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The killer cell lectin-like receptor B1 (KLRB1) 503T>C polymorphism (rs1135816) and acute rejection after liver transplantation.

Abstract：

:The killer cell lectin-like receptor B1 (KLRB1) gene encodes for CD161 expressed by different subsets of leukocytes involved in the development of acute liver transplant rejection. The single nucleotide polymorphism (SNP) 503T>C (rs1135816) in the KLRB1 gene represents a missense mutation modifying functional properties of CD161. The aim of our study is to determine whether the SNP 503T>C is associated with acute liver transplant rejection. We genotyped the SNP for 163 liver recipients without acute rejection, 125 recipients with a single acute rejection, and 53 recipients with multiple acute rejections. The genotype frequencies within the groups did not show any significant difference. Our data suggest that the SNP 503T>C has no impact on the susceptibility of acute liver transplant rejection.

journal_name

HLA

journal_title

HLA

authors

Thude H,Rother S,Sterneck M,Klempnauer J,Nashan B,Schwinzer R,Koch M

doi

10.1111/tan.13172

subject

Has Abstract

pub_date

2018-01-01 00:00:00

pages

52-55

issue

1

eissn

2059-2302

issn

2059-2310

journal_volume

91

pub_type

杂志文章

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