Inferring protein domain interactions from databases of interacting proteins.

Abstract:

:We describe domain pair exclusion analysis (DPEA), a method for inferring domain interactions from databases of interacting proteins. DPEA features a log odds score, Eij, reflecting confidence that domains i and j interact. We analyzed 177,233 potential domain interactions underlying 26,032 protein interactions. In total, 3,005 high-confidence domain interactions were inferred, and were evaluated using known domain interactions in the Protein Data Bank. DPEA may prove useful in guiding experiment-based discovery of previously unrecognized domain interactions.

journal_name

Genome Biol

journal_title

Genome biology

authors

Riley R,Lee C,Sabatti C,Eisenberg D

doi

10.1186/gb-2005-6-10-r89

keywords:

subject

Has Abstract

pub_date

2005-01-01 00:00:00

pages

R89

issue

10

eissn

1474-7596

issn

1474-760X

pii

gb-2005-6-10-r89

journal_volume

6

pub_type

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