Abstract：
:Gastroesophageal reflux disease (GERD) is a gastrointestinal motility disorder that results from the reflux of stomach contents into the esophagus or oral cavity resulting in symptoms or complications. The typical symptoms of GERD are heartburn and regurgitation of gastric contents into the oropharynx. GERD affects quality of life and may cause erosive esophagitis, esophageal strictures, and Barrett esophagus, a precursor to esophageal adenocarcinoma. GERD is a clinical diagnosis and is most effectively treated with proton-pump inhibitors (PPIs). Long-term use of PPIs is associated with bone fractures, chronic renal disease, acute renal disease, community-acquired pneumonia, and Clostridium difficile intestinal infection.
journal_name
Prim Carejournal_title
Primary careauthors
Kellerman R,Kintanar Tdoi
10.1016/j.pop.2017.07.001subject
Has Abstractpub_date
2017-12-01 00:00:00pages
561-573issue
4eissn
0095-4543issn
1558-299Xpii
S0095-4543(17)30095-7journal_volume
44pub_type
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