradiol does not, confirms the hypothesis that ATD acts on aromatase. The most attractive explanation for the defeminization effect of ATD is then an estrogen-like action of ATD.

journal_name

Exp Brain Res

authors

Slama A,Gogan F,Sarrieau A,Vial M,Rostene W,Kordon C

doi

10.1007/BF00340477

subject

Has Abstract

pub_date

1986-01-01 00:00:00

pages

407-10

issue

3

eissn

0014-4819

issn

1432-1106

journal_volume

64

pub_type

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