Abstract:
:Protein kinases are critical to cellular signalling and post-translational gene regulation, but their biological substrates are difficult to identify. We show that cyclin-dependent kinase (CDK) consensus motifs are frequently clustered in CDK substrate proteins. Based on this, we introduce a new computational strategy to predict the targets of CDKs and use it to identify new biologically interesting candidates. Our data suggest that regulatory modules may exist in protein sequence as clusters of short sequence motifs.
journal_name
Genome Bioljournal_title
Genome biologyauthors
Moses AM,Hériché JK,Durbin Rdoi
10.1186/gb-2007-8-2-r23subject
Has Abstractpub_date
2007-01-01 00:00:00pages
R23issue
2eissn
1474-7596issn
1474-760Xpii
gb-2007-8-2-r23journal_volume
8pub_type
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