Transcriptomic profiling revealed key signaling pathways for cold tolerance and acclimation of two carp species.

abstract：BACKGROUND:Genome-scale pooled CRISPR screens are powerful tools for identifying genetic dependencies across varied cellular processes. The vast majority of CRISPR screens reported to date have focused exclusively on the perturbation of protein-coding gene function. However, protein-coding genes comprise < 2% of the se...

journal_title：BMC genomics

authors： Borys SM,Younger ST

更新日期：2020-01-31 00:00:00

abstract：BACKGROUND:The monophyly of flatfishes has not been supported in many molecular phylogenetic studies. The monophyly of Pleuronectoidei, which comprises all but one family of flatfishes, is broadly supported. However, the Psettodoidei, comprising the single family Psettodidae, is often found to be most closely related t...

journal_title：BMC genomics

authors： Shi W,Chen S,Kong X,Si L,Gong L,Zhang Y,Yu H

更新日期：2018-05-25 00:00:00

abstract：BACKGROUND:Cytoplasmic male sterility (CMS) is an inability to produce functional pollen that is caused by mutation of the mitochondrial genome. Comparative analyses of mitochondrial genomes of lines with and without CMS in several species have revealed structural differences between genomes, including extensive rearra...

journal_title：BMC genomics

authors： Jo YD,Choi Y,Kim DH,Kim BD,Kang BC

更新日期：2014-07-04 00:00:00

abstract：BACKGROUND:The capacity of European pear fruit (Pyrus communis L.) to ripen after harvest develops during the final stages of growth on the tree. The objective of this study was to characterize changes in 'Bartlett' pear fruit physico-chemical properties and transcription profiles during fruit maturation leading to att...

journal_title：BMC genomics

authors： Nham NT,de Freitas ST,Macnish AJ,Carr KM,Kietikul T,Guilatco AJ,Jiang CZ,Zakharov F,Mitcham EJ

更新日期：2015-10-09 00:00:00

abstract：BACKGROUND:Many reptiles exhibit temperature-dependent sex determination (TSD). The initial cue in TSD is incubation temperature, unlike genotypic sex determination (GSD) where it is determined by the presence of specific alleles (or genetic loci). We used patterns of gene expression to identify candidates for genes wi...

journal_title：BMC genomics

authors： Chojnowski JL,Braun EL

更新日期：2012-07-15 00:00:00

abstract：BACKGROUND:Recent studies have demonstrated an unexpected complexity of transcription in eukaryotes. The majority of the genome is transcribed and only a little fraction of these transcripts is annotated as protein coding genes and their splice variants. Indeed, most transcripts are the result of antisense, overlapping...

journal_title：BMC genomics

authors： Calabrese C,Mangiulli M,Manzari C,Paluscio AM,Caratozzolo MF,Marzano F,Kurelac I,D'Erchia AM,D'Elia D,Licciulli F,Liuni S,Picardi E,Attimonelli M,Gasparre G,Porcelli AM,Pesole G,Sbisà E,Tullo A

更新日期：2013-12-05 00:00:00

abstract：BACKGROUND:BAC-based physical maps provide for sequencing across an entire genome or a selected sub-genomic region of biological interest. Such a region can be approached with next-generation whole-genome sequencing and assembly as if it were an independent small genome. Using the minimum tiling path as a guide, specif...

journal_title：BMC genomics

authors： Feltus FA,Saski CA,Mockaitis K,Haiminen N,Parida L,Smith Z,Ford J,Staton ME,Ficklin SP,Blackmon BP,Cheng CH,Schnell RJ,Kuhn DN,Motamayor JC

更新日期：2011-07-27 00:00:00

abstract：BACKGROUND:The epithelium is the first line of defense against pathogens. Notably the epithelial cells lining the respiratory track are crucial in sensing airborne microbes and mounting an effective immune response via the expression of target genes such as cytokines and chemokines. Gene expression regulation following...

journal_title：BMC genomics

authors： Borghini L,Hibberd M,Davila S

更新日期：2018-12-27 00:00:00

abstract：BACKGROUND:Recent studies have shown that human populations have experienced a complex demographic history, including a recent epoch of rapid population growth that led to an excess in the proportion of rare genetic variants in humans today. This excess can impact the burden of private mutations for each individual, de...

journal_title：BMC genomics

authors： Gao F,Keinan A

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:The Brassicaceae family is an exemplary model for studying plant polyploidy. The Brassicaceae knowledge-base includes the well-annotated Arabidopsis thaliana reference sequence; well-established evidence for three rounds of whole genome duplication (WGD); and the conservation of genomic structure, with 24 co...

journal_title：BMC genomics

authors： Kim J,Lee J,Choi JP,Park I,Yang K,Kim MK,Lee YH,Nou IS,Kim DS,Min SR,Park SU,Kim H

更新日期：2014-07-18 00:00:00

abstract：BACKGROUND:The establishment of C4 photosynthesis in maize is associated with differential accumulation of gene transcripts and proteins between bundle sheath and mesophyll photosynthetic cell types. We have physically separated photosynthetic cell types in the leaf blade to characterize differences in gene expression ...

journal_title：BMC genomics

authors： Sawers RJ,Liu P,Anufrikova K,Hwang JT,Brutnell TP

更新日期：2007-01-09 00:00:00

abstract：BACKGROUND:The Per-Arnt-Sim (PAS) domain represents a ubiquitous structural fold that is involved in bacterial sensing and adaptation systems, including several virulence related functions. Although PAS domains and the subclass of PhoQ-DcuS-CitA (PDC) domains have a common structure, there is limited amino acid sequenc...

journal_title：BMC genomics

authors： Shah N,Gaupp R,Moriyama H,Eskridge KM,Moriyama EN,Somerville GA

更新日期：2013-07-31 00:00:00

abstract：BACKGROUND:Dermal papilla cells (DPCs), the "signaling center" of hair follicle (HF), delicately master continual growth of hair in mammals including cashmere, the fine fiber annually produced by secondary HF embedded in cashmere goat skins. Such unparalleled capacity bases on their exquisite character in instructing t...

journal_title：BMC genomics

authors： Ma S,Wang Y,Zhou G,Ding Y,Yang Y,Wang X,Zhang E,Chen Y

更新日期：2019-06-20 00:00:00

abstract：BACKGROUND:The unisexual Amazon molly (Poecilia formosa) originated from a hybridization between two sexual species, the sailfin molly (Poecilia latipinna) and the Atlantic molly (Poecilia mexicana). The Amazon molly reproduces clonally via sperm-dependent parthenogenesis (gynogenesis), in which the sperm of closely re...

journal_title：BMC genomics

authors： Schedina IM,Groth D,Schlupp I,Tiedemann R

更新日期：2018-01-03 00:00:00

abstract：BACKGROUND:Macrosatellites are some of the largest variable number tandem repeats in the human genome, but what role these unusual sequences perform is unknown. Their importance to human health is clearly demonstrated by the 4q35 macrosatellite D4Z4 that is associated with the onset of the muscle degenerative disease f...

journal_title：BMC genomics

authors： Tremblay DC,Alexander G Jr,Moseley S,Chadwick BP

更新日期：2010-11-15 00:00:00

abstract：BACKGROUND:Thymoma is a heterogeneous group of tumors in biology and clinical behavior. Even though thymoma is divided into five subgroups following the World Health Organization classification, the nature of the disease is mixed within the subgroups. RESULTS:We investigated the molecular characteristics of genetic ch...

journal_title：BMC genomics

authors： Lee GY,Yang WI,Jeung HC,Kim SC,Seo MY,Park CH,Chung HC,Rha SY

更新日期：2007-09-03 00:00:00

abstract：BACKGROUND:Single-cell (sc) sequencing performs unbiased profiling of individual cells and enables evaluation of less prevalent cellular populations, often missed using bulk sequencing. However, the scale and the complexity of the sc datasets poses a great challenge in its utility and this problem is further exacerbate...

journal_title：BMC genomics

authors： Kumar N,Golhar R,Sharma KS,Holloway JL,Sarangi S,Neuhaus I,Walsh AM,Pitluk ZW

更新日期：2021-01-06 00:00:00

abstract：BACKGROUND:Cells transformed by human adenoviruses (Ad) exhibit differential capacities to induce tumours in immunocompetent rodents; for example, Ad12-transformed rodent cells are oncogenic whereas Ad5-transformed cells are not. The E1A gene determines oncogenic phenotype, is a transcriptional regulator and dysregulat...

journal_title：BMC genomics

authors： Strath J,Georgopoulos LJ,Kellam P,Blair GE

更新日期：2009-02-06 00:00:00

abstract：BACKGROUND:The common marmoset monkey (Callithrix jacchus), a small non-endangered New World primate native to eastern Brazil, is becoming increasingly used as a non-human primate model in biomedical research, drug development and safety assessment. In contrast to the growing interest for the marmoset as an animal mode...

journal_title：BMC genomics

authors： Datson NA,Morsink MC,Atanasova S,Armstrong VW,Zischler H,Schlumbohm C,Dutilh BE,Huynen MA,Waegele B,Ruepp A,de Kloet ER,Fuchs E

更新日期：2007-06-25 00:00:00

abstract：BACKGROUND:Whole-exome sequencing (WES) is rapidly evolving into a tool of choice for rapid, and inexpensive identification of molecular genetic lesions within targeted regions of the human genome. While biases in WES coverage of nucleotides in targeted regions are recognized, it is not well understood how repetition o...

journal_title：BMC genomics

authors： Cherukuri PF,Maduro V,Fuentes-Fajardo KV,Lam K,NISC Comparative Sequencing Program.,Adams DR,Tifft CJ,Mullikin JC,Gahl WA,Boerkoel CF

更新日期：2015-11-25 00:00:00

abstract：BACKGROUND:Bread wheat has a large complex genome that makes whole genome resequencing costly. Therefore, genome complexity reduction techniques such as sequence capture make re-sequencing cost effective. With a high-quality draft wheat genome now available it is possible to design capture probe sets and to use them to...

journal_title：BMC genomics

authors： Olohan L,Gardiner LJ,Lucaci A,Steuernagel B,Wulff B,Kenny J,Hall N,Hall A

更新日期：2018-04-13 00:00:00

abstract：BACKGROUND:Calcium-dependent protein kinase (CPK) is one of the main Ca2+ combined protein kinase that play significant roles in plant growth, development and response to multiple stresses. Despite an important member of the stress responsive gene family, little is known about the evolutionary history and expression pa...

journal_title：BMC genomics

authors： Zhang M,Liu Y,He Q,Chai M,Huang Y,Chen F,Wang X,Liu Y,Cai H,Qin Y

更新日期：2020-01-23 00:00:00

abstract：BACKGROUND:TEs pervade mammalian genomes. However, compared with mice, fewer studies have focused on the TE expression patterns in rat, particularly the comparisons across different organs, developmental stages and sexes. In addition, TEs can influence the expression of nearby genes. The temporal and spatial influences...

journal_title：BMC genomics

authors： Dong Y,Huang Z,Kuang Q,Wen Z,Liu Z,Li Y,Yang Y,Li M

更新日期：2017-08-29 00:00:00

abstract：BACKGROUND:Understanding the processes that drive the evolution of snake venom is a topic of great research interest in molecular and evolutionary toxinology. Recent studies suggest that ontogenetic changes in venom composition are genetically controlled rather than environmentally induced. However, the molecular mecha...

journal_title：BMC genomics

authors： Durban J,Pérez A,Sanz L,Gómez A,Bonilla F,Rodríguez S,Chacón D,Sasa M,Angulo Y,Gutiérrez JM,Calvete JJ

更新日期：2013-04-10 00:00:00

abstract：BACKGROUND:Meiotic recombination is a fundamental evolutionary process. It not only generates diversity, but influences the efficacy of natural selection and genome evolution. There can be significant heterogeneity in recombination rates within and between species, however this variation is not well understood outside ...

journal_title：BMC genomics

authors： Gion JM,Hudson CJ,Lesur I,Vaillancourt RE,Potts BM,Freeman JS

更新日期：2016-08-09 00:00:00

abstract：BACKGROUND:There is no effective method to obtain genome information from single-celled unculturable organisms such as radiolarians. Even worse, such organisms are often very difficult to collect. Sequence analysis of 18S rDNA has been carried out, but obtaining the data has been difficult and it has provided a rather ...

journal_title：BMC genomics

authors： Kouduka M,Matuoka A,Nishigaki K

更新日期：2006-06-02 00:00:00

abstract：BACKGROUND:NOD26-like intrinsic proteins (NIPs) that belong to the aquaporin superfamily are plant-specific and exhibit a similar three-dimensional structure. Experimental evidences however revealed that functional divergence should have extensively occurred among NIP genes. It is therefore intriguing to further invest...

journal_title：BMC genomics

authors： Liu Q,Wang H,Zhang Z,Wu J,Feng Y,Zhu Z

更新日期：2009-07-15 00:00:00

abstract：BACKGROUND:Glandular trichomes produce a wide variety of commercially important secondary metabolites in many plant species. The most prominent anti-malarial drug artemisinin, a sesquiterpene lactone, is produced in glandular trichomes of Artemisia annua. However, only limited genomic information is currently available...

journal_title：BMC genomics

authors： Wang W,Wang Y,Zhang Q,Qi Y,Guo D

更新日期：2009-10-09 00:00:00

abstract：BACKGROUND:Despite substantial progress in mosquito genomic and genetic research, few cis-regulatory elements (CREs), DNA sequences that control gene expression, have been identified in mosquitoes or other non-model insects. Formaldehyde-assisted isolation of regulatory elements paired with DNA sequencing, FAIRE-seq, i...

journal_title：BMC genomics

authors： Behura SK,Sarro J,Li P,Mysore K,Severson DW,Emrich SJ,Duman-Scheel M

更新日期：2016-05-10 00:00:00

abstract：BACKGROUND:Exosomes, endosome-derived membrane microvesicles, contain specific RNA transcripts that are thought to be involved in cell-cell communication. These RNA transcripts have great potential as disease biomarkers. To characterize exosomal RNA profiles systemically, we performed RNA sequencing analysis using thre...

journal_title：BMC genomics

authors： Huang X,Yuan T,Tschannen M,Sun Z,Jacob H,Du M,Liang M,Dittmar RL,Liu Y,Liang M,Kohli M,Thibodeau SN,Boardman L,Wang L

更新日期：2013-05-10 00:00:00