Penta is associated with an increased female-male mortality ratio: cohort study from Bangladesh.

Abstract:

:Diphtheria-tetanus-pertussis (DTP) vaccine may be associated with excess female deaths. There are few studies of possible nonspecific effects of the DTP-containing vaccine Penta (DTP-hepatitis B-Haemophilus influenzae type b). We therefore investigated whether Penta vaccinations were associated with excess female deaths in rural Bangladesh. Between June 29, 2011 and April 20, 2016, we examined the mortality rates of 7644 children followed between 6 weeks and 9 months of age. We analyzed mortality using crude mortality rate ratio (MRR) and age-adjusted MRR (aMRR) from a Cox proportional hazards model. Mortality was analyzed according to sex, number of doses of Penta, and the order in which BCG and Penta were administered. During follow-up, 43 children died. For children who were only BCG vaccinated (BCG-only), the adjusted F/M MRR was 0.47 (0.09-2.48). However, among children who had Penta as their most recent vaccination, the adjusted F/M MRR was 9.91 (1.16-84.44). Hence, the adjusted F/M MRR differed significantly for BCG-only and for Penta as the most recent administered vaccination. Although the mortality rate was low in rural Bangladesh, there was a marked difference between adjusted F/M MRR's for children vaccinated with BCG-only compared with children where Penta was the most recent administered vaccination. Although usually ascribed to differential treatment and access to care, DTP-containing vaccines may be part of the explanation for the excessive female mortality reported in some regions.

journal_name

Hum Vaccin Immunother

authors

Hanifi SMA,Biering-Sørensen S,Jensen AKG,Aaby P,Bhuiya A

doi

10.1080/21645515.2020.1763084

subject

Has Abstract

pub_date

2020-06-23 00:00:00

pages

1-8

eissn

2164-5515

issn

2164-554X

pub_type

杂志文章
  • EV71 vaccination impact on the incidence of encephalitis in patients with hand, foot and mouth disease.

    abstract::In order to analyze the effect of EV71 vaccination on the incidence of encephalitis in patients with HFMD, 292 cases were vaccinated, and 2,486 cases were not vaccinated which were collected in 2018 and 2019. It shows that the incidence rate of encephalitis in vaccinated patients was significantly lower than that in n...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章

    doi:10.1080/21645515.2020.1851129

    authors: Li J,Yin X,Lin A,Nie X,Liu L,Liu S,Li N,Wang P,Song S,Wang S,Xu D

    更新日期:2021-01-31 00:00:00

  • Regional variations in HPV vaccination among 9-17 year old adolescent females from the BRFSS, 2008-2010.

    abstract::Human papillomavirus (HPV) vaccine uptake among 18-26 y old women varies by geographic region in the US. However, little is known about regional variations in vaccination among girls who are in the vaccine's targeted age groups. Regional variation in HPV vaccination among female adolescents (9-17 y old) was examined u...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章

    doi:10.4161/21645515.2014.980202

    authors: Hirth JM,Rahman M,Smith JS,Berenson AB

    更新日期:2014-01-01 00:00:00

  • HPV vaccine hesitancy among parents in Italy: a cross-sectional study.

    abstract::This cross-sectional survey determined the vaccine hesitancy related to Human papillomavirus (HPV) and the determinants among parents of adolescents aged 12 and 13 years in Italy. Data was collected through a self-administered questionnaire. Two-thirds of the parents (66.7%) had heard of HPV infection and knew that th...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章

    doi:10.1080/21645515.2020.1744367

    authors: Della Polla G,Pelullo CP,Napolitano F,Angelillo IF

    更新日期:2020-11-01 00:00:00

  • Cost-effectiveness analysis of a multicomponent meningococcal serogroup B vaccine in hypothetic epidemic situation in a middle-income country.

    abstract:UNLABELLED:NmenB vaccine (4CMenB) is now available, but studies on the cost-effectiveness of vaccine introduction in a country outbreak situation are lacking. The aim of this study was to evaluate the cost-effectiveness of 4CMenB in the context of a hypothetical epidemic outbreak in Chile. We analyzed the direct and in...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章

    doi:10.1080/21645515.2015.1010885

    authors: Izquierdo G,Torres JP,Santolaya ME,Valenzuela MT,Vega J,Chomali M

    更新日期:2015-01-01 00:00:00

  • Influenza in temperate and tropical Asia: a review of epidemiology and vaccinology.

    abstract::The impact of seasonal influenza has been under-appreciated in Asia and surveillance data lags in most other regions. The variety of influenza circulation patterns in Asia - largely due to the range of climates - has also only recently been recognized and its effect on the burden of disease is not fully understood. Re...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章

    doi:10.1080/21645515.2019.1703455

    authors: Young BE,Chen M

    更新日期:2020-07-02 00:00:00

  • Patient characteristics of Medicare beneficiaries who report not getting influenza and pneumococcal vaccinations, 2001-2013.

    abstract::Background: Despite long standing recommendations of pneumococcal and influenza vaccination for adults age 65 years and older and wide-spread availability to vaccination services, vaccination coverage in the United states is low. We sought to explore reasons patients reportedly did not receive these vaccines.Methods: ...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章

    doi:10.1080/21645515.2019.1688033

    authors: Shen AK,Warnock R,Selna W,Chu S,Kelman JA

    更新日期:2020-05-03 00:00:00

  • ReadyVax: A new mobile vaccine information app.

    abstract::Vaccine information of varying quality is available through many different sources. We describe the creation, release and utilization of ReadyVax, a new mobile smartphone app providing access to trustworthy, evidence-based vaccine information for a target audience of healthcare providers, pharmacists, and patients (in...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章

    doi:10.1080/21645515.2016.1263779

    authors: Bednarczyk RA,Frew PM,Salmon DA,Whitney E,Omer SB

    更新日期:2017-05-04 00:00:00

  • Evaluating impact of school outreach vaccination programme in Hong Kong influenza season 2018 - 2019.

    abstract::School-based vaccination, as a means to mitigate seasonal influenza outbreak, depends on attaining adequate coverage rate. We evaluated the potential of a fully subsidized school outreach vaccination (SOV) program to achieve epidemic prevention potential in Hong Kong. The purpose of this study was to evaluate the impa...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章

    doi:10.1080/21645515.2019.1678357

    authors: Lau YL,Wong WHS,Hattangdi-Haridas SR,Chow CB

    更新日期:2020-04-02 00:00:00

  • Hepatitis A vaccination and its immunological and epidemiological long-term effects - a review of the evidence.

    abstract::Hepatitis A virus (HAV) infections continue to represent a significant disease burden causing approximately 200 million infections, 30 million symptomatic illnesses and 30,000 deaths each year. Effective and safe hepatitis A vaccines have been available since the early 1990s. Initially developed for individual prophyl...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章

    doi:10.1080/21645515.2020.1819742

    authors: Herzog C,Van Herck K,Van Damme P

    更新日期:2020-12-16 00:00:00

  • Economic analysis of the first 20 years of universal hepatitis B vaccination program in Italy: an a posteriori evaluation and forecast of future benefits.

    abstract::Italy was one of the first countries in the world to introduce a routine vaccination program against HBV for newborns and 12-y-old children. From a clinical point of view, such strategy was clearly successful. The objective of our study was to verify whether, at 20 y from its implementation, hepatitis B universal vacc...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章

    doi:10.4161/hv.23827

    authors: Boccalini S,Taddei C,Ceccherini V,Bechini A,Levi M,Bartolozzi D,Bonanni P

    更新日期:2013-05-01 00:00:00

  • The effect of social determinants on immunization programs.

    abstract::Vaccine preventable diseases have been responsible for a significant portion of childhood mortality in low-income countries, and have been re-emerging in medium- and high-income countries. The effectiveness of routine childhood immunization programs relies on multiple factors. Social determinants have the potential to...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章,评审

    doi:10.4161/hv.19003

    authors: Glatman-Freedman A,Nichols K

    更新日期:2012-03-01 00:00:00

  • High dose hepatitis B vaccine is not effective in patients using immunomodulatory drugs: a pilot study.

    abstract::In patients undergoing immunotherapy, the quality of the immune response is reduced, which may negatively affect the efficacy of vaccination. This study was conducted in order to evaluate the efficacy of the hepatitis B virus (HBV) vaccine in patients using immunomodulators. Seronegative patients for HBV who were usin...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章

    doi:10.1080/21645515.2019.1574151

    authors: Haykir Solay A,Eser F

    更新日期:2019-01-01 00:00:00

  • Coverage of HPV-Related Information on Chinese Social Media: a Content Analysis of Articles in Zhihu.

    abstract::Information about human papillomavirus (HPV) disease and its vaccination has been increasingly communicated and discussed on social media platforms. The current study aims to investigate the coverage of HPV-related information on one of the most popular Chinese social media - Zhihu. Data for this study were user-gener...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章

    doi:10.1080/21645515.2020.1729028

    authors: Li J,Zheng H

    更新日期:2020-10-02 00:00:00

  • Allergen immunotherapy for allergic respiratory diseases.

    abstract::Allergen specific immunotherapy involves the repeated administration of allergen products in order to induce clinical and immunologic tolerance to the offending allergen. Immunotherapy is the only etiology-based treatment that has the potential for disease modification, as reflected by longterm remission following its...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章,评审

    doi:10.4161/hv.21629

    authors: Cappella A,Durham SR

    更新日期:2012-10-01 00:00:00

  • Rotavirus genotypes in Malaysia and universal rotavirus vaccination.

    abstract::Group A rotavirus (RV-A) genotypes isolated in Malaysia was studied to estimate the effectiveness of a universal RV-A vaccination in Malaysia. A simple mathematical model was used, with input from a two-year, two-center, prospective study on hospitalization of RV-A gastroenteritis (RVGE) in young children, published d...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章

    doi:10.4161/hv.21577

    authors: Lee WS,Lim BT,Chai PF,Kirkwood CD,Lee JK

    更新日期:2012-10-01 00:00:00

  • Current opinion and review on peanut oral immunotherapy.

    abstract::In the last decade, peanut oral immunotherapy research has shown promise as an alternative treatment to avoidance in peanut-allergic patients. Research has not only focused on desensitization, but also on immunologic changes and sustained-tolerance. This article reviews the current literature and the historical backgr...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章,评审

    doi:10.4161/hv.32190

    authors: Deol S,Bird JA

    更新日期:2014-01-01 00:00:00

  • An overview of sipuleucel-T: autologous cellular immunotherapy for prostate cancer.

    abstract::Sipuleucel-T, the first autologous active cellular immunotherapy approved by the United States Food and Drug Administration, is designed to stimulate an immune response to prostate cancer. Sipuleucel-T is manufactured by culturing a patient's peripheral blood mononuclear cells (including antigen presenting cells) with...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章,评审

    doi:10.4161/hv.18769

    authors: Wesley JD,Whitmore J,Trager J,Sheikh N

    更新日期:2012-04-01 00:00:00

  • Dendritic cell targeted vaccines: Recent progresses and challenges.

    abstract::Dendritic cells (DCs) are known to be a set of morphology, structure and function of heterogeneous professional antigen presenting cells (APCs), as well as the strongest functional antigen presenting cells, which can absorb, process and present antigens. As the key regulators of innate and adaptive immune responses, D...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章

    doi:10.1080/21645515.2015.1105415

    authors: Chen P,Liu X,Sun Y,Zhou P,Wang Y,Zhang Y

    更新日期:2016-03-03 00:00:00

  • Predictive factors associated with the acceptance of pandemic and seasonal influenza vaccination in health care workers and students in Tuscany, Central Italy.

    abstract::Assessing the beliefs and attitudes of Health Care Workers (HCW) to influenza and influenza vaccination can be useful in overcoming low compliance rates. The purpose of our study is to evaluate the opinion of HCW and students regarding influenza, influenza vaccine and the factors associated with vaccination compliance...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章

    doi:10.4161/hv.26036

    authors: Bonaccorsi G,Lorini C,Santomauro F,Guarducci S,Pellegrino E,Puggelli F,Balli M,Bonanni P

    更新日期:2013-12-01 00:00:00

  • DNA electroporation in rabbits as a method for generation of high-titer neutralizing antisera: examples of the botulinum toxins types A, B, and E.

    abstract::Raising high titer antibodies in animals is usually performed by protein immunization, which requires the long and sometimes difficult step of production of the recombinant protein. DNA immunization is an alternative to recombinant proteins, only requiring the building of an eukaryotic expression plasmid. Thanks to ef...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章

    doi:10.4161/hv.25192

    authors: Burgain A,Rochard A,Trollet C,Mazuet C,Popoff MR,Escriou V,Scherman D,Bigey P

    更新日期:2013-10-01 00:00:00

  • Evaluation of the thermal stability and the protective efficacy of spray-dried HPV vaccine, Gardasil® 9.

    abstract::High-risk human papillomavirus (HPV) types are responsible for nearly all cases of cervical cancers. Cervarix® and Gardasil® 9 are the current prophylactic vaccines available that protect against the majority of HPVs associated with cancer. Although these vaccines are highly effective, HPV vaccine implementation has b...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章

    doi:10.1080/21645515.2019.1593727

    authors: Kunda NK,Peabody J,Zhai L,Price DN,Chackerian B,Tumban E,Muttil P

    更新日期:2019-01-01 00:00:00

  • Role and plasticity of Th1 and Th17 responses in immunity to Staphylococcus aureus.

    abstract::The human commensal Staphylococcus aureus (SA) is a leading cause of skin/soft tissue and surgical-site infections, and bacteremia. Functional antibodies and T-cell-mediated immunity, particularly Th1/Th17 responses, are thought to mediate protection. Vaccine development may be hindered by modulation of vaccine-induce...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章,随机对照试验

    doi:10.1080/21645515.2019.1613126

    authors: Ferraro A,Buonocore SM,Auquier P,Nicolas I,Wallemacq H,Boutriau D,van der Most RG

    更新日期:2019-01-01 00:00:00

  • HPV vaccine acceptability and willingness-related factors among Chinese adolescents: a nation-wide study.

    abstract:BACKGROUND:Adolescents are the primary target population for human papillomavirus (HPV) vaccination. The objective of this study is to explore the acceptability of HPV vaccines and evaluate factors related to willingness to be vaccinated among Chinese adolescents. METHODS:A nation-wide survey was conducted across 14 s...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章

    doi:10.1080/21645515.2020.1812314

    authors: Zhang X,Wang Z,Ren Z,Li Z,Ma W,Gao X,Zhang R,Qiao Y,Li J

    更新日期:2020-10-29 00:00:00

  • Trends involving monoclonal antibody (mAb) research and commercialization: A scientometric analysis of IMS Lifecycle R&D Focus Database (1980-2016).

    abstract::This article aims to explore the trends of monoclonal antibodies (mAbs) research and commercialization, mainly to examine the development trajectories by a contrastive exploration of successful and unsuccessful mAb. This work is based on two sets of R&D project reports, consisting of 517 discontinued mAb project repor...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章

    doi:10.1080/21645515.2017.1420445

    authors: Lai Y,Suo S,Wang R,Kong X,Hu Y,Tang D,Shi H,Chen S,Hu H

    更新日期:2018-04-03 00:00:00

  • The role of the thymus in COVID-19 disease severity: implications for antibody treatment and immunization.

    abstract::The thymus is a largely neglected organ but plays a significant role in the regulation of adaptive immune responses. The effect of aging on the thymus and immune senescence is well established, and the resulting inflammaging is found to be implicated in the development of many chronic diseases including atherosclerosi...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章

    doi:10.1080/21645515.2020.1818519

    authors: Kellogg C,Equils O

    更新日期:2020-10-16 00:00:00

  • Infection-enhancing lipopeptides do not improve intranasal immunization of cotton rats with a delta-G candidate live-attenuated human respiratory syncytial virus vaccine.

    abstract::Development of live-attenuated human respiratory syncytial virus (HRSV) vaccines has proven to be difficult. Several vaccine candidates were found to be over-attenuated and displayed limited immunogenicity. Recently, we identified three synthetic cationic lipopeptides that enhanced paramyxovirus infections in vitro. T...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章

    doi:10.4161/hv.26096

    authors: Tien Nguyen D,Boes J,van Amerongen G,van Remmerden Y,Yüksel S,Guichelaar T,Osterhaus AD,de Swart RL

    更新日期:2013-12-01 00:00:00

  • Post-marketing surveillance study to assess the safety and tolerability of an Inactivated Poliomyelitis Vaccine in Indian children.

    abstract:OBJECTIVE:To evaluate the incidence of adverse events following administration of an Inactivated poliomyelitis vaccine (IPV) manufactured by Serum Institute of India Pvt. Ltd., Pune, India. METHODS:A single 0.5 ml dose of the IPV was administered intramuscularly to children attending private clinics or out-patient dep...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章

    doi:10.1080/21645515.2017.1356960

    authors: Sharma H,Dhere R,Parekh S,Shewale S

    更新日期:2017-11-02 00:00:00

  • The human potential of a recombinant pandemic influenza vaccine produced in tobacco plants.

    abstract::Rapid production of influenza vaccine antigen is an important challenge when a new pandemic occurs. Production of recombinant antigens in plants is a quick, cost effective and up scalable new strategy for influenza vaccine production. In this study, we have characterized a recombinant influenza haemagglutinin antigen ...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 临床试验,杂志文章

    doi:10.4161/hv.19503

    authors: Jul-Larsen Å,Madhun AS,Brokstad KA,Montomoli E,Yusibov V,Cox RJ

    更新日期:2012-05-01 00:00:00

  • Lot-to-lot consistency study of the fully liquid pentavalent DTwP-HepB-Hib vaccine Quinvaxem (®) demonstrating clinical equivalence, suitability of the vaccine as a booster and concomitant administration with measles vaccine.

    abstract::This double-blind, randomized study evaluated the immunogenicity and safety of three production lots of the fully liquid combination DTwP-Hep-Hib vaccine, Quinvaxem (®) (Crucell, The Netherlands) in 360 healthy infants aged 42-64 d old given at 6, 10 and 14 weeks of age (Core Study). The Core Study was followed by an...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.4161/hv.21095

    authors: Aspinall S,Traynor D,Bedford P,Hartmann K

    更新日期:2012-08-01 00:00:00

  • Economic evaluation of Varicella vaccination: results of a systematic review.

    abstract:INTRODUCTION:The aim of the present study is to review the economic burden of varicella disease and the benefit of universal varicella vaccination in different settings pending its implementation in all Italian regions. MATERIALS AND METHODS:Research was conducted using PubMed, Scopus and ISI databases. Score quality ...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章,评审

    doi:10.4161/hv.25228

    authors: Unim B,Saulle R,Boccalini S,Taddei C,Ceccherini V,Boccia A,Bonanni P,La Torre G

    更新日期:2013-09-01 00:00:00