Re-assembly of nineteenth-century smallpox vaccine genomes reveals the contemporaneous use of horsepox and horsepox-related viruses in the USA.

Abstract:

:According to a recent article published in Genome Biology, Duggan and coworkers sequenced and partially assembled five genomes of smallpox vaccines from the nineteenth century. No information regarding the ends of genomes was presented, and they are important to understand the evolutionary relationship of the different smallpox vaccine genomes during the centuries. We re-assembled the genomes, which include the largest genomes in the vaccinia lineage and one true horsepox strain. Moreover, the assemblies reveal a diverse genetic structure in the genome ends. Our data emphasize the concurrent use of horsepox and horsepox-related viruses as the smallpox vaccine in the nineteenth century.

journal_name

Genome Biol

journal_title

Genome biology

authors

Brinkmann A,Souza ARV,Esparza J,Nitsche A,Damaso CR

doi

10.1186/s13059-020-02202-0

subject

Has Abstract

pub_date

2020-12-04 00:00:00

pages

286

issue

1

eissn

1474-7596

issn

1474-760X

pii

10.1186/s13059-020-02202-0

journal_volume

21

pub_type

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