Abstract:
PURPOSE:PET is a useful tool for detecting the presence and extent of brain tau accumulation. However, most first-generation tau PET tracers are limited for high off-target binding and detection of tau in non-Alzheimer disease (AD). This study evaluated potential clinical applications of F-PI-2620 as a novel PET tracer with a high binding affinity for tau deposition in AD and non-AD tauopathies. METHODS:Twenty-six participants diagnosed with either mild cognitive impairment, probable AD, frontotemporal dementia, or parkinsonism, as well as healthy controls underwent a 60- to 90-minute brain PET scan after 7 mci (259 MBq) injection of F-PI-2620. Some participants had previous PET scans using F-THK-5351 or F-FP-CIT for dopamine transporter imaging. RESULTS:All participants showed no increase in off-target binding in basal ganglia on F-PI-2620 PET images, as noted for first-generation tau tracers. Aβ+ mild cognitive impairment or AD patients showed diverse cortical F-PI-2620 uptake in frontotemporoparietal cortex that correlated with Mini-Mental Status Examination (ρ = -0.692, P = 0.013). Aβ+ Parkinson disease with dementia and (Aβ unknown) primary progressive aphasia patients also showed increased F-PI-2620 uptakes in the frontotemporoparietal cortex. Patients with parkinsonism showed increased uptakes in the pallidum compared with Aβ- healthy controls (left: 1.41 ± 0.14 vs 1.04 ± 0.13, P = 0.014; right: 1.18 ± 0.16 vs 0.95 ± 0.07, P = 0.014). CONCLUSIONS:F-PI-2620 PET might be a sensitive tool to detect cortical tau deposits in patients with Aβ+ AD and Aβ+ non-AD tauopathies. Furthermore, this study showed that "off-target" binding in the basal ganglia does not affect F-PI-2620.
journal_name
Clin Nucl Medjournal_title
Clinical nuclear medicineauthors
Oh M,Oh SJ,Lee SJ,Oh JS,Roh JH,Chung SJ,Lee JH,Lee CS,Kim JSdoi
10.1097/RLU.0000000000003261subject
Has Abstractpub_date
2020-11-01 00:00:00pages
841-847issue
11eissn
0363-9762issn
1536-0229journal_volume
45pub_type
杂志文章abstract::We diagnosed a 62-year-old man with lung cancer, well-differentiated squamous cell carcinoma, on the right upper lobe and left lower lobe. He had a history of myelodysplastic syndrome and refractory anemia with ringed sideroblasts diagnosed 5 years earlier. The patient's ¹⁸F-FDG PET/CT for the clinical staging of lung...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000000698
更新日期:2015-07-01 00:00:00
abstract::This report describes a 19-year-old man with interruption of the inferior vena cava with azygos continuation. Both radionuclide venography and MRI clearly showed venous return of the lower limbs through prominent collateral systems. ...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000001847
更新日期:2017-12-01 00:00:00
abstract::After a total or near total thyroidectomy and radioiodine ablation therapy for differential thyroid cancer (DTC), routine follow-up methods are (131)I or (131)I whole-body scanning (WBS) as well as serum thyroglobulin (Tg) and anti-thyroglobulin (anti-Tg) levels. We describe a case of a 41-year-old woman with follicul...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0b013e3182814c4d
更新日期:2013-03-01 00:00:00
abstract::During a Tc-99m DTPA study, activity simultaneously appeared in the kidneys and in a right lateral band. This was due to an inflammatory tract and not to urinary drainage. ...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-198601000-00020
更新日期:1986-01-01 00:00:00
abstract:BACKGROUND:The present study aimed to better define the usefulness of F-FDG PET/CT in predicting pathological tumor response (PTR) and survival in patients with noncardia gastric cancer treated with preoperative chemotherapy. METHODS:Seventy-one patients were recruited in 6 Italian centers. The SUV of F-FDG PET/CT was...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000002911
更新日期:2020-03-01 00:00:00
abstract::Reoperative surgery in the neck for recurrent differentiated thyroid cancer (DTC) is associated with increased morbidity compared with primary surgery. Radioguided occult lesion localization was recently proposed in patients with DTC recurrences. Here we report on the combination of radioguided occult lesion localizat...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0b013e3182641d01
更新日期:2013-04-01 00:00:00
abstract::The regional cerebral blood flow in 31 patients was semiquantitatively measured with SPECT using N-isopropyl iodo-amphetamine (I-123 IMP). Of the 31 patients, 9 had Binswanger's disease (BD) (mean age: 64.2 years), 10 had Alzheimer's disease (AD) (mean age: 66.8 years), and 12 were neurologically normal (mean age: 67....
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-199304000-00013
更新日期:1993-04-01 00:00:00
abstract::Anthracyclines are one of the most commonly used and potent chemotherapeutic agents. Doxorubicin (Adriamycin) is one common anthracycline used to treat many solid tumors including breast, sarcomas, gynecologic and hematological malignancies, such as leukemias and lymphomas. However, its use is often limited due to dos...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章,评审
doi:10.1097/RLU.0b013e3181b7d76f
更新日期:2009-11-01 00:00:00
abstract::We present a case of a 61-year-old man with history of prostate cancer and rising PSA levels referred for restaging. Ga-PSMA-11 PET/CT identified 2 lung nodules with low and moderate PSMA uptake. Subsequent F-FDG PET/CT showed high hypermetabolism in the nodule with low PSMA uptake, and low hypermetabolism in the nodu...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000002367
更新日期:2019-01-01 00:00:00
abstract::A 61-year-old man with Hodgkin lymphoma (mixed type), with lymph node manifestations and extranodal and bone marrow involvement in both supra- and infradiaphragmatic locations (stage 4), had dyspnea and tachycardia on echocardiography. There were pleural and pericardial effusions and thickening of the epicardium and p...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/01.rlu.0000082666.85547.94
更新日期:2003-09-01 00:00:00
abstract::Urinothorax or urothorax, the presence of urine in the pleural space, is a rare complication of percutaneous access to the kidney for the management of complex renal and proximal ureteral calculi and ureteropelvic junction obstruction. Other causes such as blunt renal trauma, ureteral instrumentation, or ureteral surg...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0b013e31818bf181
更新日期:2008-12-01 00:00:00
abstract::A 5-week old jaundiced female underwent hepatobiliary scintigraphy using technetium-99m disofenin. Early images suggested right-sided cardiac activity. A nearly symmetric, bilobed liver with left-sided predominance was discovered. No biliary ducts, gallbladder, or small bowel activity were demonstrated up to 24 hours ...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-198701000-00015
更新日期:1987-01-01 00:00:00
abstract:AIM:The purpose of this study was to conduct a systematic review of the published literature to assess the role (indications, advantages, and limitations) of SPECT/CT for the detection of sentinel lymph node (SLN) in breast cancer. METHODS:The authors searched PubMed for published literature in English addressing this...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章,meta分析
doi:10.1097/RLU.0b013e31829af8c0
更新日期:2014-05-01 00:00:00
abstract:BACKGROUND AND AIM:Papillary thyroid carcinomas smaller than 1 cm are classified as papillary microcarcinomas (PMCs). Papillary microcarcinomas are usually considered low-risk tumors; however in some cases, PMCs behave aggressively and metastasize early, giving rise to clinically metastatic disease. Debate exists in th...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0b013e318279bc65
更新日期:2013-01-01 00:00:00
abstract::The feasibility of using low doses of I-131 (30 mCi) for ablation of thyroid remnants following surgery for papillary and follicular thyroid carcinoma was examined in 21 patients. Six weeks following near-total thyroidectomy and three days following intramuscular thyroid-stimulating hormone (10 IU), patients were give...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-198104000-00005
更新日期:1981-04-01 00:00:00
abstract::The results of liver, bone, and brain scans in 84 patients with recurrent or metastatic malignant melanoma were reviewed. The liver scan was initially positive in 18% (14/78) and ultimately in 32% (25/78). Serum alkaline phosphatase and lactic dehydrogenase were elevated in 92%. These patients ultimately developed pos...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:
更新日期:1979-12-01 00:00:00
abstract::Tc-99m HMPAO, a lipophilic radiotracer used as a brain SPECT imaging agent in the diagnosis of strokes and dementias, is normally localized in the brain and the heart and is excreted through the kidneys (50%) and the hepatobiliary system (14% to 30%). There is no pulmonary localization except in the lungs of smokers. ...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-199109000-00012
更新日期:1991-09-01 00:00:00
abstract::A child with an asymptomatic mass in the lower right thorax was evaluated with sonography, intravenous urography, and radionuclide renography. High renal ectopia was only diagnosed with radionuclide renography. ...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-198309000-00004
更新日期:1983-09-01 00:00:00
abstract::A 24-year-old female gymnast had a 3-month history of bilateral forearm pain. A Tc-99m MDP bone scan demonstrated focally increased activity in the radial shafts on blood pool and delayed images, characteristic of fatigue fractures. Fatigue fractures commonly occur in the lower extremities. Upper extremity fatigue fra...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-199408000-00002
更新日期:1994-08-01 00:00:00
abstract::We present a woman with a history of Gaucher disease and secondary portal hypertension. She went to hospital for treatment of resistant fever without apparent cause. A conventional study of fever of unknown origin did not show any pathology. For this reason, she was referred to our department for a PET/CT, which did n...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000000369
更新日期:2014-04-01 00:00:00
abstract:PURPOSE:Fully automated synthesis of 11C-labeled 2β-carbomethoxy-3β-(4-fluorophenyl)tropane (11C CFT) as a dopamine transporter positron emission tomography (PET) tracer is performed with Sep-Pak purification, which cannot separate 11C CFT from nor-β-CFT and will result in the residual precursor nor-β-CFT in the final ...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章,随机对照试验
doi:10.1097/RLU.0b013e31824c5fae
更新日期:2012-08-01 00:00:00
abstract::Mycotic aneurysm is a rare and life-threatening disorder. Computed tomography (CT) is considered to be the best diagnostic imaging modality that can detect an abdominal aortic aneurysm and changes in the surrounding structures. More recently, F-18 fluorodeoxyglucose (FDG) PET would seem to hold promise for the diagnos...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0b013e31817793a0
更新日期:2008-07-01 00:00:00
abstract::A 41-year-old man from South Asia presented with a several months' history of unilateral nasal obstruction and bleeding. At nasal endoscopy, two strawberry-like, friable, polypoid masses in the upper airways were detected. The patient's clinical trait was compatible with an infectious disease. F-FDG PET/MRI was perfor...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000003138
更新日期:2020-10-01 00:00:00
abstract::A case of non-Hodgkin's lymphoma of the abdomen studied by gallium SPECT imaging is reported. The tomographic slices accurately demonstrated the location of residual disease after chemotherapy in the region of the transverse mesocolon. Previous transmission CT had shown considerable persistent retroperitoneal lymphade...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-198605000-00014
更新日期:1986-05-01 00:00:00
abstract::Three patients in whom Caroli's disease was diagnosed by cholangiographic methods were studied by scintigraphy with Tc-99m DISIDA. Cholescintigrams showed an intense concentration of the radionuclide in the form of round spots near the hepatic hilus in late images. In two patients with cholestasis, a delayed hepatic c...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-198507000-00006
更新日期:1985-07-01 00:00:00
abstract::A 50-year-old man with recently diagnosed prostate cancer was referred for Ga-prostate-specific membrane antigen (PSMA) PET/CT with elevated prostate-specific antigen. PET/CT demonstrated increased PSMA uptake in an undisplaced transverse fracture of the L1 vertebral body. This case illustrates that PSMA uptake can oc...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000001599
更新日期:2017-06-01 00:00:00
abstract::A 72-year-old man with a history of prostate adenocarcinoma initially managed by radical prostatectomy and salvage radiation therapy underwent resection of a left vas deferens recurrence identified on PSMA PET. Despite an initial response, PSA failed to fall below 3.5 ng/L, prompting re-evaluation with PSMA PET/CT: a ...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000003136
更新日期:2020-09-01 00:00:00
abstract:PURPOSE:The study aimed to investigate the value of clinical variables and rest gated single-photon emission computed tomography (SPECT) in predicting cardiac deaths in medically treated dilated cardiomyopathy (DCM) patients. METHODS:This is a retrospective study. Fifty-six consecutive hospitalized DCM patients who un...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0b013e318292eedf
更新日期:2013-07-01 00:00:00
abstract::Here we describe a 77-year-old man with a solitary fibrous tumor of the pleura showing increasing tracer uptake at Ga-DOTATOC PET/CT, demonstrating that solitary fibrous tumor of the pleura may overexpress somatostatin receptors, therefore mimicking neuroendocrine tumors at somatostatin receptor PET/CT. ...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000001648
更新日期:2017-06-01 00:00:00
abstract::A case of a sebaceous carcinoma is presented. This carcinoma of the skin appendages requires diagnosis by histopathology because the clinical appearance is often atypical. Because of the frequency of metastases to local lymph nodes and bone, a careful physical examination and appropriate radiologic/scintigraphic exami...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-199305000-00012
更新日期:1993-05-01 00:00:00