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Detection of novel and confirmation of very rare and rare HLA alleles by next generation sequencing in Croatia.

Abstract：

:Routine HLA typing in clinical practice encompassing solid organ and hematopoietic stem cells transplantation programs, disease association typing, volunteer marrow donor typing and population studies, provided a large dataset for studying HLA allele polymorphism in the Croatian population which led to the identification of new, very rare and rare HLA alleles. Over the last 4 years we have identified six new HLA alleles (HLA-A*01:200, A*02:836, A*11:01:01:44, B*08:251, B*18:169 and C*05:46:01:02) and a number of very rare (HLA-B*08:78, DRB1*12:39, DRB1*13:23:02 and DQB1*06:09:04) or rare (HLA-A*24:41, B*39:40:01N, B*51:78:01, DRB1*01:31 and DRB1*14:111) alleles using sequence-based typing methods. The reported data enhance the knowledge about HLA polymorphisms in the Croatian population and provide a foundation for further studies in population genetics.

journal_name

HLA

journal_title

HLA

authors

Burek Kamenaric M,Maskalan M,Grubic Z,Stingl Jankovic K,Zunec R

doi

10.1111/tan.13905

subject

Has Abstract

pub_date

2020-07-01 00:00:00

pages

70-75

issue

1

eissn

2059-2302

issn

2059-2310

journal_volume

96

pub_type

杂志文章

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