Abstract:
:The environment contains a huge array of allergens, primarily proteins or glycoproteins, to which the atopic individual may become sensitized. In situations of high exposure and highly reactive substances, even nonatopic individuals may develop allergic antibodies. The individual's response depends on the underlying immune responsiveness, the dosage, frequency, route, and possibly the chemical nature of the allergen. Most allergenic sources contain multiple allergenic determinants, as demonstrated by characterization of pollen and mold extracts. Major allergens are acidic proteins with weights in the 20,000 to 40,000 dalton range, and pIs in the 4 to 6 range. Minor allergens may be larger or smaller and either acidic or basic. These conclusions are based on the isolation of a relatively small number of allergens. Cross-reactivity data, especially with the pollens, are useful in the rational formulation of immunotherapy extracts. Considering the wealth of allergenic pollens, information available to date is very scanty. Data on molds, epidermals, and mites are even more preliminary or conflicting. As further research proceeds on purifying and characterizing allergens, a number of these questions and conflicts will be resolved.
journal_name
Prim Carejournal_title
Primary careauthors
Weber RWsubject
Has Abstractpub_date
1987-09-01 00:00:00pages
435-45issue
3eissn
0095-4543issn
1558-299Xjournal_volume
14pub_type
杂志文章相关文献
PRIMARY CARE文献大全abstract::Guillain-Barré syndrome and its clinical variants are a group of rapidly progressing, potentially debilitating neurologic disorders that may have significant morbidity/mortality if left unrecognized or untreated. The most common symptoms include ascending limb weakness and paralysis, which may progress to respiratory ...
journal_title:Primary care
pub_type: 杂志文章,评审
doi:10.1016/j.pop.2015.01.001
更新日期:2015-06-01 00:00:00
abstract::Prevention of infection in the elderly is far preferable to treatment of the disease, and can be promoted through precautionary measures when undertaking invasive procedures in older patients as well as through the administration of available vaccines. Difficulties in diagnosing bacterial pneumonia, influenza, tubercu...
journal_title:Primary care
pub_type: 杂志文章
doi:
更新日期:1982-03-01 00:00:00
abstract::Patellofemoral pain syndrome is common among athletes and non-athletes. It results from an imbalance of forces acting on the patellofemoral joint, which leads to increased strain on the peripatellar soft tissues, increased patellofemoral joint stress, or both. The most important risk factors are overuse, quadriceps we...
journal_title:Primary care
pub_type: 杂志文章
doi:10.1016/j.pop.2004.07.006
更新日期:2004-12-01 00:00:00
abstract::Pregnancy in the diabetic is no longer the universal tragedy for mother and child that it once was but avoidable fetal loss wil continue to occur unless gestational diabetes is detected, and unless meticulous control and monitoring of the insulin dependent diabetic is maintained. As Kinch has so succinctly stated "car...
journal_title:Primary care
pub_type: 杂志文章
doi:
更新日期:1977-12-01 00:00:00
abstract::It is estimated that 8% to 12% of American youths have experienced at least one sexual assault in their lifetime, making childhood sexual abuse (CSA) an important public health problem that is likely to be encountered by primary care providers. Use of screening tools and understanding the principles behind targeted cl...
journal_title:Primary care
pub_type: 杂志文章,评审
doi:10.1016/j.pop.2016.01.005
更新日期:2016-06-01 00:00:00
abstract::We have reviewed the current uses of ultrasound in obstetrics. The referring physician must have a clear understanding of the limitations and potential of obstetric ultrasound. The reason for requesting a particular examination should be conveyed to the ultrasonographer. Accurate dating of a particular pregnancy requi...
journal_title:Primary care
pub_type: 杂志文章
doi:
更新日期:1983-06-01 00:00:00
abstract::Kidney transplant recipients (KTRs) commonly present with complex medical issues that are best managed jointly by both their primary care physician and the kidney transplant center. Hypertension, diabetes, dyslipidemias, and obesity are frequently present in the KTR population and the successful management of these co...
journal_title:Primary care
pub_type: 杂志文章,评审
doi:10.1016/j.pop.2014.08.009
更新日期:2014-12-01 00:00:00
abstract::Psychiatric problems constitute one of the prime reasons for failure in levodopa therapy in Parkinson's disease. While a variety of symptoms may be seen, the levodopa itself does not produce a defined set of psychiatric symptoms. The single most important factor determining the psychiatric response to levodopa therapy...
journal_title:Primary care
pub_type: 杂志文章
doi:
更新日期:1977-09-01 00:00:00
abstract::Various forms of vegetarian diets are discussed and evaluated for their nutritional adequacy. Health, philosophical, religious, ecological, and economic concerns are suggested as possible reasons for these alternate dietary lifestyles. Nutrients of specific concern ot the vegetarian are highlighted and suggestions giv...
journal_title:Primary care
pub_type: 杂志文章,评审
doi:
更新日期:1982-09-01 00:00:00
abstract::The radiographic evaluation of the arthritides still relies primarily on the plain films that are readily available to every practicing clinician. The radiographic examination serves primarily to confirm the clinician's diagnosis based on the history, clinical findings, and laboratory studies and to document the sever...
journal_title:Primary care
pub_type: 杂志文章,评审
doi:
更新日期:1993-12-01 00:00:00
abstract::All patients with pain must be taken seriously, and both organic and emotional factors investigated. Cultural aspects, early developmental experience, and highly personal meanings may influence the individual's perception of and reaction to pain; specific psychiatric pain states may be identified as well. Treatment is...
journal_title:Primary care
pub_type: 杂志文章
doi:
更新日期:1975-03-01 00:00:00
abstract::STI are among the most common pathological conditions affecting sexually active adolescents. Both screening of asymptomatic adolescents and a thoughtful, thorough approach to the evaluation of symptoms are critical measures in STI identification and control. ...
journal_title:Primary care
pub_type: 杂志文章
doi:10.1016/j.pop.2006.01.007
更新日期:2006-06-01 00:00:00
abstract::The groin, the lowest portion of the abdominal wall near the junction with the thigh, is the site of a disproportionately large amount of dermatologic disease. Because of its close proximity to the genitalia it is the site of numerous sexually transmitted disorders. Maceration of the skin, which can occur quite readil...
journal_title:Primary care
pub_type: 杂志文章
doi:
更新日期:1978-06-01 00:00:00
abstract::Adolescents are often at higher risk for acquiring sexually transmitted infections (STIs). Medical providers should be alert for both asymptomatic and symptomatic STIs, and follow appropriate screening guidelines. Moreover, providers need to know how to best administer adolescent-friendly confidential care, treatment,...
journal_title:Primary care
pub_type: 杂志文章,评审
doi:10.1016/j.pop.2014.05.011
更新日期:2014-09-01 00:00:00
abstract::Multidisciplinary management in the diagnosis and management of patients with ocular inflammatory disease is often critical. The workup of uveitis or scleritis may reveal an underlying systemic disease. Recognition of inflammation by the primary care physician can facilitate prompt referral to a uveitis specialist and...
journal_title:Primary care
pub_type: 杂志文章,评审
doi:10.1016/j.pop.2015.05.003
更新日期:2015-09-01 00:00:00
abstract::The high prevalence of stimulant abuse and its harmful consequences make the screening, diagnosis, and referral for treatment of persons with stimulant abuse a top concern for primary care providers. Having a working knowledge of use patterns, clinical symptomatology, end-organ effects, and advances in treatment of st...
journal_title:Primary care
pub_type: 杂志文章,评审
doi:10.1016/j.pop.2010.11.004
更新日期:2011-03-01 00:00:00
abstract::The most common conditions of gastroenteritis in children and avoidance of errors in their management are emphasized in this article. ...
journal_title:Primary care
pub_type: 杂志文章
doi:
更新日期:1984-09-01 00:00:00
abstract::Gastroesophageal reflux disease (GERD) is a gastrointestinal motility disorder that results from the reflux of stomach contents into the esophagus or oral cavity resulting in symptoms or complications. The typical symptoms of GERD are heartburn and regurgitation of gastric contents into the oropharynx. GERD affects qu...
journal_title:Primary care
pub_type: 杂志文章,评审
doi:10.1016/j.pop.2017.07.001
更新日期:2017-12-01 00:00:00
abstract::The rational use of laboratory testing to investigate early, undifferentiated joint pain depends heavily on a detailed history and careful physical examination. Nevertheless, several diagnostic tests have some discriminatory function in the initial evaluation of soft tissues and joint complaints, given the correct cli...
journal_title:Primary care
pub_type: 杂志文章,评审
doi:10.1016/j.pop.2010.07.010
更新日期:2010-12-01 00:00:00
abstract::This article explains the proposed pathophysiology, evidence of efficacy, and adverse effects of several complementary and alternative medicine modalities, for the treatment of allergic conditions, such as traditional Chinese medicine formula, herbal treatments, acupuncture, and homeopathy. ...
journal_title:Primary care
pub_type: 杂志文章,评审
doi:10.1016/j.pop.2016.04.012
更新日期:2016-09-01 00:00:00
abstract::Upper extremity musculoskeletal disorders such as DeQuervain's tendonitis, carpal tunnel syndrome, and rotator cuff tendonitis have become increasingly common among working people in the United States. Extensive epidemiological investigation indicates that the adverse ergonomic exposures of force, repetition, vibratio...
journal_title:Primary care
pub_type: 杂志文章,评审
doi:10.1016/s0095-4543(05)70180-9
更新日期:2000-12-01 00:00:00
abstract::Physical therapy and manual medicine for low back pain encompass many different treatment modalities. There is a vast variety of techniques that physical therapists commonly use in the treatment of low back pain. Some of the therapies include, but are certainly not limited to, education, exercise, lumbar traction, man...
journal_title:Primary care
pub_type: 杂志文章,评审
doi:10.1016/j.pop.2012.06.006
更新日期:2012-09-01 00:00:00
abstract::In this article, two cases are presented that illustrate that the principles underlying medical practice and religious scruples are often the same. The author argues, therefore, that better understanding of religious traditions that inform patients' views might diminish seeming conflicts in the provision of medical ca...
journal_title:Primary care
pub_type: 杂志文章
doi:
更新日期:1986-06-01 00:00:00
abstract::Breast self-exam, clinical breast exam and mammography are the primary screening modalities for the early detection of breast cancer. In this article, we review the epidemiology of breast cancer and methodologic considerations in screening for breast cancer. For each screening modality, we assess the evidence for its ...
journal_title:Primary care
pub_type: 杂志文章,评审
doi:
更新日期:1989-03-01 00:00:00
abstract::Classification of patients with prostatic complaints into one of the categories of bacterial or nonbacterial prostatitis or prostatodynia (see Table 3) enables a physician to give rational advice to men with confusing symptoms. By examining the prostatic fluid of patients with prostatic symptoms, a physician may easil...
journal_title:Primary care
pub_type: 杂志文章
doi:
更新日期:1985-12-01 00:00:00
abstract::When prescribing drugs for patients who are pregnant or lactating, a clinician needs to ask the following questions: (1) Is pharmacotherapy necessary? (2) What drug can be used that has the lowest potential toxicity according to current knowledge? (3) What pharmacokinetic parameters does the drug follow during pregnan...
journal_title:Primary care
pub_type: 杂志文章,评审
doi:
更新日期:1990-09-01 00:00:00
abstract::Kidney stones affect more than 5% of adults in the United States, and the prevalence is rising. The fundamental cause for all stones is supersaturation of urine with respect to the stone components; factors affecting solubility include urine volume, pH, and total solute excretion. Calcium stones are the most common in...
journal_title:Primary care
pub_type: 杂志文章,评审
doi:10.1016/j.pop.2008.01.005
更新日期:2008-06-01 00:00:00
abstract::Benign prostatic hyperplasia (BPH) is the most common benign adenoma in men, affecting nearly all of them. BPH represents a clinically significant cause of bladder outflow obstruction in up to 40% of men. The growing frequency of diagnosis is due to increasing life expectancy and a trend toward seeking medical advice ...
journal_title:Primary care
pub_type: 杂志文章,评审
doi:10.1016/j.pop.2010.04.004
更新日期:2010-09-01 00:00:00
abstract::Care of the patient with tracheostomy is not difficult if care is taken to define clearly the needs of the particular patient. An awareness of the goals of care, daily maintenance, and possible complications is necessary to successful management. ...
journal_title:Primary care
pub_type: 杂志文章
doi:
更新日期:1978-09-01 00:00:00
abstract::Mental health and primary care delivery systems have evolved to operate differently. For example, attention to multiple medical issues, health maintenance, and structured diagnostic procedures are standard elements of primary care rarely incorporated into mental health care. A multidisciplinary treatment approach, gro...
journal_title:Primary care
pub_type: 杂志文章,评审
doi:10.1016/j.pop.2007.05.007
更新日期:2007-09-01 00:00:00