Intertumoral Heterogeneity of 18F-FDG and 68Ga-PSMA Uptake in Prostate Cancer Pulmonary Metastases.

Abstract:

:We present a case of a 61-year-old man with history of prostate cancer and rising PSA levels referred for restaging. Ga-PSMA-11 PET/CT identified 2 lung nodules with low and moderate PSMA uptake. Subsequent F-FDG PET/CT showed high hypermetabolism in the nodule with low PSMA uptake, and low hypermetabolism in the nodule with moderate PSMA uptake. The isolated pulmonary findings and metabolic appearance is an atypical presentation of prostate cancer metastases and raised concern for a second primary malignancy. Fine-needle aspiration of the F-FDG active lung nodule confirmed metastatic prostatic adenocarcinoma that subsequently responded to androgen deprivation therapy and abiraterone acetate.

journal_name

Clin Nucl Med

authors

Perez PM,Hope TA,Behr SC,van Zante A,Small EJ,Flavell RR

doi

10.1097/RLU.0000000000002367

subject

Has Abstract

pub_date

2019-01-01 00:00:00

pages

e28-e32

issue

1

eissn

0363-9762

issn

1536-0229

journal_volume

44

pub_type

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