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Can sequence determine function?

Abstract：

:The functional annotation of proteins identified in genome sequencing projects is based on similarities to homologs in the databases. As a result of the possible strategies for divergent evolution, homologous enzymes frequently do not catalyze the same reaction, and we conclude that assignment of function from sequence information alone should be viewed with some skepticism.

journal_name

Genome Biol

journal_title

Genome biology

authors

Gerlt JA,Babbitt PC

doi

10.1186/gb-2000-1-5-reviews0005

keywords:

subject

Has Abstract

pub_date

2000-01-01 00:00:00

pages

REVIEWS0005

issue

5

eissn

1474-7596

issn

1474-760X

journal_volume

1

pub_type

杂志文章,评审

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