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3-Pyrroline N-oxide bis(carbamate) tumor inhibitors as analogues of indicine N-oxide.

Abstract：

:The 2,3-bis[[(N-methylcarbamoyl)oxy]methyl]-3-pyrroline 1-oxide 5 was synthesized and tested in the murine P388 lymphocytic leukemia model. The compound showed significant reproducible activity and was more potent than indicine N-oxide. 1-Methyl-2-phenyl-3,4-bis[[(N-2- propylcarbamoyl)oxy]methyl]-3-pyrroline N-oxide (6) was less active than 5, and the 5,5-dimethyl analogue of 6, the pyrroline N-oxide 7, was inactive. The N-oxide 7 cannot be converted to a pyrrole in vivo because of the gem-dimethyl substitution at C-5.

journal_name

J Med Chem

journal_title

Journal of medicinal chemistry

authors

Anderson WK,Milowsky AS

doi

10.1021/jm00394a036

subject

Has Abstract

pub_date

1987-11-01 00:00:00

pages

2144-7

issue

11

eissn

0022-2623

issn

1520-4804

journal_volume

30

pub_type

杂志文章

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