Selective linkage of mitochondrial enzymes to intracellular calcium stores differs between human-induced pluripotent stem cells, neural stem cells, and neurons.

abstract：:The expression and distribution of mRNA encoding preproatrial natriuretic peptide (ppANP) in rat brain has been investigated by in situ hybridization of two 35S-labeled synthetic DNA oligonucleotides, based on a cDNA clone sequence that encodes rat ppANP. The highest relative concentrations of ppANP mRNA were detected...

journal_title：Journal of neurochemistry

authors： Gundlach AL,Knobe KE

更新日期：1992-08-01 00:00:00

abstract：:In view of a cytoprotective effect of elastase inhibitor on chemokine-mediated tissue injury, we examined the neuroprotective effect of ONO-5046, a specific inhibitor of neutrophil elastase, in rats with spinal cord injury. Standardized spinal cord compression markedly increased cytokine-induced neutrophil chemo-attra...

journal_title：Journal of neurochemistry

authors： Tonai T,Shiba K,Taketani Y,Ohmoto Y,Murata K,Muraguchi M,Ohsaki H,Takeda E,Nishisho T

更新日期：2001-09-01 00:00:00

abstract：:Glutathione-S-transferase activity in the brain of male mammals (rat and mouse) was found to be relatively lower than in that of females. In contrast, the male aves (pigeon, kite, vulture, and crow) exhibited comparatively higher activity in brain glutathione-S-transferase than the corresponding females. Postnatal dev...

journal_title：Journal of neurochemistry

authors： Das M,Dixit R,Seth PK,Mukhtar H

更新日期：1981-04-01 00:00:00

abstract：:Multiple molecular defects trigger cell death in amyotrophic lateral sclerosis (ALS). Among these, altered transcriptional activity may perturb many cellular functions, leading to a cascade of secondary pathological effects. We showed that pharmacological treatment, using the histone deacetylase inhibitor sodium pheny...

journal_title：Journal of neurochemistry

authors： Ryu H,Smith K,Camelo SI,Carreras I,Lee J,Iglesias AH,Dangond F,Cormier KA,Cudkowicz ME,Brown RH Jr,Ferrante RJ

更新日期：2005-06-01 00:00:00

abstract：:Hippocampal neurons are affected by chronic stress and have a high density of cytoplasmic mineralocorticoid and glucocorticoid receptors (MR and GR). Detailed studies on the genomic effects of the stress hormone corticosterone at physiologically relevant concentrations on different steps in synaptic transmission are l...

journal_title：Journal of neurochemistry

authors： Chatterjee S,Sikdar SK

更新日期：2014-02-01 00:00:00

abstract：:We have investigated the transport characteristics of dehydroepiandrosterone sulfate (DHEAS), a neuroactive steroid, at the blood-brain barrier (BBB) in a series of functional in vivo and in vitro studies. The apparent BBB efflux rate constant of [(3)H]DHEAS evaluated by the brain efflux index method was 2.68 x 10(-2)...

journal_title：Journal of neurochemistry

authors： Asaba H,Hosoya K,Takanaga H,Ohtsuki S,Tamura E,Takizawa T,Terasaki T

更新日期：2000-11-01 00:00:00

abstract：:Two biochemical strategies using nick translation-type of incubation and terminal tranferase-catalyzed reaction were used to assess single-(SSB) and double-strand (DSB) breaks in DNA of permeabilized neurons isolated from young, adult, and old rat cerebral cortex. Both SSBs and DSBs accumulate with age. On prior treat...

journal_title：Journal of neurochemistry

authors： Mandavilli BS,Rao KS

更新日期：1996-10-01 00:00:00

abstract：:The K+-stimulated efflux of endogenous taurine from primary rat cerebellar astrocyte cultures prepared from 7-9-day-old rats was studied at 16-18 days in vitro using HPLC analysis. Taurine efflux was dose-dependent at K+ concentrations between 10 mM and 80 mM, with an EC50 of approximately 50 mM. Maximum stimulation o...

journal_title：Journal of neurochemistry

authors： Philibert RA,Rogers KL,Allen AJ,Dutton GR

更新日期：1988-07-01 00:00:00

abstract：:The effect of clinical, spontaneous-onset seizures on extracellular fluid lactate was investigated by the method of lactography, the in vivo on-line measurement of lactate levels using microdialysis. Studies of experimental animals have suggested that generation of extracellular lactate as measured by microdialysis is...

journal_title：Journal of neurochemistry

authors： During MJ,Fried I,Leone P,Katz A,Spencer DD

更新日期：1994-06-01 00:00:00

abstract：:TrkA is a receptor tyrosine kinase for nerve growth factor (NGF). Recent studies indicate that NGF regulates not only activation of trkA kinase but also expression of the trkA gene. To further define NGF actions on trkA, we examined binding and signaling through trkA after both short and long intervals of NGF treatmen...

journal_title：Journal of neurochemistry

authors： Zhou J,Valletta JS,Grimes ML,Mobley WC

更新日期：1995-09-01 00:00:00

abstract：:The roles of the intracellular calcium pool involved in regulating the Ca2+ profile and the neuronal survival rate during development were studied by using thapsigargin (TG), a specific inhibitor of endoplasmic reticulum (ER) Ca2+-ATPase in cultured cerebellar granule neurons. Measuring the neuronal [Ca2+]i directly i...

journal_title：Journal of neurochemistry

authors： Yao CJ,Lin CW,Lin-Shiau SY

更新日期：1999-08-01 00:00:00

abstract：:We have previously shown that in cell extracts from rat striatum, cyclic AMP response element (CRE) binding protein (CREB), rather than AP-1 proteins, preferentially interacts with the CRE-2 element of the proenkephalin second messenger-inducible enhancer, even under conditions in which AP-1 proteins are highly induce...

journal_title：Journal of neurochemistry

authors： Konradi C,Cole RL,Green D,Senatus P,Leveque JC,Pollack AE,Grossbard SJ,Hyman SE

更新日期：1995-09-01 00:00:00

abstract：:Drebrin is a well-known side-binding protein of F-actin in the brain. Immunohistochemical data suggest that the peripheral parts of growing axons are enriched in the drebrin E isoform and mature axons are not. It has also been observed that drebrin E is concentrated in the growth cones of PC12 cells. These data strong...

journal_title：Journal of neurochemistry

authors： Mizui T,Kojima N,Yamazaki H,Katayama M,Hanamura K,Shirao T

更新日期：2009-04-01 00:00:00

abstract：:The release of endogenous 5-hydroxytryptamine (5-HT), substance P (SP), and neurokinin A (NKA) from superfused tissue slices of rat ventral lumbar spinal cord, where SP and NKA coexist with 5-HT in terminals of descending bulbospinal neurons, was investigated. Electrical field stimulation was performed using square-wa...

journal_title：Journal of neurochemistry

authors： Franck J,Brodin E,Fried G

更新日期：1993-08-01 00:00:00

abstract：:Prolonged stress affects homeostasis in various organs and induces stress-associated disorders. We examined the cellular changes of pituitary gland under the continuous stress condition using a rat model in which rats were kept in a cage filled with water to a height of 1.5 cm for up to 5 days. Among the pituitary hor...

journal_title：Journal of neurochemistry

authors： Ogawa T,Shishioh-Ikejima N,Konishi H,Makino T,Sei H,Kiryu-Seo S,Tanaka M,Watanabe Y,Kiyama H

更新日期：2009-06-01 00:00:00

abstract：:Hyperexcitability of the hippocampus is a commonly observed phenomenon in the years preceding a diagnosis of Alzheimer's disease (AD). Our previous work suggests a dysregulation in glutamate neurotransmission may mediate this hyperexcitability, and glutamate dysregulation correlates with cognitive deficits in the rTg(...

journal_title：Journal of neurochemistry

authors： Hunsberger HC,Weitzner DS,Rudy CC,Hickman JE,Libell EM,Speer RR,Gerhardt GA,Reed MN

更新日期：2015-10-01 00:00:00

abstract：:The precursors for neurotrophins are proteolytically cleaved to form biologically active mature molecules which activate their receptors p75NTR and trks. A recent study showed that the precursor for nerve growth factor (NGF) can bind to p75NTR with a high affinity and induces apoptosis of neurons in vitro. Mutation in...

journal_title：Journal of neurochemistry

authors： Zhou XF,Song XY,Zhong JH,Barati S,Zhou FH,Johnson SM

更新日期：2004-11-01 00:00:00

abstract：:Substrate-induced endocytic trafficking of dopamine transporter (DAT) has been observed, but little is known about the regulation of DAT oligomerization by substrate. The present study investigates the effect on substrates on DAT oligomerization and explores a potential link with the presence of DAT at the cell surfac...

journal_title：Journal of neurochemistry

authors： Chen N,Reith ME

更新日期：2008-05-01 00:00:00

abstract：:Proper brain function in the nervous system relies on the accurate establishment of synaptic contacts during development. Countless synapses populate the adult brain in an orderly fashion. In each synapse, a presynaptic terminal loaded with neurotransmitters-containing synaptic vesicles is perfectly aligned to an arra...

journal_title：Journal of neurochemistry

authors： Pinto MJ,Almeida RD

更新日期：2016-12-01 00:00:00

abstract：:Recent studies have indicated that various growth factors are involved in synaptic functions; however, the precise mechanisms remain unclear. In order to elucidate the molecular mechanisms of the growth factor-mediated regulation of presynaptic functions, the effects of epidermal growth factor (EGF) and insulin-like g...

journal_title：Journal of neurochemistry

authors： Itakura M,Yamamori S,Kuwahara R,Sekiguchi M,Takahashi M

更新日期：2005-07-01 00:00:00

abstract：:A method was developed for direct and continuous detection of secretion of ATP from primary monolayer cultures of bovine adrenal chromaffin cells. ATP, which is costored with catecholamines within adrenal chromaffin cells, was released into the incubation medium, where it reacted with firefly luciferin-luciferase prod...

journal_title：Journal of neurochemistry

authors： White TD,Bourke JE,Livett BG

更新日期：1987-10-01 00:00:00

abstract：:The uptake of glutamate and other acidic amino acids into barnacle single muscle fibres has been characterized. The uptake of glutamate consists of two components, one Na-independent and one Na-dependent. The Na-dependent uptake is saturable (half-maximal at 250 microM external glutamate) and is inhibited by a variety...

journal_title：Journal of neurochemistry

authors： Revest PA,Baker PF

更新日期：1988-01-01 00:00:00

abstract：:The effect of cerebral hypoxia-ischemia (HI) on levels and tyrosine phosphorylation of the NMDA receptor was examined in 7- (P7) and 21 (P21)-day-old rats. Unilateral HI was administered by ligation of the right common carotid artery and exposure to an atmosphere of 8% O2/92% N2 for 2 (P7) or 1.5 (P21) h. This duratio...

journal_title：Journal of neurochemistry

authors： Gurd JW,Bissoon N,Beesley PW,Nakazawa T,Yamamoto T,Vannucci SJ

更新日期：2002-08-01 00:00:00

abstract：:Nicotinic acetylcholine receptors play important roles in numerous cognitive processes as well as in several debilitating central nervous system (CNS) disorders. In order to fully elucidate the diverse roles of nicotinic acetylcholine receptors in CNS function and dysfunction, a detailed knowledge of their cellular an...

journal_title：Journal of neurochemistry

authors： Moser N,Mechawar N,Jones I,Gochberg-Sarver A,Orr-Urtreger A,Plomann M,Salas R,Molles B,Marubio L,Roth U,Maskos U,Winzer-Serhan U,Bourgeois JP,Le Sourd AM,De Biasi M,Schröder H,Lindstrom J,Maelicke A,Changeux JP,Weve

更新日期：2007-07-01 00:00:00

abstract：:The decrease in receptor-stimulated cyclic AMP production after chronic ethanol exposure was suggested previously to be secondary to an ethanol-induced increase in extracellular adenosine. The present study was undertaken to ascertain whether a similar mechanism was responsible for the ethanol-induced desensitization ...

journal_title：Journal of neurochemistry

authors： Rabin RA,Fiorella D,Van Wylen DG

更新日期：1993-03-01 00:00:00

abstract：:Binding of tetanus toxin to rat brain membranes was of lower affinity and capacity when binding was determined in 150 mM NaCl, 50 mM Tris-HCl (pH 7.4) than in 25 mM Tris-acetate (pH 6.0). Binding under both conditions was reduced by treating the membranes with neuraminidase. Pronase treatment, however, reduced toxin b...

journal_title：Journal of neurochemistry

authors： Critchley DR,Habig WH,Fishman PH

更新日期：1986-07-01 00:00:00

abstract：:Modulation of acetylcholine (ACh) release from superfused hippocampal slices was examined when the release of ACh was stimulated by exposure of slices to elevated K+ concentration. Evoked release was not sensitive to inhibition by 0.1 microM tetrodotoxin, but it could be inhibited in a dose-dependent manner by a musca...

journal_title：Journal of neurochemistry

authors： Benishin CG

更新日期：1990-12-01 00:00:00

abstract：:The development of the specific binding sites for L-[3H]glutamic acid (KD = 370 nM) and for [3H]kainic acid (KD = 39 nM) was studied in the rat cerebellum. Specific binding at both sites remains low during the first week after birth but increases markedly during the second and third weeks after birth, when glutamaterg...

journal_title：Journal of neurochemistry

authors： Slevin JT,Coyle JT

更新日期：1981-08-01 00:00:00

abstract：:Previous studies have indicated that the brains of DBA/2J (D2) mice have a more heavily myelinated CNS than those of C57BL/6J (B6) at postnatal days 17-21. However, the amount of myelin in the brains of F1 (B6 X D2) hybrids is even higher than in their parental strains. To investigate further factors involved in regul...

journal_title：Journal of neurochemistry

authors： Sato C,Yu RK

更新日期：1987-10-01 00:00:00

abstract：:The effect of angiotensin (Ang) IV, an inhibitor of insulin-regulated aminopeptidase (IRAP), on extracellular dopamine levels in the striatum of freely moving rats was examined using in vivo microdialysis. The Ang IV was administered locally in the striatum through the microdialysis probe. A concentration-dependent (1...

journal_title：Journal of neurochemistry

authors： Stragier B,Sarre S,Vanderheyden P,Vauquelin G,Fournié-Zaluski MC,Ebinger G,Michotte Y

更新日期：2004-09-01 00:00:00