Abstract:
BACKGROUND:The development of the rumen is an important physiological challenge for young ruminants. Previous studies have shown that starter feeding can effectively facilitate the growth and development of the rumen in ruminants. However, the mechanism through which starter feeding stimulates the development of the rumen is not clear. Here, we performed an integrated analysis in ruminal microbiota and a host transcriptomic profile in a lamb model with the intervention of starter feed to understand the ruminal microbiome-host crosstalk in stimulating the development of the ruminal epithelium. RESULTS:Decreased ruminal pH and increased acetate and butyrate concentrations in the rumen, followed by increasing rumen organ index, were observed in lambs supplemented with starter. Using metagenome sequencing in combination with 16S rRNA and 18S rRNA gene amplicon sequencing, the results showed the abundance of acetate-producing Mitsuokella spp., lactate-producing Sharpea spp., lactate-utilizing Megasphaera spp., and Entodinium spp. was enriched in rumen microbial communities in the starter-feed group. The abundances of genes involved in sugar degradation were decreased in starter-feed lambs, but the GH13 encoding α-amylase was obviously increased. Rumen epithelial transcriptome analysis revealed that seven differentially expressed genes, including MAPK1, PIK3CB, TNFSF10, ITGA6, SNAI2, SAV1, and DLG, related to the cell growth module were upregulated, and BAD's promotion of cell death was downregulated. Correlation analysis revealed that the increase in the concentrations of acetate and butyrate significantly correlated with the expression of these genes, which indicates acetate and butyrate likely acted as important drivers in the ruminal microbiome-host crosstalk. CONCLUSIONS:The present study comprehensively describes the symbiotic relationship between the rumen microbiota and the host in lambs after starter feeding. Our data demonstrates that the microbiome-driven generation of acetate and butyrate mediated the growth-related genes' regulation of the growth-associated signalling pathway in the ruminal epithelium. These co-development networks regulated many physiological processes in the epithelium, including papillae morphology and rumen epithelial growth.
journal_name
Microbiomejournal_title
Microbiomeauthors
Lin L,Xie F,Sun D,Liu J,Zhu W,Mao Sdoi
10.1186/s40168-019-0701-ysubject
Has Abstractpub_date
2019-06-03 00:00:00pages
83issue
1issn
2049-2618pii
10.1186/s40168-019-0701-yjournal_volume
7pub_type
杂志文章相关文献
Microbiome文献大全abstract:BACKGROUND:Alterations of gut microbiota are associated with colorectal cancer (CRC) in different populations and several bacterial species were found to contribute to the tumorigenesis. The potential use of gut microbes as markers for early diagnosis has also been reported. However, cohort specific noises may distort ...
journal_title:Microbiome
pub_type: 杂志文章
doi:10.1186/s40168-018-0451-2
更新日期:2018-04-11 00:00:00
abstract::The human gut microbiota is increasingly recognized for its important or even decisive role in health. As it becomes clear that microbiota and host mutually affect and depend on each other in an intimate relationship, a holistic view of the gut microbiota-host association imposes itself. Ideally, a stable state of equ...
journal_title:Microbiome
pub_type: 杂志文章,评审
doi:10.1186/s40168-018-0466-8
更新日期:2018-05-01 00:00:00
abstract:BACKGROUND:The newborn mammal is rapidly colonized by a complex microbial community, whose importance for host health is becoming increasingly clear. Understanding the forces that shape the early community, especially during the nursing period, is critical to gain insight into how this consortium of microbes is assembl...
journal_title:Microbiome
pub_type: 杂志文章
doi:10.1186/s40168-015-0091-8
更新日期:2015-07-01 00:00:00
abstract:BACKGROUND:The caecal microbiota plays a key role in chicken health and performance, influencing digestion and absorption of nutrients, and contributing to defence against colonisation by invading pathogens. Measures of productivity and resistance to pathogen colonisation are directly influenced by chicken genotype, bu...
journal_title:Microbiome
pub_type: 杂志文章
doi:10.1186/s40168-018-0501-9
更新日期:2018-06-23 00:00:00
abstract:BACKGROUND:The study of the microbial communities in the built environment is of critical importance as humans spend the majority of their time indoors. While the microorganisms in living spaces, especially those in the air, can impact health and well-being, little is known of their identity and the processes that dete...
journal_title:Microbiome
pub_type: 杂志文章
doi:10.1186/s40168-015-0128-z
更新日期:2015-12-10 00:00:00
abstract:BACKGROUND:Increasing evidence reveals the importance of the microbiome in health and disease and inseparable host-microbial dependencies. Host-microbe interactions are highly relevant in patients receiving allogeneic hematopoietic stem cell transplantation (HSCT), i.e., a replacement of the cellular components of the ...
journal_title:Microbiome
pub_type: 杂志文章
doi:10.1186/s40168-019-0745-z
更新日期:2019-09-13 00:00:00
abstract:BACKGROUND:Lower respiratory tract infection (LRTI) is a major contributor to respiratory failure requiring intubation and mechanical ventilation. LRTI also occurs during mechanical ventilation, increasing the morbidity and mortality of intubated patients. We sought to understand the dynamics of respiratory tract micro...
journal_title:Microbiome
pub_type: 杂志文章
doi:10.1186/s40168-016-0151-8
更新日期:2016-02-11 00:00:00
abstract:BACKGROUND:Most studies describing the human gut microbiome in healthy and diseased states have emphasized the bacterial component, but the fungal microbiome (i.e., the mycobiome) is beginning to gain recognition as a fundamental part of our microbiome. To date, human gut mycobiome studies have primarily been disease c...
journal_title:Microbiome
pub_type: 杂志文章
doi:10.1186/s40168-017-0373-4
更新日期:2017-11-25 00:00:00
abstract:BACKGROUND:Preterm infants are at risk of developing intestinal dysbiosis with an increased proportion of Gammaproteobacteria. In this study, we sought the clinical determinants of the relative abundance of feces-associated Gammaproteobacteria in very low birth weight (VLBW) infants. Fecal microbiome was characterized ...
journal_title:Microbiome
pub_type: 杂志文章
doi:10.1186/s40168-018-0547-8
更新日期:2018-09-12 00:00:00
abstract:BACKGROUND:Taxonomic profiles of vaginal microbial communities can be sorted into a discrete number of categories termed community state types (CSTs). This approach is advantageous because collapsing a hyper-dimensional taxonomic profile into a single categorical variable enables efforts such as data exploration, epide...
journal_title:Microbiome
pub_type: 杂志文章
doi:10.1186/s40168-020-00934-6
更新日期:2020-11-23 00:00:00
abstract:BACKGROUND:Wheat residues are a crucial determinant of the epidemiology of Septoria tritici blotch, as they support the sexual reproduction of the causal agent Zymoseptoria tritici. We aimed to characterize the effect of infection with this fungal pathogen on the microbial communities present on wheat residues and to i...
journal_title:Microbiome
pub_type: 杂志文章
doi:10.1186/s40168-019-0736-0
更新日期:2019-08-30 00:00:00
abstract:BACKGROUND:The interplay between hosts and their associated microbiome is now recognized as a fundamental basis of the ecology, evolution, and development of both players. These interdependencies inspired a new view of multicellular organisms as "metaorganisms." The goal of the Collaborative Research Center "Origin and...
journal_title:Microbiome
pub_type: 杂志文章
doi:10.1186/s40168-019-0743-1
更新日期:2019-09-14 00:00:00
abstract:BACKGROUND:Dental calculus, calcified oral plaque biofilm, contains microbial and host biomolecules that can be used to study historic microbiome communities and host responses. Dental calculus does not typically accumulate as much today as historically, and clinical oral microbiome research studies focus primarily on ...
journal_title:Microbiome
pub_type: 历史文章,杂志文章
doi:10.1186/s40168-019-0717-3
更新日期:2019-07-06 00:00:00
abstract:BACKGROUND:Early disruption of the microbial community may influence life-long health. Environmental toxicants can contaminate breast milk and the developing infant gut microbiome is directly exposed. We investigated whether environmental toxicants in breastmilk affect the composition and function of the infant gut mic...
journal_title:Microbiome
pub_type: 杂志文章
doi:10.1186/s40168-019-0645-2
更新日期:2019-02-27 00:00:00
abstract:BACKGROUND:pH is frequently reported as the main driver for prokaryotic community structure in soils. However, pH changes are also linked to "spillover effects" on other chemical parameters (e.g., availability of Al, Fe, Mn, Zn, and Cu) and plant growth, but these indirect effects on the microbial communities are rarel...
journal_title:Microbiome
pub_type: 杂志文章
doi:10.1186/s40168-018-0482-8
更新日期:2018-06-11 00:00:00
abstract:BACKGROUND:Whole-genome "shotgun" (WGS) metagenomic sequencing is an increasingly widely used tool for analyzing the metagenomic content of microbiome samples. While WGS data contains gene-level information, it can be challenging to analyze the millions of microbial genes which are typically found in microbiome experim...
journal_title:Microbiome
pub_type: 杂志文章
doi:10.1186/s40168-019-0722-6
更新日期:2019-08-01 00:00:00
abstract:BACKGROUND:Given their adaptation to nutrient-poor and drought environments, cycads are vital models for plant-microbiome interaction research because they are likely to host an important reservoir of beneficial microbes that may support cycad survival. However, a comprehensive understanding of the diversity and commun...
journal_title:Microbiome
pub_type: 杂志文章
doi:10.1186/s40168-019-0770-y
更新日期:2019-12-02 00:00:00
abstract:BACKGROUND:Bacterial vaginosis (BV), the most common vaginal condition of reproductive-aged women, is associated with a highly diverse and heterogeneous microbiota. Here we present a proof-of-principle analysis to uncover the function of the microbiota using meta-RNA-seq to uncover genes and pathways that potentially d...
journal_title:Microbiome
pub_type: 杂志文章
doi:10.1186/2049-2618-1-12
更新日期:2013-04-12 00:00:00
abstract:BACKGROUND:Whole genome amplification (WGA) is a challenging, key step in metagenomic studies of samples containing minute amounts of DNA, such as samples from low biomass environments. It is well known that multiple displacement amplification (MDA), the most commonly used WGA method for microbial samples, skews the ge...
journal_title:Microbiome
pub_type: 杂志文章
doi:10.1186/s40168-016-0197-7
更新日期:2016-10-06 00:00:00
abstract:BACKGROUND:Sub-therapeutic antibiotics are widely used as growth promoters in the poultry industry; however, the resulting antibiotic resistance threatens public health. A plant-derived growth promoter, Macleaya cordata extract (MCE), with effective ingredients of benzylisoquinoline alkaloids, is a potential alternativ...
journal_title:Microbiome
pub_type: 杂志文章
doi:10.1186/s40168-018-0590-5
更新日期:2018-11-27 00:00:00
abstract:BACKGROUND:Understanding microbial interactions in engineering bioprocesses is important to enhance and optimize performance outcomes and requires dissection of the multi-layer complexities of microbial communities. However, unraveling microbial interactions as well as substrates involved in complex microbial communiti...
journal_title:Microbiome
pub_type: 杂志文章
doi:10.1186/s40168-019-0634-5
更新日期:2019-02-06 00:00:00
abstract:BACKGROUND:The use of culture-independent nucleic acid techniques, such as ribosomal RNA gene cloning library analysis, has unveiled the tremendous microbial diversity that exists in natural environments. In sharp contrast to this great achievement is the current difficulty in cultivating the majority of bacterial spec...
journal_title:Microbiome
pub_type: 杂志文章
doi:10.1186/2049-2618-1-4
更新日期:2013-01-09 00:00:00
abstract:BACKGROUND:Deep-sea hydrothermal vents are hotspots for productivity and biodiversity. Thermal pyrolysis and circulation produce fluids rich in hydrocarbons and reduced compounds that stimulate microbial activity in surrounding sediments. Several studies have characterized the diversity of Guaymas Basin (Gulf of Califo...
journal_title:Microbiome
pub_type: 杂志文章
doi:10.1186/s40168-017-0322-2
更新日期:2017-08-23 00:00:00
abstract:BACKGROUND:The photic zone of aquatic habitats is subjected to strong physicochemical gradients. To analyze the fine-scale variations in the marine microbiome, we collected seven samples from a single offshore location in the Mediterranean at 15 m depth intervals during a period of strong stratification, as well as two...
journal_title:Microbiome
pub_type: 杂志文章
doi:10.1186/s40168-018-0513-5
更新日期:2018-07-10 00:00:00
abstract::Following publication of the original article [1], the authors reported an error in Figure 1 and a text on page 13. In Figure 1, some areas are missing and the correct figure is presented here. On page 13, the sentence should be updated to the following (change has been indicated in bold italics). ...
journal_title:Microbiome
pub_type: 已发布勘误
doi:10.1186/s40168-019-0763-x
更新日期:2019-11-14 00:00:00
abstract:BACKGROUND:Metagenomics is revolutionizing the study of microorganisms and their involvement in biological, biomedical, and geochemical processes, allowing us to investigate by direct sequencing a tremendous diversity of organisms without the need for prior cultivation. Unicellular eukaryotes play essential roles in mo...
journal_title:Microbiome
pub_type: 杂志文章
doi:10.1186/s40168-020-00808-x
更新日期:2020-04-03 00:00:00
abstract:BACKGROUND:Parkinson's disease (PD) is a neurodegenerative disorder with no absolute cure. The evidence of the involvement of gut microbiota in PD pathogenesis suggests the need to identify certain molecule(s) derived from the gut microbiota, which has the potential to manage PD. Osteocalcin (OCN), an osteoblast-secret...
journal_title:Microbiome
pub_type: 杂志文章
doi:10.1186/s40168-020-00988-6
更新日期:2021-01-31 00:00:00
abstract::The vaginal microbiota plays a significant role in health and disease of the female reproductive tract. Next-generation sequencing techniques based upon the analysis of bacterial 16S rRNA genes permit in-depth study of vaginal microbial community structure to a level of detail not possible with standard culture-based ...
journal_title:Microbiome
pub_type: 杂志文章,评审
doi:10.1186/s40168-016-0203-0
更新日期:2016-11-01 00:00:00
abstract:BACKGROUND:The correct establishment of the human gut microbiota represents a crucial development that commences at birth. Different hypotheses propose that the infant gut microbiota is derived from, among other sources, the mother's fecal/vaginal microbiota and human milk. RESULTS:The composition of bifidobacterial c...
journal_title:Microbiome
pub_type: 杂志文章
doi:10.1186/s40168-017-0282-6
更新日期:2017-06-26 00:00:00
abstract:BACKGROUND:Microorganisms have long been associated with oxic and anoxic degradation of hydrocarbons in oil reservoirs and oil production facilities. While we can readily determine the abundance of microorganisms in the reservoir and study their activity in the laboratory, it has been challenging to resolve what microb...
journal_title:Microbiome
pub_type: 杂志文章
doi:10.1186/s40168-017-0392-1
更新日期:2018-01-05 00:00:00