Abstract:
:It has been theorized that Calmette-Guérin bacillus may prevent or reduce the severity of COVID-19 through a nonspecific stimulation of the immune system. A preliminary assessment of SARS-CoV-2 infection rates and outcomes among 2803 individuals affected with high risk non-muscle-invasive bladder cancer and treated with intra-bladder instillation of BCG, showed no evidence of a protective effect. However, the interpretation of these data need some caution, due to the low prevalence of infection (<1%) observed within this population, along with the fact that intra-bladder administration cannot mirror the usual intradermal administration of BCG, in particular in patients partially immunocompromised. Confirmation by larger prospective studies is required.
journal_name
Hum Vaccin Immunotherjournal_title
Human vaccines & immunotherapeuticsauthors
Fedeli U,Porreca A,Colicchia M,Schievano E,Artibani W,Biasio LR,Palù Gdoi
10.1080/21645515.2020.1805994subject
Has Abstractpub_date
2020-09-03 00:00:00pages
1-2eissn
2164-5515issn
2164-554Xpub_type
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