Proliferation and benevolence-A framework for dissecting the mechanisms of microbial virulence and health promotion.

Abstract:

:Key topics in the study of host-microbe interactions-such as the prevention of drug resistance and the exploitation of beneficial effects of bacteria-would benefit from concerted efforts with both mechanistic and evolutionary approaches. But due to differences in intellectual traditions, insights gained in one field rarely benefit the other. Here, we develop a conceptual and analytical framework for the integrated study of host-microbe interactions. This framework partitions the health effects of microbes and the effector molecules they produce into components with different evolutionary implications. It thereby facilitates the prediction of evolutionary responses to inhibition and exploitation of specific molecular mechanisms.

journal_name

Evol Appl

authors

Wollein Waldetoft K,Råberg L,Lood R

doi

10.1111/eva.12952

subject

Has Abstract

pub_date

2020-03-31 00:00:00

pages

879-888

issue

5

issn

1752-4571

pii

EVA12952

journal_volume

13

pub_type

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