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Improvement in HLA-C typing by a new sequence-specific oligonucleotides kit.

Abstract：

:PCR-sequence-specific oligonucleotide (PCR-SSO) is commonly used for HLA-typing. We recently replaced LabType SSO HD kit for HLA-C typing with the XR kit (OneLambda, Inc.). We used 137 patients' samples representing unique most likely HLA-C allele combinations to compare these kits' performance. The XR kit decreased the number of allele ambiguities with a median of 26.1% (first to third quartiles 20% to 36.2%, range 0% to 96.1%). The XR kit did not resolve all the common, intermediate and well-documented HLA allele ambiguities, which may be important in the clinical setting. The XR kit eliminated 23.6% of null allele ambiguities. In conclusion, the HLA-C XR kit provides a moderate yet valuable improvement of HLA-typing resolution in comparison with the HLA-C HD kit.

journal_name

HLA

journal_title

HLA

authors

Cargou M,Ralazamahaleo M,Blouin L,Guidicelli G,Visentin J

doi

10.1111/tan.13986

subject

Has Abstract

pub_date

2020-09-01 00:00:00

pages

323-328

issue

3

eissn

2059-2302

issn

2059-2310

journal_volume

96

pub_type

杂志文章

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