Abstract:
:Key topics in the study of host-microbe interactions-such as the prevention of drug resistance and the exploitation of beneficial effects of bacteria-would benefit from concerted efforts with both mechanistic and evolutionary approaches. But due to differences in intellectual traditions, insights gained in one field rarely benefit the other. Here, we develop a conceptual and analytical framework for the integrated study of host-microbe interactions. This framework partitions the health effects of microbes and the effector molecules they produce into components with different evolutionary implications. It thereby facilitates the prediction of evolutionary responses to inhibition and exploitation of specific molecular mechanisms.
journal_name
Evol Appljournal_title
Evolutionary applicationsauthors
Wollein Waldetoft K,Råberg L,Lood Rdoi
10.1111/eva.12952subject
Has Abstractpub_date
2020-03-31 00:00:00pages
879-888issue
5issn
1752-4571pii
EVA12952journal_volume
13pub_type
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