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Relevance of donor-specific antibody monitoring after kidney transplantation: Findings from the Collaborative Transplant Study and the Heidelberg Transplant Center.

Abstract：

:Monitoring of donor-specific HLA antibodies (DSA) has become part of the clinical routine in kidney transplantation. This paper gives a brief overview on data from the Collaborative Transplant Study (CTS) and the Heidelberg Transplant Center on the clinical relevance of post-transplant DSA monitoring in patients undergoing renal transplantation. The obtained findings underline the importance of DSA monitoring in the post-operative course in immunologically high-risk patients and patients with deterioration of graft function. Especially in patients with a pre-activated immune system, a gap in the immunosuppressive therapy appear to lead to persistence, reappearance or de novo occurrence of strong, complement-activating DSA, resulting in severe antibody-mediated rejection (AMR) and, without timely intervention, in AMR-related graft loss.

journal_name

HLA

journal_title

HLA

authors

Süsal C,Aykut G,Morath C,Fichtner A,Unterrainer C,Scherer S,Tran TH,Mehrabi A,Zeier M,Tönshoff B

doi

10.1111/tan.13665

subject

Has Abstract

pub_date

2019-12-01 00:00:00

pages

11-15

eissn

2059-2302

issn

2059-2310

journal_volume

94 Suppl 2

pub_type

杂志文章,多中心研究

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