Abstract:
PURPOSE:Investigation of potential improvements in dynamic CT perfusion measurements by exploitation of improved visualization of contrast agent in virtual monoenergetic reconstructions of images acquired with dual-energy computed tomography (DECT). METHOD:For 17 patients with pancreatic carcinoma, dynamic dual-source DECT acquisitions were performed at 80kVp/Sn140kVp every 1.5 s over 51 s. Virtual monoenergetic images (VMI) were reconstructed for photon energies between 40 keV and 150 keV (5 keV steps). Using the maximum-slope model, perfusion maps of blood flow were calculated from VMIs and 80kVp images and compared quantitatively with regard to blood flow measured in regions of interest in healthy tissue and carcinoma, standard deviation (SD), and absolute-difference-to-standard-deviation ratio (ADSDR) of measurements. RESULTS:On average, blood flow calculated from VMIs increased with increasing energy levels from 114.3 ± 37.2 mL/100 mL/min (healthy tissue) and 45.6 ± 25.3 mL/100 mL/min (carcinoma) for 40 keV to 128.6 ± 58.9 mL/100 mL/min (healthy tissue) and 75.5 ± 49.8 mL/100 mL/min (carcinoma) for 150 keV, compared to 114.2 ± 37.4 mL/100 mL/min (healthy tissue) and 46.5 ± 26.6 mL/100 mL/min (carcinoma) for polyenergetic 80kVp. Differences in blood flow between tissue types were significant for all energies. Differences between perfusion maps calculated from VMIs and 80kVp images were not significant below 110 keV. SD and ADSDR were significantly better for perfusion maps calculated from VMIs at energies between 40 keV and 55 keV than for those calculated from 80kVp images. Compared to effective dose of dynamic 80kVp acquisitions (4.6 ± 2.2mSv), dose of dynamic DECT/VMI acquisitions (8.0 ± 3.7mSv) was higher. CONCLUSIONS:Perfusion maps of blood flow based on low-energy VMIs between 40 keV and 55 keV offer improved robustness and quality of quantitative measurements over those calculated from 80kVp image data (reference standard), albeit at increased patient radiation exposure.
journal_name
Eur J Radioljournal_title
European journal of radiologyauthors
Skornitzke S,Kauczor HU,Stiller Wdoi
10.1016/j.ejrad.2020.109262subject
Has Abstractpub_date
2020-10-01 00:00:00pages
109262eissn
0720-048Xissn
1872-7727pii
S0720-048X(20)30451-4journal_volume
131pub_type
杂志文章abstract:OBJECTIVE:Breasts with malignant tumors can demonstrate a general increased vascularity compared to the contralateral breast and a prominent blood vessel adjacent to the tumor on magnetic resonance imaging (MRI). The aim of the study was to further characterize these alterations in blood supply by location of the tumor...
journal_title:European journal of radiology
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journal_title:European journal of radiology
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journal_title:European journal of radiology
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