Abstract:
:The domestic yak (Bos grunniens) from the Qinghai-Tibet Plateau is an important animal model in high-altitude adaptation studies. Here, we performed the genome-wide selective sweep analysis to identify the candidate copy number variation (CNV) for the high-altitude adaptation of yaks. A total of 531 autosomal CNVs were determined from 29 yak genome-wide resequencing data (15 high- and 14 low-altitude distributions) by using a CNV caller with a CNV identification interval > 5 kb, CNV silhouette score > 0.7, and minimum allele frequency > 0.05. Most high-frequency CNVs were located at the exonic (44.63%) and intergenic (46.52%) regions. In accordance with the results of the selective sweep analysis, 7 candidate CNVs were identified from the interaction of the top 20 CNVs with highest divergence from the FST and VST between the low (LA) and high (HA) altitudes. Five genes (i.e., GRIK4, IFNLR1, LOC102275985, GRHL3, and LOC102275713) were also annotated from the seven candidate CNVs and their upstream and downstream ranges at 300 kb. GRIK4, IFNLR1, and LOC102275985 were enriched in five known signal pathways, namely, glutamatergic synapse, JAK-STAT signaling pathway, cytokine-cytokine receptor interaction, neuroactive ligand-receptor interaction, and olfactory transduction. These pathways are involved in the environmental adaptability and various physiological functions of animals, especially the physiological regulation under a hypoxic environment. The results of this study advanced the understanding of CNV as an important genomic structure variant type that contributes to HA adaptation and helped further explain the molecular mechanisms underlying the altitude adaptability of yaks.
journal_name
3 Biotechjournal_title
3 Biotechauthors
Guang-Xin E,Yang BG,Zhu YB,Duang XH,Basang WD,Luo XL,An TWdoi
10.1007/s13205-020-02254-wsubject
Has Abstractpub_date
2020-06-01 00:00:00pages
259issue
6eissn
2190-572Xissn
2190-5738pii
2254journal_volume
10pub_type
相关文献
3 Biotech文献大全abstract::Marine sediments accommodate plethora of diverse microorganisms with varying ecological functions. In the present study, we isolated bacteria from surficial sediments of south east Arabian Sea (AS) and evaluated their bioactive potentials. A total of 131 isolates belonging to the phylum: γ-Proteobacteria (63%), Bacill...
journal_title:3 Biotech
pub_type: 杂志文章
doi:10.1007/s13205-016-0556-x
更新日期:2016-12-01 00:00:00
abstract::Isolation of high-quality RNA from weed plants such as Parthenium hysterophorus is a difficult task due to the hindrance caused by numerous secondary metabolites. Such metabolites not only affect the quality and yield of RNA, but also limit the quality of downstream applications. Therefore, the present study was under...
journal_title:3 Biotech
pub_type: 杂志文章
doi:10.1007/s13205-017-1003-3
更新日期:2017-12-01 00:00:00
abstract::The aim of this study was to explore the anti-psoriatic effect and potential mechanism of Angelica polysaccharide (APS) on an in vitro HaCaT cell model. MTS assay was performed to determine whether APS has the ability to inhibit the proliferation of HaCaT cells. RNA-sequencing (RNA-seq) was performed to investigate th...
journal_title:3 Biotech
pub_type: 杂志文章
doi:10.1007/s13205-019-1828-z
更新日期:2019-08-01 00:00:00
abstract::Alkaline hydrogen peroxide (AHP) as a pretreatment effectively enhances the increasing enzymatic digestibility of oil palm trunk (OPT) for conversion to biofuels and bioproducts in the biorefinery processes. The effect of hydrogen peroxide concentration (1-5%), temperature (50-90 °C), and time (30-90 min) were studied...
journal_title:3 Biotech
pub_type: 杂志文章
doi:10.1007/s13205-020-02169-6
更新日期:2020-04-01 00:00:00
abstract::In the present study, the growth conditions and accumulation of ectoines (ectoine and hydroxyectoine) by Paludifilum halophilum DSM 102817T under salt stress conditions have been investigated. The productivity assay of this strain for ectoines revealed that the highest cellular content was reached in the minimal gluco...
journal_title:3 Biotech
pub_type: 杂志文章
doi:10.1007/s13205-020-02512-x
更新日期:2020-12-01 00:00:00
abstract::Energy efficiency ratio is significant in completely estimating lignocellulosic biomass pretreatment. In this work, rice straw (RS) was pretreated by ultra-high pressure (UHP), ionic liquid microemulsion (ILM), and a combination of UHP and ILM (ILM + UHP) at mild temperature. The chemical composition, crystalline stru...
journal_title:3 Biotech
pub_type: 杂志文章
doi:10.1007/s13205-018-1216-0
更新日期:2018-04-01 00:00:00
abstract::Parthenium hysterophorus is a noxious weed in America, Asia, Africa and Australia. This weed is considered to be a cause of allergic respiratory problems, contact dermatitis, mutagenicity in human and livestock. Crop production is drastically reduced owing to its allelopathy. Also aggressive dominance of this weed thr...
journal_title:3 Biotech
pub_type: 杂志文章
doi:10.1007/s13205-011-0007-7
更新日期:2011-07-01 00:00:00
abstract::A one-step formic acid-catalyzed organosolv process using a low-boiling point acid-solvent system was studied for fractionation of sugarcane bagasse. Compared to H2SO4, the use of formic acid as a promoter resulted in higher efficiency and selectivity on removals of hemicellulose and lignin with increased enzymatic di...
journal_title:3 Biotech
pub_type: 杂志文章
doi:10.1007/s13205-018-1244-9
更新日期:2018-05-01 00:00:00
abstract::In this study, analytical profiling of the bevacizumab (BVZ) biosimilars (N = 3) approved in India were evaluated for charge heterogeneity, isoelectric focusing, aggregation and in vitro potency analysis. The charge variants were characterized using high performance cation-exchange chromatography (CEX-HPLC), capillary...
journal_title:3 Biotech
pub_type: 杂志文章
doi:10.1007/s13205-020-02506-9
更新日期:2020-12-01 00:00:00
abstract::The natural estrogen 17β-estradiol (17β-E2) is a major endocrine disruptor. Accordingly, due to their frequent presence in global surface waters, prolonged exposure to estrogen-contaminated water may disrupt sexual development in animals. It has adverse effects on wildlife and humans. To date, the most effective strat...
journal_title:3 Biotech
pub_type:
doi:10.1007/s13205-020-2155-0
更新日期:2020-04-01 00:00:00
abstract::This paper has studied the success of implantation for 16 commercial active dry yeasts (ADYs) during industrial fermentation (30) and the impact of these yeasts during spontaneous fermentations (19) in 10 wineries from the Denomination of Origin "Vinos de Madrid" over two consecutive years. Yeasts strains were identif...
journal_title:3 Biotech
pub_type: 杂志文章
doi:10.1007/s13205-019-1913-3
更新日期:2019-11-01 00:00:00
abstract::The current study aimed at exploring the diversity of bacterial lactase genes in the intestinal mucosa of mice with dysbacterial diarrhea induced by antibiotics and to provide experimental basis for antibiotics-induced diarrhea. Mice model of dysbacterial diarrhea was established by gastric perfusion with mixture of c...
journal_title:3 Biotech
pub_type: 杂志文章
doi:10.1007/s13205-018-1191-5
更新日期:2018-03-01 00:00:00
abstract::In the present study, we investigated radiation mitigating activities of Psidium guajava L. (P. guajava) against whole-body X- ray induced damages in albino Wistar rat model. The animals were orally administered with 200 mg/kg bodyweight of hydroalcoholic leaf extract of P. guajava for five consecutive days and on the...
journal_title:3 Biotech
pub_type: 杂志文章
doi:10.1007/s13205-020-02484-y
更新日期:2020-12-01 00:00:00
abstract::The aim of this study was to produce sugarcane plantlets from cell suspension culture and study its genetic fidelity using molecular markers. The study was carried out using sugarcane varieties Co 86032 and Q117. Callus cultures of both the varieties were optimized using six different callus induction media. After scr...
journal_title:3 Biotech
pub_type: 杂志文章
doi:10.1007/s13205-016-0579-3
更新日期:2017-05-01 00:00:00
abstract::The complex starter culture for artificial pit mud (APMSC) hosts a wide variety of microbial communities that play a crucial role in Chinese strong-flavor Baijiu production. Based on its organoleptic properties, the quality of APMSC can be divided into normal and inferior quality grades. However, the relationship betw...
journal_title:3 Biotech
pub_type: 杂志文章
doi:10.1007/s13205-019-1622-y
更新日期:2019-03-01 00:00:00
abstract::Somatic cloning, also known as somatic cell nuclear transfer (SCNT), is a promising technology which has been expected to rapidly extend the population of elaborately selected breeding boars with superior production performance. Chinese Guike No. 1 pig breed is a novel swine specialized strain incorporated with the pe...
journal_title:3 Biotech
pub_type: 杂志文章
doi:10.1007/s13205-016-0525-4
更新日期:2016-12-01 00:00:00
abstract::The present study illustrates optimization and synergetic potential of alga Chlorella pyrenoidosa for lipid production and remediation of Dairy industry wastewater (DIWW) through response surface methodology (RSM). Maximum lipid productivity of 34.41% was obtained under 50% DIWW supplemented with 0 mg L-1 nitrate (NO3...
journal_title:3 Biotech
pub_type: 杂志文章
doi:10.1007/s13205-018-1342-8
更新日期:2018-08-01 00:00:00
abstract::Selection of the raw material and its efficient utilization are the critical factors in economization of second generation (2G) ethanol production. Fermentation of the released sugars into ethanol by a suitable ethanol producing microorganism using cheap media ingredients is the cornerstone of the overall process. Thi...
journal_title:3 Biotech
pub_type: 杂志文章
doi:10.1007/s13205-012-0098-9
更新日期:2013-10-01 00:00:00
abstract::The immobilization of enzymes improves their stability in non-conventional media such as organic solvents. In this work, the effects of solvents (DMSO, methanol, ethanol, and n-propanol) on the endoglucanase Cel9A activity and stability were studied. Then, the enzymes were stabilized by its immobilization on chitosan ...
journal_title:3 Biotech
pub_type: 杂志文章
doi:10.1007/s13205-019-1794-5
更新日期:2019-07-01 00:00:00
abstract::Although endophytic bacteria are known to colonize Panax ginseng, little is known about their diversity and roles. We addressed in the present study by comparing endophytic bacterial populations in P. ginseng plants of different ages (2-6 years) and in various tissue types (root, stem, leaf, and flower stalk). A total...
journal_title:3 Biotech
pub_type:
doi:10.1007/s13205-018-1417-6
更新日期:2018-09-01 00:00:00
abstract::Today, the role of nanotechnology in human life is undeniable as a broad range of industries, particularly food and medicine sectors, have been dramatically influenced. Nanomaterials can contribute to food safety by forming new nano-sized ingredients with modified physicochemical characteristics. Nanotechnologies can ...
journal_title:3 Biotech
pub_type: 杂志文章,评审
doi:10.1007/s13205-020-02409-9
更新日期:2020-10-01 00:00:00
abstract::The effects of corn steep liquor (CSL) on hydrocarbon degradation and microbial community structure and function was evaluated in field-moist soil microcosms. Chronically polluted soil treated with CSL (AB4) and an untreated control (3S) was compared over a period of 6 weeks. Gas chromatographic fingerprints of residu...
journal_title:3 Biotech
pub_type: 杂志文章
doi:10.1007/s13205-019-1580-4
更新日期:2019-02-01 00:00:00
abstract::Laccases (benzenediol: oxygen oxidoreductase, EC 1.10.3.2) are multi-copper enzymes which catalyze the oxidation of a wide range of phenolic and non-phenolic aromatic compounds in the presence or absence of a mediator. Till date, laccases have mostly been isolated from fungi and plants, whereas laccase from bacteria h...
journal_title:3 Biotech
pub_type: 杂志文章,评审
doi:10.1007/s13205-017-0955-7
更新日期:2017-10-01 00:00:00
abstract::This bibliometric-based review analyses the trends in 1010 published articles (1990 to mid-2018) on the high-value application of Chlorella, and illustrates the evolution and latest tendencies at a global level by the number of publications and their distribution, issuing institutions and countries or regions, the sou...
journal_title:3 Biotech
pub_type: 杂志文章
doi:10.1007/s13205-020-2102-0
更新日期:2020-03-01 00:00:00
abstract::Trehalose is a non-reducing disaccharide sugar that widely exists in a variety of organisms, such as bacteria and eukaryotes except the vertebrates. It plays an important role in a number of critical metabolic functions especially in response to stressful environmental conditions. However, the biosynthetic pathways of...
journal_title:3 Biotech
pub_type: 杂志文章
doi:10.1007/s13205-017-0983-3
更新日期:2017-10-01 00:00:00
abstract::In this work we evaluated methanolic extracts from different parts (leaves, seeds, fruit peel and pulp) of Chamaerops humilis L. for antioxidant activity and the ability to inhibit enzymes linked with neurodegenerative diseases: acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and tyrosinase (TYR). The total ...
journal_title:3 Biotech
pub_type: 杂志文章
doi:10.1007/s13205-018-1110-9
更新日期:2018-02-01 00:00:00
abstract::Phosphoglucomutase (PGM) is a key enzyme in glycolysis and gluconeogenesis, regulating both glycogen and trehalose metabolism in insects. In this study, we explored the potential function of phosphoglucomutase (PGM) using RNA interference technology in Nilaparvata lugens, the brown planthopper. PGM1 and PGM2 were foun...
journal_title:3 Biotech
pub_type: 杂志文章
doi:10.1007/s13205-020-2053-5
更新日期:2020-02-01 00:00:00
abstract::Biomass of Aspergillus awamori was investigated for mycochemicals, total phenolic compounds (TPC), condensed tannin content (CTC), free-radical scavenging potential (FRSP), and DNA damage protection activity. FRSP was determined using DPPH, ABTS, FRAP (Ferric reducing antioxidant power), metal chelating activity, and ...
journal_title:3 Biotech
pub_type: 杂志文章
doi:10.1007/s13205-017-0834-2
更新日期:2017-07-01 00:00:00
abstract::Head and neck squamous cell carcinoma (HNSCC) is the sixth most common non-skin cancer in the world. Tobacco chewing is implicated with most of the cases of HNSCC but this type of cancer is increasing in non-tobacco chewers as well. This study was instigated to provide comprehensive variant and gene-level data in HNSC...
journal_title:3 Biotech
pub_type: 杂志文章
doi:10.1007/s13205-014-0267-0
更新日期:2015-10-01 00:00:00
abstract::We have isolated three novel strains of Trichoderma (two T. harzianum and one T. atroviride) from wild mushroom and tree bark, and evaluated their biocontrol potential against Sclerotium delphinii infecting cultivated cotton seedlings. T. harzianum strain CICR-G, isolated as a natural mycoparasite on a tree-pathogenic...
journal_title:3 Biotech
pub_type: 杂志文章
doi:10.1007/s13205-013-0150-4
更新日期:2014-06-01 00:00:00