Changes of the human skin microbiota upon chronic exposure to polycyclic aromatic hydrocarbon pollutants.

Abstract:

BACKGROUND:Polycyclic aromatic hydrocarbons (PAHs) are of environmental and public health concerns and contribute to adverse skin attributes such as premature skin aging and pigmentary disorder. However, little information is available on the potential roles of chronic urban PAH pollutant exposure on the cutaneous microbiota. Given the roles of the skin microbiota have on healthy and undesirable skin phenotypes and the relationships between PAHs and skin properties, we hypothesize that exposure of PAHs may be associated with changes in the cutaneous microbiota. In this study, the skin microbiota of over two hundred Chinese individuals from two cities in China with varying exposure levels of PAHs were characterized by bacterial and fungal amplicon and shotgun metagenomics sequencing. RESULTS:Skin site and city were strong parameters in changing microbial communities and their assembly processes. Reductions of bacterial-fungal microbial network structural integrity and stability were associated with skin conditions (acne and dandruff). Multivariate analysis revealed associations between abundances of Propionibacterium and Malassezia with host properties and pollutant exposure levels. Shannon diversity increase was correlated to exposure levels of PAHs in a dose-dependent manner. Shotgun metagenomics analysis of samples (n = 32) from individuals of the lowest and highest exposure levels of PAHs further highlighted associations between the PAHs quantified and decrease in abundances of skin commensals and increase in oral bacteria. Functional analysis identified associations between levels of PAHs and abundance of microbial genes of metabolic and other pathways with potential importance in host-microbe interactions as well as degradation of aromatic compounds. CONCLUSIONS:The results in this study demonstrated the changes in composition and functional capacities of the cutaneous microbiota associated with chronic exposure levels of PAHs. Findings from this study will aid the development of strategies to harness the microbiota in protecting the skin against pollutants. Video Abstract.

journal_name

Microbiome

journal_title

Microbiome

authors

Leung MHY,Tong X,Bastien P,Guinot F,Tenenhaus A,Appenzeller BMR,Betts RJ,Mezzache S,Li J,Bourokba N,Breton L,Clavaud C,Lee PKH

doi

10.1186/s40168-020-00874-1

subject

Has Abstract

pub_date

2020-06-26 00:00:00

pages

100

issue

1

issn

2049-2618

pii

10.1186/s40168-020-00874-1

journal_volume

8

pub_type

杂志文章
  • The occurrence of potato common scab correlates with the community composition and function of the geocaulosphere soil microbiome.

    abstract:BACKGROUND:Soil microorganisms can mediate the occurrence of plant diseases. Potato common scab (CS) is a refractory disease caused by pathogenic Streptomyces that occurs worldwide, but little is known about the interactions between CS and the soil microbiome. In this study, four soil-root system compartments (geocaulo...

    journal_title:Microbiome

    pub_type: 杂志文章

    doi:10.1186/s40168-019-0629-2

    authors: Shi W,Li M,Wei G,Tian R,Li C,Wang B,Lin R,Shi C,Chi X,Zhou B,Gao Z

    更新日期:2019-02-01 00:00:00

  • Facultative methanotrophs are abundant at terrestrial natural gas seeps.

    abstract:BACKGROUND:Natural gas contains methane and the gaseous alkanes ethane, propane and butane, which collectively influence atmospheric chemistry and cause global warming. Methane-oxidising bacteria, methanotrophs, are crucial in mitigating emissions of methane as they oxidise most of the methane produced in soils and the...

    journal_title:Microbiome

    pub_type: 杂志文章

    doi:10.1186/s40168-018-0500-x

    authors: Farhan Ul Haque M,Crombie AT,Ensminger SA,Baciu C,Murrell JC

    更新日期:2018-06-28 00:00:00

  • A comparison of methods used to unveil the genetic and metabolic pool in the built environment.

    abstract:BACKGROUND:A majority of indoor residential microbes originate from humans, pets, and outdoor air and are not adapted to the built environment (BE). Consequently, a large portion of the microbes identified by DNA-based methods are either dead or metabolically inactive. Although many exceptions have been noted, the ribo...

    journal_title:Microbiome

    pub_type: 杂志文章

    doi:10.1186/s40168-018-0453-0

    authors: Gomez-Silvan C,Leung MHY,Grue KA,Kaur R,Tong X,Lee PKH,Andersen GL

    更新日期:2018-04-16 00:00:00

  • MetaEuk-sensitive, high-throughput gene discovery, and annotation for large-scale eukaryotic metagenomics.

    abstract:BACKGROUND:Metagenomics is revolutionizing the study of microorganisms and their involvement in biological, biomedical, and geochemical processes, allowing us to investigate by direct sequencing a tremendous diversity of organisms without the need for prior cultivation. Unicellular eukaryotes play essential roles in mo...

    journal_title:Microbiome

    pub_type: 杂志文章

    doi:10.1186/s40168-020-00808-x

    authors: Levy Karin E,Mirdita M,Söding J

    更新日期:2020-04-03 00:00:00

  • Maternal inheritance of bifidobacterial communities and bifidophages in infants through vertical transmission.

    abstract:BACKGROUND:The correct establishment of the human gut microbiota represents a crucial development that commences at birth. Different hypotheses propose that the infant gut microbiota is derived from, among other sources, the mother's fecal/vaginal microbiota and human milk. RESULTS:The composition of bifidobacterial c...

    journal_title:Microbiome

    pub_type: 杂志文章

    doi:10.1186/s40168-017-0282-6

    authors: Duranti S,Lugli GA,Mancabelli L,Armanini F,Turroni F,James K,Ferretti P,Gorfer V,Ferrario C,Milani C,Mangifesta M,Anzalone R,Zolfo M,Viappiani A,Pasolli E,Bariletti I,Canto R,Clementi R,Cologna M,Crifò T,Cusumano

    更新日期:2017-06-26 00:00:00

  • Feasibility of using alternative swabs and storage solutions for paired SARS-CoV-2 detection and microbiome analysis in the hospital environment.

    abstract:BACKGROUND:Determining the role of fomites in the transmission of SARS-CoV-2 is essential in the hospital setting and will likely be important outside of medical facilities as governments around the world make plans to ease COVID-19 public health restrictions and attempt to safely reopen economies. Expanding COVID-19 t...

    journal_title:Microbiome

    pub_type: 杂志文章

    doi:10.1186/s40168-020-00960-4

    authors: Minich JJ,Ali F,Marotz C,Belda-Ferre P,Chiang L,Shaffer JP,Carpenter CS,McDonald D,Gilbert J,Allard SM,Allen EE,Knight R,Sweeney DA,Swafford AD

    更新日期:2021-01-22 00:00:00

  • The human gallbladder microbiome is related to the physiological state and the biliary metabolic profile.

    abstract:BACKGROUND:The microbial populations of the human intestinal tract and their relationship to specific diseases have been extensively studied during the last decade. However, the characterization of the human bile microbiota as a whole has been hampered by difficulties in accessing biological samples and the lack of ade...

    journal_title:Microbiome

    pub_type: 杂志文章

    doi:10.1186/s40168-019-0712-8

    authors: Molinero N,Ruiz L,Milani C,Gutiérrez-Díaz I,Sánchez B,Mangifesta M,Segura J,Cambero I,Campelo AB,García-Bernardo CM,Cabrera A,Rodríguez JI,González S,Rodríguez JM,Ventura M,Delgado S,Margolles A

    更新日期:2019-07-04 00:00:00

  • Gut-dependent microbial translocation induces inflammation and cardiovascular events after ST-elevation myocardial infarction.

    abstract:BACKGROUND:Post-infarction cardiovascular remodeling and heart failure are the leading cause of myocardial infarction (MI)-driven death during the past decades. Experimental observations have involved intestinal microbiota in the susceptibility to MI in mice; however, in humans, identifying whether translocation of gut...

    journal_title:Microbiome

    pub_type: 杂志文章

    doi:10.1186/s40168-018-0441-4

    authors: Zhou X,Li J,Guo J,Geng B,Ji W,Zhao Q,Li J,Liu X,Liu J,Guo Z,Cai W,Ma Y,Ren D,Miao J,Chen S,Zhang Z,Chen J,Zhong J,Liu W,Zou M,Li Y,Cai J

    更新日期:2018-04-03 00:00:00

  • Genomic insights into potential interdependencies in microbial hydrocarbon and nutrient cycling in hydrothermal sediments.

    abstract:BACKGROUND:Deep-sea hydrothermal vents are hotspots for productivity and biodiversity. Thermal pyrolysis and circulation produce fluids rich in hydrocarbons and reduced compounds that stimulate microbial activity in surrounding sediments. Several studies have characterized the diversity of Guaymas Basin (Gulf of Califo...

    journal_title:Microbiome

    pub_type: 杂志文章

    doi:10.1186/s40168-017-0322-2

    authors: Dombrowski N,Seitz KW,Teske AP,Baker BJ

    更新日期:2017-08-23 00:00:00

  • Antimicrobial-specific response from resistance gene carriers studied in a natural, highly diverse microbiome.

    abstract:BACKGROUND:Antimicrobial resistance (AMR) is a major threat to public health. Microorganisms equipped with AMR genes are suggested to have partially emerged from natural habitats; however, this hypothesis remains inconclusive so far. To understand the consequences of the introduction of exogenic antimicrobials into nat...

    journal_title:Microbiome

    pub_type: 杂志文章

    doi:10.1186/s40168-020-00982-y

    authors: Wicaksono WA,Kusstatscher P,Erschen S,Reisenhofer-Graber T,Grube M,Cernava T,Berg G

    更新日期:2021-01-27 00:00:00

  • Context and the human microbiome.

    abstract::Human microbiome reference datasets provide epidemiological context for researchers, enabling them to uncover new insights into their own data through meta-analyses. In addition, large and comprehensive reference sets offer a means to develop or test hypotheses and can pave the way for addressing practical study desig...

    journal_title:Microbiome

    pub_type: 杂志文章,评审

    doi:10.1186/s40168-015-0117-2

    authors: McDonald D,Birmingham A,Knight R

    更新日期:2015-11-04 00:00:00

  • Genomic characterization of the uncultured Bacteroidales family S24-7 inhabiting the guts of homeothermic animals.

    abstract:BACKGROUND:Our view of host-associated microbiota remains incomplete due to the presence of as yet uncultured constituents. The Bacteroidales family S24-7 is a prominent example of one of these groups. Marker gene surveys indicate that members of this family are highly localized to the gastrointestinal tracts of homeot...

    journal_title:Microbiome

    pub_type: 杂志文章

    doi:10.1186/s40168-016-0181-2

    authors: Ormerod KL,Wood DL,Lachner N,Gellatly SL,Daly JN,Parsons JD,Dal'Molin CG,Palfreyman RW,Nielsen LK,Cooper MA,Morrison M,Hansbro PM,Hugenholtz P

    更新日期:2016-07-07 00:00:00

  • Seasonal, spatial, and maternal effects on gut microbiome in wild red squirrels.

    abstract:BACKGROUND:Our understanding of gut microbiota has been limited primarily to findings from human and laboratory animals, but what shapes the gut microbiota in nature remains largely unknown. To fill this gap, we conducted a comprehensive study of gut microbiota of a well-studied North American red squirrel (Tamiasciuru...

    journal_title:Microbiome

    pub_type: 杂志文章

    doi:10.1186/s40168-017-0382-3

    authors: Ren T,Boutin S,Humphries MM,Dantzer B,Gorrell JC,Coltman DW,McAdam AG,Wu M

    更新日期:2017-12-21 00:00:00

  • Identification of discriminatory antibiotic resistance genes among environmental resistomes using extremely randomized tree algorithm.

    abstract:BACKGROUND:The interconnectivities of built and natural environments can serve as conduits for the proliferation and dissemination of antibiotic resistance genes (ARGs). Several studies have compared the broad spectrum of ARGs (i.e., "resistomes") in various environmental compartments, but there is a need to identify u...

    journal_title:Microbiome

    pub_type: 杂志文章

    doi:10.1186/s40168-019-0735-1

    authors: Gupta S,Arango-Argoty G,Zhang L,Pruden A,Vikesland P

    更新日期:2019-08-29 00:00:00

  • Mobile antibiotic resistome in wastewater treatment plants revealed by Nanopore metagenomic sequencing.

    abstract:BACKGROUND:Wastewater treatment plants (WWTPs) are recognized as hotspots for horizontal gene transfer (HGT) of antibiotic resistance genes (ARGs). Despite our understanding of the composition and distribution of ARGs in WWTPs, the genetic location, host, and fate of ARGs remain largely unknown. RESULTS:In this study,...

    journal_title:Microbiome

    pub_type: 杂志文章

    doi:10.1186/s40168-019-0663-0

    authors: Che Y,Xia Y,Liu L,Li AD,Yang Y,Zhang T

    更新日期:2019-03-21 00:00:00

  • Novel facultative Methylocella strains are active methane consumers at terrestrial natural gas seeps.

    abstract:BACKGROUND:Natural gas seeps contribute to global climate change by releasing substantial amounts of the potent greenhouse gas methane and other climate-active gases including ethane and propane to the atmosphere. However, methanotrophs, bacteria capable of utilising methane as the sole source of carbon and energy, pla...

    journal_title:Microbiome

    pub_type: 杂志文章

    doi:10.1186/s40168-019-0741-3

    authors: Farhan Ul Haque M,Crombie AT,Murrell JC

    更新日期:2019-10-04 00:00:00

  • Bacterial community composition of chronic periodontitis and novel oral sampling sites for detecting disease indicators.

    abstract:BACKGROUND:Periodontitis is an infectious and inflammatory disease of polymicrobial etiology that can lead to the destruction of bones and tissues that support the teeth. The management of chronic periodontitis (CP) relies heavily on elimination or at least control of known pathogenic consortia associated with the dise...

    journal_title:Microbiome

    pub_type: 杂志文章

    doi:10.1186/2049-2618-2-32

    authors: Galimanas V,Hall MW,Singh N,Lynch MD,Goldberg M,Tenenbaum H,Cvitkovitch DG,Neufeld JD,Senadheera DB

    更新日期:2014-08-26 00:00:00

  • Correction to: Microbiome definition re-visited: old concepts and new challenges.

    abstract::An amendment to this paper has been published and can be accessed via the original article. ...

    journal_title:Microbiome

    pub_type: 已发布勘误

    doi:10.1186/s40168-020-00905-x

    authors: Berg G,Rybakova D,Fischer D,Cernava T,Vergès MC,Charles T,Chen X,Cocolin L,Eversole K,Corral GH,Kazou M,Kinkel L,Lange L,Lima N,Loy A,Macklin JA,Maguin E,Mauchline T,McClure R,Mitter B,Ryan M,Sarand I,Smidt H

    更新日期:2020-08-20 00:00:00

  • The unsolved problem of otitis media in indigenous populations: a systematic review of upper respiratory and middle ear microbiology in indigenous children with otitis media.

    abstract:BACKGROUND:Otitis media (OM) imposes a great burden of disease in indigenous populations around the world, despite a variety of treatment and prevention programs. Improved understanding of the pathogenesis of OM in indigenous populations is required to advance treatment and reduce prevalence. We conducted a systematic ...

    journal_title:Microbiome

    pub_type: 杂志文章

    doi:10.1186/s40168-018-0577-2

    authors: Coleman A,Wood A,Bialasiewicz S,Ware RS,Marsh RL,Cervin A

    更新日期:2018-11-05 00:00:00

  • A metagenomic approach from aphid's hemolymph sheds light on the potential roles of co-existing endosymbionts.

    abstract:BACKGROUND:Aphids are known to live in symbiosis with specific bacteria, called endosymbionts which can be classified as obligate or accessory. Buchnera aphidicola is generally the only obligatory symbiont present in aphids, supplying essential nutrients that are missing in the plants phloem to its host. Pentalonia nig...

    journal_title:Microbiome

    pub_type: 杂志文章

    doi:10.1186/s40168-015-0130-5

    authors: De Clerck C,Fujiwara A,Joncour P,Léonard S,Félix ML,Francis F,Jijakli MH,Tsuchida T,Massart S

    更新日期:2015-12-15 00:00:00

  • Microbial differences between dental plaque and historic dental calculus are related to oral biofilm maturation stage.

    abstract:BACKGROUND:Dental calculus, calcified oral plaque biofilm, contains microbial and host biomolecules that can be used to study historic microbiome communities and host responses. Dental calculus does not typically accumulate as much today as historically, and clinical oral microbiome research studies focus primarily on ...

    journal_title:Microbiome

    pub_type: 历史文章,杂志文章

    doi:10.1186/s40168-019-0717-3

    authors: Velsko IM,Fellows Yates JA,Aron F,Hagan RW,Frantz LAF,Loe L,Martinez JBR,Chaves E,Gosden C,Larson G,Warinner C

    更新日期:2019-07-06 00:00:00

  • The chicken gut metagenome and the modulatory effects of plant-derived benzylisoquinoline alkaloids.

    abstract:BACKGROUND:Sub-therapeutic antibiotics are widely used as growth promoters in the poultry industry; however, the resulting antibiotic resistance threatens public health. A plant-derived growth promoter, Macleaya cordata extract (MCE), with effective ingredients of benzylisoquinoline alkaloids, is a potential alternativ...

    journal_title:Microbiome

    pub_type: 杂志文章

    doi:10.1186/s40168-018-0590-5

    authors: Huang P,Zhang Y,Xiao K,Jiang F,Wang H,Tang D,Liu D,Liu B,Liu Y,He X,Liu H,Liu X,Qing Z,Liu C,Huang J,Ren Y,Yun L,Yin L,Lin Q,Zeng C,Su X,Yuan J,Lin L,Hu N,Cao H,Huang S,Guo Y,Fan W,Zeng J

    更新日期:2018-11-27 00:00:00

  • CloVR-ITS: Automated internal transcribed spacer amplicon sequence analysis pipeline for the characterization of fungal microbiota.

    abstract:BACKGROUND:Besides the development of comprehensive tools for high-throughput 16S ribosomal RNA amplicon sequence analysis, there exists a growing need for protocols emphasizing alternative phylogenetic markers such as those representing eukaryotic organisms. RESULTS:Here we introduce CloVR-ITS, an automated pipeline ...

    journal_title:Microbiome

    pub_type: 杂志文章

    doi:10.1186/2049-2618-1-6

    authors: White JR,Maddox C,White O,Angiuoli SV,Fricke WF

    更新日期:2013-02-04 00:00:00

  • A two-stage microbial association mapping framework with advanced FDR control.

    abstract:BACKGROUND:In microbiome studies, it is important to detect taxa which are associated with pathological outcomes at the lowest definable taxonomic rank, such as genus or species. Traditionally, taxa at the target rank are tested for individual association, followed by the Benjamini-Hochberg (BH) procedure to control fo...

    journal_title:Microbiome

    pub_type: 杂志文章

    doi:10.1186/s40168-018-0517-1

    authors: Hu J,Koh H,He L,Liu M,Blaser MJ,Li H

    更新日期:2018-07-25 00:00:00

  • Transplanted human fecal microbiota enhanced Guillain Barré syndrome autoantibody responses after Campylobacter jejuni infection in C57BL/6 mice.

    abstract:BACKGROUND:Campylobacter jejuni is the leading antecedent infection to the autoimmune neuropathy Guillain-Barré syndrome (GBS), which is accompanied by an autoimmune anti-ganglioside antibody attack on peripheral nerves. Previously, we showed that contrasting immune responses mediate C. jejuni induced colitis and autoi...

    journal_title:Microbiome

    pub_type: 杂志文章

    doi:10.1186/s40168-017-0284-4

    authors: Brooks PT,Brakel KA,Bell JA,Bejcek CE,Gilpin T,Brudvig JM,Mansfield LS

    更新日期:2017-08-08 00:00:00

  • Two sampling methods yield distinct microbial signatures in the nasopharynges of asthmatic children.

    abstract:BACKGROUND:The nasopharynx is a reservoir for pathogens associated with respiratory illnesses, such as asthma. Next-generation sequencing (NGS) has been used to characterize the nasopharyngeal microbiome during health and disease. Most studies so far have surveyed the nasopharynx as a whole; however, less is known abou...

    journal_title:Microbiome

    pub_type: 杂志文章

    doi:10.1186/s40168-016-0170-5

    authors: Pérez-Losada M,Crandall KA,Freishtat RJ

    更新日期:2016-06-16 00:00:00

  • Microbe observation and cultivation array (MOCA) for cultivating and analyzing environmental microbiota.

    abstract:BACKGROUND:The use of culture-independent nucleic acid techniques, such as ribosomal RNA gene cloning library analysis, has unveiled the tremendous microbial diversity that exists in natural environments. In sharp contrast to this great achievement is the current difficulty in cultivating the majority of bacterial spec...

    journal_title:Microbiome

    pub_type: 杂志文章

    doi:10.1186/2049-2618-1-4

    authors: Gao W,Navarroli D,Naimark J,Zhang W,Chao SH,Meldrum DR

    更新日期:2013-01-09 00:00:00

  • Rumen metagenome and metatranscriptome analyses of low methane yield sheep reveals a Sharpea-enriched microbiome characterised by lactic acid formation and utilisation.

    abstract:BACKGROUND:Enteric fermentation by farmed ruminant animals is a major source of methane and constitutes the second largest anthropogenic contributor to global warming. Reducing methane emissions from ruminants is needed to ensure sustainable animal production in the future. Methane yield varies naturally in sheep and i...

    journal_title:Microbiome

    pub_type: 杂志文章

    doi:10.1186/s40168-016-0201-2

    authors: Kamke J,Kittelmann S,Soni P,Li Y,Tavendale M,Ganesh S,Janssen PH,Shi W,Froula J,Rubin EM,Attwood GT

    更新日期:2016-10-19 00:00:00

  • Ruminal microbiome-host crosstalk stimulates the development of the ruminal epithelium in a lamb model.

    abstract:BACKGROUND:The development of the rumen is an important physiological challenge for young ruminants. Previous studies have shown that starter feeding can effectively facilitate the growth and development of the rumen in ruminants. However, the mechanism through which starter feeding stimulates the development of the ru...

    journal_title:Microbiome

    pub_type: 杂志文章

    doi:10.1186/s40168-019-0701-y

    authors: Lin L,Xie F,Sun D,Liu J,Zhu W,Mao S

    更新日期:2019-06-03 00:00:00

  • Bloom and bust: intestinal microbiota dynamics in response to hospital exposures and Clostridium difficile colonization or infection.

    abstract:BACKGROUND:Clostridium difficile infection (CDI) is the leading infectious cause of nosocomial diarrhea. Hospitalized patients are at increased risk of developing CDI because they are exposed to C. difficile spores through contact with the hospital environment and often receive antibiotics and other medications that ca...

    journal_title:Microbiome

    pub_type: 杂志文章

    doi:10.1186/s40168-016-0156-3

    authors: Vincent C,Miller MA,Edens TJ,Mehrotra S,Dewar K,Manges AR

    更新日期:2016-03-14 00:00:00