Abstract:
:Adverse drug reactions (ADR) can be broadly categorised as either on-target or off-target. On-target ADRs arise as a direct consequence of the pharmacological properties of the drug and are therefore predictable and dose-dependent. On-target ADRs comprise the majority (>80%) of ADRs, relate to the drug's interaction with its known pharmacological target and are a result of a complex interplay of genetic and ecologic factors. In contrast, off-target ADRs, including immune-mediated ADRs (IM-ADRs), are due to unintended pharmacological interactions such as inadvertent ligation of host cell receptors or non-pharmacological interactions mediated through an adaptive immune response. IM-ADRs can be classified according to the primary immune cell involved and include B-cell-mediated (Gell-Coombs type I-III reactions) and T-cell-mediated (Gell-Coombs type IV or delayed hypersensitivity) reactions. IM-ADRs mediated by T cells are associated with phenotypically distinct clinical diagnoses and can vary from a mild delayed rash to a life-threatening cutaneous, systemic or organ disease, such as Stephen Johnson syndrome/toxic epidermal necrolysis, drug reaction with eosinophilia and systemic symptoms and drug-induced liver disease. T-cell-mediated ADRs are strongly linked to the carriage of particular HLA risk alleles which are in the case of abacavir hypersensitivity and HLA-B*57:01 has led to translation into the clinic as a routine screening test. In this review, we will discuss the immunogenetics and pathogenesis of IM-ADRs and how HLA associations inform both pre-drug screening strategies and mechanistic understanding.
journal_name
HLAjournal_title
HLAauthors
Redwood AJ,Pavlos RK,White KD,Phillips EJdoi
10.1111/tan.13183subject
Has Abstractpub_date
2018-01-01 00:00:00pages
3-16issue
1eissn
2059-2302issn
2059-2310journal_volume
91pub_type
杂志文章,评审相关文献
HLA文献大全abstract::HLA-DRB3 allelic polymorphism on HLA-DRB1*03:01-positive haplotypes was investigated among 104 cadaveric donors typed for HLA-A, -B, -DRB1, and -DRB3. Only HLA-DRB3*01:01:02 and -DRB3*02:02:01:01 alleles were detected among HLA-DRB1*03:01-positive individuals and their distribution depended on HLA-B*08 presence: nearl...
journal_title:HLA
pub_type: 杂志文章
doi:10.1111/tan.13328
更新日期:2018-09-01 00:00:00
abstract::A one nucleotide replacement in codon 261 of HLA-B*40:01:01 results in a novel allele, HLA-B*40:247. ...
journal_title:HLA
pub_type: 杂志文章
doi:10.1111/tan.13029
更新日期:2017-08-01 00:00:00
abstract::HLA-B*50:01:09 differs by a synonymous nucleotide exchange in codon 17 from B*50:01:01. ...
journal_title:HLA
pub_type: 杂志文章
doi:10.1111/tan.13258
更新日期:2018-06-01 00:00:00
abstract::HLA-A*24:480 differs from HLA-A*24:02:01:01 in codon 178 in exon 3. ...
journal_title:HLA
pub_type: 杂志文章
doi:10.1111/tan.13865
更新日期:2020-09-01 00:00:00
abstract::Identification of the novel HLA-C*14:02:34 allele that differs from HLA-C*14:02:01 at one position in exon 1. ...
journal_title:HLA
pub_type: 杂志文章
doi:10.1111/tan.14049
更新日期:2020-11-01 00:00:00
abstract::One nucleotide replacement at residue 559 of HLA-B*07:05:01:01 or B*07:06:01 results in a novel allele, HLA-B*07:269. ...
journal_title:HLA
pub_type: 杂志文章
doi:10.1111/tan.12879
更新日期:2016-10-01 00:00:00
abstract::HLA-B*15:539 differs from HLA-B*15:151 by two nucleotide substitutions. ...
journal_title:HLA
pub_type: 杂志文章
doi:10.1111/tan.13624
更新日期:2019-10-01 00:00:00
abstract::PCR-sequence-specific oligonucleotide (PCR-SSO) is commonly used for HLA-typing. We recently replaced LabType SSO HD kit for HLA-C typing with the XR kit (OneLambda, Inc.). We used 137 patients' samples representing unique most likely HLA-C allele combinations to compare these kits' performance. The XR kit decreased t...
journal_title:HLA
pub_type: 杂志文章
doi:10.1111/tan.13986
更新日期:2020-09-01 00:00:00
abstract::The novel ERAP1 allelic variant is a missense polymorphism leading to the Arg53Pro substitution. ...
journal_title:HLA
pub_type: 杂志文章
doi:10.1111/tan.13262
更新日期:2018-03-26 00:00:00
abstract::HLA-C*01:154 has a single nucleotide substitution at position 312 C > A when compared with HLA-C*01:02. ...
journal_title:HLA
pub_type: 杂志文章
doi:10.1111/tan.13809
更新日期:2020-05-01 00:00:00
abstract::HLA-C*03:02:17 differs from HLA-C*03:02:02:01 by one nucleotide substitution at position 393. ...
journal_title:HLA
pub_type: 杂志文章
doi:10.1111/tan.13286
更新日期:2018-04-25 00:00:00
abstract::HLA-B*08:242 differs from HLA-B*08:01:01:01 in codons 33 and 36 of exon 2. ...
journal_title:HLA
pub_type: 杂志文章
doi:10.1111/tan.13617
更新日期:2019-10-01 00:00:00
abstract::HLA-DPA1*01:03:16 differs from HLA-DPA1*01:03:01:03 by one nucleotide substitution in codon 171 in exon 3. ...
journal_title:HLA
pub_type: 杂志文章
doi:10.1111/tan.13745
更新日期:2020-02-01 00:00:00
abstract::HLA-A*02:934 has one nucleotide change from HLA-A*02:01:01:01 at nucleotide 308. ...
journal_title:HLA
pub_type: 杂志文章
doi:10.1111/tan.14152
更新日期:2020-11-26 00:00:00
abstract::HLA-DRB1*11:245 differs from HLA-DRB1*11:01:01:01 by one nucleotide substitution at position 505 (A>G). ...
journal_title:HLA
pub_type: 杂志文章
doi:10.1111/tan.13463
更新日期:2019-02-01 00:00:00
abstract::Routine HLA typing in clinical practice encompassing solid organ and hematopoietic stem cells transplantation programs, disease association typing, volunteer marrow donor typing and population studies, provided a large dataset for studying HLA allele polymorphism in the Croatian population which led to the identificat...
journal_title:HLA
pub_type: 杂志文章
doi:10.1111/tan.13905
更新日期:2020-07-01 00:00:00
abstract::One nucleotide substitution at position 276 of HLA-B*52:01:01 results in a novel allele, HLA-B*52:70. ...
journal_title:HLA
pub_type: 杂志文章
doi:10.1111/tan.13089
更新日期:2017-10-01 00:00:00
abstract::HLA-C*02:185 differs from HLA-C*02:02:02:01 by one nucleotide substitution at codon 180 in exon 3. ...
journal_title:HLA
pub_type: 杂志文章
doi:10.1111/tan.13911
更新日期:2020-09-01 00:00:00
abstract::Two nucleotide replacements within HLA-B*40:01:01 result in the novel allele, HLA-B*40:01:45. ...
journal_title:HLA
pub_type: 杂志文章
doi:10.1111/tan.13099
更新日期:2017-11-01 00:00:00
abstract::The new HLA-B*39:01:01:04 allele differs from HLA-B*39:01:01 by a C → T substitution in intron 1. ...
journal_title:HLA
pub_type: 杂志文章
doi:10.1111/tan.12958
更新日期:2017-02-01 00:00:00
abstract::Seven novel HLA-C alleles were detected using two next-generation sequencing technologies. ...
journal_title:HLA
pub_type: 杂志文章
doi:10.1111/tan.13890
更新日期:2020-07-01 00:00:00
abstract::HLA are functional in cancer immunosurveillance in adaptive and innate immunity pathways. In unrelated hematopoietic stem cell transplantation (HSCT) in 688 patients with hematological malignancies we compared antitumor efficacy of transplant in three models including the level of: (a) donor-recipient HLA class I mism...
journal_title:HLA
pub_type: 杂志文章
doi:10.1111/tan.13386
更新日期:2018-12-01 00:00:00
abstract::The novel allele, A*24:388N, was identified by sequence-based typing in a Chinese individual. ...
journal_title:HLA
pub_type: 杂志文章
doi:10.1111/tan.13149
更新日期:2017-12-01 00:00:00
abstract::Genomic full-length sequence of HLA-A*11:172 was identified by a group-specific sequencing approach from China. ...
journal_title:HLA
pub_type: 杂志文章
doi:10.1111/tan.13334
更新日期:2018-10-01 00:00:00
abstract::Two nucleotide changes in the 3'untranslated region of HLA-C*07:06:01:01 results in the novel allele, HLA-C*07:06:01:06. ...
journal_title:HLA
pub_type: 杂志文章
doi:10.1111/tan.13719
更新日期:2020-01-01 00:00:00
abstract::Allogeneic stem cell transplantation is a form of immunotherapy that has increased the chances of survival for patients with relapsed leukemia and high risk leukemia in remission. The major obstacles are graft-vs-host disease (GVHD) involving vital organs and infections. A most efficacious prophylaxis of GVHD is by de...
journal_title:HLA
pub_type: 杂志文章,评审
doi:10.1111/tan.13005
更新日期:2017-05-01 00:00:00
abstract::One nucleotide substitution at residue 19 of HLA-C*03:03:01:01 results in a novel allele, HLA-C*03:227. ...
journal_title:HLA
pub_type: 杂志文章
doi:10.1111/tan.12996
更新日期:2017-04-01 00:00:00
abstract::Characterization of two novel HLA-DPA1*02:01:01 variants, HLA-DPA1*02:01:01:18 and -DPA1*02:01:01:19. ...
journal_title:HLA
pub_type: 杂志文章
doi:10.1111/tan.13985
更新日期:2020-10-01 00:00:00
abstract::HLA-B*13:69 allele differs from B*13:02:01 by one nucleotide substitution at position 628 from A to C. ...
journal_title:HLA
pub_type: 杂志文章
doi:10.1111/tan.12847
更新日期:2016-09-01 00:00:00
abstract::Novel HLA-B alleles HLA-B*53:01:17 and HLA-B*58:83 are described in two patients from Guinea-Bissau. ...
journal_title:HLA
pub_type: 杂志文章
doi:10.1111/tan.13392
更新日期:2018-12-01 00:00:00