Abstract:
:We describe domain pair exclusion analysis (DPEA), a method for inferring domain interactions from databases of interacting proteins. DPEA features a log odds score, Eij, reflecting confidence that domains i and j interact. We analyzed 177,233 potential domain interactions underlying 26,032 protein interactions. In total, 3,005 high-confidence domain interactions were inferred, and were evaluated using known domain interactions in the Protein Data Bank. DPEA may prove useful in guiding experiment-based discovery of previously unrecognized domain interactions.
journal_name
Genome Bioljournal_title
Genome biologyauthors
Riley R,Lee C,Sabatti C,Eisenberg Ddoi
10.1186/gb-2005-6-10-r89keywords:
subject
Has Abstractpub_date
2005-01-01 00:00:00pages
R89issue
10eissn
1474-7596issn
1474-760Xpii
gb-2005-6-10-r89journal_volume
6pub_type
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